PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9539749-0 1998 The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid. Alitretinoin 107-126 retinol dehydrogenase 5 Mus musculus 24-51 11907141-1 2002 It has been proposed that cis-retinol dehydrogenase (cRDH) acts within the body to catalyze the oxidation of 9-cis-retinol, an oxidative step needed for 9-cis-retinoic acid synthesis, the oxidation of 11-cis-retinol [an oxidative step needed for 11-cis-retinal (visual chromophore) synthesis], and 3 alpha-hydroxysteroid transformations. Alitretinoin 153-172 retinol dehydrogenase 5 Mus musculus 26-51 11907141-1 2002 It has been proposed that cis-retinol dehydrogenase (cRDH) acts within the body to catalyze the oxidation of 9-cis-retinol, an oxidative step needed for 9-cis-retinoic acid synthesis, the oxidation of 11-cis-retinol [an oxidative step needed for 11-cis-retinal (visual chromophore) synthesis], and 3 alpha-hydroxysteroid transformations. Alitretinoin 153-172 retinol dehydrogenase 5 Mus musculus 53-57 11907141-8 2002 Moreover, we did not detect any non-visual phenotypic changes for cRDH-/- mice, suggesting that these mice do not have problems in metabolizing 3 alpha-hydroxysteroids.Thus, cRDH may act essentially in the visual cycle but is redundant for catalyzing 9-cis-retinoic acid formation and 3 alpha-hydroxysteroid metabolism. Alitretinoin 251-270 retinol dehydrogenase 5 Mus musculus 174-178 10588954-1 1999 We have identified a retinol dehydrogenase (cRDH) that catalyzes the oxidation of 9-cis- but not all-trans-retinol and proposed that this enzyme plays an important role in synthesis of the transcriptionally active retinoid, 9-cis-retinoic acid. Alitretinoin 224-243 retinol dehydrogenase 5 Mus musculus 44-48 10588954-12 1999 Taken together, these data extend our understanding of the properties of cRDH and provide additional support for our hypothesis that cRDH may play an important role in 9-cis-retinoic acid formation. Alitretinoin 168-187 retinol dehydrogenase 5 Mus musculus 133-137