PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12850506-4 2003 Enzymes involved in cholesterol metabolism (ACAT, HMG-CoA-reductase and cholesterol-7alpha-hydroxylase) are greatly influenced by cholesterol profile. Cholesterol 20-31 sterol O-acyltransferase 1 Oryctolagus cuniculus 44-48 15386586-1 2004 Alternative HPLC and solid-phase extraction column methods were developed to separate metabolites of enzymes involved in cholesterol metabolism in rabbit liver microsomes: hydroxyl-methylglutaryl-CoA reductase, cholesterol-7alpha-hydroxylase and acyl-CoA:cholesterol acyltransferase. Cholesterol 121-132 sterol O-acyltransferase 1 Oryctolagus cuniculus 246-282 12850506-4 2003 Enzymes involved in cholesterol metabolism (ACAT, HMG-CoA-reductase and cholesterol-7alpha-hydroxylase) are greatly influenced by cholesterol profile. Cholesterol 72-83 sterol O-acyltransferase 1 Oryctolagus cuniculus 44-48 11223434-7 2001 In the liver a decrease by atorvastatin in free cholesterol substrate for ACAT may amplify the effect of F 12511 on cholesteryl ester content leading to a diminution, in at least an additive manner, of the assembly and secretion of atherogenic lipoproteins in New Zealand rabbits which have developed an endogenous hypercholesterolemia. Cholesterol 48-59 sterol O-acyltransferase 1 Oryctolagus cuniculus 74-78 11773500-6 2002 The results suggest that the mechanism by which hawthorn fruit decreases serum cholesterol involves, at least in part, the inhibition of cholesterol absorption mediated by down-regulation of intestinal ACAT activity. Cholesterol 79-90 sterol O-acyltransferase 1 Oryctolagus cuniculus 202-206 11773500-6 2002 The results suggest that the mechanism by which hawthorn fruit decreases serum cholesterol involves, at least in part, the inhibition of cholesterol absorption mediated by down-regulation of intestinal ACAT activity. Cholesterol 137-148 sterol O-acyltransferase 1 Oryctolagus cuniculus 202-206 8831757-1 1996 A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol lowering in cholesterol-fed rats. Cholesterol 90-101 sterol O-acyltransferase 1 Oryctolagus cuniculus 121-125 9765329-0 1998 Stimulation of cholesterol release from rabbit foam cells by the action of a new inhibitor for acyl CoA:cholesterol acyltransferase (ACAT), HL-004. Cholesterol 15-26 sterol O-acyltransferase 1 Oryctolagus cuniculus 133-137 9699888-0 1998 HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Cholesterol 74-85 sterol O-acyltransferase 1 Oryctolagus cuniculus 22-26 9699888-0 1998 HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Cholesterol 138-149 sterol O-acyltransferase 1 Oryctolagus cuniculus 22-26 9699888-9 1998 We conclude that inhibition of HMG-CoA reductase and ACAT acts synergistically to lower plasma total and lipoprotein cholesterol levels and to limit the development of atherosclerotic lesions in the cholesterol-fed rabbit by presumably regulating cholesterol trafficking pathways within liver and vascular cells. Cholesterol 117-128 sterol O-acyltransferase 1 Oryctolagus cuniculus 53-57 9869270-0 1998 Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Cholesterol 0-11 sterol O-acyltransferase 1 Oryctolagus cuniculus 49-85 9869270-0 1998 Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Cholesterol 0-11 sterol O-acyltransferase 1 Oryctolagus cuniculus 87-91 9765329-0 1998 Stimulation of cholesterol release from rabbit foam cells by the action of a new inhibitor for acyl CoA:cholesterol acyltransferase (ACAT), HL-004. Cholesterol 15-26 sterol O-acyltransferase 1 Oryctolagus cuniculus 95-131 9699888-9 1998 We conclude that inhibition of HMG-CoA reductase and ACAT acts synergistically to lower plasma total and lipoprotein cholesterol levels and to limit the development of atherosclerotic lesions in the cholesterol-fed rabbit by presumably regulating cholesterol trafficking pathways within liver and vascular cells. Cholesterol 199-210 sterol O-acyltransferase 1 Oryctolagus cuniculus 53-57 9632372-6 1998 As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (Ar3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0. Cholesterol 301-312 sterol O-acyltransferase 1 Oryctolagus cuniculus 166-170 9519807-0 1998 HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits. Cholesterol 75-86 sterol O-acyltransferase 1 Oryctolagus cuniculus 12-16 9519807-1 1998 HL-004, N-(2,6-diisopropylphenyl) tetradecylthioacetamide, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, was evaluated concerning the possible prevention of hyperlipidemia and atherosclerosis in 1% cholesterol-fed rabbits. Cholesterol 76-87 sterol O-acyltransferase 1 Oryctolagus cuniculus 105-109 8148358-0 1994 ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Cholesterol 30-41 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 8582041-4 1996 In this work, we prepared both enantiomers and tested them for ability to inhibit ACAT (liver microsomes from cholesterol-fed rabbits) in vitro and to decrease serum total cholesterol in cholesterol-fed golden hamsters in vivo. Cholesterol 110-121 sterol O-acyltransferase 1 Oryctolagus cuniculus 82-86 7869831-2 1995 SMC from SHRSP had a higher acylCoA:cholesterol acyltransferase (ACAT) activity and accumulated more cholesterol than those from WKY. Cholesterol 36-47 sterol O-acyltransferase 1 Oryctolagus cuniculus 65-69 7852860-0 1994 Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys. Cholesterol 69-80 sterol O-acyltransferase 1 Oryctolagus cuniculus 38-42 7852860-3 1994 This ACAT inhibitor also prevented the absorption of exogenous radiolabeled cholesterol in hamsters (ED50 = 6 micrograms/kg), rabbits (ED50 1/2 10 micrograms/kg), and cynomolgus and African green monkeys (40 and 26% inhibition at 10 mg/kg, respectively). Cholesterol 76-87 sterol O-acyltransferase 1 Oryctolagus cuniculus 5-9 7852860-8 1994 These data suggest that ACAT inhibition may be a useful therapeutic approach for lowering LDL cholesterol and thereby reducing the risk of developing coronary heart disease. Cholesterol 94-105 sterol O-acyltransferase 1 Oryctolagus cuniculus 24-28 8555254-1 1996 A partial rabbit cDNA clone (14b) for ACAT has been characterized and used to demonstrate that hepatic and aortic ACAT mRNA14b abundance increased 2-3-fold in rabbits receiving a high fat/high cholesterol-diet compared to chow fed animals (Pape et al. Cholesterol 193-204 sterol O-acyltransferase 1 Oryctolagus cuniculus 38-42 8555254-1 1996 A partial rabbit cDNA clone (14b) for ACAT has been characterized and used to demonstrate that hepatic and aortic ACAT mRNA14b abundance increased 2-3-fold in rabbits receiving a high fat/high cholesterol-diet compared to chow fed animals (Pape et al. Cholesterol 193-204 sterol O-acyltransferase 1 Oryctolagus cuniculus 114-118 7616126-14 1995 These data indicate that ACAT mRNA14b levels increase in a tissue specific manner in response to dietary fat and cholesterol. Cholesterol 113-124 sterol O-acyltransferase 1 Oryctolagus cuniculus 25-29 7811746-5 1995 The acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity was enhanced in the high cholesterol diet groups, and the activity in M-CSF-treated groups decreased. Cholesterol 20-31 sterol O-acyltransferase 1 Oryctolagus cuniculus 49-53 7869831-3 1995 By using SMC from SHRSP, the effects of a novel ACAT inhibitor, HL-004, on the accumulation and removal of cholesterol were investigated. Cholesterol 107-118 sterol O-acyltransferase 1 Oryctolagus cuniculus 48-52 7869831-7 1995 These effects of HL-004 on cholesterol levels showed a good parallel to ACAT inhibition. Cholesterol 27-38 sterol O-acyltransferase 1 Oryctolagus cuniculus 72-76 7869831-8 1995 It would thus appear that the suppression of cholesterol accumulation and the removal of cholesterol in SMC by HL-004 can be attributed to its ACAT inhibition in the cell, which reduces the content of intracellular CE. Cholesterol 45-56 sterol O-acyltransferase 1 Oryctolagus cuniculus 143-147 7869831-8 1995 It would thus appear that the suppression of cholesterol accumulation and the removal of cholesterol in SMC by HL-004 can be attributed to its ACAT inhibition in the cell, which reduces the content of intracellular CE. Cholesterol 89-100 sterol O-acyltransferase 1 Oryctolagus cuniculus 143-147 8148358-0 1994 ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Cholesterol 59-70 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 1453550-11 1992 The activity of acyl CoA: cholesterol acyltransferase (ACAT) in intestinal mucosa and the concentration of hepatic cholesterol were similar in animals treated over one year with pravastatin 50 mg/kg/day or with placebo. Cholesterol 26-37 sterol O-acyltransferase 1 Oryctolagus cuniculus 55-59 8119857-2 1994 IC50 values for the effect of AS-186a, b, c, d, and g against ACAT activity of the microsomes from cholesterol-fed rabbit liver were calculated to be 22.9, 8.2, 11.5, 12.4, and 13.9 microM, respectively. Cholesterol 99-110 sterol O-acyltransferase 1 Oryctolagus cuniculus 62-66 8463871-4 1993 Cholesterol feeding induced higher free cholesterol concentrations in hepatic and intestinal microsomes of both hypo- and hyperresponders and higher activity of hepatic acyl-CoA:cholesterol acyltransferase (ACAT). Cholesterol 0-11 sterol O-acyltransferase 1 Oryctolagus cuniculus 169-205 8463871-4 1993 Cholesterol feeding induced higher free cholesterol concentrations in hepatic and intestinal microsomes of both hypo- and hyperresponders and higher activity of hepatic acyl-CoA:cholesterol acyltransferase (ACAT). Cholesterol 0-11 sterol O-acyltransferase 1 Oryctolagus cuniculus 207-211 8463871-5 1993 Hepatic ACAT activity was significantly lower in cholesterol-fed hyperresponders than in hyporesponders, which may have contributed to the observed higher free cholesterol concentrations in hepatic microsomes of cholesterol-fed hyperresponders. Cholesterol 49-60 sterol O-acyltransferase 1 Oryctolagus cuniculus 8-12 8463871-5 1993 Hepatic ACAT activity was significantly lower in cholesterol-fed hyperresponders than in hyporesponders, which may have contributed to the observed higher free cholesterol concentrations in hepatic microsomes of cholesterol-fed hyperresponders. Cholesterol 160-171 sterol O-acyltransferase 1 Oryctolagus cuniculus 8-12 8463871-5 1993 Hepatic ACAT activity was significantly lower in cholesterol-fed hyperresponders than in hyporesponders, which may have contributed to the observed higher free cholesterol concentrations in hepatic microsomes of cholesterol-fed hyperresponders. Cholesterol 160-171 sterol O-acyltransferase 1 Oryctolagus cuniculus 8-12 1354584-8 1992 The microsomal fraction isolated from cholesterol-fed rabbit aortas exhibited a progressive elevation in ACAT activity as time on the diet increased. Cholesterol 38-49 sterol O-acyltransferase 1 Oryctolagus cuniculus 105-109 1354584-14 1992 In the cholesterol-fed rabbits, total arterial cholesterol and ACAT activity showed a significant (P less than 0.05) inverse correlation to FABP activity with correlation coefficients of -0.93 and -0.95, respectively. Cholesterol 7-18 sterol O-acyltransferase 1 Oryctolagus cuniculus 63-67 1617286-0 1992 Inhibition of ACAT activity after 7-oxo-PGI2 treatment in cholesterol-fed rabbits. Cholesterol 58-69 sterol O-acyltransferase 1 Oryctolagus cuniculus 14-18 1617286-4 1992 Cholesterol feeding increased ACAT activity compared to the control group which was not fed with cholesterol: 16.84 nmol/mg prot./h and 10.03 nmol/mg prot./h, respectively. Cholesterol 0-11 sterol O-acyltransferase 1 Oryctolagus cuniculus 30-34 2335515-1 1990 Acyl-coenzyme A (CoA):cholesterol acyltransferase (ACAT) catalyzes the intracellular fatty acid esterification of cholesterol and is thought to play a key role in lipoprotein metabolism and atherogenesis. Cholesterol 22-33 sterol O-acyltransferase 1 Oryctolagus cuniculus 51-55 1884884-1 1991 Serum lipoproteins and key hepatic and intestinal enzymes regulating cholesterol synthesis, esterification and catabolism, namely 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, acyl coenzyme A: cholesterol-o-acyltransferase (ACAT) and cholesterol 7 alpha-hydroxylase respectively, were compared in two hypercholesterolaemic rabbit models - the cholesterol-fed animal and the hypercholesterolaemic diabetic animal. Cholesterol 69-80 sterol O-acyltransferase 1 Oryctolagus cuniculus 236-240 1854363-3 1991 In the present report we have characterized three components involved in cholesterol homeostasis: the B/E (LDL) receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase activity (HMG-CoA reductase, EC 1.1.1.34) and acyl-coenzyme A: cholesterol acyltransferase activity (ACAT, EC 2.3.1.26) in the livers of the hypercholesterolemia-resistant rabbits. Cholesterol 73-84 sterol O-acyltransferase 1 Oryctolagus cuniculus 271-275 1854363-9 1991 The basal activity of ACAT in hepatic membranes was significantly lower in the resistant rabbits compared to normal rabbits (138 +/- 11 vs 268 +/- 19 pmol cholesteryl ester/min/mg in resistant and normal rabbits respectively); when fed a 0.25% cholesterol-enriched diet, the enzyme was induced 6-fold in normal animals but was increased only 2-fold in the resistant animal. Cholesterol 244-255 sterol O-acyltransferase 1 Oryctolagus cuniculus 22-26 2242095-0 1990 Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis: implications for drug discovery. Cholesterol 33-44 sterol O-acyltransferase 1 Oryctolagus cuniculus 14-18 2242095-1 1990 The regulation of aortic ACAT by a cholesterol substrate pool (CSP) was investigated in a rabbit progression/regression model of dietary-induced atherosclerosis. Cholesterol 35-46 sterol O-acyltransferase 1 Oryctolagus cuniculus 25-29 2242095-4 1990 ACAT activity assayed in the absence vs. the presence of exogenous cholesterol was used as a qualitative measure of the amount of cholesterol in the CSP. Cholesterol 67-78 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 2242095-4 1990 ACAT activity assayed in the absence vs. the presence of exogenous cholesterol was used as a qualitative measure of the amount of cholesterol in the CSP. Cholesterol 130-141 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 7636880-2 1995 Novel N-(4-oxochroman-8-yl)amide derivatives 1 were synthesized and tested for their ability to inhibit rabbit small intestinal ACAT (acyl-CoA:cholesterol acyltransferase) in vitro and to lower serum total cholesterol in cholesterol-fed rats in vivo. Cholesterol 143-154 sterol O-acyltransferase 1 Oryctolagus cuniculus 128-132 3665423-7 1987 Conversely, the capacity to esterify cholesterol as measured by ACAT activities was considerably greater in both sites in the rabbit compared to the rat. Cholesterol 37-48 sterol O-acyltransferase 1 Oryctolagus cuniculus 64-68 2742865-5 1989 To clarify the mechanism of action, the effects of MK-733 on acyl coenzyme A:cholesterol acyltransferase (ACAT) and cholesterol esterase activities, which are thought to participate in the absorption of cholesterol, were examined. Cholesterol 77-88 sterol O-acyltransferase 1 Oryctolagus cuniculus 106-110 2742865-9 1989 The inhibitory effect of MK-733 on cholesterol absorption in cholesterol-fed rabbits is though to be related to a reduction in microsomal ACAT activity in the intestinal mucosa. Cholesterol 61-72 sterol O-acyltransferase 1 Oryctolagus cuniculus 138-142 3689204-8 1987 Reesterification of 3H-cholesterol was negligible in the presence of the ACAT inhibitor and amounted to 37.1% in control cells. Cholesterol 20-34 sterol O-acyltransferase 1 Oryctolagus cuniculus 73-77 2899399-1 1988 This study shows that amniotic fluid enhances cholesterol esterification in arterial wall, as measured by in vitro assay of acyl-CoA:cholesterol acyltransferase (ACAT) activity and by incorporation of oleic acid to cholesteryl esters in cultured fetal aortas and smooth muscle cells. Cholesterol 46-57 sterol O-acyltransferase 1 Oryctolagus cuniculus 162-166 3358947-10 1988 The reductions in both hepatic tissue and macrophage-rich granuloma tissue esterified cholesterol accumulation are considered to be due largely to cellular ACAT inhibition, and the altered distribution and composition of the plasma lipoproteins. Cholesterol 86-97 sterol O-acyltransferase 1 Oryctolagus cuniculus 156-160 3675707-14 1987 Correlation coefficients between enzyme activities, plasma cholesterol levels and aortic cholesterol levels indicated (a) a positive correlation of NCE activity with plasma cholesterol, (b) a negative correlation of NCE and ACE with aortic-cholesteryl ester content, and (c) no significant correlation of ACAT activity with either plasma cholesterol or aortic cholesterol content, indicating other factors are involved. Cholesterol 89-100 sterol O-acyltransferase 1 Oryctolagus cuniculus 305-309 3675707-14 1987 Correlation coefficients between enzyme activities, plasma cholesterol levels and aortic cholesterol levels indicated (a) a positive correlation of NCE activity with plasma cholesterol, (b) a negative correlation of NCE and ACE with aortic-cholesteryl ester content, and (c) no significant correlation of ACAT activity with either plasma cholesterol or aortic cholesterol content, indicating other factors are involved. Cholesterol 89-100 sterol O-acyltransferase 1 Oryctolagus cuniculus 305-309 3675707-14 1987 Correlation coefficients between enzyme activities, plasma cholesterol levels and aortic cholesterol levels indicated (a) a positive correlation of NCE activity with plasma cholesterol, (b) a negative correlation of NCE and ACE with aortic-cholesteryl ester content, and (c) no significant correlation of ACAT activity with either plasma cholesterol or aortic cholesterol content, indicating other factors are involved. Cholesterol 89-100 sterol O-acyltransferase 1 Oryctolagus cuniculus 305-309 3675707-14 1987 Correlation coefficients between enzyme activities, plasma cholesterol levels and aortic cholesterol levels indicated (a) a positive correlation of NCE activity with plasma cholesterol, (b) a negative correlation of NCE and ACE with aortic-cholesteryl ester content, and (c) no significant correlation of ACAT activity with either plasma cholesterol or aortic cholesterol content, indicating other factors are involved. Cholesterol 89-100 sterol O-acyltransferase 1 Oryctolagus cuniculus 305-309 3807053-6 1986 This finding indicates that the inhibition of cholesterol absorption by DL-MA depends on the inhibition of ACAT by this compound, in view of the fact that D-MA is a more effective inhibitor of cholesterol absorption than L-MA. Cholesterol 46-57 sterol O-acyltransferase 1 Oryctolagus cuniculus 107-111 3720921-4 1986 The higher Vmax is attributable to the saturation of ACAT with not only oleoyl-CoA, but also cholesterol. Cholesterol 93-104 sterol O-acyltransferase 1 Oryctolagus cuniculus 53-57 3720921-5 1986 The observation that exogenous cholesterol was necessary for the determination of maximal ACAT activity indicates that under normal conditions the endogenous level of microsomal cholesterol does not saturate ACAT. Cholesterol 31-42 sterol O-acyltransferase 1 Oryctolagus cuniculus 90-94 3720921-5 1986 The observation that exogenous cholesterol was necessary for the determination of maximal ACAT activity indicates that under normal conditions the endogenous level of microsomal cholesterol does not saturate ACAT. Cholesterol 178-189 sterol O-acyltransferase 1 Oryctolagus cuniculus 90-94 3720921-6 1986 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol 117-128 sterol O-acyltransferase 1 Oryctolagus cuniculus 9-13 3720921-6 1986 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol 117-128 sterol O-acyltransferase 1 Oryctolagus cuniculus 166-170 3720921-6 1986 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol 117-128 sterol O-acyltransferase 1 Oryctolagus cuniculus 9-13 3720921-6 1986 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol 117-128 sterol O-acyltransferase 1 Oryctolagus cuniculus 166-170 3720921-7 1986 Using this approach, it was found that hypercholesterolemia results in the expansion of the cholesterol substrate pool of ACAT. Cholesterol 44-55 sterol O-acyltransferase 1 Oryctolagus cuniculus 122-126 6712779-0 1984 Diazepam inhibits cholesterol esterification by arterial ACAT and plasma LCAT, in vitro. Cholesterol 18-29 sterol O-acyltransferase 1 Oryctolagus cuniculus 57-61 3559400-9 1987 In animals ingesting the cholesterol diets, intestinal reductase was significantly decreased, whereas intestinal ACAT activity was increased in rabbits ingesting the cocoa butter and cholesterol diet when compared to their controls. Cholesterol 25-36 sterol O-acyltransferase 1 Oryctolagus cuniculus 113-117 3559400-9 1987 In animals ingesting the cholesterol diets, intestinal reductase was significantly decreased, whereas intestinal ACAT activity was increased in rabbits ingesting the cocoa butter and cholesterol diet when compared to their controls. Cholesterol 183-194 sterol O-acyltransferase 1 Oryctolagus cuniculus 113-117 3942557-2 1986 After 2 weeks, arterial acyl CoA: cholesterol acyltransferase (ACAT) activity tended to be reduced by chlorpromazine treatment with no affect on net arterial cholesterol. Cholesterol 34-45 sterol O-acyltransferase 1 Oryctolagus cuniculus 63-67 3942557-3 1986 After 12 weeks of treatment, arterial ACAT activity was significantly reduced and was paralleled by a reduction in net arterial cholesterol, a reduction in the esterified cholesterol/unesterified cholesterol ratio, and a reduction in lipid staining intensity as determined histologically with oil red O staining of aortic cross sections. Cholesterol 128-139 sterol O-acyltransferase 1 Oryctolagus cuniculus 38-42 3942557-3 1986 After 12 weeks of treatment, arterial ACAT activity was significantly reduced and was paralleled by a reduction in net arterial cholesterol, a reduction in the esterified cholesterol/unesterified cholesterol ratio, and a reduction in lipid staining intensity as determined histologically with oil red O staining of aortic cross sections. Cholesterol 171-182 sterol O-acyltransferase 1 Oryctolagus cuniculus 38-42 3942557-3 1986 After 12 weeks of treatment, arterial ACAT activity was significantly reduced and was paralleled by a reduction in net arterial cholesterol, a reduction in the esterified cholesterol/unesterified cholesterol ratio, and a reduction in lipid staining intensity as determined histologically with oil red O staining of aortic cross sections. Cholesterol 171-182 sterol O-acyltransferase 1 Oryctolagus cuniculus 38-42 2410671-1 1985 Various antihypertensive agents were studied in vitro to determine their effects on cholesterol esterification by arterial ACAT (acylCoA:cholesterol acyltransferase; E.C. Cholesterol 84-95 sterol O-acyltransferase 1 Oryctolagus cuniculus 123-127 2410671-1 1985 Various antihypertensive agents were studied in vitro to determine their effects on cholesterol esterification by arterial ACAT (acylCoA:cholesterol acyltransferase; E.C. Cholesterol 84-95 sterol O-acyltransferase 1 Oryctolagus cuniculus 129-164 4085969-6 1985 These results suggest that ACAT activity in microsomes was affected not only by the amount of microsomal cholesterol, but also by an extra-microsomal soluble protein such as lipoproteins. Cholesterol 105-116 sterol O-acyltransferase 1 Oryctolagus cuniculus 27-31 6712779-3 1984 The studies presented here indicate that diazepam, the most widely used benzodiazepine, is an inhibitor of cholesterol esterification by ACAT in vitro in atheromatous rabbit aortas, in microsomes isolated from atheromatous rabbit aortas, and in normal rat aortas. Cholesterol 107-118 sterol O-acyltransferase 1 Oryctolagus cuniculus 137-141 6854150-0 1983 beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification. Cholesterol 62-73 sterol O-acyltransferase 1 Oryctolagus cuniculus 91-95 6631233-3 1983 The stimulation of ACAT activity by 25-hydroxycholesterol was inversely related to microsomal cholesterol content. Cholesterol 46-57 sterol O-acyltransferase 1 Oryctolagus cuniculus 19-23 6631233-12 1983 The effect of 25-hydroxycholesterol on ACAT is dependent upon the availability of cholesterol to the enzyme. Cholesterol 24-35 sterol O-acyltransferase 1 Oryctolagus cuniculus 39-43 6631233-15 1983 ACAT catalyzes the esterification of two separate pools of cholesterol within the enterocyte, i.e., newly synthesized cholesterol and membrane cholesterol. Cholesterol 59-70 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 6631233-15 1983 ACAT catalyzes the esterification of two separate pools of cholesterol within the enterocyte, i.e., newly synthesized cholesterol and membrane cholesterol. Cholesterol 118-129 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 6631233-15 1983 ACAT catalyzes the esterification of two separate pools of cholesterol within the enterocyte, i.e., newly synthesized cholesterol and membrane cholesterol. Cholesterol 118-129 sterol O-acyltransferase 1 Oryctolagus cuniculus 0-4 6631241-1 1983 Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3.1.26) and mucosal cytosol by cholesterol esterase (EC 3.1.1.13) was studied. Cholesterol 18-29 sterol O-acyltransferase 1 Oryctolagus cuniculus 78-114 6631241-1 1983 Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3.1.26) and mucosal cytosol by cholesterol esterase (EC 3.1.1.13) was studied. Cholesterol 18-29 sterol O-acyltransferase 1 Oryctolagus cuniculus 116-120 6631241-3 1983 N-(1-oxo-9-octadecenyl)-DL-tryptophan(Z)ethyl ester, an inhibitor of cholesterol absorption, was found to inhibit in vitro ACAT in mucosal microsomes at concentrations of 2-20 nmol/0.5 ml incubation mixture, but had no effect on cholesterol esterase in the cytosol at similar concentrations. Cholesterol 69-80 sterol O-acyltransferase 1 Oryctolagus cuniculus 123-127 6631241-11 1983 9: 55-62) indicating mucosal ACAT plays a significant role in cholesterol absorption. Cholesterol 62-73 sterol O-acyltransferase 1 Oryctolagus cuniculus 29-33 6852207-1 1983 Chlorpromazine (CPZ), a major tranquilizer, was found to be a potent inhibitor of acylCoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in isolated arterial microsomes and in intact arterial tissue from the rat and cholesterol-fed rabbit in vitro. Cholesterol 90-101 sterol O-acyltransferase 1 Oryctolagus cuniculus 119-123 6854150-16 1983 beta-Sitosterol: esterification by intestinal acylcoenzyme A:cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification. Cholesterol 61-72 sterol O-acyltransferase 1 Oryctolagus cuniculus 90-94 7126624-0 1982 Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-CoA: cholesterol acyltransferase activity in rabbit intestinal microsomes. Cholesterol 34-45 sterol O-acyltransferase 1 Oryctolagus cuniculus 68-105 7126624-4 1982 Both diets containing cholesterol increased acyl-CoA: cholesterol acyltransferase activity; however, the safflower oil plus cholesterol diet was a more potent stimulator than coconut oil plus cholesterol. Cholesterol 22-33 sterol O-acyltransferase 1 Oryctolagus cuniculus 44-81 7159486-1 1982 Bezafibrate markedly reduced the activity of fatty acyl CoA:cholesterol acyltransferase (ACAT) in the microsomal fraction of aortas from cholesterol-fed rabbits, while clofibrate was a less potent inhibitor. Cholesterol 60-71 sterol O-acyltransferase 1 Oryctolagus cuniculus 89-93