PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31421166-3 2019 Here we report the identification of the compound Bardoxolone methyl (CDDO-me) as a potent inhibitor of the Hrd1 ubiquitin ligase-mediated ERAD, which possesses a broad-spectrum activity against both DENV and ZIKV. bardoxolone methyl 50-68 synoviolin 1 Homo sapiens 108-112 31421166-3 2019 Here we report the identification of the compound Bardoxolone methyl (CDDO-me) as a potent inhibitor of the Hrd1 ubiquitin ligase-mediated ERAD, which possesses a broad-spectrum activity against both DENV and ZIKV. bardoxolone methyl 70-77 synoviolin 1 Homo sapiens 108-112 31421166-4 2019 Cellular thermal shift assay (CETSA) suggested that CDDO-me binds to grp94, a key component of the Hrd1 pathway, at a low nanomolar concentration, whereas interaction was not detected with its paralog Hsp90. bardoxolone methyl 52-59 synoviolin 1 Homo sapiens 99-103