PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22393274-0	2012	Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts.	halofuginone	0-12	SMAD family member 3	Homo sapiens	28-33	
22393274-11	2012	Interestingly, under our experimental conditions, halofuginone treatment led to reduced protein expression of Smad3, which was both dose- and time-dependent.	halofuginone	50-62	SMAD family member 3	Homo sapiens	110-115	
17180598-3	2007	Halofuginone, an inhibitor of liver fibrosis, inhibits TGF-beta-dependent Smad3 phosphorylation in human HSCs in culture.	halofuginone	0-12	SMAD family member 3	Homo sapiens	74-79	
23480137-3	2008	Halofuginone, an inhibitor of the Smad3 phosphorylation, downstream of the TGFbeta signaling, inhibits the activation of fibroblasts and their ability to synthesize the extracellular matrix, regardless of their origin or location.	halofuginone	0-12	SMAD family member 3	Homo sapiens	34-39	
21117034-8	2011	Halofuginone, an inhibitor of Smad3 phosphorylation downstream of TGFbeta signaling, inhibits the activation of fibroblasts and their ability to synthesize ECM, regardless of their origin or location.	halofuginone	0-12	SMAD family member 3	Homo sapiens	30-35	
18714394-9	2008	Halofuginone, an inhibitor of myofibroblasts" activation and Smad3 phosphorylation, inhibited tumor development in xenografts derived from renal carcinoma cells harboring a reciprocal ASPL-TFE3 fusion transcript.	halofuginone	0-12	SMAD family member 3	Homo sapiens	61-66	
33433355-3	2021	Here we analyze the antifibrotic mechanisms of Halofuginone (HF), a drug reportedly able to inhibit the TGF-beta1-Smad3 pathway and to attenuate collagen synthesis, in an in-vitro keloid model using patient-derived Keloid Fibroblasts (KFs) isolated from fibrotic tissue collected during the "Scar Wars" clinical study (NCT NCT03312166).	halofuginone	47-59	SMAD family member 3	Homo sapiens	114-119	
28986385-5	2017	Four modes of actions of halofuginone against fibrosis have been presented: 1) Inhibition of mothers against decapentaplegic homolog 3 (Smad3) phosphorylation downstream of the TGF-beta signaling pathway, 2) reduction of collagen amounts, 3) decreases in ECM protein, and 4) selective prevention of Th17 cell differentiation.	halofuginone	25-37	SMAD family member 3	Homo sapiens	93-134	
28986385-5	2017	Four modes of actions of halofuginone against fibrosis have been presented: 1) Inhibition of mothers against decapentaplegic homolog 3 (Smad3) phosphorylation downstream of the TGF-beta signaling pathway, 2) reduction of collagen amounts, 3) decreases in ECM protein, and 4) selective prevention of Th17 cell differentiation.	halofuginone	25-37	SMAD family member 3	Homo sapiens	136-141	
12869955-8	2003	Inhibition of collagen synthesis by halofuginone is achieved by inhibiting transforming growth factor beta-dependent Smad3 phosphorylation.	halofuginone	36-48	SMAD family member 3	Homo sapiens	117-122	
26015407-2	2015	Because we recently demonstrated that TGF-beta/Smad cascade plays a crucial role in osteosarcoma metastatic progression, we investigated the effect of halofuginone, identified as an inhibitor of the TGF-beta/Smad3 cascade, on osteosarcoma progression.	halofuginone	151-163	SMAD family member 3	Homo sapiens	208-213	
26015407-6	2015	Moreover, halofuginone inhibits the TGF-beta/Smad3 cascade and the response of TGF-beta key targets involved in the metastases dissemination process such as MMP-2.	halofuginone	10-22	SMAD family member 3	Homo sapiens	45-50	
25569515-3	2015	At present two modes of halofuginone actions have been described: (1) Inhibition of Smad3 phosphorylation downstream of the TGFbeta signaling pathway results in inhibition of fibroblasts-to-myofibroblasts transition and fibrosis.	halofuginone	24-36	SMAD family member 3	Homo sapiens	84-89	
23845969-0	2014	Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts.	halofuginone	0-12	SMAD family member 3	Homo sapiens	28-33