PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26773964-2 2015 The aim of this study was to evaluate the influence of CYP3A5 polymorphism on the increase in CYP3A activity after living kidney transplantation, by measuring the plasma concentration of 4beta-hydroxycholesterol. cholest-5-ene-3,4-diol 187-211 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 55-61 30826567-8 2019 RESULTS: Significantly higher plasma 4beta-hydroxycholesterol concentration was observed in recipients with CYP3A5*1 allele (n = 23) compared to those without the allele (n = 40), and the cut-off value was 40.0 ng/mL. cholest-5-ene-3,4-diol 37-61 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 108-114 27236640-0 2016 Relationship between the plasma fentanyl and serum 4beta-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain. cholest-5-ene-3,4-diol 51-75 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 85-91 27236640-1 2016 This study aimed to evaluate the relationship between the concentrations of plasma fentanyl and serum 4beta-hydroxycholesterol based on CYP3A5 genotype and gender in cancer patients. cholest-5-ene-3,4-diol 102-126 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 136-142 27236640-6 2016 The serum 4beta-hydroxycholesterol concentration and its ratio to total cholesterol were significantly lower in the CYP3A5*3/*3 group than in the *1 allele carrier group. cholest-5-ene-3,4-diol 10-34 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 116-122 27236640-10 2016 In conclusion, CYP3A5*3 and gender affected the plasma fentanyl and serum 4beta-hydroxycholesterol concentrations in cancer patients. cholest-5-ene-3,4-diol 74-98 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 15-21 35181316-1 2022 4beta-Hydroxycholesterol (4beta-OHC) is formed by CYP3A4 and CYP3A5 and has drawn attention as an endogenous phenotyping probe for CYP3A activity. cholest-5-ene-3,4-diol 0-24 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 61-67 24135442-0 2014 Association of plasma concentration of 4beta-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients. cholest-5-ene-3,4-diol 39-63 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 69-75 24135442-5 2014 Plasma concentrations of 4beta-hydroxycholesterol were 57.1 +- 11.2, 42.1 +- 11.8, and 34.5 +- 7.3 ng/ml in recipients with CYP3A5*1/*1 (n = 5), *1/*3 (n = 15), and *3/*3 (n = 25) genotypes, respectively, with significant differences between three genotypes. cholest-5-ene-3,4-diol 25-49 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 124-130 24135442-7 2014 Multiple regression analysis identified the number of CYP3A5*3 alleles in genotype, plasma concentration of 3-INDS, and body weight as independent variables associated with plasma concentration of 4beta-hydroxycholesterol. cholest-5-ene-3,4-diol 197-221 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 54-60 20231858-7 2011 CYP3A5 genotype significantly correlated with the plasma 4beta-hydroxycholesterol concentration (P=0.003) and 4beta-hydroxycholesterol/cholesterol ratio (P=0.0002). cholest-5-ene-3,4-diol 57-81 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 0-6 20231858-7 2011 CYP3A5 genotype significantly correlated with the plasma 4beta-hydroxycholesterol concentration (P=0.003) and 4beta-hydroxycholesterol/cholesterol ratio (P=0.0002). cholest-5-ene-3,4-diol 110-134 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 0-6 20231858-8 2011 The omeprazole/omeprazole sulfone ratio was significantly correlated with 4beta-hydroxycholesterol and 4beta-hydroxycholesterol/cholesterol ratio in CYP3A5*0/*0 genotypes but not in individuals carrying the CYP3A5*1 allele. cholest-5-ene-3,4-diol 103-127 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 149-155 20231858-10 2011 A clear gene-dose effect implies plasma 4beta-hydroxycholesterol level as a useful endogenous biomarker for total CYP3A activity (CYP3A5 plus CYP3A4) whereas the omeprazole/omeprazole sulfone ratio reflects mainly CYP3A4 activity. cholest-5-ene-3,4-diol 40-64 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 130-136 18300941-0 2008 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. cholest-5-ene-3,4-diol 0-24 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 75-81 18300941-1 2008 OBJECTIVES: To study the potential endogenous marker of CYP3A activity, 4beta-hydroxycholesterol, and its relation to sex and the CYP3A5 geno/haplotypes and compare with CYP3A4/5 catalyzed 3-hydroxylation of quinine in the three major races. cholest-5-ene-3,4-diol 72-96 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 130-136