PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21827824-6	2012	Furthermore, olmesartan treatment significantly abrogated the downregulation of ACE-2 and Ang-(1-7) mas R protein expression in diabetic kidney mice.	olmesartan	13-23	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	80-85	
27210827-5	2016	Additionally, the degree of downregulation of the ACE-AngII-AT1 axis and upregulation of the ACE2-Ang(1-7)-Mas axis was higher in response to Olmesartan, Candesartan and Losartan administration in vivo and in vitro.	olmesartan	142-152	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	93-97	
27210827-7	2016	Furthermore, only Olmesartan and Candesartan could downregulate the ACE-AngII-AT1 axis and upregulate the ACE2-Ang(1-7)-Mas axis in vitro.	olmesartan	18-28	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	106-110	
27210827-8	2016	Our data suggest that Olmesartan, Candesartan and Losartan could effectively inhibit pressure overload-induced cardiac remodeling even when with knockdown of Ang II, possibly through upregulation of the expression of the ACE2-Ang(1-7)-Mas axis and downregulation of the expression of the ACE-AngII-AT1 axis.	olmesartan	22-32	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	221-225	
26886190-0	2016	Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.	olmesartan	0-10	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	128-132	
22665126-8	2012	Increased ACE2 expression in the injured artery was also observed by treatment of wild-type mice with an angiotensin II type 1 receptor blocker, olmesartan.	olmesartan	145-155	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	10-14	
31390839-2	2019	Here, we report that treatment of olmesartan effectively targets the feedback loop between the renin-angiotensin system (RAS) and transforming growth factor beta (TGFbeta) signals in tubular epithelial cells and preserves renal angiotensin-converting enzyme 2 (ACE2) expression in the kidney of Col4a3-/- mice, a murine model of experimental AS.	olmesartan	34-44	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	261-265	
21946695-9	2011	Co-administration of an angiotensin II type 1 (AT1) receptor blocker (ARB), olmesartan, inhibited L-NAME-induced cardiovascular remodeling and improved the reduction in cardiac ACE2.	olmesartan	76-86	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	177-181	
21946695-12	2011	An ARB, olmesartan, blunted cardiac remodeling induced by NO inhibition with RAS activation partially through the ACE2/Ang-(1-7)/Mas axis in addition to directly through its classical ACE/Ang II/AT1 receptor axis-blocking action.	olmesartan	8-18	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	114-118	
20186149-9	2010	In addition, treatment with AT1 receptor blocker olmesartan significantly, but not totally, ameliorated the functional and morphological deterioration of diabetic nephropathy in ACE2-KO mice.	olmesartan	49-59	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	178-182	
31390839-6	2019	Concurrent upregulation of TNFalpha-converting enzyme and downregulation of ACE2 suggested RAS activation in Col4a3-/- mice, which was prevented by olmesartan.	olmesartan	148-158	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	76-80