PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34476934-9 2021 PRMT5 was enhanced in cigarette smoke extract-induced 16HBE. 16hbe 54-59 protein arginine methyltransferase 5 Homo sapiens 0-5 34476934-10 2021 Knockdown of PRMT5 increased cell viability of cigarette smoke extract-induced 16HBE, and attenuated cigarette smoke extract-induced increase of IL-6, IL-8, TNF-alpha, and IL-1beta. 16hbe 79-84 protein arginine methyltransferase 5 Homo sapiens 13-18 34476934-11 2021 Up-regulation of C-X-C Motif Chemokine 10 (CXCL10) in cigarette smoke extract-induced 16HBE was restored by knockdown of PRMT5. 16hbe 86-91 protein arginine methyltransferase 5 Homo sapiens 121-126 34476934-13 2021 Moreover, PRMT5 silence-induced increase of cell viability in cigarette smoke extract-induced 16HBE was reversed by over-expression of CXCL10. 16hbe 94-99 protein arginine methyltransferase 5 Homo sapiens 10-15 34476934-14 2021 CONCLUSION: Knockdown of PRMT5 promoted cell viability of cigarette smoke extract-induced 16HBE, and reduced inflammation through down-regulation of CXCL10. 16hbe 90-95 protein arginine methyltransferase 5 Homo sapiens 25-30