PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20616155-7 2010 Moreover, the redox status of the 2-Cys Prx was imbalanced in the ntrc mutant but not in the trxx mutant. 2-cys 34-39 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 66-70 20616155-8 2010 These results show that NTRC is the most relevant pathway for chloroplast 2-Cys Prx reduction in vivo, but the antioxidant function of this system is not essential. 2-cys 74-79 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 24-28 19825629-1 2009 NADPH thioredoxin reductase C (NTRC) is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase (NTR) and thioredoxin (TRX) activities for the efficient reduction of 2-Cys peroxiredoxin (2-Cys PRX). 2-cys 177-182 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-29 19825629-1 2009 NADPH thioredoxin reductase C (NTRC) is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase (NTR) and thioredoxin (TRX) activities for the efficient reduction of 2-Cys peroxiredoxin (2-Cys PRX). 2-cys 177-182 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 31-35 19825629-1 2009 NADPH thioredoxin reductase C (NTRC) is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase (NTR) and thioredoxin (TRX) activities for the efficient reduction of 2-Cys peroxiredoxin (2-Cys PRX). 2-cys 198-203 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-29 19825629-1 2009 NADPH thioredoxin reductase C (NTRC) is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase (NTR) and thioredoxin (TRX) activities for the efficient reduction of 2-Cys peroxiredoxin (2-Cys PRX). 2-cys 198-203 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 31-35 33142810-5 2020 Interestingly, Arabidopsis mutants combining the deficiencies of x- or f-type Trxs and NTRC display very severe growth inhibition phenotypes, which are partially rescued by decreased levels of 2-Cys peroxiredoxins (Prxs). 2-cys 193-198 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 87-91 19825615-1 2009 Chloroplast 2-Cys peroxiredoxins (2-Cys Prxs) are efficiently reduced by NADPH Thioredoxin reductase C (NTRC). 2-cys 12-17 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 104-108 19825615-1 2009 Chloroplast 2-Cys peroxiredoxins (2-Cys Prxs) are efficiently reduced by NADPH Thioredoxin reductase C (NTRC). 2-cys 34-39 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 104-108 19825615-4 2009 NTRC deficiency caused a lower content of fully reduced 2-Cys Prxs, which was undetectable in darkness, suggesting that NTRC is the most important pathway for 2-Cys Prx reduction, probably the only one during the night. 2-cys 56-61 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-4 19825615-4 2009 NTRC deficiency caused a lower content of fully reduced 2-Cys Prxs, which was undetectable in darkness, suggesting that NTRC is the most important pathway for 2-Cys Prx reduction, probably the only one during the night. 2-cys 159-164 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-4 19825615-7 2009 2-Cys Prx overoxidation was lower in the NTRC mutant. 2-cys 0-5 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 41-45 19825615-8 2009 These results show the important function of NTRC to maintain the redox equilibrium of chloroplast 2-Cys Prxs. 2-cys 99-104 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 45-49 18625226-3 2008 A specific involvement of NTRC during biosynthesis of protochlorophyllide is indicated from in vitro aerobic cyclase assays in which the conversion of Mg-protoporhyrin monomethyl ester into protochlorophyllide is stimulated by addition of the NTRC/2-Cys peroxiredoxin system. 2-cys 248-253 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 26-30 34618130-4 2021 However, NTRC was proposed to participate in redox regulation of additional targets, prompting inquiry into whether the function of NTRC depends on its capacity to maintain the redox balance of 2-Cys Prxs or by direct redox interaction with chloroplast enzymes. 2-cys 194-199 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 132-136 34618130-7 2021 These results suggest that the most relevant function of NTRC is in controlling the redox balance of 2-Cys Prxs. 2-cys 101-106 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 57-61 33142810-6 2020 These findings indicate that the reducing capacity of Trxs f and x is modulated by the redox balance of 2-Cys Prxs, which is controlled by NTRC. 2-cys 104-109 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 139-143 28692378-4 2017 NTRC efficiently reduces 2-Cys peroxiredoxins (Prxs), hence having antioxidant function. 2-cys 25-30 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-4 31294455-7 2019 The identification of proteins co-purified in these complexes by MS revealed the relevance of the NTRC-2-Cys PRX system in the redox regulation of multiple chloroplast processes. 2-cys 103-108 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 98-102 29078290-0 2017 NTRC-dependent redox balance of 2-Cys peroxiredoxins is needed for optimal function of the photosynthetic apparatus. 2-cys 32-37 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-4 29078290-4 2017 NTRC efficiently reduces 2-Cys peroxiredoxins (Prxs), thus having antioxidant function, but also participates in redox regulation of metabolic pathways previously established to be regulated by Trxs. 2-cys 25-30 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 0-4 29078290-6 2017 Here we show that decreased levels of 2-Cys Prxs suppress the phenotype of the Arabidopsis thaliana ntrc KO mutant. 2-cys 38-43 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 100-104 29078290-7 2017 The excess of oxidized 2-Cys Prxs in NTRC-deficient plants drains reducing power from chloroplast Trxs, which results in low efficiency of light energy utilization and impaired redox regulation of Calvin-Benson cycle enzymes. 2-cys 23-28 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 37-41 29078290-8 2017 Moreover, the dramatic phenotype of the ntrc-trxf1f2 triple mutant, lacking NTRC and f-type Trxs, was also suppressed by decreased 2-Cys Prxs contents, as the ntrc-trxf1f2-Delta2cp mutant partially recovered the efficiency of light energy utilization and exhibited WT rate of CO2 fixation and growth phenotype. 2-cys 131-136 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 40-44 29078290-10 2017 It is proposed that the Fd-FTR-Trx and NTRC redox systems are linked by the redox balance of 2-Cys Prxs, which is crucial for chloroplast function. 2-cys 93-98 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 39-43 25560178-5 2015 In chloroplasts, the redox status of 2-Cys Prxs is highly dependent on NADPH-thioredoxin reductase C (NTRC) and Srx; however, the relationship of these activities in determining the level of 2-Cys Prx overoxidation is unknown. 2-cys 37-42 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 71-100 25560178-5 2015 In chloroplasts, the redox status of 2-Cys Prxs is highly dependent on NADPH-thioredoxin reductase C (NTRC) and Srx; however, the relationship of these activities in determining the level of 2-Cys Prx overoxidation is unknown. 2-cys 37-42 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 102-106 25560178-8 2015 The deficiency of NTRC causes reduced overoxidation of 2-Cys Prxs, whereas the deficiency of Srx has the opposite effect. 2-cys 55-60 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 18-22 25560178-9 2015 Moreover, in vitro analyses show that the disulfide bond linking the resolving and peroxidatic cysteines protects the latter from overoxidation, thus explaining the dominant role of NTRC on the level of 2-Cys Prx overoxidation in vivo. 2-cys 203-208 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 182-186 25560178-11 2015 Additionally, the low level of 2-Cys Prx overoxidation in the ntrc mutant is light dependent, suggesting that the redox status of 2-Cys Prxs in chloroplasts depends on light rather than the circadian clock. 2-cys 31-36 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 62-66 25560178-11 2015 Additionally, the low level of 2-Cys Prx overoxidation in the ntrc mutant is light dependent, suggesting that the redox status of 2-Cys Prxs in chloroplasts depends on light rather than the circadian clock. 2-cys 130-135 NADPH-dependent thioredoxin reductase C Arabidopsis thaliana 62-66