PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22867529-5 2013 The docking results also showed that the formation of new H-bonds between the N-H of the ethylenediamine group linked to the 6-alkoxy site and Asp776/Cys773 in the binding pocket of EGFR makes compounds 19 (IC50=12.1+-1.6 nM) and 20 (IC50=13.6+-0.8 nM) the most potent EGFR inhibitors in this class and worthy of further modification to obtain more potent anticancer compounds. ethylenediamine 89-104 epidermal growth factor receptor Homo sapiens 182-186 22867529-5 2013 The docking results also showed that the formation of new H-bonds between the N-H of the ethylenediamine group linked to the 6-alkoxy site and Asp776/Cys773 in the binding pocket of EGFR makes compounds 19 (IC50=12.1+-1.6 nM) and 20 (IC50=13.6+-0.8 nM) the most potent EGFR inhibitors in this class and worthy of further modification to obtain more potent anticancer compounds. ethylenediamine 89-104 epidermal growth factor receptor Homo sapiens 269-273