PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19007306-2	2009	Amongst the diverse risk factors contributing to the degenerative process, high cholesterol causes a reduction in the effectiveness of the otherwise therapeutic inhibitors of AChE.	Cholesterol	80-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	175-179	
24166183-8	2014	Notably, LDL cholesterol increased in a dose-dependent manner the activity of AChE in SH-SY5Y cells.	Cholesterol	13-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82	
23936743-1	2013	Acetylcholinesterase and Butyrylcholinesterase share unravelling link with components of metabolic syndromes that"s characterised by low levels of HDL cholesterol, obesity, high fast aldohexose levels, hyper-trigliceridaemia and high blood pressure, by regulation of cholinergic transmission and therefore the enzyme activity within a living system.	Cholesterol	151-162	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20	
19007306-8	2009	This model may also be used to assess and predict the effectiveness of AChE inhibitors, which are traditionally used for the treatment of cognitive impairment, under pathological (high-cholesterol) conditions.	Cholesterol	185-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75	
2935999-3	1985	After loading with cholesterol activity of acetylcholinesterase was increased while ATPase and glyceraldehyde-3-phosphate dehydrogenase activities were decreased.	Cholesterol	19-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63	
661822-1	1978	Modification of the lipid phase structure of the erythrocyte membrane by phospholipases A2, C and D as well as the partial depletion of cholesterol was shown to be accompanied by the change of the acetylcholinesterase (AChE) UV-sensitivity.	Cholesterol	136-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	197-217	
3917684-7	1985	We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol.	Cholesterol	174-185	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40	
661822-1	1978	Modification of the lipid phase structure of the erythrocyte membrane by phospholipases A2, C and D as well as the partial depletion of cholesterol was shown to be accompanied by the change of the acetylcholinesterase (AChE) UV-sensitivity.	Cholesterol	136-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	219-223	
661822-2	1978	The ability of UV-light to change the catalytic properties (Km) of the membrane-bound AChE not observed for free AChE (constant value of Km) and known as the phenomenon of photochemical allotopy, is retained in the cholesterol depleted membranes and disappears after an enzymatic treatment of the membranes by phospholipases.	Cholesterol	215-226	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90	
656488-1	1978	Gel-filtration of 0,6 M NaCl and 0,6 M NaCl--0,1% Triton X-100 extracts of freshly isolated sarcolemma through Sepharose 2B (1,5 X 72 cm) has revealed one symmetric peak of acetylcholinesterase activity containing phospholipid and cholesterol, moving faster than fibrinogen and tyreoglobulin.	Cholesterol	231-242	acetylcholinesterase (Cartwright blood group)	Homo sapiens	173-193	
29441784-4	2018	Interestingly, by combining the quenching and recognition ability of silver nanoparticles (AgNPs) with the optical capacity of CDs, a label-free strategy for specifically monitoring H2O2-generated biocatalytic processes was proposed, such as glucose oxidase-induced conversion of glucose, cholesterol oxidase-catalyzed oxidization of cholesterol, and bienzyme of acetylcholinesterase and choline oxidase-mediated reaction of acetylcholine.	Cholesterol	289-300	acetylcholinesterase (Cartwright blood group)	Homo sapiens	363-383	
32708417-6	2020	The activity of AChE and the HMGR were inhibited by the extracts giving IC50 values of 15.0 +- 0.1 microg/mL and 4.2 +- 0.1 microg/mL, respectively and 45% of the cholesterol permeation inhibition.	Cholesterol	163-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-20	
30463700-5	2019	As a corollary, we propose that any treatment or process that leads to a slight decrease in cholesterol content in the membranes can efficiently enhance the inhibitory activity of EGCG, which can have important consequences in all the pathologies where the inhibition of AChE is recommended.	Cholesterol	92-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	271-275