PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28853575-4	2017	The pyrazolopyrimidine-based core differs structurally from that of aminopyrimidine-based third-generation EGFR inhibitors and therefore constitutes a new set of inhibitors that target this mechanism of drug resistance.	2-aminopyrimidine	68-83	epidermal growth factor receptor	Homo sapiens	107-111	
34534838-0	2021	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno (3,2-c)pyridine as potent EGFR inhibitors.	2-aminopyrimidine	47-62	epidermal growth factor receptor	Homo sapiens	136-140	
34534838-1	2021	To resolve the problem of drug resistance caused by epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer, we used the principle of collocation to design and synthesize a series of aminopyrimidine derivatives with 4,5,6,7-tetrahydrothieno (3,2-c)pyridine side chains (according to the binding mode of AZD9291 to EGFRT790M) for use as EGFRL858R/T790M kinase inhibitors.	2-aminopyrimidine	207-222	epidermal growth factor receptor	Homo sapiens	52-84	
34534838-1	2021	To resolve the problem of drug resistance caused by epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer, we used the principle of collocation to design and synthesize a series of aminopyrimidine derivatives with 4,5,6,7-tetrahydrothieno (3,2-c)pyridine side chains (according to the binding mode of AZD9291 to EGFRT790M) for use as EGFRL858R/T790M kinase inhibitors.	2-aminopyrimidine	207-222	epidermal growth factor receptor	Homo sapiens	86-90	
34819010-4	2022	Based on our previous studies, we assumed that a hybrid of aminopyrimidine derivatives as EGFR inhibitors and benzocheromen derivatives as cytotoxic agents can induce apoptosis in EGFR positive cancer cells.	2-aminopyrimidine	59-74	epidermal growth factor receptor	Homo sapiens	90-94	
34819010-4	2022	Based on our previous studies, we assumed that a hybrid of aminopyrimidine derivatives as EGFR inhibitors and benzocheromen derivatives as cytotoxic agents can induce apoptosis in EGFR positive cancer cells.	2-aminopyrimidine	59-74	epidermal growth factor receptor	Homo sapiens	180-184	
30204041-0	2018	Unraveling structural requirements of amino-pyrimidine T790M/L858R double mutant EGFR inhibitors: 2D and 3D QSAR study.	2-aminopyrimidine	38-54	epidermal growth factor receptor	Homo sapiens	81-85	
26451770-0	2015	Novel hydrazone moiety-bearing aminopyrimidines as selective inhibitors of epidermal growth factor receptor T790M mutant.	2-aminopyrimidine	31-47	epidermal growth factor receptor	Homo sapiens	75-107	
26451770-2	2015	Here, a series of novel aminopyrimidines bearing a hydrazone moiety were identified as potent and selective EGFR inhibitors.	2-aminopyrimidine	24-40	epidermal growth factor receptor	Homo sapiens	108-112