PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30285579-0 2019 Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling. tomatidine 0-10 LOC222344 Homo sapiens 112-117 30285579-7 2019 At the molecular level, tomatidine abrogated phosphorylation of c-Jun N-terminal kinase (JNK)/p38, NF-kappaB, and protein kinase B (Akt) pathway proteins by suppressing RANK expression, inhibiting the binding of TRAF6 to RANK, and downregulating the osteoclastogenesis marker-related protein expression. tomatidine 24-34 LOC222344 Homo sapiens 212-217 30285579-8 2019 In summary, these data demonstrated that tomatidine attenuated osteoclast formation and function by modulating multiple TRAF6-mediated pathways. tomatidine 41-51 LOC222344 Homo sapiens 120-125