PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19136614-5 2009 mCRP binding depends on membrane cholesterol content and is synergistically mediated by the putative cholesterol binding consensus sequence of CRP (aa 35-47) and the C-terminal octapeptide (aa 199-206). Cholesterol 33-44 C-reactive protein Homo sapiens 1-4 19136614-5 2009 mCRP binding depends on membrane cholesterol content and is synergistically mediated by the putative cholesterol binding consensus sequence of CRP (aa 35-47) and the C-terminal octapeptide (aa 199-206). Cholesterol 101-112 C-reactive protein Homo sapiens 1-4 19280766-3 2009 We here review recent findings that have linked plasma CRP levels to single nucleotide polymorphisms in hepatic nuclear factor (HNF) 1-alpha, a transcription factor with a wide range of functions, including many involved in cholesterol, bile acid, and lipoprotein metabolism. Cholesterol 224-235 C-reactive protein Homo sapiens 55-58 19583145-11 2009 The association between CRP and common carotid artery intima-media thickness remained highly significant after controlling for body mass index, blood pressure, total cholesterol, low density lipoprotein cholesterol, triglycerides, glycosylated hemoglobin and smoking (p < 0.01). Cholesterol 166-177 C-reactive protein Homo sapiens 24-27 19565136-8 2009 There was a positive correlation between CRP and total cholesterol (rs = 0.21,p = 0.05), CRP and LDL-cholesterol (rs=0.22,p=0.04) and between CRP and leukocyte count (rs = 0.32, p = 0.02) in both groups. Cholesterol 55-66 C-reactive protein Homo sapiens 41-44 19565136-8 2009 There was a positive correlation between CRP and total cholesterol (rs = 0.21,p = 0.05), CRP and LDL-cholesterol (rs=0.22,p=0.04) and between CRP and leukocyte count (rs = 0.32, p = 0.02) in both groups. Cholesterol 101-112 C-reactive protein Homo sapiens 89-92 19565136-8 2009 There was a positive correlation between CRP and total cholesterol (rs = 0.21,p = 0.05), CRP and LDL-cholesterol (rs=0.22,p=0.04) and between CRP and leukocyte count (rs = 0.32, p = 0.02) in both groups. Cholesterol 101-112 C-reactive protein Homo sapiens 89-92 19575548-7 2009 Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, gamma-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Cholesterol 79-90 C-reactive protein Homo sapiens 206-209 19019628-8 2009 RESULTS: When we compared CRP and serum lipids, we found a statistically significant negative correlation between levels of CRP and total cholesterol (P < 0.05), HDL (P < 0.01), and LDL (P < 0.05). Cholesterol 138-149 C-reactive protein Homo sapiens 26-29 19019628-8 2009 RESULTS: When we compared CRP and serum lipids, we found a statistically significant negative correlation between levels of CRP and total cholesterol (P < 0.05), HDL (P < 0.01), and LDL (P < 0.05). Cholesterol 138-149 C-reactive protein Homo sapiens 124-127 19019628-11 2009 CONCLUSION: A significant negative correlation between levels of inflammation markers (neopterin in urine, CRP) and total cholesterol and HDL was found. Cholesterol 122-133 C-reactive protein Homo sapiens 107-110 19166691-4 2009 Effects within subgroups (age, gender, race, body mass index, diabetes mellitus, metabolic syndrome, CAD, baseline CRP or lipids, and statin potency) and correlations between CRP and LDL cholesterol were also examined. Cholesterol 187-198 C-reactive protein Homo sapiens 175-178 19166691-11 2009 Correlations between changes in CRP and changes in LDL cholesterol were weakly positive and significant only when ezetimibe was added to statin treatment. Cholesterol 55-66 C-reactive protein Homo sapiens 32-35 19297430-6 2009 When we used previously established categories to define CRP concentrations (low, <1 mg/L; intermediate, 1-3 mg/L; or high, >3 mg/L), we found a CRP x diet interaction on change in triglyceride concentrations (P = 0.03) and trends for CRP x diet interaction on change in LDL (P = 0.06) and total cholesterol (P = 0.07). Cholesterol 302-313 C-reactive protein Homo sapiens 57-60 19297430-6 2009 When we used previously established categories to define CRP concentrations (low, <1 mg/L; intermediate, 1-3 mg/L; or high, >3 mg/L), we found a CRP x diet interaction on change in triglyceride concentrations (P = 0.03) and trends for CRP x diet interaction on change in LDL (P = 0.06) and total cholesterol (P = 0.07). Cholesterol 302-313 C-reactive protein Homo sapiens 151-154 19297430-6 2009 When we used previously established categories to define CRP concentrations (low, <1 mg/L; intermediate, 1-3 mg/L; or high, >3 mg/L), we found a CRP x diet interaction on change in triglyceride concentrations (P = 0.03) and trends for CRP x diet interaction on change in LDL (P = 0.06) and total cholesterol (P = 0.07). Cholesterol 302-313 C-reactive protein Homo sapiens 151-154 19035968-6 2009 Arachidonic acid correlated inversely with HBAI in UC and total and HDL cholesterol were inversely related to C-reactive protein (CRP) in CD while HDL correlated with CRP in UC. Cholesterol 72-83 C-reactive protein Homo sapiens 110-128 19035968-6 2009 Arachidonic acid correlated inversely with HBAI in UC and total and HDL cholesterol were inversely related to C-reactive protein (CRP) in CD while HDL correlated with CRP in UC. Cholesterol 72-83 C-reactive protein Homo sapiens 130-133 19130414-8 2009 A significant positive correlation between CRP and body mass index, waist circumference, glucose at admission, resistin, and leptin and a negative relation of CRP to HDL-cholesterol and adiponectin were observed. Cholesterol 170-181 C-reactive protein Homo sapiens 159-162 18206145-9 2009 In control subjects, CRP and C3 correlated with glucose and triglyceride, only CRP correlated with nonesterified fatty acids and cholesterol, and ASP correlated with triglyceride (again, all correlations were significant), whereas in subjects with PCOS, several of these correlations were lost, as a result of consistently higher levels of CRP and ASP regardless of BMI. Cholesterol 129-140 C-reactive protein Homo sapiens 79-82 18206145-9 2009 In control subjects, CRP and C3 correlated with glucose and triglyceride, only CRP correlated with nonesterified fatty acids and cholesterol, and ASP correlated with triglyceride (again, all correlations were significant), whereas in subjects with PCOS, several of these correlations were lost, as a result of consistently higher levels of CRP and ASP regardless of BMI. Cholesterol 129-140 C-reactive protein Homo sapiens 79-82 19008869-8 2009 In treated HIV, subjects with higher CRP had significantly higher total cholesterol, VAT, and IMCL. Cholesterol 72-83 C-reactive protein Homo sapiens 37-40 18360022-8 2008 Furthermore, CRP was positively correlated with BMI, VFA, SFA, TG, high-density lipoprotein (HDL)-cholesterol, atherosclerosis index (AI), immunoreactive insulin (IRI) and HOMA-IR in simple regression analysis. Cholesterol 98-109 C-reactive protein Homo sapiens 13-16 18486609-10 2008 CONCLUSIONS: The pharmacologic intervention of endogenous CRP by PEt-based compounds, or the use of exogenously prepared CRP-PEt complexes, may turn out to be an effective approach to capture native LDL cholesterol in vivo to prevent the development of atherosclerosis. Cholesterol 203-214 C-reactive protein Homo sapiens 121-124 23105739-13 2008 CRP levels in stroke patients showed significant correlation with total cholesterol and LDL (p<0.001), Lp (a) (p=0.002) and atherogenic indices (p<0.05). Cholesterol 72-83 C-reactive protein Homo sapiens 0-3 18313449-4 2008 Maternal CRP level was correlated with maternal cholesterol and aortic atherosclerosis of children. Cholesterol 48-59 C-reactive protein Homo sapiens 9-12 18313449-8 2008 CONCLUSION: CRP level during pregnancy is a predictor of increased atherogenesis in children of hypercholesterolemic mothers, albeit a weaker one than maternal cholesterol. Cholesterol 101-112 C-reactive protein Homo sapiens 12-15 18096828-3 2008 Clinically relevant concentrations of CRP significantly reduced cholesterol efflux from THP-1 and PBMCs to apoA-I or HDL. Cholesterol 64-75 C-reactive protein Homo sapiens 38-41 18096828-6 2008 Reducing superoxide anion by antioxidant seleno-L-methionine or SOD mimetic (MnTBAP) effectively abolished the CRP-induced decrease in cholesterol efflux and the expression of ABCA1 and ABCG1. Cholesterol 135-146 C-reactive protein Homo sapiens 111-114 18096828-8 2008 CONCLUSIONS: CRP inhibits cholesterol efflux from human foam cells derived from THP-1 and PBMCs in vitro though oxidative stress, ERK1/2 activation, and downregulation of intracellular cholesterol transport molecules ABCA1 and ABCG1. Cholesterol 26-37 C-reactive protein Homo sapiens 13-16 18096828-8 2008 CONCLUSIONS: CRP inhibits cholesterol efflux from human foam cells derived from THP-1 and PBMCs in vitro though oxidative stress, ERK1/2 activation, and downregulation of intracellular cholesterol transport molecules ABCA1 and ABCG1. Cholesterol 185-196 C-reactive protein Homo sapiens 13-16 18725428-5 2008 RESULTS: Past-year MDD was associated with increased CRP concentration levels (4.31 mg/L for participants who reported episodes of MDD in the past year versus 3.65 mg/L for those who did not; p = .003), and the odds ratio for incident IHD associated with higher CRP concentration was 2.02 (comparing the top versus bottom quartile of CRP; 95% Confidence Interval (CI) = 1.52-2.68), adjusted for cigarette smoking, diabetes, systolic blood pressure, body mass index, and cholesterol. Cholesterol 470-481 C-reactive protein Homo sapiens 53-56 18493107-11 2008 In multiple logistic regression analysis, diabetes showed a significant age-adjusted association with elevated CRP levels [Odds Ratio = 2.03, Confidence Interval (1.38-2.98); p<0.0001] after adjusting for sex, LDL-cholesterol, HDL-cholesterol blood pressure, smoking and body mass index. Cholesterol 217-228 C-reactive protein Homo sapiens 111-114 18493107-11 2008 In multiple logistic regression analysis, diabetes showed a significant age-adjusted association with elevated CRP levels [Odds Ratio = 2.03, Confidence Interval (1.38-2.98); p<0.0001] after adjusting for sex, LDL-cholesterol, HDL-cholesterol blood pressure, smoking and body mass index. Cholesterol 234-245 C-reactive protein Homo sapiens 111-114 18096828-0 2008 C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells. Cholesterol 28-39 C-reactive protein Homo sapiens 0-18 18096828-1 2008 OBJECTIVE: The objective of this study was to determine the effects and potential mechanisms of C-reactive protein (CRP) on cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis. Cholesterol 124-135 C-reactive protein Homo sapiens 96-114 18096828-1 2008 OBJECTIVE: The objective of this study was to determine the effects and potential mechanisms of C-reactive protein (CRP) on cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis. Cholesterol 124-135 C-reactive protein Homo sapiens 116-119 17964679-10 2008 In multiple linear regression analysis, the independent variable that most strongly explained the CRP level was WC, which was followed by HDL-cholesterol. Cholesterol 142-153 C-reactive protein Homo sapiens 98-101 18360022-9 2008 In multiple stepwise regression analysis, VFA and HDL-cholesterol were predominant determinants of CRP in HD patients. Cholesterol 54-65 C-reactive protein Homo sapiens 99-102 19378424-8 2008 Serum CRP, TNFalpha, sTNFAR2, but not IL-6, were associated with low insulin sensitivity, total body fat, abdominal obesity, hyperinsulinemia, hypertriglyceridemia, low HDL cholesterol and small LDL particles, i.e. the metabolic syndrome. Cholesterol 173-184 C-reactive protein Homo sapiens 6-9 17693973-8 2007 In univariate regression analysis CRP was related to obesity, HDL-cholesterol, fasting glucose, glucose at admission and adipokines but only glucose at admission and resistin were the independent positive factors and adiponectin an independent negative factor associated with CRP levels (R2= 51.1%). Cholesterol 66-77 C-reactive protein Homo sapiens 34-37 17719297-7 2007 RESULTS: Higher CRP levels were positively associated with PAD, independent of smoking, waist circumference, body mass index, blood pressure, glycosylated hemoglobin, serum total cholesterol, and other confounders. Cholesterol 179-190 C-reactive protein Homo sapiens 16-19 18163969-4 2007 Recently, the National Cholesterol Education Program, through the Adult Treatment Panel III guidelines, identified CRP and another marker of inflammation, the fibrinogen, as "emerging risk factors," suggesting that their measurement may improve the estimations of absolute risk obtained using the traditional cardiovascular risk factors. Cholesterol 23-34 C-reactive protein Homo sapiens 115-118 17512573-3 2007 RESULTS: CRP was higher in ASV than RSV and HS, and negatively correlated with HDL-cholesterol and Apo-AI. Cholesterol 83-94 C-reactive protein Homo sapiens 9-12 17049532-6 2007 In univariate analysis, CRP levels correlated positively with total cholesterol (p=0.01), LDL cholesterol (p=0.001), triglycerides (p=0.04) and Framingham risk score (p=0.006), and negatively with HDL cholesterol (p=0.004). Cholesterol 68-79 C-reactive protein Homo sapiens 24-27 17049532-6 2007 In univariate analysis, CRP levels correlated positively with total cholesterol (p=0.01), LDL cholesterol (p=0.001), triglycerides (p=0.04) and Framingham risk score (p=0.006), and negatively with HDL cholesterol (p=0.004). Cholesterol 94-105 C-reactive protein Homo sapiens 24-27 17049532-6 2007 In univariate analysis, CRP levels correlated positively with total cholesterol (p=0.01), LDL cholesterol (p=0.001), triglycerides (p=0.04) and Framingham risk score (p=0.006), and negatively with HDL cholesterol (p=0.004). Cholesterol 94-105 C-reactive protein Homo sapiens 24-27 17049532-9 2007 In multivariate analysis, independent factors associated with the highest quartile of serum CRP concentrations (0.49 mg/dl) were LDL-cholesterol (p<0.001), HDL-cholesterol (p=0.001), cigarette smoking (p=0.019) and current ART (p=0.021). Cholesterol 133-144 C-reactive protein Homo sapiens 92-95 17049532-9 2007 In multivariate analysis, independent factors associated with the highest quartile of serum CRP concentrations (0.49 mg/dl) were LDL-cholesterol (p<0.001), HDL-cholesterol (p=0.001), cigarette smoking (p=0.019) and current ART (p=0.021). Cholesterol 163-174 C-reactive protein Homo sapiens 92-95 17953926-8 2007 In males, there were significant direct correlations between the C-reactive protein concentration and body mass index, total fat mass, central adiposity, waist circumference, and low-density lipoprotein (LDL) cholesterol level. Cholesterol 209-220 C-reactive protein Homo sapiens 65-83 17953926-10 2007 Boys in the highest C-reactive protein tertile had a significantly higher body mass index, total fat mass, LDL cholesterol level, and waist circumference. Cholesterol 111-122 C-reactive protein Homo sapiens 20-38 17655623-6 2007 Hs-CRP levels correlated to body mass index (r = 0.411, p = 0.003), diastolic blood pressure (r = 0.323, p = 0.021), fibrinogen (r = 0.447 and p = 0.004) and HDL cholesterol levels (r =-0.461 and p = 0.001). Cholesterol 162-173 C-reactive protein Homo sapiens 3-6 17702268-10 2007 CRP showed a significant positive association with current smoking, waist-hip ratio (WHR), LDL-cholesterol, triglycerides, leptin, and insulin, independent of age, sex, and BMI. Cholesterol 95-106 C-reactive protein Homo sapiens 0-3 17702268-11 2007 Significant independent negative associations for CRP were observed with HDL-cholesterol (HDL), insulin sensitivity (quantitative insulin sensitivity check index [QUICKI]), and hours of exercise. Cholesterol 77-88 C-reactive protein Homo sapiens 50-53 17382928-6 2007 The presence of the TCCG haplotype was associated with greater CRP concentrations in Caucasian women (p=0.0004) and this relationship was maintained after adjustment for age, BMI, smoking, diabetes, and cholesterol-lowering therapy (p=0.003). Cholesterol 203-214 C-reactive protein Homo sapiens 63-66 17451439-9 2007 Highly sensitive C-reactive protein was elevated in the group with cholesterol levels higher than 251 mg.dL(-1). Cholesterol 67-78 C-reactive protein Homo sapiens 17-35 17785926-6 2007 The mean values of CRP were significantly higher in current smokers than in nonsmokers after adjustment for age, body mass index (BMI), systolic blood pressure, total cholesterol, log triglycerides, high-density lipoprotein cholesterol (HDL-C), fasting glucose, and drinking habit (p=0.011). Cholesterol 167-178 C-reactive protein Homo sapiens 19-22 17577433-7 2007 CONCLUSION: The high level hs-CRP is in close relation with acute stroke, and blood pressure, serum fasting blood glucose and cholesterol are significant and independent risk factors that might influence the level of hs-CRP. Cholesterol 126-137 C-reactive protein Homo sapiens 220-223 17633905-5 2007 The relationship between a patient"s baseline plasma level of CRP and future vascular risk has been consistent in several studies, and in most cases has proven independent of major "traditional" risk factors such as age, smoking, cholesterol levels, blood pressure and diabetes. Cholesterol 230-241 C-reactive protein Homo sapiens 62-65 16703189-7 2006 In partial correlation, plasma CRP positively correlated with body mass index (p<0.001), waist circumference (p<0.001), waist-to-hip ratio (p<0.01), total cholesterol (p<0.001), LDL-cholesterol (p=0.033), triglyceride (p=0.023), and fasting blood glucose (p=0.043) in patients with metabolic syndrome. Cholesterol 164-175 C-reactive protein Homo sapiens 31-34 17512355-0 2007 Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein: a meta-analysis. Cholesterol 62-73 C-reactive protein Homo sapiens 96-114 17350919-8 2007 The hs-CRP was correlated with total cholesterol (p = 0.039) and EPO-dose (p = 0.03) in diabetics, while with serum fibrinogen (p = 0.025) in non-diabetics. Cholesterol 37-48 C-reactive protein Homo sapiens 7-10 17359487-0 2007 Vascular stiffness in familial hypercholesterolaemia is associated with C-reactive protein and cholesterol burden. Cholesterol 36-47 C-reactive protein Homo sapiens 72-90 17359487-3 2007 The aims of this study were to quantify atherosclerosis and arterial stiffness and to evaluate their relationship with high sensitive C-reactive protein (hs-CRP) and the level of exposure to high serum cholesterol in FH patients. Cholesterol 202-213 C-reactive protein Homo sapiens 134-152 17468081-10 2007 Hence the present study shows that serum CRP concentrations are increased in patients with classical coronary risk factors, and that they may be modulated by dietary cholesterol. Cholesterol 166-177 C-reactive protein Homo sapiens 41-44 16682979-3 2007 RESULTS: Mean (95% CI) CRP in women and men was 4.06 cholesterol (3.53, 4.66) mg/l and 3.42 (2.94, 3.97) mg/l, respectively (P=NS). Cholesterol 53-64 C-reactive protein Homo sapiens 23-26 17214052-14 2006 c-reactive protein was also higher in patients with extracranial carotid stenosis but their cholesterol and low-density lipoprotein were significantly lower than those with intracranial disease. Cholesterol 92-103 C-reactive protein Homo sapiens 0-18 17023703-7 2006 At baseline, BMI was highly correlated with tHcy (r = 0.39, P = 0.003) and CRP (r = 0.55, P < 0.0001), whereas HDL cholesterol was correlated with CRP (r = -0.30, P = 0.02). Cholesterol 118-129 C-reactive protein Homo sapiens 150-153 16918582-8 2006 Moreover, increasing CRP concentration in this paediatric population was associated with an enhanced CV risk profile, consisting of increased adiposity, higher insulin resistance, worsening lipid profile (higher total cholesterol, triglycerides, low-density lipoprotein cholesterol, apolipoprotein B and total cholesterol : high-density-lipoprotein cholesterol ratio), increased leptin and decreased adiponectin. Cholesterol 218-229 C-reactive protein Homo sapiens 21-24 16918582-8 2006 Moreover, increasing CRP concentration in this paediatric population was associated with an enhanced CV risk profile, consisting of increased adiposity, higher insulin resistance, worsening lipid profile (higher total cholesterol, triglycerides, low-density lipoprotein cholesterol, apolipoprotein B and total cholesterol : high-density-lipoprotein cholesterol ratio), increased leptin and decreased adiponectin. Cholesterol 270-281 C-reactive protein Homo sapiens 21-24 17003600-8 2006 In the female group, however, log hs-CRP was significantly correlated (P < .05) with total cholesterol (r = 0.30), low-density lipoprotein (r = 0.27), tryglycerides (r = 0.51), and body mass index (r = 0.36). Cholesterol 94-105 C-reactive protein Homo sapiens 37-40 16784936-5 2006 An original analysis of available data shows that the ability of a lipid-lowering therapy to reduce the C-reactive protein level is closely correlated with its efficacy in LDL cholesterol reduction. Cholesterol 176-187 C-reactive protein Homo sapiens 104-122 16713426-6 2006 Furthermore, CRP levels increased with increasing number of metabolic syndrome risk factors, as defined by the National Cholesterol Education Program Adult Treatment Panel III, regardless of race and sex (P for trend<0001). Cholesterol 120-131 C-reactive protein Homo sapiens 13-16 17468081-8 2007 In the dyslipidaemic patients, approximately 4% of the variation in serum CRP could be explained by dietary cholesterol intake (p = 0.015, 2.8%), and weakly by dietary vitamin C intake (p = 0.06, 1.2%). Cholesterol 108-119 C-reactive protein Homo sapiens 74-77 17584094-6 2007 Subjects manifesting with identical low density cholesterol and/or blood pressure levels have different rates of cardiovascular accidents on the basis of different circulating CRP concentrations. Cholesterol 48-59 C-reactive protein Homo sapiens 176-179 16908949-7 2006 It was shown that age, smoking status, systolic blood pressure (SBP) and LDL cholesterol were significantly associated with IMT in subjects in the lower CRP groups (CRP-1 approximately CRP-3), and age, SBP and presence of diabetes mellitus in the highest CRP group (CRP-4). Cholesterol 77-88 C-reactive protein Homo sapiens 153-156 16908949-7 2006 It was shown that age, smoking status, systolic blood pressure (SBP) and LDL cholesterol were significantly associated with IMT in subjects in the lower CRP groups (CRP-1 approximately CRP-3), and age, SBP and presence of diabetes mellitus in the highest CRP group (CRP-4). Cholesterol 77-88 C-reactive protein Homo sapiens 165-168 16908949-7 2006 It was shown that age, smoking status, systolic blood pressure (SBP) and LDL cholesterol were significantly associated with IMT in subjects in the lower CRP groups (CRP-1 approximately CRP-3), and age, SBP and presence of diabetes mellitus in the highest CRP group (CRP-4). Cholesterol 77-88 C-reactive protein Homo sapiens 165-168 16908949-8 2006 To further investigate whether the interaction between CRP and conventional risk factors could influence IMT, a general linear model demonstrated that interaction between CRP and the presence of diabetes mellitus (F = 4.754 p = 0.030) was significantly associated with IMT, in addition to sex, age, SBP, antihypertensive drug use, LDL cholesterol and HDL cholesterol. Cholesterol 335-346 C-reactive protein Homo sapiens 171-174 16908949-8 2006 To further investigate whether the interaction between CRP and conventional risk factors could influence IMT, a general linear model demonstrated that interaction between CRP and the presence of diabetes mellitus (F = 4.754 p = 0.030) was significantly associated with IMT, in addition to sex, age, SBP, antihypertensive drug use, LDL cholesterol and HDL cholesterol. Cholesterol 355-366 C-reactive protein Homo sapiens 171-174 16703189-7 2006 In partial correlation, plasma CRP positively correlated with body mass index (p<0.001), waist circumference (p<0.001), waist-to-hip ratio (p<0.01), total cholesterol (p<0.001), LDL-cholesterol (p=0.033), triglyceride (p=0.023), and fasting blood glucose (p=0.043) in patients with metabolic syndrome. Cholesterol 194-205 C-reactive protein Homo sapiens 31-34 15950309-6 2005 CRP levels were significantly but marginally correlated with waist circumference (r=0.18), triglyceride (r=0.14), blood pressure (r=0.11), HDL-cholesterol (r=-0.10), and fasting glucose (r=0.09) (all P values<0.01). Cholesterol 143-154 C-reactive protein Homo sapiens 0-3 16581701-10 2006 Elevated serum C-reactive protein (CRP) or orosomucoid grouped the subjects with high and low serum HDL-cholesterol concentrations better than history of infection alone. Cholesterol 104-115 C-reactive protein Homo sapiens 15-33 16581701-10 2006 Elevated serum C-reactive protein (CRP) or orosomucoid grouped the subjects with high and low serum HDL-cholesterol concentrations better than history of infection alone. Cholesterol 104-115 C-reactive protein Homo sapiens 35-38 16176811-10 2006 The decrease in CRP levels to 30 week inversely correlated with the increase in HDL-cholesterol (r=-0.47, p=0.005). Cholesterol 84-95 C-reactive protein Homo sapiens 16-19 16636979-10 2006 CRP was correlated positively with plasma levels of triglycerides (r=0.19, p=0.002), C-peptide (r=0.21, p=0.004), postprandial glucose (r=0.17, p=0.009), albuminuria (r=0.16, p=0.020), and inversely with HDL cholesterol (r=-0.20, p=0.002) in type 2 diabetic patients. Cholesterol 208-219 C-reactive protein Homo sapiens 0-3 16314875-9 2006 In men, CRP was independently and positively associated to waist circumference, smoking, diastolic blood pressure, uric acid and triglycerides, and negatively associated to HDL-cholesterol. Cholesterol 177-188 C-reactive protein Homo sapiens 8-11 16054696-3 2006 Cholesterol-lowering drugs statins also lower CRP. Cholesterol 0-11 C-reactive protein Homo sapiens 46-49 17201275-6 2006 There was a positive correlation between hs-CRP level and the activity of the disease according to ECLAM score, ES value, IgG and IgM levels, hematological disturbances (anemia, leucopenia, and/or thrombocytopenia) , and a negative correlation with total cholesterol level, HDLC there was a moderate correlation between hs-CRP and a maximal IMC value. Cholesterol 255-266 C-reactive protein Homo sapiens 44-47 15950309-7 2005 Odds ratios of the highest quartile of CRP for each component of MS; i.e., waist circumference, triglyceride, glucose metabolism, blood pressure, and HDL-cholesterol were 2.36, 1.79, 1.70, 1.32 and 1.28, respectively. Cholesterol 154-165 C-reactive protein Homo sapiens 39-42 16238678-10 2005 In men, the multivariate correlates of CRP included waist circumference (P<0.0001), smoking (<0.0001) and HDL cholesterol (P=0.024) (inverse association). Cholesterol 116-127 C-reactive protein Homo sapiens 39-42 16216995-2 2005 However, the extent to which high CRP levels (>3 mg/L) may be attributable to high cholesterol levels and other CHD risk factors has not been well defined. Cholesterol 86-97 C-reactive protein Homo sapiens 34-37 15987707-7 2005 The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P<0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P<0.001). Cholesterol 207-218 C-reactive protein Homo sapiens 25-43 15987707-7 2005 The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P<0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P<0.001). Cholesterol 224-235 C-reactive protein Homo sapiens 25-43 15829284-5 2005 CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation. Cholesterol 143-154 C-reactive protein Homo sapiens 0-3 16137286-9 2005 CONCLUSION: The relationship between IL-6 and plasma CRP and cholesterol levels in nonagenarians with enhanced systemic inflammation differs from that of middle-aged subjects. Cholesterol 61-72 C-reactive protein Homo sapiens 53-56 16109328-8 2005 In separate backward elimination multiple regression analyses, log CRP was significantly associated with AIX (P = .038) and pulse pressure (P = .036), and marginally significantly associated with PWV (P = .054), after adjustment for heart rate, height, and coronary heart disease (CHD) risk factors (age, sex, body mass index, mean arterial pressure, total cholesterol, HDL cholesterol, diabetes, hypertension, and history of smoking). Cholesterol 357-368 C-reactive protein Homo sapiens 67-70 16109328-8 2005 In separate backward elimination multiple regression analyses, log CRP was significantly associated with AIX (P = .038) and pulse pressure (P = .036), and marginally significantly associated with PWV (P = .054), after adjustment for heart rate, height, and coronary heart disease (CHD) risk factors (age, sex, body mass index, mean arterial pressure, total cholesterol, HDL cholesterol, diabetes, hypertension, and history of smoking). Cholesterol 374-385 C-reactive protein Homo sapiens 67-70 16054551-7 2005 CONCLUSIONS: In normal-weight women, ln-CRP was significantly associated with BMI, PAI-1, serum insulin, and HDL-cholesterol. Cholesterol 113-124 C-reactive protein Homo sapiens 40-43 16130007-10 2005 The CRP level showed a strong correlation only with the serum concentration of cholesterol (r=0.49, p < 0.000), and did not correlate with the serum albumin of the MHD patients. Cholesterol 79-90 C-reactive protein Homo sapiens 4-7 15867284-1 2005 Recent evidence suggests that individuals with high concentrations of C-reactive protein (CRP), a marker of inflammation, are less responsive to cholesterol-lowering diets. Cholesterol 145-156 C-reactive protein Homo sapiens 70-88 15867284-1 2005 Recent evidence suggests that individuals with high concentrations of C-reactive protein (CRP), a marker of inflammation, are less responsive to cholesterol-lowering diets. Cholesterol 145-156 C-reactive protein Homo sapiens 90-93 15867284-7 2005 Regardless of protein source, those with low CRP exhibited significant decreases in LDL cholesterol (-3.5%) and the LDL:HDL cholesterol ratio (-4.8%), whereas those with high CRP had significant increases in LDL cholesterol (+4.8%), the LDL:HDL cholesterol ratio (+5.2%), apolipoprotein B (+3.8%), and lipoprotein(a) (+13.5%) compared with the run-in diet. Cholesterol 88-99 C-reactive protein Homo sapiens 45-48 15867284-7 2005 Regardless of protein source, those with low CRP exhibited significant decreases in LDL cholesterol (-3.5%) and the LDL:HDL cholesterol ratio (-4.8%), whereas those with high CRP had significant increases in LDL cholesterol (+4.8%), the LDL:HDL cholesterol ratio (+5.2%), apolipoprotein B (+3.8%), and lipoprotein(a) (+13.5%) compared with the run-in diet. Cholesterol 124-135 C-reactive protein Homo sapiens 45-48 15867284-7 2005 Regardless of protein source, those with low CRP exhibited significant decreases in LDL cholesterol (-3.5%) and the LDL:HDL cholesterol ratio (-4.8%), whereas those with high CRP had significant increases in LDL cholesterol (+4.8%), the LDL:HDL cholesterol ratio (+5.2%), apolipoprotein B (+3.8%), and lipoprotein(a) (+13.5%) compared with the run-in diet. Cholesterol 124-135 C-reactive protein Homo sapiens 45-48 15998471-0 2005 Serum resistin is associated with C-reactive protein & LDL cholesterol in type 2 diabetes and coronary artery disease in a Saudi population. Cholesterol 63-74 C-reactive protein Homo sapiens 34-52 15979442-4 2005 Women with greater hs-CRP concentrations showed deterioration in their metabolic risk profiles, including abdominal obesity, greater triglyceride and lower HDL cholesterol concentrations, and lower insulin sensitivity compared with women with lower hs-CRP levels. Cholesterol 160-171 C-reactive protein Homo sapiens 22-25 15979442-5 2005 Fifty-nine percent of women with high hs-CRP concentrations had the metabolic syndrome as recently defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Cholesterol 143-154 C-reactive protein Homo sapiens 41-44 15979442-5 2005 Fifty-nine percent of women with high hs-CRP concentrations had the metabolic syndrome as recently defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Cholesterol 240-251 C-reactive protein Homo sapiens 41-44 15939816-0 2005 Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects. Cholesterol 0-11 C-reactive protein Homo sapiens 30-48 15829284-5 2005 CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation. Cholesterol 143-154 C-reactive protein Homo sapiens 97-100 15829284-5 2005 CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation. Cholesterol 143-154 C-reactive protein Homo sapiens 97-100 15687975-8 2005 The hs CRP concentrations were significantly correlated with total cholesterol, total cholesterol/HDL-cholesterol ratio, and LDL cholesterol for the 2 groups of patients. Cholesterol 86-97 C-reactive protein Homo sapiens 7-10 15686768-3 2005 The addition of CRP to standard lipid screening may improve global risk prediction among those with high as well as low cholesterol. Cholesterol 120-131 C-reactive protein Homo sapiens 16-19 15801991-17 2005 Limitations include no serum levels prior to statin use and small sample size; thus, future studies are needed to address the relationship between cholesterol and CRP and the mechanism of action of statins on CRP. Cholesterol 147-158 C-reactive protein Homo sapiens 163-166 15788980-6 2005 The availability of high sensibility assays for CRP should provide a valuable tool for identifying patients at risk of cardiovascular events in primary prevention in conjunction with lowering LDL cholesterol and may also have utility in the treatment of acute coronary syndromes with percutaneous coronary intervention (PCI) therapy. Cholesterol 196-207 C-reactive protein Homo sapiens 48-51 15618238-12 2005 In univariate analysis, DeltaCCA-IMT correlated positively with age (R = 0.32, P = 0.03), BMI (R = 0.29, P = 0.05) and mean concentrations of CRP (R = 0.37, P = 0.01), TNFalpha (0.52, P = 0.0002), but inversely with HDL-cholesterol (R = -0.37, P = 0.01). Cholesterol 220-231 C-reactive protein Homo sapiens 142-145 15766555-0 2005 C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles. Cholesterol 50-61 C-reactive protein Homo sapiens 0-18 15766555-2 2005 We previously found binding of CRP to cholesterol in modified low density lipoprotein (LDL) particles. Cholesterol 38-49 C-reactive protein Homo sapiens 31-34 15766555-3 2005 Here, we characterize the interaction between CRP and cholesterol in more detail. Cholesterol 54-65 C-reactive protein Homo sapiens 46-49 15766555-4 2005 When lipids of native LDL were separated by thin-layer chromatography, CRP bound only to cholesterol. Cholesterol 89-100 C-reactive protein Homo sapiens 71-74 15766555-5 2005 When various cholesterol analogues were compared for their ability to bind CRP, we found that any modification of the 3beta-OH group blocked binding of CRP to cholesterol. Cholesterol 13-24 C-reactive protein Homo sapiens 75-78 15766555-5 2005 When various cholesterol analogues were compared for their ability to bind CRP, we found that any modification of the 3beta-OH group blocked binding of CRP to cholesterol. Cholesterol 13-24 C-reactive protein Homo sapiens 152-155 15766555-5 2005 When various cholesterol analogues were compared for their ability to bind CRP, we found that any modification of the 3beta-OH group blocked binding of CRP to cholesterol. Cholesterol 159-170 C-reactive protein Homo sapiens 75-78 15766555-5 2005 When various cholesterol analogues were compared for their ability to bind CRP, we found that any modification of the 3beta-OH group blocked binding of CRP to cholesterol. Cholesterol 159-170 C-reactive protein Homo sapiens 152-155 15766555-6 2005 Similarly, enrichment of LDL with cholesterol but not with its analogues triggered the binding of CRP to LDL. Cholesterol 34-45 C-reactive protein Homo sapiens 98-101 15766555-7 2005 Finally, with the aid of anti-CRP monoclonal antibodies and by molecular modeling, we obtained evidence for involvement of the phosphorylcholine-binding site of CRP in cholesterol binding. Cholesterol 168-179 C-reactive protein Homo sapiens 30-33 15766555-7 2005 Finally, with the aid of anti-CRP monoclonal antibodies and by molecular modeling, we obtained evidence for involvement of the phosphorylcholine-binding site of CRP in cholesterol binding. Cholesterol 168-179 C-reactive protein Homo sapiens 161-164 15766555-8 2005 Thus, CRP can bind to cholesterol, and the interaction is mediated by the phosphorylcholine-binding site of CRP and the 3beta-hydroxyl group of cholesterol. Cholesterol 22-33 C-reactive protein Homo sapiens 6-9 15766555-8 2005 Thus, CRP can bind to cholesterol, and the interaction is mediated by the phosphorylcholine-binding site of CRP and the 3beta-hydroxyl group of cholesterol. Cholesterol 22-33 C-reactive protein Homo sapiens 108-111 15766555-8 2005 Thus, CRP can bind to cholesterol, and the interaction is mediated by the phosphorylcholine-binding site of CRP and the 3beta-hydroxyl group of cholesterol. Cholesterol 144-155 C-reactive protein Homo sapiens 6-9 15803114-9 2005 CRP showed a positive correlation with BMI, insulin, homeostasis model assessment (HOMA), triglycerides, alanine aminotransferase (ALT), uric acid, PAI-1, fibrinogen and interleukin 6 (IL-6), and correlated negatively with apolipoprotein A-I and high-density lipoprotein cholesterol (HDL-C). Cholesterol 271-282 C-reactive protein Homo sapiens 0-3 15687975-8 2005 The hs CRP concentrations were significantly correlated with total cholesterol, total cholesterol/HDL-cholesterol ratio, and LDL cholesterol for the 2 groups of patients. Cholesterol 67-78 C-reactive protein Homo sapiens 7-10 15687975-8 2005 The hs CRP concentrations were significantly correlated with total cholesterol, total cholesterol/HDL-cholesterol ratio, and LDL cholesterol for the 2 groups of patients. Cholesterol 86-97 C-reactive protein Homo sapiens 7-10 15687975-8 2005 The hs CRP concentrations were significantly correlated with total cholesterol, total cholesterol/HDL-cholesterol ratio, and LDL cholesterol for the 2 groups of patients. Cholesterol 86-97 C-reactive protein Homo sapiens 7-10 15785026-8 2005 Subjects who reported regularly exercising, individuals with a history of heart disease and those with lower total cholesterol levels were less likely to have elevated CRP levels. Cholesterol 115-126 C-reactive protein Homo sapiens 168-171 15635109-3 2005 METHODS: We evaluated relationships between the LDL cholesterol and CRP levels achieved after treatment with 80 mg of atorvastatin or 40 mg of pravastatin per day and the risk of recurrent myocardial infarction or death from coronary causes among 3745 patients with acute coronary syndromes. Cholesterol 52-63 C-reactive protein Homo sapiens 68-71 15635109-6 2005 For patients with post-treatment LDL cholesterol levels of more than 70 mg per deciliter, the rates of recurrent events were 4.6 per 100 person-years among those with CRP levels of more than 2 mg per liter and 3.2 events per 100 person-years among those with CRP levels of less than 2 mg per liter; the respective rates among those with LDL cholesterol levels of less than 70 mg per deciliter were 3.1 and 2.4 events per 100 person-years (P<0.001). Cholesterol 37-48 C-reactive protein Homo sapiens 167-170 15635109-6 2005 For patients with post-treatment LDL cholesterol levels of more than 70 mg per deciliter, the rates of recurrent events were 4.6 per 100 person-years among those with CRP levels of more than 2 mg per liter and 3.2 events per 100 person-years among those with CRP levels of less than 2 mg per liter; the respective rates among those with LDL cholesterol levels of less than 70 mg per deciliter were 3.1 and 2.4 events per 100 person-years (P<0.001). Cholesterol 37-48 C-reactive protein Homo sapiens 259-262 15635109-6 2005 For patients with post-treatment LDL cholesterol levels of more than 70 mg per deciliter, the rates of recurrent events were 4.6 per 100 person-years among those with CRP levels of more than 2 mg per liter and 3.2 events per 100 person-years among those with CRP levels of less than 2 mg per liter; the respective rates among those with LDL cholesterol levels of less than 70 mg per deciliter were 3.1 and 2.4 events per 100 person-years (P<0.001). Cholesterol 341-352 C-reactive protein Homo sapiens 167-170 15635110-8 2005 The correlation between the reduction in LDL cholesterol levels and that in CRP levels was weak but significant in the group as a whole (r=0.13, P=0.005), but not in either treatment group alone. Cholesterol 45-56 C-reactive protein Homo sapiens 76-79 16642663-6 2005 An inverse correlation of serum CRP with serum cholesterol and triglyceride levels and a near significant positive correlations of CRP with serum ALP and with serum intact parathormone (iPTH) were found too. Cholesterol 47-58 C-reactive protein Homo sapiens 32-35 16642663-10 2005 The positive correlation of high serum iPTH with inflammation implies further need to control hyperphosphatemia and secondary hyperparathyroidism in HD patients, also inverse correlation of serum CRP with cholesterol and triglyceride further support the malnutrition-inflammation complex syndrome (MICS) which frequently seen in hemodialysis patients (Tab. Cholesterol 205-216 C-reactive protein Homo sapiens 196-199 16739870-9 2005 At two hours postprandial, we found a significant nonparametric correlation between CRP level and total cholesterol (p=0.01), which remained significant even after adjusting for age, BMI, HbA1c and blood pressure values (adjusted p=0.018). Cholesterol 104-115 C-reactive protein Homo sapiens 84-87 16739870-10 2005 Patients in the lowest quartile for CRP level compared to those in the highest quartile had lower fasting apolipoprotein B levels (146 vs 197 mg/dl, p=0.042), lower postprandial blood glucose levels (188 vs 241 mg/dl, p=0.035) and lower nonHDL-cholesterol levels (148 vs 192 mg/dl, p=0.005). Cholesterol 244-255 C-reactive protein Homo sapiens 36-39 15571826-1 2004 BACKGROUND: Statins and cholesterol absorption inhibitors lower the concentration of C-reactive protein (CRP). Cholesterol 24-35 C-reactive protein Homo sapiens 105-108 15580061-3 2004 DESIGN: We investigated whether variations in blood lipids and plasma C-reactive protein induced by low-cholesterol/low-saturated fat diet are associated with variations in large-artery stiffness in hypercholesterolaemia. Cholesterol 104-115 C-reactive protein Homo sapiens 70-88 15379752-6 2004 Among the potential confounding factors analysed, smoking, body mass index, total cholesterol (P < 0.05 for all) and diabetes (P = 0.056) were positively correlated with CRP level. Cholesterol 82-93 C-reactive protein Homo sapiens 173-176 15571826-1 2004 BACKGROUND: Statins and cholesterol absorption inhibitors lower the concentration of C-reactive protein (CRP). Cholesterol 24-35 C-reactive protein Homo sapiens 85-103 15536598-4 2004 In accordance with previous findings, increased levels of CRP were associated with high body mass index (BMI) (P = .012), triglycerides (P = .001), systolic blood pressure (P = .019), cholesterol/high-density lipoprotein (HDL) ratio (P = .009), and low HDL cholesterol (P = .001). Cholesterol 184-195 C-reactive protein Homo sapiens 58-61 15535926-11 2004 CONCLUSIONS: These results confirm findings from previous studies that atorvastatin reduce CRP levels in a largely LDL cholesterol independent manner. Cholesterol 119-130 C-reactive protein Homo sapiens 91-94 15356091-6 2004 Statistically significant differences were seen at all CRP cutoffs in the levels of TG, HDL, and non-HDL cholesterol and the CRF, but no differences were seen in total cholesterol and LDL cholesterol levels. Cholesterol 105-116 C-reactive protein Homo sapiens 55-58 15336815-9 2004 A significant negative correlation was found between CRP and HDL cholesterol or QUICKI. Cholesterol 65-76 C-reactive protein Homo sapiens 53-56 15356091-7 2004 CRP levels correlated with non-HDL cholesterol levels (r = 0.16, P = 0.0236) and the CRF (r = 0.18, P = 0.14), but not with levels of HDL or TG. Cholesterol 35-46 C-reactive protein Homo sapiens 0-3 15309577-5 2004 Along the clinical course, changes in cholesterol were clearly paralleled by opposite changes in C-reactive protein, which was the best correlate of cholesterol (r2=0.70, p<0.0001). Cholesterol 38-49 C-reactive protein Homo sapiens 97-115 15309577-5 2004 Along the clinical course, changes in cholesterol were clearly paralleled by opposite changes in C-reactive protein, which was the best correlate of cholesterol (r2=0.70, p<0.0001). Cholesterol 149-160 C-reactive protein Homo sapiens 97-115 15309577-9 2004 C-reactive protein (CRP, mg/dl) and alkaline phosphatase (ALKPH, U/L) together in the same regression explained 79% of the variability of cholesterol (CHOL, mmol/L): CHOL=5.90-0.74[Log(e)CRP]+0.004[ALKPH]; multiple r2=0.79, p<0.0001. Cholesterol 138-149 C-reactive protein Homo sapiens 0-18 15309577-9 2004 C-reactive protein (CRP, mg/dl) and alkaline phosphatase (ALKPH, U/L) together in the same regression explained 79% of the variability of cholesterol (CHOL, mmol/L): CHOL=5.90-0.74[Log(e)CRP]+0.004[ALKPH]; multiple r2=0.79, p<0.0001. Cholesterol 151-155 C-reactive protein Homo sapiens 0-18 15309577-9 2004 C-reactive protein (CRP, mg/dl) and alkaline phosphatase (ALKPH, U/L) together in the same regression explained 79% of the variability of cholesterol (CHOL, mmol/L): CHOL=5.90-0.74[Log(e)CRP]+0.004[ALKPH]; multiple r2=0.79, p<0.0001. Cholesterol 166-170 C-reactive protein Homo sapiens 0-18 15206152-4 2004 Hs CRP is increased in the subjects with low HDL-cholesterol and high triglyceride. Cholesterol 49-60 C-reactive protein Homo sapiens 3-6 15262834-2 2004 METHODS AND RESULTS: We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. Cholesterol 92-103 C-reactive protein Homo sapiens 66-69 15262834-2 2004 METHODS AND RESULTS: We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. Cholesterol 189-200 C-reactive protein Homo sapiens 66-69 15154943-8 2004 There was a positive correlation of CRP with body mass index (BMI), triglycerides, uric acid, fasting glucose, oral glucose tolerance test (OGTT) 1-h glucose, OGTT 2-h glucose, and a negative correlation with HDL cholesterol. Cholesterol 213-224 C-reactive protein Homo sapiens 36-39 15334028-8 2004 The level of C-reactive protein increased on the second day after withdrawal of statin therapy (2,590.14 +/- 1,045.05 vs. 1,257.95 +/- 207.99 ng/ml); however, the total cholesterol and LDL-chol did not increase during the 3-day period after withdrawal of statin therapy. Cholesterol 169-180 C-reactive protein Homo sapiens 13-31 14993913-9 2004 Stepwise multivariate linear regression analysis identified BMI, triglyceride levels, HDL cholesterol levels (inversely), and fasting glucose as independently related to CRP levels. Cholesterol 90-101 C-reactive protein Homo sapiens 170-173 15518420-13 2004 On the basis of the conducted research and statistic calculations it is justified to point the correlation between the concentration of C-reactive protein and HDL cholesterol in the group of patients with the detected Chlamydia bacteria in comparison to the group of patients with no infection. Cholesterol 163-174 C-reactive protein Homo sapiens 136-154 15242238-6 2004 CRP levels were associated with total and regional body fat, the anthropometric index of weight, age, and with some metabolic alterations (HDL-cholesterol and triglyceride levels, systolic blood pressure, and fasting insulin and LDL-cholesterol levels). Cholesterol 143-154 C-reactive protein Homo sapiens 0-3 15242238-6 2004 CRP levels were associated with total and regional body fat, the anthropometric index of weight, age, and with some metabolic alterations (HDL-cholesterol and triglyceride levels, systolic blood pressure, and fasting insulin and LDL-cholesterol levels). Cholesterol 233-244 C-reactive protein Homo sapiens 0-3 14609606-1 2003 C-reactive protein levels may identify patients likely to benefit from lowering low-density lipoprotein (LDL) cholesterol to ultra-low levels. Cholesterol 110-121 C-reactive protein Homo sapiens 0-18 14706052-8 2004 A negative correlation was found between CRP and HDL-cholesterol (r = 0.12, P < 0.0001) and physical activity (r = 0.11, P = 0.002). Cholesterol 53-64 C-reactive protein Homo sapiens 41-44 14609606-2 2003 We find that above-average C-reactive protein with statin therapy predicts failure of carotid intima-media thickness regression in those with currently defined optimal LDL cholesterol (<100 mg/dl) but not if LDL cholesterol is <70 mg/dl. Cholesterol 172-183 C-reactive protein Homo sapiens 27-45 14609606-2 2003 We find that above-average C-reactive protein with statin therapy predicts failure of carotid intima-media thickness regression in those with currently defined optimal LDL cholesterol (<100 mg/dl) but not if LDL cholesterol is <70 mg/dl. Cholesterol 215-226 C-reactive protein Homo sapiens 27-45 14520627-6 2003 The MIS and serum concentrations of high-sensitivity C-reactive protein, interleukin 6 (IL-6), tumor necrosis factor-alpha, and lactate dehydrogenase had positive correlation with required EPO dose and EPO responsiveness index (EPO divided by hemoglobin), whereas serum total iron binding capacity (TIBC), prealbumin and total cholesterol, as well as blood lymphocyte count had statistically significant but negative correlations with indices of refractory anemia. Cholesterol 327-338 C-reactive protein Homo sapiens 53-71 12975259-8 2003 Reductions in CRP and SAA were observed in patients with unstable angina and non-Q-wave myocardial infarction, with initial LDL cholesterol <3.2 or > or =3.2 mmol/L (125 mg/dL), age > or =65 or <65 years, and in men and women. Cholesterol 128-139 C-reactive protein Homo sapiens 14-17 12948037-12 2003 So, not in patients with simply AVS but in patients under higher cardiovascular risks, investigation of CRP plus lipid levels might provide benefit with respect to preventive treatment and benefit from cholesterol-lowering drugs can be expected in such kind of patients. Cholesterol 202-213 C-reactive protein Homo sapiens 104-107 12915501-6 2003 Based on the authors" estimates, three serial determinations of C-reactive protein should be done to achieve a reliability of 0.75, the value they found for total cholesterol. Cholesterol 163-174 C-reactive protein Homo sapiens 64-82 14506615-5 2003 CRP showed a strong and negative association with high-density lipoprotein (HDL)-cholesterol (r = -0.26, P =.0005) and a marginal and positive association with triglyceride (r = 0.14, P =.05). Cholesterol 81-92 C-reactive protein Homo sapiens 0-3 14506615-7 2003 Multiple regression analysis indicated that serum CRP was positively related to serum leptin (P =.003) and QTc interval (P =.01), and negatively correlated with HDL-cholesterol (P =.01, R(2) = 0.15). Cholesterol 165-176 C-reactive protein Homo sapiens 50-53 12847067-8 2003 Total and LDL cholesterol were reduced to a greater degree in those with a "low" (below median) compared with a "high" (above median) baseline CRP (total, -9.8% versus -3%; P for interaction=0.006; LDL cholesterol, -11.8% versus -3%; P for interaction=0.009). Cholesterol 14-25 C-reactive protein Homo sapiens 143-146 12887727-1 2003 C-reactive protein (CRP) is one of the important risk factors for atherosclerosis, and its serum level is lowered by popular cholesterol-lowering drugs, statins. Cholesterol 125-136 C-reactive protein Homo sapiens 0-18 12887727-1 2003 C-reactive protein (CRP) is one of the important risk factors for atherosclerosis, and its serum level is lowered by popular cholesterol-lowering drugs, statins. Cholesterol 125-136 C-reactive protein Homo sapiens 20-23 12876093-0 2003 Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. Cholesterol 34-45 C-reactive protein Homo sapiens 95-113 12835213-3 2003 Among men and women not using hormone replacement therapy (HRT), CRP levels were significantly related to 10-year Framingham Coronary Heart Disease Risk categories [total cholesterol (TC) score for men and women: r=0.29 and r=0.22, respectively; LDL cholesterol score for men and women: r=0.29 and r=0.22, respectively, all probability values <0.01]. Cholesterol 171-182 C-reactive protein Homo sapiens 65-68 12835213-3 2003 Among men and women not using hormone replacement therapy (HRT), CRP levels were significantly related to 10-year Framingham Coronary Heart Disease Risk categories [total cholesterol (TC) score for men and women: r=0.29 and r=0.22, respectively; LDL cholesterol score for men and women: r=0.29 and r=0.22, respectively, all probability values <0.01]. Cholesterol 250-261 C-reactive protein Homo sapiens 65-68 12847067-11 2003 CONCLUSIONS: In this study, the presence of increased CRP was associated with less total and LDL cholesterol reduction and a greater increase in triglycerides from a reduced-fat/low-cholesterol diet. Cholesterol 97-108 C-reactive protein Homo sapiens 54-57 12847067-11 2003 CONCLUSIONS: In this study, the presence of increased CRP was associated with less total and LDL cholesterol reduction and a greater increase in triglycerides from a reduced-fat/low-cholesterol diet. Cholesterol 182-193 C-reactive protein Homo sapiens 54-57 12549983-7 2003 The change in the log-transformed CRP concentration correlated with the change in the log-transformed LDL cholesterol concentration. Cholesterol 106-117 C-reactive protein Homo sapiens 34-37 12911252-10 2003 CRP was significantly associated with HDL cholesterol but not triglyceride, or systolic blood pressure, concentration after controlling for BMI. Cholesterol 42-53 C-reactive protein Homo sapiens 0-3 12654581-1 2003 A simple blood test for C-reactive protein is joining cholesterol screening as an early warning for heart disease. Cholesterol 54-65 C-reactive protein Homo sapiens 24-42 12631131-9 2003 RESULTS: Elevated CRP levels were positively associated with cardiovascular and renal risk factors: age, body mass index, blood pressure, serum cholesterol level, smoking, plasma glucose level and elevated urinary albumin excretion. Cholesterol 144-155 C-reactive protein Homo sapiens 18-21 12549983-10 2003 The correlation between the reductions in CRP and LDL cholesterol differs from the findings of other published studies, and should prompt further investigation of the mechanism by which statins reduce CRP. Cholesterol 54-65 C-reactive protein Homo sapiens 42-45 12468765-9 2002 In addition, ORs for progression of atherosclerosis associated with high CRP levels were as high as those associated with the traditional cardiovascular risk factors high cholesterol, hypertension, and smoking. Cholesterol 171-182 C-reactive protein Homo sapiens 73-76 12407643-7 2002 Univariate comparisons between subjects with or without elevated CRP levels (>10 mg/L) showed that CRP level elevation was associated significantly (P < 0.05) with greater doses of human recombinant erythropoietin and lower levels of hemoglobin, serum iron, transferrin saturation (TSat), albumin averaged over the 3 preceding months, total cholesterol, and triglycerides. Cholesterol 347-358 C-reactive protein Homo sapiens 102-105 12102655-6 2002 Consistent with this hypothesis were the following findings: (i) increasing the amount of non-esterified cholesterol in LDL with cyclodextrin increased, and decreasing its amount decreased, the binding of CRP to LDL; (ii) modification of non-esterified cholesterol in LDL by cholesterol oxidase decreased the binding of CRP to LDL; and (iii) CRP bound to purified non-esterified cholesterol. Cholesterol 105-116 C-reactive protein Homo sapiens 205-208 12103255-9 2002 CONCLUSIONS: Our results suggest that individuals with elevated CRP levels, many of whom do not meet current National Cholesterol Education Program guidelines for drug treatment, may receive a substantial benefit from statin therapy. Cholesterol 118-129 C-reactive protein Homo sapiens 64-67 12398959-5 2002 Significant but weak correlations were observed between baseline CRP values and baseline levels of LDL cholesterol and high-density lipoprotein (HDL) cholesterol, but not with TGs. Cholesterol 103-114 C-reactive protein Homo sapiens 65-68 12398959-5 2002 Significant but weak correlations were observed between baseline CRP values and baseline levels of LDL cholesterol and high-density lipoprotein (HDL) cholesterol, but not with TGs. Cholesterol 150-161 C-reactive protein Homo sapiens 65-68 12398959-8 2002 Although CRP change was weakly correlated with changes in LDL cholesterol, TGs, and HDL cholesterol, results of regression analyses showed that only baseline CRP and treatment allocation were significant predictors of CRP response after 6 weeks of study drug administration. Cholesterol 88-99 C-reactive protein Homo sapiens 9-12 12208482-2 2002 In this setting, C-reactive protein (CRP) was shown to add predictive value to cholesterol levels. Cholesterol 79-90 C-reactive protein Homo sapiens 17-35 12208482-2 2002 In this setting, C-reactive protein (CRP) was shown to add predictive value to cholesterol levels. Cholesterol 79-90 C-reactive protein Homo sapiens 37-40 12422112-8 2002 An inverse linear correlation was found between total cholesterol/low density lipoprotein cholesterol and C-reactive protein (P <.001 and P <.04, respectively). Cholesterol 54-65 C-reactive protein Homo sapiens 106-124 12102655-0 2002 Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein. Cholesterol 95-106 C-reactive protein Homo sapiens 11-29 12102655-0 2002 Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein. Cholesterol 95-106 C-reactive protein Homo sapiens 129-147 12102655-5 2002 In these two forms of modified LDL, non-esterified cholesterol was susceptible to cholesterol oxidase, indicating exposure of non-esterified cholesterol on particle surfaces and suggesting a role for non-esterified cholesterol in mediating CRP binding. Cholesterol 51-62 C-reactive protein Homo sapiens 240-243 12033985-6 2002 On incubation with macrophages, the immobilized CRP-bound LDL aggregates were readily taken up by the cells, as demonstrated by immunofluorescence microscopy, by the cellular accumulation of cholesterol and by the overexpression of adipophilin. Cholesterol 191-202 C-reactive protein Homo sapiens 48-51 12102655-6 2002 Consistent with this hypothesis were the following findings: (i) increasing the amount of non-esterified cholesterol in LDL with cyclodextrin increased, and decreasing its amount decreased, the binding of CRP to LDL; (ii) modification of non-esterified cholesterol in LDL by cholesterol oxidase decreased the binding of CRP to LDL; and (iii) CRP bound to purified non-esterified cholesterol. Cholesterol 105-116 C-reactive protein Homo sapiens 320-323 12102655-6 2002 Consistent with this hypothesis were the following findings: (i) increasing the amount of non-esterified cholesterol in LDL with cyclodextrin increased, and decreasing its amount decreased, the binding of CRP to LDL; (ii) modification of non-esterified cholesterol in LDL by cholesterol oxidase decreased the binding of CRP to LDL; and (iii) CRP bound to purified non-esterified cholesterol. Cholesterol 105-116 C-reactive protein Homo sapiens 320-323 12102655-6 2002 Consistent with this hypothesis were the following findings: (i) increasing the amount of non-esterified cholesterol in LDL with cyclodextrin increased, and decreasing its amount decreased, the binding of CRP to LDL; (ii) modification of non-esterified cholesterol in LDL by cholesterol oxidase decreased the binding of CRP to LDL; and (iii) CRP bound to purified non-esterified cholesterol. Cholesterol 253-264 C-reactive protein Homo sapiens 205-208 12102655-6 2002 Consistent with this hypothesis were the following findings: (i) increasing the amount of non-esterified cholesterol in LDL with cyclodextrin increased, and decreasing its amount decreased, the binding of CRP to LDL; (ii) modification of non-esterified cholesterol in LDL by cholesterol oxidase decreased the binding of CRP to LDL; and (iii) CRP bound to purified non-esterified cholesterol. Cholesterol 253-264 C-reactive protein Homo sapiens 205-208 12102655-8 2002 Taken together, these findings suggest that CRP can bind to modified lipoproteins, notably to the non-esterified cholesterol on their surface. Cholesterol 113-124 C-reactive protein Homo sapiens 44-47 12362497-14 2002 There was statistically significant negative correlation between CRP level and HDL-cholesterol and Apo-A levels. Cholesterol 83-94 C-reactive protein Homo sapiens 65-68 12362497-16 2002 CONCLUSIONS: Our study confirmed findings by other authors that there is a relationship between CRP level and other coronary heart disease factors such as W/H ratio and HDL-cholesterol. Cholesterol 173-184 C-reactive protein Homo sapiens 96-99 11577954-19 2001 CONCLUSIONS: The extent of increase in CRP levels in periodontitis patients depends on the severity of the disease after adjusting for age, smoking, body mass index, triglycerides, and cholesterol. Cholesterol 185-196 C-reactive protein Homo sapiens 39-42 12197410-10 2002 Some papers deal with antiinflammatory effects of statins, because these lower CRP levels so they also lower atherosclerotic risk through not only lowering of cholesterol levels. Cholesterol 159-170 C-reactive protein Homo sapiens 79-82 11692019-11 2001 After adjustment for smoking, total/HDL cholesterol, systolic blood pressure, and diabetes, the increase in risk across CRP quartiles remained statistically significant for both men (P=0.0365) and women (P=0.0084). Cholesterol 40-51 C-reactive protein Homo sapiens 120-123 11564380-7 2001 In multiple regression models, blood fibrinogen, waist circumference, total cholesterol, and physical activity grade were independently associated with log CRP concentrations. Cholesterol 76-87 C-reactive protein Homo sapiens 156-159 11564380-12 2001 Thus, CRP values serve as a marker of prevalent CHD risk in populations with low cholesterol levels. Cholesterol 81-92 C-reactive protein Homo sapiens 6-9 11742871-12 2001 Body mass index and other markers of the metabolic syndrome (HDL cholesterol, triglycerides, diabetes, and high blood pressure) are significant determinants of CRP levels in this population. Cholesterol 65-76 C-reactive protein Homo sapiens 160-163 11557252-5 2001 This increased risk is independent of other biochemical and clinical risk factors, and the association between high CRP and an abnormal cholesterol ratio significantly increases the risk in the individual patient. Cholesterol 136-147 C-reactive protein Homo sapiens 116-119 11368701-7 2001 In multivariable analyses, the total cholesterol-HDL-C ratio was the strongest lipid predictor of risk (relative risk [RR] for those in the highest vs lowest quartile, 3.9; 95% confidence interval [CI], 1.7-8.6), while CRP was the strongest nonlipid predictor (RR for the highest vs lowest quartile, 2.8; 95% CI, 1.3-5.9). Cholesterol 37-48 C-reactive protein Homo sapiens 219-222 11395043-7 2001 CRP, SAA and fibrinogen levels were markedly lower among CHD patients using cholesterol-lowering medication as compared to non-users. Cholesterol 76-87 C-reactive protein Homo sapiens 0-3 10783054-7 2000 The correlation coefficient of CRP was lower than that of other classical risk factors, such as body-mass index (BMI), blood pressure, and total and high-density lipoprotein (HDL) cholesterol. Cholesterol 180-191 C-reactive protein Homo sapiens 31-34 11128362-4 2000 A negative correlation was found between C-reactive protein and HDL cholesterol (R = 0.13, P < 0.0001). Cholesterol 68-79 C-reactive protein Homo sapiens 41-59 11305526-7 2001 Among several markers of systemic inflammation, CRP shows the strongest associations with vascular events, and the addition of CRP to total cholesterol dramatically improves risk prediction. Cholesterol 140-151 C-reactive protein Homo sapiens 127-130 11127936-6 2000 CRP decreased significantly (sign test P = 0.03) during treatment, and the changes of CRP were significantly associated with changes in HDL cholesterol (r = -0.45; P < 0.001) and apolipoprotein A1 (r = -0.40; P < 0.001) but not with changes in LDL cholesterol or triglycerides. Cholesterol 140-151 C-reactive protein Homo sapiens 86-89 11127936-6 2000 CRP decreased significantly (sign test P = 0.03) during treatment, and the changes of CRP were significantly associated with changes in HDL cholesterol (r = -0.45; P < 0.001) and apolipoprotein A1 (r = -0.40; P < 0.001) but not with changes in LDL cholesterol or triglycerides. Cholesterol 254-265 C-reactive protein Homo sapiens 86-89 11127936-7 2000 The change in HDL cholesterol explained 20% of the change in CRP during statin treatment. Cholesterol 18-29 C-reactive protein Homo sapiens 61-64 11123505-5 2000 C-reactive protein was, in addition to smoking, associated with several cardiovascular risk factors: age, obesity, diabetes, blood pressure, triglycerides and inversely associated to HDL cholesterol. Cholesterol 187-198 C-reactive protein Homo sapiens 0-18 11123505-6 2000 Adjustment for these variables, especially for total cholesterol, HDL cholesterol and triglycerides, substantially decreased the risk of myocardial infarction for persons in the highest quintile of C-reactive protein, compared to those in the lowest quintile, to 1.3 (95% CI: 0.9-1.9). Cholesterol 53-64 C-reactive protein Homo sapiens 198-216 11123505-6 2000 Adjustment for these variables, especially for total cholesterol, HDL cholesterol and triglycerides, substantially decreased the risk of myocardial infarction for persons in the highest quintile of C-reactive protein, compared to those in the lowest quintile, to 1.3 (95% CI: 0.9-1.9). Cholesterol 70-81 C-reactive protein Homo sapiens 198-216 10783054-8 2000 A subgroup of individuals with higher levels of CRP at both baseline and follow-up measurements had higher BMI, hemoglobin Alc, and plasma fibrinogen, and lower levels of HDL-cholesterol than others, even after adjusting for age, sex, and smoking status in a multiple logistic model. Cholesterol 175-186 C-reactive protein Homo sapiens 48-51 10569656-4 1999 There were significant positive associations between CRP levels and age, number of cigarettes smoked per day, body mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, lipoprotein(a), apolipoprotein B, tissue-type plasminogen activator antigen, D-dimers, total homocysteine, and fibrinogen (all p values <0.05). Cholesterol 172-183 C-reactive protein Homo sapiens 53-56 9351386-6 1997 CRP levels were also associated with coagulation factors VIIc, IXc, and Xc; HDL cholesterol (negative) and triglyceride; diabetes status; diuretic use; ECG abnormalities; and level of exercise. Cholesterol 80-91 C-reactive protein Homo sapiens 0-3 10451065-8 1999 CRP showed a significant correlation with apo A1 (r = -0.44, p<0.01) and HDL-cholesterol (r = -0.35, p<0.05). Cholesterol 80-91 C-reactive protein Homo sapiens 0-3 9610529-0 1998 C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Cholesterol 65-76 C-reactive protein Homo sapiens 0-18 9775136-6 1998 The authors are researching a correlation between the intensity of the acute phase response represented by CRP levels, and a reduced cholesterol level, or a hypertriglyceridemia, or lymphocytopenia. Cholesterol 133-144 C-reactive protein Homo sapiens 107-110 9775136-12 1998 Moreover a significant response exists with reduced cholesterol levels between group 4 (mean CRP level 250 (73) mg/L) and group 1. Cholesterol 52-63 C-reactive protein Homo sapiens 93-96 9775136-15 1998 CONCLUSIONS: The authors report a negative correlation of total cholesterol to CRP levels at the early stage of infections diseases. Cholesterol 64-75 C-reactive protein Homo sapiens 79-82 9403745-11 1997 There was a direct correlation between triglyceride and C-reactive protein concentrations, and an inverse correlation between cholesterol and C-reactive protein. Cholesterol 126-137 C-reactive protein Homo sapiens 142-160 9403745-15 1997 There was a significant direct correlation between triglyceride and C-reactive protein and an inverse correlation between cholesterol and C-reactive protein, suggesting that the changes in lipids in critically ill patients may be partly attributable to the acute-phase response. Cholesterol 122-133 C-reactive protein Homo sapiens 138-156 33801995-8 2021 A positive relationship between cholesterol intake and CRP concentration (p = 0.038; r = 0.342) was also found in the N group. Cholesterol 32-43 C-reactive protein Homo sapiens 55-58 7845427-8 1995 In patients with high serum cholesterol levels, the risk of coronary events rose with increasing levels of fibrinogen and C-reactive protein, but the risk remained low even given high serum cholesterol levels in the presence of low fibrinogen concentrations. Cholesterol 28-39 C-reactive protein Homo sapiens 122-140 8616412-11 1996 C Reactive protein concentration was associated with raised serum fibrinogen, sialic acid, total cholesterol, triglyceride, glucose, and apolipoprotein B values. Cholesterol 97-108 C-reactive protein Homo sapiens 0-18 8339522-3 1993 Statistical analysis reveals a significant inverse relationship between changes in C-reactive protein and changes in the plasma ratio of esterified to total cholesterol (r = -0.78; p < 0.001) as well as in plasma apoA-I concentration (r = -0.64; p < 0.01). Cholesterol 157-168 C-reactive protein Homo sapiens 83-101 34080928-0 2021 The Ratios of Triglycerides and C-reactive protein to High density-lipoprotein -cholesterol as valid biochemical markers of the Nascent Metabolic Syndrome. Cholesterol 80-91 C-reactive protein Homo sapiens 32-50 34925916-9 2021 Spearman"s correlation analyses showed that there was significant positive correlation between hs-CRP levels and waist circumference, total triglycerides, total cholesterol, age, body mass index, and homeostasis model assessment of insulin resistance index. Cholesterol 161-172 C-reactive protein Homo sapiens 98-101 34744148-3 2021 Our work was conducted to discuss and compare the predictive ability of the high-sensitivity C-reactive protein to high-density lipoprotein cholesterol ratio (CHR) with other existing indices, for example, neutrophil high-density lipoprotein ratio (NHR) and neutrophil lymphocyte ratio (NLR), in the severity of CAD patients.Based on the results of coronary angiography, patients were divided into the CAD+ group, CAD- group, and control group. Cholesterol 140-151 C-reactive protein Homo sapiens 93-111 34673211-3 2022 RESULTS: After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-gamma had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. Cholesterol 46-57 C-reactive protein Homo sapiens 280-283 34673211-3 2022 RESULTS: After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-gamma had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. Cholesterol 71-82 C-reactive protein Homo sapiens 280-283 34080928-2 2021 The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) is a good biomarker of MetS in certain populations C-reactive protein (CRP) has also been also shown to be a biomarker of MetS. Cholesterol 60-71 C-reactive protein Homo sapiens 132-150 34080928-2 2021 The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) is a good biomarker of MetS in certain populations C-reactive protein (CRP) has also been also shown to be a biomarker of MetS. Cholesterol 60-71 C-reactive protein Homo sapiens 152-155 34868746-8 2021 High sensitivity CRP was significantly and positively correlated to age, body mass index (BMI), total cholesterol, low-density lipoprotein, cholesterol, and waist-hip ratio. Cholesterol 102-113 C-reactive protein Homo sapiens 17-20 34868746-8 2021 High sensitivity CRP was significantly and positively correlated to age, body mass index (BMI), total cholesterol, low-density lipoprotein, cholesterol, and waist-hip ratio. Cholesterol 140-151 C-reactive protein Homo sapiens 17-20 34212994-11 2021 In addition, a significant corre-lation was observed between the cholesterol, triglycerides and the CRP level at the time of hospitalisa-tion and mortality. Cholesterol 65-76 C-reactive protein Homo sapiens 100-103 35217714-0 2022 Sex-dependent relationship of C-reactive protein levels with HDL-cholesterol and HDL-phospholipid concentrations in children. Cholesterol 65-76 C-reactive protein Homo sapiens 30-48 34406246-4 2021 RESULTS: Highly sensitive C-reactive protein levels differed significantly among the groups (p<0.001) and found to be highest in the low-density lipoprotein cholesterol tertile 1 and lowest in the low-density lipoprotein cholesterol tertile 3 (post-hoc p-values: tertile 1 vs. 2 <0.001; tertile 1 vs. 3 <0.001; tertile 2 vs. 3=0.019). Cholesterol 157-168 C-reactive protein Homo sapiens 26-44 34406246-5 2021 There was a negative correlation between hs-CRP and both low-density lipoprotein cholesterol (r=-0.332, p<0.001) and total cholesterol (r=-0.326, p<0.001). Cholesterol 123-134 C-reactive protein Homo sapiens 44-47 35590447-10 2022 Changes in clinical scores were inversely correlated with total cholesterol changes (R -186, P = .014), as was CRP with total cholesterol and LDL-c (R -0.292 and R -0.259, P < .001). Cholesterol 126-137 C-reactive protein Homo sapiens 111-114 34819702-12 2021 There was a strong negative correlation between CRP levels and HDL cholesterol levels in patients with PsA, rho = 0.42, p = 0.0132. Cholesterol 67-78 C-reactive protein Homo sapiens 48-51 35217714-2 2022 Our study analyzes the influence of obesity-related parameters in the relationship of high-sensitivity C-reactive protein (hs-CRP) with HDL-cholesterol and HDL-phospholipid in male and female adolescents. Cholesterol 140-151 C-reactive protein Homo sapiens 103-121 35217714-2 2022 Our study analyzes the influence of obesity-related parameters in the relationship of high-sensitivity C-reactive protein (hs-CRP) with HDL-cholesterol and HDL-phospholipid in male and female adolescents. Cholesterol 140-151 C-reactive protein Homo sapiens 126-129 35217714-5 2022 hs-CRP levels were inversely related to HDL-cholesterol and HDL-phospholipid in males but not in females, and were positively related to leptin concentrations in both sexes but were not related to adiponectin levels. Cholesterol 44-55 C-reactive protein Homo sapiens 3-6 35217714-8 2022 After adjusting by leptin and adiponectin, males in the highest hs-CRP tertile showed significantly lower levels of HDL-cholesterol and HDL-phospholipid than those in tertiles 1 and 2, while no significant differences in HDL-cholesterol and HDL-phospholipid concentrations by hs-CRP tertile were observed in females. Cholesterol 120-131 C-reactive protein Homo sapiens 67-70 33224343-7 2020 Conclusions: This finding suggests a new mechanism of interaction between statins and CRP that could be independent of the putative cholesterol-lowering activity of statins. Cholesterol 132-143 C-reactive protein Homo sapiens 86-89 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Cholesterol 90-101 C-reactive protein Homo sapiens 0-3 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Cholesterol 139-150 C-reactive protein Homo sapiens 0-3 7382134-0 1980 Change in permeability of liposomal membranes mediated by C-reactive protein and its inhibition by cholesterol. Cholesterol 99-110 C-reactive protein Homo sapiens 58-76 33728195-15 2021 Logistic regression analysis in the control group showed that the odds ratio for increasing remnant cholesterol above the cut-off value was determined as 2.01 for low bioavailable vitamin D and 1.1 for elevated CRP. Cholesterol 100-111 C-reactive protein Homo sapiens 211-214 33334321-7 2020 Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Cholesterol 173-184 C-reactive protein Homo sapiens 65-68 33334321-8 2020 Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. Cholesterol 218-229 C-reactive protein Homo sapiens 42-45 33334321-8 2020 Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. Cholesterol 234-245 C-reactive protein Homo sapiens 42-45 33334321-8 2020 Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. Cholesterol 234-245 C-reactive protein Homo sapiens 42-45 35217714-9 2022 In summary, high hs-CRP levels were associated with lower plasma HDL-cholesterol and HDL-phospholipid concentrations in male adolescents irrespective of adipokines, while in females, HDL-related parameters are not associated with hs-CRP concentrations. Cholesterol 69-80 C-reactive protein Homo sapiens 20-23 35010714-13 2022 The most common correct scores for homocysteine, triglycerides, and CRP were SDA, cholesterol by Jews, glucose by Muslims, and HDL by Catholics. Cholesterol 82-93 C-reactive protein Homo sapiens 68-71 3195982-5 1988 In the acute phase there was a tendency to a negative correlation of erythrocyte sedimentation rate and of C-reactive protein with serum cholesterol and/or HDL cholesterol. Cholesterol 137-148 C-reactive protein Homo sapiens 107-125 3195982-5 1988 In the acute phase there was a tendency to a negative correlation of erythrocyte sedimentation rate and of C-reactive protein with serum cholesterol and/or HDL cholesterol. Cholesterol 160-171 C-reactive protein Homo sapiens 107-125 7338519-5 1981 Agglutination of liposomes caused by CRP was dependent on the fatty acid composition of phosphatidylcholine, cholesterol content and temperature. Cholesterol 109-120 C-reactive protein Homo sapiens 37-40 7462634-3 1981 We have previously presented a model for CRP-membrane interactions using liposomes composed of dimyristoyl phosphatidylcholine (DMPC), cholesterol (CHOL), stearylamine (SA), and galactosyl ceramide. Cholesterol 135-146 C-reactive protein Homo sapiens 41-44 7462634-3 1981 We have previously presented a model for CRP-membrane interactions using liposomes composed of dimyristoyl phosphatidylcholine (DMPC), cholesterol (CHOL), stearylamine (SA), and galactosyl ceramide. Cholesterol 148-152 C-reactive protein Homo sapiens 41-44 7462634-12 1981 However, increasing the amount of CHOL in the membrane was found to increase C activation while decreasing CRP binding. Cholesterol 34-38 C-reactive protein Homo sapiens 107-110 33787283-6 2021 In those with a Fontan, high-density lipoprotein cholesterol was inversely correlated with body mass index (r=-0.30, P<0.0001), high-sensitivity C-reactive protein (r=-0.27, P=0.0006), and alanine aminotransferase (r=-0.18, P=0.02) but not with other liver disease markers. Cholesterol 49-60 C-reactive protein Homo sapiens 145-163 31646893-8 2021 Partial correlation analysis showed that the mean least oxygen saturation was significantly correlated with CRP after adjustment for BMI Pearson"s correlation coefficients examining the relationship between BMI and total cholesterol; TG and CRP were found to be 0.531, 0.401, and 0.321. Cholesterol 221-232 C-reactive protein Homo sapiens 108-111 32653486-9 2020 In correlation analysis, HDL-cholesterol concentration was negatively correlated with C-reactive protein (CRP, r = -0.396, P < 0.001) and positively correlated with lymphocytes (r = 0.336, P < 0.001). Cholesterol 29-40 C-reactive protein Homo sapiens 86-104 32653486-9 2020 In correlation analysis, HDL-cholesterol concentration was negatively correlated with C-reactive protein (CRP, r = -0.396, P < 0.001) and positively correlated with lymphocytes (r = 0.336, P < 0.001). Cholesterol 29-40 C-reactive protein Homo sapiens 106-109 32919309-3 2020 Patients with complications showed higher levels of CRP and C4 positively correlated with Triglycerides and Cholesterol concentrations. Cholesterol 108-119 C-reactive protein Homo sapiens 52-55 32982379-7 2020 Ideal body mass index (BMI), physical activity, smoking status and total cholesterol all had significant impacts on hs-CRP levels, with ideal BMI having the largest impact. Cholesterol 73-84 C-reactive protein Homo sapiens 119-122 31744333-11 2020 CONCLUSIONS: In statin-treated patients with atherosclerotic cardiovascular disease, remnant cholesterol was associated with coronary atheroma progression regardless of conventional lipid parameters, C-reactive protein or clinical risk factors. Cholesterol 93-104 C-reactive protein Homo sapiens 200-218 33044103-5 2020 RESULTS: Multiple linear regression analysis showed that serum oestradiol levels were inversely associated with CRP levels in premenopausal women (beta coefficient = -0.298) after adjusting for age, body mass index, smoking, mean arterial pressure, and levels of fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, aspartate aminotransferase, and alanine aminotransferase. Cholesterol 327-338 C-reactive protein Homo sapiens 112-115 32503322-6 2020 Overall, hs-CRP levels had a correlation with total cholesterol (p < 0.05) and a trend of correlation with HbA1c (p = 0.054) levels. Cholesterol 52-63 C-reactive protein Homo sapiens 12-15 31770074-8 2020 hs-CRP was positively associated with body mass index (BMI) z-score (P < 0.001) and HbA1c (P = 0.012), and negatively with HDL cholesterol (P = 0.029), after adjusting confounding variables, including age, sex, BMI, white blood cell count, PA, and nutritional factors. Cholesterol 127-138 C-reactive protein Homo sapiens 3-6 31770074-10 2020 Conclusions: Elevated hs-CRP is associated with high BMI z-score and HbA1c, and low HDL cholesterol in Korean children and adolescents. Cholesterol 88-99 C-reactive protein Homo sapiens 25-28 30249443-8 2018 Concentrations of cholesterol (total, LDL, HDL, non-HDL) were also lower at 2 weeks in patients treated with infliximab compared to placebo, but only in those patients with CRP >5 mg/L at baseline (all p < 0.05). Cholesterol 18-29 C-reactive protein Homo sapiens 173-176 31411090-0 2019 Association Between Baseline, Achieved, and Reduction of CRP and Cardiovascular Outcomes After LDL Cholesterol Lowering with Statins or Ezetimibe: A Systematic Review and Meta-Analysis. Cholesterol 99-110 C-reactive protein Homo sapiens 57-60 31222137-5 2019 The evaluation of the benefits of drugs may lead to individualized therapy for CKD patients: Cholesterol-lowering treatment for CKD patients with high levels of both LDLc and CRP is suggested. Cholesterol 93-104 C-reactive protein Homo sapiens 175-178 30885233-15 2019 Decreasing HDL-cholesterol levels were associated with increasing triglyceride levels (p < 0.001), increasing high-sensitive C-reactive protein (hs-CRP) levels (p = 0.021), younger age (p < 0.001), male sex (p < 0.001), and depression (p = 0.045). Cholesterol 15-26 C-reactive protein Homo sapiens 129-147 30249443-10 2018 Additionally, our findings suggest a causal relationship between increased inflammation and high cholesterol in depression, as a single infusion of infliximab reduced cholesterol in TRD patients with high CRP compared to placebo. Cholesterol 97-108 C-reactive protein Homo sapiens 205-208 29730525-6 2018 Since IL-1beta production leads to increased levels of IL-6 and C-reactive protein, this could be a mechanistic link between early deposition of cholesterol crystals within the vessel wall to the macrophage-monocyte interactions that initiate fatty streaks and promote local atherosclerotic progression. Cholesterol 145-156 C-reactive protein Homo sapiens 64-82 29976096-2 2018 Among the multiple mechanisms of inflammation, the arterial deposition of lipids and particularly of cholesterol crystals is the one responsible for the activation of inflammasome NLRP3, followed by the rise of circulating markers, mainly C-reactive protein (CRP). Cholesterol 101-112 C-reactive protein Homo sapiens 239-257 29976096-2 2018 Among the multiple mechanisms of inflammation, the arterial deposition of lipids and particularly of cholesterol crystals is the one responsible for the activation of inflammasome NLRP3, followed by the rise of circulating markers, mainly C-reactive protein (CRP). Cholesterol 101-112 C-reactive protein Homo sapiens 259-262 28882065-10 2018 Approximately 9.7% of the variation in serum high-sensitive C-reactive protein in diabetic non-hypertensive patients could be explained by body mass index, and intake of sodium, iron and cholesterol. Cholesterol 187-198 C-reactive protein Homo sapiens 60-78 28882065-11 2018 In the healthy subjects, approximately 4.4% of the total variation in serum high-sensitive C-reactive protein concentration could be explained by cholesterol consumption and waist circumference. Cholesterol 146-157 C-reactive protein Homo sapiens 91-109 28882065-13 2018 There was a significant association between dietary factors include zinc, iron, sodium and cholesterol and serum high-sensitive C-reactive protein, while there was an inverse association between dietary calcium and serum high-sensitive C-reactive protein in diabetic hypertensive individuals. Cholesterol 91-102 C-reactive protein Homo sapiens 128-146 28369752-3 2017 Accumulation of excess cholesterol due to the presence of increased circulating LDL promotes endothelium dysfunction and activation, which is associated with increased production of pro-inflammatory cytokines, overexpression of adhesion molecules, chemokines and C-reactive protein (CRP), increased generation of reactive oxygen species and reduction of nitric oxide levels and bioavailability. Cholesterol 23-34 C-reactive protein Homo sapiens 263-281 29683202-4 2018 We confirmed that serum total cholesterol and uric acid were elevated in pre-eclamptic compared to healthy pregnancies and correlated positively to high sensitivity C-reactive protein (hsCRP) and the pre-eclampsia marker soluble fms-like tyrosine kinase-1 (sFlt-1). Cholesterol 30-41 C-reactive protein Homo sapiens 165-183 29426615-9 2018 In univariate analyses, significant correlations were observed between childhood HDL-cholesterol (risk ratio (95% CI) for 1-SD change (0.58 (0.42-0.79)) and CRP concentrations (1.20 (1.01-1.43)) with IBD. Cholesterol 85-96 C-reactive protein Homo sapiens 157-160 29426615-10 2018 The inverse association between HDL-cholesterol and IBD remained significant (0.57 (0.39-0.82)) in a multivariable model including data on age, sex and CRP. Cholesterol 36-47 C-reactive protein Homo sapiens 152-155 29938421-15 2018 CRP had got significant correlation with total cholesterol and LDL and non-significant correlation with triglycerides. Cholesterol 47-58 C-reactive protein Homo sapiens 0-3 29664424-8 2018 The level of CRP was negatively correlated with HDL cholesterol (r=-0.275; p=0.032) and total cholesterol level (r=-0.313; p=0.014) in FMF patients. Cholesterol 52-63 C-reactive protein Homo sapiens 13-16 29664424-8 2018 The level of CRP was negatively correlated with HDL cholesterol (r=-0.275; p=0.032) and total cholesterol level (r=-0.313; p=0.014) in FMF patients. Cholesterol 94-105 C-reactive protein Homo sapiens 13-16 29723366-8 2018 HDL-cholesterol level was higher in normal C-reactive protein patients (t=1.98; P=0.05). Cholesterol 4-15 C-reactive protein Homo sapiens 43-61 28369752-3 2017 Accumulation of excess cholesterol due to the presence of increased circulating LDL promotes endothelium dysfunction and activation, which is associated with increased production of pro-inflammatory cytokines, overexpression of adhesion molecules, chemokines and C-reactive protein (CRP), increased generation of reactive oxygen species and reduction of nitric oxide levels and bioavailability. Cholesterol 23-34 C-reactive protein Homo sapiens 283-286 28646711-8 2017 In the high CRP (> 2322ng/mL) group, patients in the VPA + memantine arm had a significantly decreased in their CRP (p= 0.009), total cholesterol (p= 0.002), LDL (p= 0.002) levels, BMI (p= 0.001), and waist circumference (p< 0.001), compared to those in the VPA + placebo arm. Cholesterol 137-148 C-reactive protein Homo sapiens 12-15 28649659-7 2017 Finally, the presence of crown-like structures was positively associated with systemic markers such as the Triglyceride/High-density lipoprotein-cholesterol ratio serum C-reactive protein and glucose/(HbA1c) glycated Haemoglobin. Cholesterol 145-156 C-reactive protein Homo sapiens 169-187 28764912-8 2017 CRP was inconsistently associated with elevated fasting glucose, insulin levels, serum triglycerides, total cholesterol levels, and low high density lipoprotein (HDL) levels. Cholesterol 108-119 C-reactive protein Homo sapiens 0-3 28336391-11 2017 CONCLUSION: We have found a significant positive association between the dietary intake of fat, protein, cholesterol and sodium and hs-CRP level, and an inverse correlation between dietary carbohydrate and fiber and serum hs-CRP in a large representative Iranian population. Cholesterol 105-116 C-reactive protein Homo sapiens 135-138 28537577-9 2017 Of the metabolic syndrome components, elevated waist circumference, low high-density lipoprotein-cholesterol and high triglycerides were significantly related to CRP in a graded (dose-response) manner. Cholesterol 97-108 C-reactive protein Homo sapiens 162-165 32313849-8 2017 Serum albumin and serum-cholesterol levels correlated negatively significantly with s-CRP levels (R2=0.247, p<0.001 and R2=0.06, p<0.001, respectively) in the hip fracture group. Cholesterol 24-35 C-reactive protein Homo sapiens 86-89 28900428-0 2017 C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques. Cholesterol 28-39 C-reactive protein Homo sapiens 0-18 28900428-10 2017 CRP, PTX3, and SAP were all found in atherosclerotic plaques and were located mainly in the cholesterol-rich necrotic core, but co-localization with the terminal C5b-9 complement complex was only found for CRP. Cholesterol 92-103 C-reactive protein Homo sapiens 0-3 27395328-9 2017 An animal-sourced pattern (animal protein, cobalamin, cholesterol and omega-6) was positively associated with CRP (p for trend across quartiles 0.057). Cholesterol 54-65 C-reactive protein Homo sapiens 110-113 27073847-7 2016 There was a positive correlation between the levels of hs-CRP and total cholesterol (P = 0.001), low-density lipoprotein cholesterol (P = 0.013), and triglycerides (P = 0.0014) in the first trimester. Cholesterol 72-83 C-reactive protein Homo sapiens 58-61 28086966-6 2017 The remnant cholesterol associated with high sensitivity C-reactive protein, neutrophil count and fibrinogen (R 2 = 0.20, 0.12 and 0.14; P = 0.000, 0.036 and 0.010 respectively). Cholesterol 12-23 C-reactive protein Homo sapiens 57-75 27381673-5 2016 Higher rolling speed was observed in T2DM patients (P < 0.01) which strongly correlated with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as well as established cardiovascular risk factors (cholesterol, high-sensitive C-reactive protein (CRP) and HbA1c). Cholesterol 240-251 C-reactive protein Homo sapiens 268-286 27381673-5 2016 Higher rolling speed was observed in T2DM patients (P < 0.01) which strongly correlated with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as well as established cardiovascular risk factors (cholesterol, high-sensitive C-reactive protein (CRP) and HbA1c). Cholesterol 240-251 C-reactive protein Homo sapiens 288-291 26705388-7 2016 Cholesterol crystals initiate inflammation via NLRP3 inflammasome leading to interleukin-1beta (IL-1beta) production inducing C-reactive protein. Cholesterol 0-11 C-reactive protein Homo sapiens 126-144 27230043-0 2016 Beyond Coronary Calcification, Family History, and C-Reactive Protein: Cholesterol Efflux Capacity and Cardiovascular Risk Prediction. Cholesterol 71-82 C-reactive protein Homo sapiens 51-69 28178951-8 2017 After multivariate adjustment for T2D risk factors such as lifestyle, body mass index, plasma triglycerides and HDL cholesterol, the OR comparing the extreme quartiles of hs-CRP was 1.74 [95% CI 1.12-2.70; P for trend = 0.016]. Cholesterol 116-127 C-reactive protein Homo sapiens 174-177 29877557-10 2017 The rate of hs CRP were significantly correlated with HA1c, total cholesterol, the LDL-C, index atherogenicity microalbuminuria and duration of diabetes for the two patient groups. Cholesterol 66-77 C-reactive protein Homo sapiens 15-18 25987110-7 2015 Notably, we detected a significant association between increased total cholesterol and high CRP levels (p=0.002). Cholesterol 71-82 C-reactive protein Homo sapiens 92-95 26606398-5 2016 Decreases in the 28-joint Disease Activity Score, the C-reactive protein level, or the erythrocyte sedimentation rate were associated with increases in levels of HDL cholesterol, LDL cholesterol, and total cholesterol in all treatment groups (P < 0.001-0.035). Cholesterol 166-177 C-reactive protein Homo sapiens 54-72 26606398-5 2016 Decreases in the 28-joint Disease Activity Score, the C-reactive protein level, or the erythrocyte sedimentation rate were associated with increases in levels of HDL cholesterol, LDL cholesterol, and total cholesterol in all treatment groups (P < 0.001-0.035). Cholesterol 183-194 C-reactive protein Homo sapiens 54-72 26606398-5 2016 Decreases in the 28-joint Disease Activity Score, the C-reactive protein level, or the erythrocyte sedimentation rate were associated with increases in levels of HDL cholesterol, LDL cholesterol, and total cholesterol in all treatment groups (P < 0.001-0.035). Cholesterol 183-194 C-reactive protein Homo sapiens 54-72 26266357-6 2015 Participation in CRP was related to the lower probability of having high total cholesterol (23% vs 32%, P < 0.05), fasting glucose (11% vs 18%, P = 0.05), HbA1c (8% vs 16%, P = 0.05), and body mass index (27% vs 37%, P < 0.05). Cholesterol 79-90 C-reactive protein Homo sapiens 17-20 25832339-13 2015 The associations between cholesterol intake and risk of T2D, plasma glucose, serum insulin, and C-reactive protein were mainly nonsignificant, especially after accounting for egg consumption. Cholesterol 25-36 C-reactive protein Homo sapiens 96-114 23716069-0 2014 Analysis and modelling of cholesterol and high-density lipoprotein cholesterol changes across the range of C-reactive protein levels in clinical practice as an aid to better understanding of inflammation-lipid interactions. Cholesterol 26-37 C-reactive protein Homo sapiens 107-125 25911075-0 2015 Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children. Cholesterol 6-17 C-reactive protein Homo sapiens 90-108 25911075-0 2015 Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children. Cholesterol 46-57 C-reactive protein Homo sapiens 90-108 25661410-8 2015 RESULTS: In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipoprotein-cholesterol (beta = -5.797 [-11.500 to -0.093]), femoral IMT (beta = 0.062 [0.008-0.116]), and the sum of femoral and carotid IMT (beta = 1.107 [0.223-1.919]), but only in the group without sports participation. Cholesterol 122-133 C-reactive protein Homo sapiens 49-67 25880559-15 2015 CONCLUSIONS: Risk of metabolic syndrome, hyperglycaemia and diabetes, and elevated high-sensitivity CRP may be affected by childhood BMI and skinfold thickness, while risk of hypertension, raised triglycerides and reduced HDL cholesterol is associated more strongly with BMI gain from childhood to adulthood. Cholesterol 226-237 C-reactive protein Homo sapiens 100-103 25904961-7 2015 Before adjusting for age and BMI, CRP was correlated with LDL (r= 0.16, p= 0.03), total cholesterol (TC) (r= 0.17, p= 0. Cholesterol 88-99 C-reactive protein Homo sapiens 34-37 25672297-9 2015 Additionally, a significantly positive correlation was found between the levels of high-sensitivity C-reactive protein and low-density lipoprotein-cholesterol (p= 0.014, r = +0.320) in patient group. Cholesterol 146-158 C-reactive protein Homo sapiens 100-118 25393688-7 2014 Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol intake. Cholesterol 146-157 C-reactive protein Homo sapiens 97-100 23716069-4 2014 Our hypothesis was that there would be an inverse association between raised CRP levels and both TC and HDL-cholesterol levels. Cholesterol 108-119 C-reactive protein Homo sapiens 77-80 23716069-10 2014 There was an inverse relationship between HDL-cholesterol and CRP. Cholesterol 46-57 C-reactive protein Homo sapiens 62-65 24107546-0 2014 A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Cholesterol 119-130 C-reactive protein Homo sapiens 65-83 23757435-9 2013 CRP concentration was significantly and directly associated with change in systolic blood pressure (SBP) and waist circumference but inversely associated with HDL cholesterol. Cholesterol 163-174 C-reactive protein Homo sapiens 0-3 23982521-5 2013 RESULTS: The length of psoriasis remission correlated negatively and significantly with cholesterol levels, which correlated significantly and positively with C-reactive protein (CRP). Cholesterol 88-99 C-reactive protein Homo sapiens 159-177 23982521-5 2013 RESULTS: The length of psoriasis remission correlated negatively and significantly with cholesterol levels, which correlated significantly and positively with C-reactive protein (CRP). Cholesterol 88-99 C-reactive protein Homo sapiens 179-182 23982521-7 2013 Patients with cholesterol levels <200 mg/dL (n = 13) presented a significantly longer remission, lower BMI and triglycerides values, and a trend towards lower PASI and CRP values than those with high cholesterol (n = 30). Cholesterol 14-25 C-reactive protein Homo sapiens 171-174 25078741-10 2014 The US-CRP median was of 0.3 mg/L (range: 0.3 mg/L-6.8 mg/L), and it was positively and significantly correlated with BMI (ss = 0.226, p = 0.032) and LDL-C (ss = -0.267, p = 0.007) and negatively associated with cholesterol (ss = -0.267, p = 0.007). Cholesterol 212-223 C-reactive protein Homo sapiens 7-10 24586854-10 2014 High sensitivity C-reactive protein (hsCRP) was positively correlated with traditional cardio-metabolic risk factors including waist circumference (r = 0.127, p = 0.05), triglycerides (r = 0.19, p = 0.003) and Total Cholesterol: High Density Lipoprotein ratio (TC:LDL) (r = 0.225, p<0.001). Cholesterol 216-227 C-reactive protein Homo sapiens 17-35 23744403-8 2013 Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all <0.0001), and with higher blood pressure and lower HDL-cholesterol levels. Cholesterol 229-240 C-reactive protein Homo sapiens 10-13 23926208-5 2013 A 1-mmol/L(39 mg/dL) higher level of nonfasting remnant cholesterol was associated observationally with a 37% (95% confidence interval, 35-39) higher C-reactive protein level and causally with a 28% (95% confidence interval, 10-48) higher level. Cholesterol 56-67 C-reactive protein Homo sapiens 150-168 23926208-6 2013 For LDL cholesterol, a 1-mmol/L (39-mg/dL) higher level was associated observationally with a 7% (95% confidence interval, 6-7) higher C-reactive protein level, but we found no causal association. Cholesterol 8-19 C-reactive protein Homo sapiens 135-153 23922673-8 2013 When patients were divided into three groups according to time-integrated lipid levels, as expected, patients with LDL cholesterol and/or triglyceride levels in the third tertile had persistently higher ESR and CRP levels. Cholesterol 119-130 C-reactive protein Homo sapiens 211-214 24250693-10 2013 However, the higher serum CRP levels were only observed in those with the low serum HDL-cholesterol levels. Cholesterol 88-99 C-reactive protein Homo sapiens 26-29 23460074-8 2013 After multivariable adjustment, change in C-reactive protein, but not the Disease Activity Score in 28 joints, was associated with change in LDL cholesterol (P = 0.03) and total cholesterol (P = 0.01). Cholesterol 145-156 C-reactive protein Homo sapiens 42-60 23460074-8 2013 After multivariable adjustment, change in C-reactive protein, but not the Disease Activity Score in 28 joints, was associated with change in LDL cholesterol (P = 0.03) and total cholesterol (P = 0.01). Cholesterol 178-189 C-reactive protein Homo sapiens 42-60 23507424-0 2013 Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive protein. Cholesterol 63-74 C-reactive protein Homo sapiens 111-129 23837221-4 2013 C-reactive protein was correlated with fibrinogen, HbA1c, LDL-cholesterol, BMI, WC, WHR and C index. Cholesterol 62-73 C-reactive protein Homo sapiens 0-18 23782463-4 2013 Statins are cholesterol-lowering agents that have been found to be anti-inflammatory agents and are also known to decrease C-reactive protein (CRP). Cholesterol 12-23 C-reactive protein Homo sapiens 123-141 23782463-4 2013 Statins are cholesterol-lowering agents that have been found to be anti-inflammatory agents and are also known to decrease C-reactive protein (CRP). Cholesterol 12-23 C-reactive protein Homo sapiens 143-146 23940437-8 2013 Body mass index (P<0.001) and total cholesterol levels (P=0.005) were positively associated with CRP levels. Cholesterol 39-50 C-reactive protein Homo sapiens 100-103 22865000-8 2013 The higher CRP group was discriminated by the above variables in addition to lower VO(2max), serum metabolic syndrome components (triglycerides, glucose, and HDL cholesterol), higher insulin, homeostasis assessment of insulin resistance, uric acid, gamma-GT, and homocysteine. Cholesterol 162-173 C-reactive protein Homo sapiens 11-14 22968297-5 2012 RESULTS: Beyond atherogenic dyslipidemia, high-Trg/normal HDL-cholesterol category was associated with elevated CRP and diabetes risk in women. Cholesterol 62-73 C-reactive protein Homo sapiens 112-115 23604041-1 2013 AIM: We aimed to study the relationship of elevated C reactive protein (CRP) levels (1.0-2.9 or >=3.0 mg/L) with carotid intima-media thickness (IMT) in Chinese adults with normal low-density lipoprotein (LDL) cholesterol (<100 mg/dL). Cholesterol 213-224 C-reactive protein Homo sapiens 72-75 23236325-10 2012 In patients with a high density lipoprotein-cholesterol level <40 mg/dL, CRP levels were reduced only in the fenofibrate group (p=0.006). Cholesterol 44-55 C-reactive protein Homo sapiens 76-79 23236325-11 2012 CONCLUSION: Fenofibrate reduced CRP levels in hypertriglyceridemic patients with high CRP and/or low high density lipoprotein-cholesterol levels and without severe overweight. Cholesterol 126-137 C-reactive protein Homo sapiens 32-35 21839006-3 2011 The results shown high levels of lipid in serum in 100 % of the patients, the highest levels of C-reactive protein corresponded with the highest levels of total cholesterol and LDL oxidized, it was suggested as a atherosclerotic disease risk. Cholesterol 161-172 C-reactive protein Homo sapiens 96-114 23350124-2 2012 Combined treatment with meksykoru to correct the atherogenic lipid profile and CRP helped reduce content CRP, total cholesterol, low-density lipoprotein cholesterol, triglycerides, factor aterohenosti and raise HDL cholesterol. Cholesterol 116-127 C-reactive protein Homo sapiens 79-82 23350124-2 2012 Combined treatment with meksykoru to correct the atherogenic lipid profile and CRP helped reduce content CRP, total cholesterol, low-density lipoprotein cholesterol, triglycerides, factor aterohenosti and raise HDL cholesterol. Cholesterol 153-164 C-reactive protein Homo sapiens 79-82 22723940-1 2012 BACKGROUND: In a previous report by our group, high levels of apolipoprotein E (apoE) were demonstrated to be associated with risk of incident cardiovascular disease in women with high levels of C-reactive protein (CRP) in the setting of both low (designated as HR1 subjects) and high (designated as HR2 subjects) levels of high-density lipoprotein cholesterol (HDL-C). Cholesterol 349-360 C-reactive protein Homo sapiens 215-218 21821723-1 2011 BACKGROUND: C-reactive protein (CRP) is purported to be a risk factor that acts independently of LDL cholesterol in predicting all-cause mortality in patients with ischemic heart disease. Cholesterol 101-112 C-reactive protein Homo sapiens 12-30 21821723-1 2011 BACKGROUND: C-reactive protein (CRP) is purported to be a risk factor that acts independently of LDL cholesterol in predicting all-cause mortality in patients with ischemic heart disease. Cholesterol 101-112 C-reactive protein Homo sapiens 32-35 22046880-7 2011 There was a positive correlation between CRP with postprandial glycemia (p = 0.004); the multivariate regression analysis revealed a statistically significant correlation between CRP and age (p = 0.001), smoking (p = 0.055), fasting glucose (p = 0.021) and triglycerides (p = 0.048) as well as between IL-6 and LDL-cholesterol (p = 0.009). Cholesterol 315-326 C-reactive protein Homo sapiens 179-182 22241816-9 2012 CONCLUSIONS: CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. Cholesterol 115-126 C-reactive protein Homo sapiens 13-16 22830205-8 2012 LDLP cholesterol decreased Blood lipids composition shifts were associated with marked reduction in the disease activity: decreased concentration of C-reactive protein, IgM rheumatoid factor, DAS28 index, improvement of the patient functional status. Cholesterol 5-16 C-reactive protein Homo sapiens 149-167 21871057-11 2011 When categorized by baseline C-reactive protein (CRP; cut point of 2 mg/L), subjects in the lower CRP sub-group benefited more from dietary intervention, including a more increase in cholesterol efflux, a greater reduction in SCD1, and a blunted postprandial lipemia. Cholesterol 183-194 C-reactive protein Homo sapiens 98-101 21870702-2 2011 MATERIAL AND METHODS: C-reactive protein measurement clinical value was examined by high sensitivity CRP method (hsCRP) and compared to clinical value of other heart attack risk factors: total cholesterol (TC) and cholesterol in HDL fraction (HDL-C), triglycerides (TG) and fibrinogen (FBG). Cholesterol 193-204 C-reactive protein Homo sapiens 22-40 21870702-2 2011 MATERIAL AND METHODS: C-reactive protein measurement clinical value was examined by high sensitivity CRP method (hsCRP) and compared to clinical value of other heart attack risk factors: total cholesterol (TC) and cholesterol in HDL fraction (HDL-C), triglycerides (TG) and fibrinogen (FBG). Cholesterol 214-225 C-reactive protein Homo sapiens 22-40 21714897-10 2011 Multivariate analysis (Cox regression) revealed that CRP/prealbumin was independently associated with mortality after adjustment for age, gender, sepsis and sequential organ failure assessment (SOFA, p = 0.027) while the others (CRP, albumin, prealbumin, cholesterol, CRP/albumin and CRP/cholesterol) became non-significantly associated. Cholesterol 255-266 C-reactive protein Homo sapiens 53-56 21714897-10 2011 Multivariate analysis (Cox regression) revealed that CRP/prealbumin was independently associated with mortality after adjustment for age, gender, sepsis and sequential organ failure assessment (SOFA, p = 0.027) while the others (CRP, albumin, prealbumin, cholesterol, CRP/albumin and CRP/cholesterol) became non-significantly associated. Cholesterol 288-299 C-reactive protein Homo sapiens 53-56 21414625-9 2011 Increased CRP levels were an independent predictor of both abnormal FMD and IMT after adjusting for age, systolic and diastolic BP and total cholesterol. Cholesterol 141-152 C-reactive protein Homo sapiens 10-13 20484132-7 2010 When all MetS traits were considered simultaneously, only low HDL cholesterol proved independently associated with CRP (F = 44.19; P < 0.001). Cholesterol 66-77 C-reactive protein Homo sapiens 115-118 21267537-6 2011 RESULTS: Elevated high sensitivity CRP (hsCRP) levels were found to be associated with prediabetes after adjusting for age, sex, race-ethnicity, education, smoking, alcohol consumption, hypertension, BMI and total cholesterol. Cholesterol 214-225 C-reactive protein Homo sapiens 35-38 20682616-5 2011 Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P <= .015), whereas lipid ratios did not correlate with CRP. Cholesterol 96-107 C-reactive protein Homo sapiens 26-44 20682616-5 2011 Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P <= .015), whereas lipid ratios did not correlate with CRP. Cholesterol 96-107 C-reactive protein Homo sapiens 46-49 21078191-7 2010 Lower HDL cholesterol, impaired glucose tolerance (IGT), and higher diastolic blood pressure were associated with having a high CRP in both men and women, while current smoking was associated with high CRP in men but not women. Cholesterol 10-21 C-reactive protein Homo sapiens 128-131 20180088-7 2010 RESULTS: For each unit increase in the depression score, the odds ratio for elevated hs-CRP (i.e., > or =90th percentile value of the age- and sex-specific CRP distribution) was 1.06 (95% confidence interval 0.79, 1.42) after adjustment for age, sex, ever smoked, language, body mass index, physical inactivity, use of medication, total cholesterol concentration, triglycerides concentration, and systolic blood pressure. Cholesterol 340-351 C-reactive protein Homo sapiens 88-91 21044014-4 2011 Cholesterol lowering by HMG-CoA reductase (statin) is beneficial for treating atherosclerotic coronary artery disease and stroke, together with reducing a surrogate-marker of inflammation, C-reactive protein (CRP). Cholesterol 0-11 C-reactive protein Homo sapiens 189-207 21044014-4 2011 Cholesterol lowering by HMG-CoA reductase (statin) is beneficial for treating atherosclerotic coronary artery disease and stroke, together with reducing a surrogate-marker of inflammation, C-reactive protein (CRP). Cholesterol 0-11 C-reactive protein Homo sapiens 209-212 21094359-6 2010 WC and the CRP rs1205 polymorphism showed the strongest relations with hsCRP, and in multiple regression analysis, gender, WC, diabetes, triglycerides, HDL cholesterol, and the 3 genetic variants explained 35.5% of the variance in hsCRP levels. Cholesterol 156-167 C-reactive protein Homo sapiens 11-14 21094359-7 2010 The 2 CRP polymorphisms, female gender, higher WC, and lower HDL cholesterol were associated with risk for having CRP concentrations >= 1 mg/L. Cholesterol 65-76 C-reactive protein Homo sapiens 114-117 19411120-0 2010 Total cholesterol content of erythrocyte membranes levels are associated with the presence of acute coronary syndrome and high sensitivity C-reactive protein. Cholesterol 6-17 C-reactive protein Homo sapiens 139-157 19411120-1 2010 In this study we assessed whether total cholesterol content of erythrocyte membranes (CEM) was associated with the presence of acute coronary syndrome (ACS) and high sensitivity C-reactive protein (hs-CRP). Cholesterol 40-51 C-reactive protein Homo sapiens 178-196 20484148-8 2010 Estrogen caused a variable response in CRP expression that was positively associated with the plasma small dense LDL-cholesterol concentration of the donors. Cholesterol 117-128 C-reactive protein Homo sapiens 39-42 20618287-7 2010 After adjusting for age, sex, total cholesterol, systolic blood pressure, smoking status, diabetes, BMI and waist circumference, the association between CRP and CVD remained significant, with a hazard ratio of 2.40 (95% CI: 1.25, 4.62) for the higher CRP group relative to the lower CRP group. Cholesterol 36-47 C-reactive protein Homo sapiens 153-156 20421792-5 2010 RECENT FINDINGS: Inflammation, as measured by C-reactive protein (CRP), has been established as an independent cardiovascular risk factor, even in persons with low-density lipoprotein (LDL)-cholesterol. Cholesterol 190-201 C-reactive protein Homo sapiens 66-69 20412290-1 2010 BACKGROUND: We recently reported high high-density lipoprotein (HDL) cholesterol as a predictor of recurrent risk in a subgroup of postinfarction patients defined by hypercholesterolemia and high C-reactive protein (CRP) levels. Cholesterol 69-80 C-reactive protein Homo sapiens 196-214 20412290-1 2010 BACKGROUND: We recently reported high high-density lipoprotein (HDL) cholesterol as a predictor of recurrent risk in a subgroup of postinfarction patients defined by hypercholesterolemia and high C-reactive protein (CRP) levels. Cholesterol 69-80 C-reactive protein Homo sapiens 216-219 21122648-11 2010 Also, because recent studies have demonstrated that high-sensitivity C-reactive protein may be a reliable marker in selecting patients for statin therapy, it could reflect the presence of intimal injury by cholesterol crystals. Cholesterol 206-217 C-reactive protein Homo sapiens 69-87 19749491-9 2009 In smokers, hs-CRP significantly correlated with BMI and HDL-cholesterol (r=0.386, p<0.01 and r=-0.307, p<0.05). Cholesterol 61-72 C-reactive protein Homo sapiens 15-18 19850309-4 2010 The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. Cholesterol 233-244 C-reactive protein Homo sapiens 47-65 19800416-0 2010 Plasma lecithin: cholesterol acyltransferase activity modifies the inverse relationship of C-reactive protein with HDL cholesterol in nondiabetic men. Cholesterol 17-28 C-reactive protein Homo sapiens 91-109 19375269-2 2009 In this study, we evaluated the levels of IMA in myocardial infarction and prostate diseases, as well as the influence of HDL cholesterol levels on C-reactive protein (CRP) and IMA levels. Cholesterol 126-137 C-reactive protein Homo sapiens 148-166 19781835-12 2009 In patients with inflammation (CRP level > 5 mg/L), the adjusted relative risk of combined vascular events was 29% greater compared with those without inflammation and a low LDL cholesterol level (LDL cholesterol < or = 123 mg/dL). Cholesterol 181-192 C-reactive protein Homo sapiens 31-34 19781835-12 2009 In patients with inflammation (CRP level > 5 mg/L), the adjusted relative risk of combined vascular events was 29% greater compared with those without inflammation and a low LDL cholesterol level (LDL cholesterol < or = 123 mg/dL). Cholesterol 204-215 C-reactive protein Homo sapiens 31-34 19804653-10 2009 The links between the cliques showed biologically relevant interactions: an inverse relationship between HDL cholesterol and the triglyceride clique (r < -0.3, P < 10(-16)), a connection between triglycerides and body mass via C-reactive protein (r > 0.3, P < 10(-16)) and intermediate-density cholesterol as the connector between lipoprotein metabolism and albuminuria (r > 0.3, P < 10(-16)). Cholesterol 109-120 C-reactive protein Homo sapiens 233-251 20412290-7 2010 However, in the high HDL-cholesterol subgroup, CRP levels were higher than the low HDL-cholesterol subgroup; and within the high HDL-cholesterol subgroup, CRP predicted risk. Cholesterol 25-36 C-reactive protein Homo sapiens 47-50 19621193-1 2009 OBJECTIVES: Aims of the study were 1) to investigate the association of C-reactive protein (CRP) with lipid (i.e. total, LDL, and HDL cholesterol, triglycerides) concentrations, and to evaluate their predictive value for mortality in very old subjects. Cholesterol 134-145 C-reactive protein Homo sapiens 72-90 19695857-4 2009 However, a reduction in CRP levels after statin treatment could be secondary to the reduced LDL cholesterol levels, and thereby less inflammation in atherosclerotic plaques. Cholesterol 96-107 C-reactive protein Homo sapiens 24-27 19621193-11 2009 In the older age group, significant inverse associations of CRP with total (p=0.002), LDL (p=0.007), and HDL cholesterol (p=0.002) were found, even after adjustment for potential confounders. Cholesterol 109-120 C-reactive protein Homo sapiens 60-63 19621193-13 2009 CONCLUSION: An inverse relationship of total, LDL, and HDL cholesterol with CRP is present in very old persons. Cholesterol 59-70 C-reactive protein Homo sapiens 76-79