PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35181316-1	2022	4beta-Hydroxycholesterol (4beta-OHC) is formed by CYP3A4 and CYP3A5 and has drawn attention as an endogenous phenotyping probe for CYP3A activity.	cholest-5-ene-3,4-diol	0-24	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	61-67	
24135442-0	2014	Association of plasma concentration of 4beta-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.	cholest-5-ene-3,4-diol	39-63	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	69-75	
30826567-8	2019	RESULTS: Significantly higher plasma 4beta-hydroxycholesterol concentration was observed in recipients with CYP3A5*1 allele (n = 23) compared to those without the allele (n = 40), and the cut-off value was 40.0 ng/mL.	cholest-5-ene-3,4-diol	37-61	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	108-114	
27236640-0	2016	Relationship between the plasma fentanyl and serum 4beta-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain.	cholest-5-ene-3,4-diol	51-75	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	85-91	
27236640-1	2016	This study aimed to evaluate the relationship between the concentrations of plasma fentanyl and serum 4beta-hydroxycholesterol based on CYP3A5 genotype and gender in cancer patients.	cholest-5-ene-3,4-diol	102-126	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	136-142	
27236640-6	2016	The serum 4beta-hydroxycholesterol concentration and its ratio to total cholesterol were significantly lower in the CYP3A5*3/*3 group than in the *1 allele carrier group.	cholest-5-ene-3,4-diol	10-34	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	116-122	
27236640-10	2016	In conclusion, CYP3A5*3 and gender affected the plasma fentanyl and serum 4beta-hydroxycholesterol concentrations in cancer patients.	cholest-5-ene-3,4-diol	74-98	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	15-21	
26773964-2	2015	The aim of this study was to evaluate the influence of CYP3A5 polymorphism on the increase in CYP3A activity after living kidney transplantation, by measuring the plasma concentration of 4beta-hydroxycholesterol.	cholest-5-ene-3,4-diol	187-211	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	55-61	
24135442-5	2014	Plasma concentrations of 4beta-hydroxycholesterol were 57.1 +- 11.2, 42.1 +- 11.8, and 34.5 +- 7.3 ng/ml in recipients with CYP3A5*1/*1 (n = 5), *1/*3 (n = 15), and *3/*3 (n = 25) genotypes, respectively, with significant differences between three genotypes.	cholest-5-ene-3,4-diol	25-49	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	124-130	
24135442-7	2014	Multiple regression analysis identified the number of CYP3A5*3 alleles in genotype, plasma concentration of 3-INDS, and body weight as independent variables associated with plasma concentration of 4beta-hydroxycholesterol.	cholest-5-ene-3,4-diol	197-221	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	54-60	
20231858-10	2011	A clear gene-dose effect implies plasma 4beta-hydroxycholesterol level as a useful endogenous biomarker for total CYP3A activity (CYP3A5 plus CYP3A4) whereas the omeprazole/omeprazole sulfone ratio reflects mainly CYP3A4 activity.	cholest-5-ene-3,4-diol	40-64	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	130-136	
20231858-7	2011	CYP3A5 genotype significantly correlated with the plasma 4beta-hydroxycholesterol concentration (P=0.003) and 4beta-hydroxycholesterol/cholesterol ratio (P=0.0002).	cholest-5-ene-3,4-diol	57-81	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	0-6	
20231858-7	2011	CYP3A5 genotype significantly correlated with the plasma 4beta-hydroxycholesterol concentration (P=0.003) and 4beta-hydroxycholesterol/cholesterol ratio (P=0.0002).	cholest-5-ene-3,4-diol	110-134	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	0-6	
20231858-8	2011	The omeprazole/omeprazole sulfone ratio was significantly correlated with 4beta-hydroxycholesterol and 4beta-hydroxycholesterol/cholesterol ratio in CYP3A5*0/*0 genotypes but not in individuals carrying the CYP3A5*1 allele.	cholest-5-ene-3,4-diol	103-127	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	149-155	
18300941-0	2008	4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.	cholest-5-ene-3,4-diol	0-24	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	75-81	
18300941-1	2008	OBJECTIVES: To study the potential endogenous marker of CYP3A activity, 4beta-hydroxycholesterol, and its relation to sex and the CYP3A5 geno/haplotypes and compare with CYP3A4/5 catalyzed 3-hydroxylation of quinine in the three major races.	cholest-5-ene-3,4-diol	72-96	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	130-136