PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18971317-10 2009 Activation of hCAR and hPXR by atorvastatin and the subsequent induction of not only CYP2B6 and CYP3A4 but also of CYP2C9 present an additional target by which atorvastatin, a widely used cholesterol-lowering drug, can modify the kinetics of numerous drugs. Cholesterol 188-199 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 85-91 26002738-2 2015 P450 enzymes play an important role in the detoxification of exogenous bioactive compounds and hydrophobic xenobiotics (e.g. carcinogens, drugs, environment pollutants, food supplements, medicines, plant products) and in the biotransformation of endogenous bioactive compounds (e.g. amino acids, cholesterol, eicosanoids, saturated/unsaturated fatty acids, melatonin, steroid hormones). Cholesterol 296-307 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 25017465-1 2014 Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. Cholesterol 110-121 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-34 23548939-9 2013 This was associated with a reduction in the P450 aromatase and P450scc (cholesterol side-chain cleavage cytochromes P450) (P450scc) protein levels but not those of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) or steroidogenic acute regulatory protein (StAR) and with a decrease in IGF-I-induced IGF-I receptor and mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation. Cholesterol 72-83 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 116-121 11416012-2 2001 low density lipoprotein (LDL) receptor, steroidogenic acute regulatory protein, and P450 cholesterol side-chain cleavage enzyme (CYP11A). Cholesterol 89-100 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 84-88 17270273-10 2007 The implications of inhibition of P450-catalzyed oxidation steps that are known or speculated to influence arachadonic acid, cholesterol, and catecholamine neurotransmitters pathways in human brain will be considered. Cholesterol 125-136 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 34-38 12045201-4 2002 The cholesterol-sensing liver X receptor competes with CXR, pregnane X receptor, or constitutive androstane receptor for regulation of drug-responsive enhancers from chicken CYP2H1, human CYP3A4, or human CYP2B6, respectively. Cholesterol 4-15 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 205-211 18992768-4 2009 PGRMC1 and its homologues regulate cholesterol synthesis by activating the P450 protein Cyp51/lanosterol demethylase, and the cholesterol synthetic pathway is an important target in cardiovascular disease and in treating infections. Cholesterol 35-46 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 75-79 16872679-1 2006 By participating in pathways of cholesterol biosynthesis and elimination, different cytochrome P450 (P450 or CYP) enzymes play an important role in maintenance of cholesterol homeostasis. Cholesterol 32-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 101-112 16872679-1 2006 By participating in pathways of cholesterol biosynthesis and elimination, different cytochrome P450 (P450 or CYP) enzymes play an important role in maintenance of cholesterol homeostasis. Cholesterol 163-174 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 101-112 15834119-3 2005 In this assay, the P450 is incubated with a fixed amount of radiolabeled cholesterol and varying concentrations of cold cholesterol followed by separation of free and protein-bound cholesterol via filtration through a membrane. Cholesterol 73-84 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-23 15834119-3 2005 In this assay, the P450 is incubated with a fixed amount of radiolabeled cholesterol and varying concentrations of cold cholesterol followed by separation of free and protein-bound cholesterol via filtration through a membrane. Cholesterol 120-131 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-23 15834119-3 2005 In this assay, the P450 is incubated with a fixed amount of radiolabeled cholesterol and varying concentrations of cold cholesterol followed by separation of free and protein-bound cholesterol via filtration through a membrane. Cholesterol 120-131 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-23 15819722-0 2005 StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies. Cholesterol 80-91 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 124-128 11844358-5 2000 Molecular genetic studies have demonstrated that CYP11a, the gene encoding P450 cholesterol side chain cleavage, is a major susceptibility locus for development of hyperandrogenism in PCOS. Cholesterol 80-91 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 75-79 1316854-0 1992 Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells. Cholesterol 18-29 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 61-82 10051404-1 1999 Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Cholesterol 176-187 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 60-65 18406240-2 1998 In this article, we present evidence from molecular genetic studies for involvement of the steroid synthesis gene CYP11a (coding for P450 cholesterol side-chain cleavage) in the aetiology of hyperandrogenism. Cholesterol 138-149 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 133-137 9455828-7 1997 We review evidence for an important role for the insulin gene minisatellite in the aetiology of anovulatory PCOS and for the gene coding for P450 cholesterol side chain cleavage (CYP11a) in the mechanism of excessive androgen secretion in women with polycystic ovaries. Cholesterol 146-157 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 141-145 7945891-7 1994 Aromatase and cholesterol side-chain cleaving P450 mRNAs, proteins, and activities are measurable in human placentas and do not seem to be affected by maternal cigarette smoking. Cholesterol 14-25 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 46-50 3663605-2 1987 Water proton relaxation rates of various complexes of cholesterol side chain cleavage cytochrome P-450 (-450scc) were investigated to gain information about the structure and dynamics of the steroid binding site. Cholesterol 54-65 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-111 2370296-13 1990 Levels of mRNA encoding cholesterol side-chain cleavage cytochrome P-450 were similarly increased in cells treated with forskolin compared with unstimulated values at each of the time points investigated. Cholesterol 24-35 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 67-72 2540088-1 1989 Aromatase, 17 alpha-hydroxylase, and cholesterol side-chain cleavage P-450 cytochromes (P-450AROM, P-450(17 alpha,) and P-450SCC, respectively) were immunohistochemically localized in nine granulosa cell tumors, 15 thecomas, ten Sertoli-Leydig cell tumors, two steroid cell tumors, five fibromas, and five sclerosing stromal tumors. Cholesterol 37-48 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 69-74 1540227-8 1992 At a high concentration (10 microM), ridogrel has a slight, if any, effect on the P450-mediated cholesterol synthesis in human liver and hepatoma cells and androgen synthesis from 17 alpha-hydroxy-20-dihydroprogesterone or pregnenolone in subcellular fractions from rat testes. Cholesterol 96-107 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 82-86 3502608-3 1987 The levels of mRNAs for the rate-limiting enzymes in the conversion of cholesterol into progesterone, namely cholesterol side-chain cleavage cytochrome P-450 and its electron donor, adrenodoxin, were higher in corpora lutea than in follicles. Cholesterol 71-82 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 152-157 3502608-3 1987 The levels of mRNAs for the rate-limiting enzymes in the conversion of cholesterol into progesterone, namely cholesterol side-chain cleavage cytochrome P-450 and its electron donor, adrenodoxin, were higher in corpora lutea than in follicles. Cholesterol 109-120 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 152-157 6723577-8 1984 4- Cyclohexylaniline and d-aminoglutethimide were also assayed for their inhibition of cytochrome P-450-catalyzed cholesterol side-chain cleavage. Cholesterol 114-125 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 98-103 3753972-0 1986 The insulin-like growth factor, somatomedin C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells. Cholesterol 72-83 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 115-120 2986550-0 1985 Regulation of steroidogenesis in rat Leydig cells in culture: effect of human chorionic gonadotropin and dibutyryl cyclic AMP on the synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin. Cholesterol 146-157 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 189-210 2986550-1 1985 Rat Leydig cells in primary culture were used as a model system to investigate the effects of human chorionic gonadotropin (hCG) and dibutyryl cyclic AMP (Bt2cAMP) on the synthesis of cholesterol side chain cleavage cytochrome P-450 (cytochrome P-450scc) and the iron-sulfur protein, adrenodoxin. Cholesterol 184-195 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 227-232 6100256-1 1984 A rate-determining step in the cAMP-dependent action of ACTH on adrenal steroid biosynthesis is the interaction of cholesterol substrate with the cholesterol side-chain cleavage cytochrome P-450 in the mitochondrion. Cholesterol 115-126 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 189-194 6100256-1 1984 A rate-determining step in the cAMP-dependent action of ACTH on adrenal steroid biosynthesis is the interaction of cholesterol substrate with the cholesterol side-chain cleavage cytochrome P-450 in the mitochondrion. Cholesterol 146-157 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 189-194 6679766-1 1983 The separation of the two domains, disclosed by limited trypsinolysis in the cholesterol side chain cleavage cytochrome P-450, by covalent chromatography on thiopropyl-Sepharose 6B is described. Cholesterol 77-88 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 120-125 6303756-0 1983 Biosynthesis of cholesterol side-chain cleavage cytochrome P-450 in human fetal adrenal cells in culture. Cholesterol 16-27 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 59-64 6303756-1 1983 An immunoglobulin G fraction from antiserum raised against cholesterol side-chain cleavage cytochrome P-450 (cytochrome P-450sec) purified from bovine adrenocortical mitochondria cross-reacted with human fetal adrenal cytochrome P-450sec in an Ouchterlony double diffusion system. Cholesterol 59-70 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 102-107 6303756-1 1983 An immunoglobulin G fraction from antiserum raised against cholesterol side-chain cleavage cytochrome P-450 (cytochrome P-450sec) purified from bovine adrenocortical mitochondria cross-reacted with human fetal adrenal cytochrome P-450sec in an Ouchterlony double diffusion system. Cholesterol 59-70 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 120-128 6303756-1 1983 An immunoglobulin G fraction from antiserum raised against cholesterol side-chain cleavage cytochrome P-450 (cytochrome P-450sec) purified from bovine adrenocortical mitochondria cross-reacted with human fetal adrenal cytochrome P-450sec in an Ouchterlony double diffusion system. Cholesterol 59-70 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 229-237 6679766-0 1983 [Separation of cholesterol-specific cytochrome P-450 regions and their localization in the polypeptide chain]. Cholesterol 15-26 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 47-52 34011532-7 2021 Treatment with inhibitors of different steps of cholesterol biosynthesis attenuated CITCO-mediated CYP2B6 induction in HepaRG cells, and Prava treatment increased HMGCR expression and inhibited CYP2B6 induction with comparable potency. Cholesterol 48-59 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 99-105 34011532-10 2021 Significance Statement The cholesterol biosynthesis inhibitor squalestatin 1 induces rat hepatic CYP2B expression indirectly, by causing accumulation of an endogenous isoprenoid that activates the constitutive androstane receptor (CAR). Cholesterol 27-38 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-102