PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17713901-2	2007	In the present paper, eight Molecular Dynamics (MD) simulations are carried out to examine the importance of structure and dynamics of water in the active site of both CDK2 and CDK5 complexes with roscovitine and indirubin analogues.	indirubin	213-222	cyclin dependent kinase 5	Homo sapiens	177-181	
14761195-3	2004	Using the cocrystal structures of various indirubins with GSK-3beta, CDK2 and CDK5/p25, we have modeled the binding of indirubins within the ATP-binding pocket of these kinases.	indirubin	42-52	cyclin dependent kinase 5	Homo sapiens	78-82	
35570516-11	2022	Docking studies of all the synthesized compounds were carried out using "structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin" (PDB ID: 1UNG), which showed favourable results with compound (Vb3), showing a MolDock Score of -85.9788 that was comparable to that of the active ligand (ALH_1288 (B)) with MolDock Score of - 87.7609.	indirubin	154-163	cyclin dependent kinase 5	Homo sapiens	116-120	
15950951-10	2005	Kenpaullone and indirubin also prevented cdk5/p25 activation mediated by colchicine.	indirubin	16-25	cyclin dependent kinase 5	Homo sapiens	41-45