PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7511888-1 1994 There is evidence from animal models that the iodine content of thyroglobulin (Tg) may influence its antigenicity in thyroid autoimmunity. Iodine 46-52 thyroglobulin Mus musculus 64-77 16547286-1 2006 Thyroglobulin (Tg) is unique in its ability to incorporate and store available iodine in the form of iodotyrosyl residues. Iodine 79-85 thyroglobulin Mus musculus 0-13 16547286-1 2006 Thyroglobulin (Tg) is unique in its ability to incorporate and store available iodine in the form of iodotyrosyl residues. Iodine 79-85 thyroglobulin Mus musculus 15-17 16547286-2 2006 Iodination of Tg has been known to increase its immunopathogenicity in experimental animals, presumably through the formation of iodine-containing neoantigenic determinants that can elicit an autoimmune response, but defined pathogenic Tg peptides carrying iodotyrosyls have not yet been identified. Iodine 129-135 thyroglobulin Mus musculus 14-16 15728526-2 2005 We report that a THB mAb recognizing the 5" iodine atom of the outer phenolic ring of thyroxine (T4) can block T cell recognition of the pathogenic thyroglobulin (Tg) peptide (2549-2560) that contains T4 at aa position 2553 (T4(2553)). Iodine 44-50 thyroglobulin Mus musculus 148-161 12023396-2 2002 One hypothesis has been that enhanced incorporation of iodine in thyroglobulin (Tg) promotes the generation of pathogenic T cell determinants. Iodine 55-61 thyroglobulin Mus musculus 65-78 10502541-12 1999 The disease, moreover, can be transferred adoptively, using spleen cells from iodine-fed donors treated in vitro with iodinated thyroglobulin. Iodine 78-84 thyroglobulin Mus musculus 128-141 10502541-14 1999 Based on T-cell proliferation, it appears that the NOD-H2(h4) strain of mice has innately a greater response to murine thyroglobulin than do other mouse strains and that the proliferation is increased even more by feeding iodine. Iodine 222-228 thyroglobulin Mus musculus 119-132 10502541-15 1999 We suggest, therefore, that the presence of iodine increases the autoantigenic potency of thyroglobulin, a major pathogenic antigen in the induction of autoimmune thyroiditis. Iodine 44-50 thyroglobulin Mus musculus 90-103 20687399-0 2010 Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. Iodine 0-6 thyroglobulin Mus musculus 18-31 20687399-0 2010 Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. Iodine 60-66 thyroglobulin Mus musculus 18-31 20687399-2 2010 The aim of the study was to examine whether the NOD.H2h4 genetic background predisposes to enhanced iodine organification in thyroglobulin (Tg), a target autoantigen in ISAT. Iodine 100-106 thyroglobulin Mus musculus 125-138 20687399-2 2010 The aim of the study was to examine whether the NOD.H2h4 genetic background predisposes to enhanced iodine organification in thyroglobulin (Tg), a target autoantigen in ISAT. Iodine 100-106 thyroglobulin Mus musculus 140-142 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. Iodine 72-78 thyroglobulin Mus musculus 128-130 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. Iodine 72-78 thyroglobulin Mus musculus 164-166 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. Iodine 72-78 thyroglobulin Mus musculus 164-166 20687399-5 2010 RESULTS: The iodine content of Tg was not significantly different between control (9.0 +/- 2.7 I atoms per monomer) and iodine-fed mice (10.9 +/- 0.3 I atoms per monomer). Iodine 13-19 thyroglobulin Mus musculus 31-33 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 122-124 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 52-53 thyroglobulin Mus musculus 122-124 3516644-6 1986 High iodine supply has a retarding effect on Tgb diffusion in the colloid of mice thyroids. Iodine 5-11 thyroglobulin Mus musculus 45-48