PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27101231-1 2016 Objectives: To determine relations between drug concentrations and the cytochrome P450-CYP2D6 genotype or phenotype among elderly patients treated with nortriptyline or venlafaxine. Venlafaxine Hydrochloride 169-180 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-93 8846618-2 1995 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Venlafaxine Hydrochloride 352-363 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-148 11516890-3 2001 Although metabolized by the cytochrome P-450 (CYP) system, venlafaxine inhibits CYP 2D6 and 3A4 to a far lesser extent than do the SSRIs. Venlafaxine Hydrochloride 59-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-49 11098412-4 2000 Based on these parameters, selecting an antidepressant medication, such as venlafaxine, that has a low potential for drug interactions at the Cytochrome P450 (CYP) enzyme system, and is easy to monitor and dose, facilitate successful treatment of patients. Venlafaxine Hydrochloride 75-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 142-157 11098412-4 2000 Based on these parameters, selecting an antidepressant medication, such as venlafaxine, that has a low potential for drug interactions at the Cytochrome P450 (CYP) enzyme system, and is easy to monitor and dose, facilitate successful treatment of patients. Venlafaxine Hydrochloride 75-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 159-162 8846618-2 1995 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Venlafaxine Hydrochloride 56-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-148 8846618-2 1995 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Venlafaxine Hydrochloride 56-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-153 19629022-6 2009 CONCLUSIONS: Considering in vitro and available clinical data, desvenlafaxine and venlafaxine appear to have low potential for pharmacokinetic drug-drug interactions via inhibiting the metabolic clearance of concomitant drugs that are substrates of various CYP enzymes, in particular CYP2D6. Venlafaxine Hydrochloride 66-77 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 257-260 11084219-1 2000 The present study was designed to determine the effect of venlafaxine on imipramine metabolism in an attempt to elucidate the potential for cytochrome P450 drug-drug interactions with venlafaxine. Venlafaxine Hydrochloride 184-195 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 140-155 8846618-2 1995 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Venlafaxine Hydrochloride 352-363 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-153