PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25522687-0	2015	Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A.	Cholesterol	0-11	surfactant protein A1	Homo sapiens	60-80	
25522687-3	2015	It was hypothesized that elevated cholesterol levels within surfactant inhibit human surfactant biophysical function and that these effects can be reversed by surfactant protein A (SP-A).	Cholesterol	34-45	surfactant protein A1	Homo sapiens	159-179	
25522687-3	2015	It was hypothesized that elevated cholesterol levels within surfactant inhibit human surfactant biophysical function and that these effects can be reversed by surfactant protein A (SP-A).	Cholesterol	34-45	surfactant protein A1	Homo sapiens	181-185	
25522687-8	2015	It is concluded that cholesterol-induced surfactant inhibition can actively contribute to physiological impairment of the lungs in mechanically ventilated patients and that SP-A levels may be important to maintain surfactant function in the presence of high cholesterol within surfactant.	Cholesterol	258-269	surfactant protein A1	Homo sapiens	173-177	
9548588-0	1998	Interaction of pulmonary surfactant protein A with dipalmitoylphosphatidylcholine and cholesterol at the air/water interface.	Cholesterol	86-97	surfactant protein A1	Homo sapiens	15-45	
9548588-1	1998	Interaction of pulmonary surfactant protein A (SP-A) with pure and binary mixed dipalmitoylphosphatidylcholine (DPPC) and cholesterol (3.5 wt%) at the air/saline, 1.5 mM CaCl2 interface was investigated using a rhomboid surface balance at 37 degrees C. Surface tension-area isotherms were measured to access the surface active properties of the monolayers.	Cholesterol	122-133	surfactant protein A1	Homo sapiens	15-45	
9548588-1	1998	Interaction of pulmonary surfactant protein A (SP-A) with pure and binary mixed dipalmitoylphosphatidylcholine (DPPC) and cholesterol (3.5 wt%) at the air/saline, 1.5 mM CaCl2 interface was investigated using a rhomboid surface balance at 37 degrees C. Surface tension-area isotherms were measured to access the surface active properties of the monolayers.	Cholesterol	122-133	surfactant protein A1	Homo sapiens	47-51	
9548588-5	1998	SP-A also reduced the collapse surface tension of pure cholesterol from 27 to 23 mN/m.	Cholesterol	55-66	surfactant protein A1	Homo sapiens	0-4	
9548588-8	1998	Although SP-A could not promote the squeeze-out of cholesterol from homogeneous mixed monolayers, it facilitated that of cholesterol domains especially when SP-A had first interacted with DPPC.	Cholesterol	121-132	surfactant protein A1	Homo sapiens	9-13	
9548588-9	1998	These results indicate that pulmonary surfactant protein A facilitates the squeeze-out of cholesterol domains from mixed monolayers by condensing DPPC and limiting lateral interactions of DPPC with cholesterol domains.	Cholesterol	90-101	surfactant protein A1	Homo sapiens	28-58	
9548588-9	1998	These results indicate that pulmonary surfactant protein A facilitates the squeeze-out of cholesterol domains from mixed monolayers by condensing DPPC and limiting lateral interactions of DPPC with cholesterol domains.	Cholesterol	198-209	surfactant protein A1	Homo sapiens	28-58	
8004321-6	1994	We found a direct relationship between CHOL and DSP (rs = 0.84, p < 0.001), SP-A and CHOL (rs = 0.40, p < 0.025), and between SP-A and DSP (rs = 0.44, p < 0.025).	Cholesterol	88-92	surfactant protein A1	Homo sapiens	79-83	
16489761-8	2006	Incorporation of cholesterol into J5 LPS/POPE liposomes at a POPE:cholesterol molar ratio of 1:0.15 blocked human SP-A or melittin-induced permeability (p < 0.05) compared to cholesterol-free liposomes.	Cholesterol	17-28	surfactant protein A1	Homo sapiens	114-118	
16489761-11	2006	Incorporation of cholesterol into the membrane enhances resistance to permeabilization by SP-A, most likely by increasing the packing density and membrane rigidity.	Cholesterol	17-28	surfactant protein A1	Homo sapiens	90-94