PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17222962-1 2007 Cytochrome P450 side-chain cleavage (CYP11A1) catalyzes the conversion of cholesterol to pregnenolone, the first step in steroidogenesis. Cholesterol 74-85 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17346171-1 2007 This article aims to give an overview on the characterization, properties and regulation of enzymes, particularly the cytochrome (CYP) P450 enzymes, in the formation of bile acids from cholesterol. Cholesterol 185-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 130-133 1628663-0 1992 The cholesterol-side-chain-cleaving cytochrome P450 spin-state equilibrium. Cholesterol 4-15 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-51 12187294-2 2002 However, this could possibly influence vitamin D 25-hydroxylation because this reaction is catalyzed in part by the mitochondrial cytochrome P-450, the enzyme responsible for the 27-hydroxylation of cholesterol. Cholesterol 199-210 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 130-146 8975714-0 1996 Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Cholesterol 120-131 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 92-107 8975714-0 1996 Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Cholesterol 120-131 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-75 8444412-4 1993 Purification and subfractionation of microsomal protein yielded a fraction of cytochrome P-450, which required NADPH and NADPH-cytochrome P-450 reductase and catalyzed 7 alpha-hydroxylation of the side-chain oxygenated 3 beta-hydroxy-delta 5-C27-steroids but was inactive toward cholesterol. Cholesterol 279-290 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 16338087-2 2006 The first step in steroidogenesis involves the delivery of free cholesterol to the inner mitochondrial membrane where it can be converted into pregnenolone by the enzyme cytochrome P450side chain cleavage. Cholesterol 64-75 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 170-185 1628663-3 1992 We have confirmed and characterised structurally the enzyme conformational changes deduced from the preceding thermodynamic analysis of the adrenal mitochondrial cholesterol-side-chain-cleaving cytochrome P450 spin-state equilibrium. Cholesterol 162-173 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 194-209 2508765-0 1989 [Study of the role of lysine residues of the cholesterol hydroxylating cytochrome P-450 by a method of chemical modification]. Cholesterol 45-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 2378912-0 1990 [Chemical modification of cholesterol-hydroxylating cytochrome P-450 from adrenal cortex mitochondria with diethylpyrocarbonate]. Cholesterol 26-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-68 35523303-0 2022 Cholesterol"s inhibition effect on entering of chlorzoxazone into phosphatidylethanolamine bilayer: Relevance to cytochrome P450 drug metabolism at endoplasmic reticulum membranes. Cholesterol 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 113-128 2790077-0 1989 [Immunochemical study of cholesterol-hydroxylating cytochrome P-450. Cholesterol 25-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-67 3675632-0 1987 [Chemical modification of cysteine residues of cholesterol-hydroxylating cytochrome P-450. Cholesterol 47-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 73-89 3191198-0 1988 [Mechanism of electron transport in the cholesterol-hydroxylating system of adrenal cortex mitochondria: a triple complex of adrenodoxin reductase, adrenodoxin and cytochrome P-450]. Cholesterol 40-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 164-181 2752065-0 1989 [Interaction of cholesterol hydroxylating cytochrome P-450 with cytochrome b5]. Cholesterol 16-27 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 42-58 3675633-0 1987 [Localization of tetranitromethane-modified tyrosine residues in the polypeptide chain of cholesterol-hydroxylating cytochrome P-450]. Cholesterol 90-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 116-133 3579320-1 1987 The cytochrome P-450-dependent cholesterol side chain cleavage system of the brain has been studied using nonsynaptic mitochondria as the source of enzymatic activity. Cholesterol 31-42 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 2990136-7 1985 Ascorbinic acid is able to overcome this blockade, indicating that cytochrome p-450 is involved in the ascorbinic acid metabolism which is obligatory for the hydroxylation of cholesterol. Cholesterol 175-186 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-83 3549274-2 1986 The pathway of biosynthesis of these steroids from cholesterol involves a sequence of transformations using cytochrome P-450 enzymes. Cholesterol 51-62 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-124 4074778-0 1985 [A shunted system of electron transport from NAD(P)H to cholesterol-hydroxylating cytochrome P-450 in adrenal cortex mitochondria]. Cholesterol 56-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-98 3320551-2 1987 The pathway of biosynthesis of these steroids from cholesterol involves a sequence of transformations using cytochrome P-450 enzymes which varies within the adrenal cortex as a result of the differential localization of enzymes within the zones. Cholesterol 51-62 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-124 3986004-0 1985 [Localization of the adrenodoxin-binding fragment of cholesterol hydroxylating cytochrome P-450 from adrenal cortex mitochondria]. Cholesterol 53-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-95 3978151-0 1985 [Effect of chemical modification of tyrosine residues of cholesterol-hydroxylating cytochrome P-450 on the interaction with high-spin effectors]. Cholesterol 57-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 83-99 4064901-0 1985 [Primary structure of cholesterol-hydroxylating cytochrome P-450 from the mitochondria of the adrenal cortex in the bull]. Cholesterol 22-33 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-64 4065184-2 1985 The subjects with a high liver cytochrome P-450, indicating hepatic microsomal enzyme induction, who showed an increase in liver size, had an elevated high-density lipoprotein concentration and high-density lipoprotein cholesterol/total cholesterol ratio, and a reduced low/high-density lipoprotein cholesterol ratio. Cholesterol 219-230 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-47 6525207-0 1984 [Molecular organization of cholesterol-hydroxylating cytochrome P-450 from adrenal cortex mitochondria. Cholesterol 27-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-69 6208195-0 1984 Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Cholesterol 54-65 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 6091677-0 1984 [Selective chemical modification of cholesterol hydroxylating cytochrome P-450 from adrenal cortex mitochondria by tetranitromethane]. Cholesterol 36-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-78 6508858-0 1984 [Localization of tetranitromethane-modified tyrosine residues in domains of cholesterol-hydroxylating cytochrome P-450]. Cholesterol 76-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 102-119 6091677-6 1984 Cholesterol and adrenodoxin protected cytochrome P-450 against inactivation by tetranitromethane. Cholesterol 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 38-54 7173298-8 1982 In the entire population, and also in subjects not taking inducing drugs, when considered separately, plasma HDL cholesterol, apoproteins A-I and A-II and the HDL cholesterol/total cholesterol ratio were significantly correlated with cytochrome P-450 concentration. Cholesterol 113-124 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 234-250 6357293-3 1983 The interaction of this protein and of the native protein with cholesterol-specific cytochrome P-450 and adrenodoxin reductase occurs in a similar way. Cholesterol 63-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-100 6305968-5 1983 Transfer of cholesterol to and from cytochrome P-450 occurred with similar first order rate constants and was also independent of the concentrations of cholesterol vesicles and P-450. Cholesterol 12-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-52 7173298-8 1982 In the entire population, and also in subjects not taking inducing drugs, when considered separately, plasma HDL cholesterol, apoproteins A-I and A-II and the HDL cholesterol/total cholesterol ratio were significantly correlated with cytochrome P-450 concentration. Cholesterol 163-174 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 234-250 7173298-8 1982 In the entire population, and also in subjects not taking inducing drugs, when considered separately, plasma HDL cholesterol, apoproteins A-I and A-II and the HDL cholesterol/total cholesterol ratio were significantly correlated with cytochrome P-450 concentration. Cholesterol 163-174 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 234-250 118858-7 1979 The interface between plants and insects is enormous, and therefore it appears probable that cytochrome P-450 will one day be shown to be important in the conversion/utilization of other plant secondary substances, e.g., synthesis of cholesterol from phytosterols, and sex pheromones from olefins, terpenes, and alkaloids. Cholesterol 234-245 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-109 223025-1 1979 Cytochrome P450 in the mitochondria of the adrenal cortex functions in the monooxygenation reactions for the biosynthesis of various steroid hormones, such as cholesterol side chain cleavage, hydroxylation at 11 beta-position and that at 18-position of the steroid structure. Cholesterol 159-170 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 184090-0 1976 Purification and characterization of adrenal cortex mitochondrial cytochrome P-450 specific for cholesterol side chain cleavage activity. Cholesterol 96-107 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 66-82 29069987-1 2018 Cytochrome P450 enzymes are required for the synthesis of cholesterol and steroid hormones. Cholesterol 58-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 1186237-0 1975 The role of cholesterol and cytochrome P-450 in the cholesterol side chain cleavage reaction in adrenal cortex and corpora lutea. Cholesterol 52-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-44 30501426-2 2018 Different CYP isoenzymes mediate metabolism of many endogenous substrates such as monoaminergic neurotransmitters, neurosteroids, cholesterol, vitamins and arachidonic acid. Cholesterol 130-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 10-13 30501426-5 2018 The article focuses on the role of cerebral CYP isoforms in the metabolism of neurotransmitters, neurosteroids, and cholesterol, and their possible involvement in animal behavior, as well as in stress, depression, schizophrenia, cognitive processes, learning, and memory. Cholesterol 116-127 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-47 4149283-0 1973 The role of cytochrome P-450 in cholesterol biosynthesis. Cholesterol 32-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-28 31730751-12 2019 Furthermore, we demonstrate that CYP-mediated oxidation of C10-BAC mitigates the potent inhibition of cholesterol biosynthesis exhibited by this short-chain BAC. Cholesterol 102-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 33-36 31730751-13 2019 Furthermore, we demonstrate that CYP-mediated oxidation of C10-BAC mitigates the potent inhibition of cholesterol biosynthesis exhibited by this short-chain BAC. Cholesterol 102-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 33-36 19495700-3 2009 This chapter describes methods for the measurement of the expression and catalytic activity of three key cytochrome P450 (CYP) enzymes involved in the production of progesterone and estrogens, aromatase (CYP19), steroid 17-hydroxylase/17,20-lyase (CYP17), and cholesterol side-chain cleavage (CYP11A). Cholesterol 260-271 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 105-120 27769286-6 2016 AGEs are associated with hyperandrogenism in PCOS possibly by altering the activity of various enzymes such as cholesterol side-chain cleavage enzyme cytochrome P450, steroidogenic acute regulatory protein, 17alpha-hydroxylase, and 3beta-hydroxysteroid dehydrogenase. Cholesterol 111-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-197 27347790-0 2016 Effect of Cholesterol on the Interaction of Cytochrome P450 Substrate Drug Chlorzoxazone with the Phosphatidylcholine Bilayer. Cholesterol 10-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-59 27347790-6 2016 In this study, the cholesterol concentration dependence of the interaction of a CYP substrate drug, chlorzoxazone (CZX), with model membranes composed of phosphatidylcholine (PC) and cholesterol was examined via differential scanning calorimetry (DSC), UV-visible spectroscopy, and X-ray diffraction. Cholesterol 19-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-83 27347790-6 2016 In this study, the cholesterol concentration dependence of the interaction of a CYP substrate drug, chlorzoxazone (CZX), with model membranes composed of phosphatidylcholine (PC) and cholesterol was examined via differential scanning calorimetry (DSC), UV-visible spectroscopy, and X-ray diffraction. Cholesterol 183-194 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-83 27347790-11 2016 The low cholesterol contents (12-20 mol %) of ER membranes might be the most suitable for the CYP drug metabolism process in ER membranes. Cholesterol 8-19 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 94-97 24618756-6 2014 Both flavoenzyme complexes exhibit a commonality of function with all CYP enzymes and are crucial for maintaining a balance of cholesterol and vitamin D metabolites. Cholesterol 127-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-73 21147774-1 2011 Cytochrome P450 (P450) 7A1 is well known as the cholesterol 7alpha-hydroxylase, the first enzyme involved in bile acid synthesis from cholesterol. Cholesterol 48-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 18815777-0 2009 Cytochrome P450 and gene activation--cholesterol elimination and regression of atherosclerosis: author reply to the commentary. Cholesterol 37-48 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 24760842-4 2014 Cytochrome P450 side chain cleavage (P450scc) converts cholesterol to pregnenolone, the rate-limiting enzymatic reaction in neurosteroidogenesis. Cholesterol 55-66 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 24362992-1 2013 Lanosterol 14a-demethylase CYP51 is the most conserved cytochrome P450 (CYP) and is a part of hepatic cholesterol synthesis. Cholesterol 102-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-70 24362992-1 2013 Lanosterol 14a-demethylase CYP51 is the most conserved cytochrome P450 (CYP) and is a part of hepatic cholesterol synthesis. Cholesterol 102-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 27-30 19495700-3 2009 This chapter describes methods for the measurement of the expression and catalytic activity of three key cytochrome P450 (CYP) enzymes involved in the production of progesterone and estrogens, aromatase (CYP19), steroid 17-hydroxylase/17,20-lyase (CYP17), and cholesterol side-chain cleavage (CYP11A). Cholesterol 260-271 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 122-125 18633604-0 2008 Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis. Cholesterol 58-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 18646550-5 2008 CYP isoenzymes participate in metabolic pathways important for proper physiological functioning of the human organism, i.e.: cholesterol, bile acid and oxysterol biosynthesis; metabolism of fatty acids, prostaglandins, prostacyclins, leukotrienes, steroid hormones, ketone bodies, vitamines A and D. CYP isoenzymes participate in the metabolism of over 80% of drugs and other xenobiotic substances which can be present in the human organism. Cholesterol 125-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 18646550-5 2008 CYP isoenzymes participate in metabolic pathways important for proper physiological functioning of the human organism, i.e.: cholesterol, bile acid and oxysterol biosynthesis; metabolism of fatty acids, prostaglandins, prostacyclins, leukotrienes, steroid hormones, ketone bodies, vitamines A and D. CYP isoenzymes participate in the metabolism of over 80% of drugs and other xenobiotic substances which can be present in the human organism. Cholesterol 125-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 300-303