PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34162861-4 2021 We identify homoharringtonine and halofuginone as the most attractive agents, reducing endogenous TMPRSS2 expression at sub-micromolar concentrations. halofuginone 34-46 transmembrane serine protease 2 Homo sapiens 98-105 34162861-6 2021 We further demonstrate that halofuginone modulates TMPRSS2 levels through proteasomal-mediated degradation that involves the E3 ubiquitin ligase component DDB1- and CUL4-associated factor 1 (DCAF1). halofuginone 28-40 transmembrane serine protease 2 Homo sapiens 51-58 32818215-4 2020 Among these, homoharringtonine and halofuginone appear the most potent agents, reducing endogenous TMPRSS2 expression at sub-micromolar concentrations. halofuginone 35-47 transmembrane serine protease 2 Homo sapiens 99-106 32818215-6 2020 We further demonstrate that halofuginone modulates TMPRSS2 levels through proteasomal-mediated degradation that involves the E3 ubiquitin ligase component DDB1- and CUL4-associated factor 1 (DCAF1). halofuginone 28-40 transmembrane serine protease 2 Homo sapiens 51-58