PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	tumor necrosis factor	Homo sapiens	93-102	
17276410-0	2007	Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	79-88	
17259331-5	2007	At nontoxic > or =10 microM, isoliquiritigenin blocked the induction of VCAM-1 and E-selectin on activated HUVEC and markedly interfered with THP-1 monocyte adhesion to TNF-alpha-activated endothelial cells.	isoliquiritigenin	32-49	tumor necrosis factor	Homo sapiens	172-181	
17259331-6	2007	Isoliquiritigenin abolished TNF-alpha-induced mRNA accumulation of VCAM-1 and E-selectin.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	28-37	
17259331-7	2007	Additionally, immunocytochemical staining revealed that isoliquiritigenin attenuated PECAM-1 expression induced by TNF-alpha.	isoliquiritigenin	56-73	tumor necrosis factor	Homo sapiens	115-124	
17259331-9	2007	Isoliquiritigenin downregulated CAM proteins in TNF-alpha-activated HUVEC at the transcriptional levels by blocking degradation of IkappaBalpha and nuclear translocation of NF-kappaB.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	48-57	
28012970-0	2017	Isoliquiritigenin inhibits TNF-alpha-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	27-36	
32117796-7	2020	Linarin, sinensetin, cedar acid, isoliquiritigenin, sinigrin, luteolin, chlorogenic acid, orientin, epigoitrin, and rupestonic acid exhibited significant effects on TNF-alpha expression, which is almost consistent with predicted results.	isoliquiritigenin	33-50	tumor necrosis factor	Homo sapiens	165-174	
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	isoliquiritigenin	26-43	tumor necrosis factor	Homo sapiens	282-290	
27539609-0	2016	Isoliquiritigenin suppresses tumor necrosis factor-alpha-induced inflammation via peroxisome proliferator-activated receptor-gamma in intestinal epithelial cells.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	29-56