PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10871319-8	2000	Angiotensin type 1 receptor (AT(1)R) blockade with EXP3174 inhibited NE release, whereas angiotensin type 2 receptor (AT(2)R) blockade with PD123319 did not.	losartan carboxylic acid	51-58	angiotensin II receptor type 1	Homo sapiens	0-27	
17991883-7	2008	Inhibition by an AT1 receptor antagonist (losartan metabolite: E3174) or catalase, confirmed that Ang II-induced DNA damage was AT1 receptor-mediated, via the induction of ROS.	losartan carboxylic acid	63-68	angiotensin II receptor type 1	Homo sapiens	128-131	
14716224-6	2004	These effects were blocked by the selective AT1-receptor antagonists EXP3174 and irbesartan (10 nmol/L).	losartan carboxylic acid	69-76	angiotensin II receptor type 1	Homo sapiens	44-47	
11683476-5	2001	The relative receptor binding affinities of currently available AT1-receptor blockers is candesartan > irbesartan > valsartan/EXP-3174/telmisartan > tasosartan > losartan > eprosartan.	losartan carboxylic acid	132-140	angiotensin II receptor type 1	Homo sapiens	64-67	
10871319-8	2000	Angiotensin type 1 receptor (AT(1)R) blockade with EXP3174 inhibited NE release, whereas angiotensin type 2 receptor (AT(2)R) blockade with PD123319 did not.	losartan carboxylic acid	51-58	angiotensin II receptor type 1	Homo sapiens	29-35	
10579749-5	1999	Among the current AT1 receptor antagonists, the rank order of the relative binding affinities (highest affinity = 1) is: candesartan 1, telmisartan 10, E3174 (the active metabolite of losartan) 10, tasosartan 20, losartan 50, eprosartan 100 and the prodrug candesartan cilexetil 280.	losartan carboxylic acid	152-157	angiotensin II receptor type 1	Homo sapiens	18-21	
8653989-1	1996	Losartan, a selective angiotensin II (AT1) receptor antagonist for hypertension, is metabolized to an active carboxylic acid metabolite, E-3174, which has a longer half-life.	losartan carboxylic acid	137-143	angiotensin II receptor type 1	Homo sapiens	38-41	
25128717-3	2014	Using the model ligand EXP3174, a small-molecule antagonist for the angiotensin II receptor type 1 (AT1R), we investigated the ligand"s affinity before and after its PEGylation and when attached to PEGylated nanoparticles.	losartan carboxylic acid	23-30	angiotensin II receptor type 1	Homo sapiens	68-98	
25128717-3	2014	Using the model ligand EXP3174, a small-molecule antagonist for the angiotensin II receptor type 1 (AT1R), we investigated the ligand"s affinity before and after its PEGylation and when attached to PEGylated nanoparticles.	losartan carboxylic acid	23-30	angiotensin II receptor type 1	Homo sapiens	100-104