PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33995066-0	2021	Boosting Akt Pathway by Rupatadine Modulates Th17/Tregs Balance for Attenuation of Isoproterenol-Induced Heart Failure in Rats.	rupatadine	24-34	AKT serine/threonine kinase 1	Rattus norvegicus	9-12	
33995066-3	2021	It also explored the role of PI3k/Akt as a possible mechanistic pathway, through which rupatadine could modulate Th17/Tregs balance to display its effect.	rupatadine	87-97	AKT serine/threonine kinase 1	Rattus norvegicus	34-37	
33995066-8	2021	Rupatadine treatment mitigated isoproterenol-induced activation of STAT-3 signaling and the imbalance in p-Akt/total Akt ratio affording marked decrease in atrogin-1 and apoptotic biomarkers.	rupatadine	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	107-110	
33995066-8	2021	Rupatadine treatment mitigated isoproterenol-induced activation of STAT-3 signaling and the imbalance in p-Akt/total Akt ratio affording marked decrease in atrogin-1 and apoptotic biomarkers.	rupatadine	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	117-120	
33995066-11	2021	In conclusion, rupatadine could be an effective therapy against the development of isoproterenol-induced heart failure where PI3K/Akt pathway seems to play a crucial role in its protective effect.	rupatadine	15-25	AKT serine/threonine kinase 1	Rattus norvegicus	130-133