PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9542475-1	1998	BACKGROUND: Losartan is metabolized by CYP2C9 and CYP3A4 to an active metabolite, E3174, which has greater antihypertensive activity than the parent compound.	losartan carboxylic acid	82-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	50-56	
19458107-1	2009	BACKGROUND: osartan is metabolized by CYP2C9 and CYP3A4 to an active metabolite, E-3174, which has greater antihypertensive activity than the parent compound.	losartan carboxylic acid	81-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55	
9542475-12	1998	On the basis of the minimal inhibitory effects observed with erythromycin, CYP3A4 appears to play a minor role in the in vivo metabolism of losartan to E3174.	losartan carboxylic acid	152-157	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81	
9551703-1	1998	OBJECTIVE: Losartan is metabolised to its active metabolite E-3174 by CYP2C9 and CYP3A4 in vitro.	losartan carboxylic acid	60-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87	
7736913-10	1995	Subsequently, it was shown that rabbit anti-CYP2C9 and anti-CYP3A3/4 inhibited the oxidation of losartan to E3174 in incubations with human liver microsomes.	losartan carboxylic acid	108-113	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-66