PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10786622-1 2000 Sterol C5-desaturase (SC5D) cDNA is an enzyme that catalyzes the dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. Cholesterol 131-142 sterol-C5-desaturase Homo sapiens 22-26 12812989-1 2003 Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Cholesterol 77-88 sterol-C5-desaturase Homo sapiens 0-24 12812989-4 2003 Sc5d (-/-) pups were stillborn, had elevated lathosterol and decreased cholesterol levels, had craniofacial defects including cleft palate and micrognathia, and limb patterning defects. Cholesterol 71-82 sterol-C5-desaturase Homo sapiens 0-4 12189593-6 2002 Sequence analysis of the SC5D gene in the patient"s DNA, showing the presence of two missense mutations (R29Q and G211D), confirmed that the patient is affected by a novel defect of cholesterol biosynthesis. Cholesterol 182-193 sterol-C5-desaturase Homo sapiens 25-29 11731337-1 2001 Sterol C5 desaturase (SC5D) converts lathosterol to 7-dehydrocholesterol in cholesterol biosynthesis. Cholesterol 61-72 sterol-C5-desaturase Homo sapiens 0-20 11731337-1 2001 Sterol C5 desaturase (SC5D) converts lathosterol to 7-dehydrocholesterol in cholesterol biosynthesis. Cholesterol 61-72 sterol-C5-desaturase Homo sapiens 22-26 11731337-2 2001 In this study, we investigated the genome structure of SC5D and transcription of the human SC5D gene to try to elucidate the mechanism by which cholesterol synthesis is regulated. Cholesterol 144-155 sterol-C5-desaturase Homo sapiens 91-95 11731337-8 2001 The expression level of SC5D mRNA extracted from human liver carcinoma cells decreased as the amount of cholesterol added to the culture medium was increased. Cholesterol 104-115 sterol-C5-desaturase Homo sapiens 24-28 34726809-10 2021 Osteoblasts reduced cholesterol synthesis in chondrocytes by reducing the expression of a series of synthetases, including Fdft1, Sqle, Lss, Cyp51, Msmo1, Nsdhl, Sc5d, Dhcr24 and Dhcr7. Cholesterol 20-31 sterol-C5-desaturase Homo sapiens 162-166 34440098-4 2021 This work is aimed at systematization and bioinformatic analysis of the available interactomics data on seventeen enzymes in the cholesterol pathway, encoded by HMGCR, MVK, PMVK, MVD, FDPS, FDFT1, SQLE, LSS, DHCR24, CYP51A1, TM7SF2, MSMO1, NSDHL, HSD17B7, EBP, SC5D, DHCR7 genes. Cholesterol 129-140 sterol-C5-desaturase Homo sapiens 261-265