PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22305277-0 2012 Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages. Cholesterol 83-94 GLI family zinc finger 2 Homo sapiens 107-112 22429094-0 2012 Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages. Cholesterol 53-64 GLI family zinc finger 2 Homo sapiens 77-82 22336243-4 2012 The enrichment of HDL(3) with human PON1 enhanced, in a dose-dependent manner, cholesterol efflux from THP-1 macrophage-like cells and ABCA1-enriched J774 macrophages. Cholesterol 79-90 GLI family zinc finger 2 Homo sapiens 103-108 22305277-3 2012 In the present study, we studied the effects of ethanolic extracts of Brazilian red propolis (EERP) on ABCA1 expression and cholesterol efflux in THP-1 macrophages. Cholesterol 124-135 GLI family zinc finger 2 Homo sapiens 146-151 22190030-6 2012 TG and free cholesterol were dramatically increased in THP-1-derived macrophages (140 and 50%, respectively; P < 0.05) and in THP-1 monocytes (160 and 95%, respectively; P < 0.05). Cholesterol 12-23 GLI family zinc finger 2 Homo sapiens 55-60 22190030-6 2012 TG and free cholesterol were dramatically increased in THP-1-derived macrophages (140 and 50%, respectively; P < 0.05) and in THP-1 monocytes (160 and 95%, respectively; P < 0.05). Cholesterol 12-23 GLI family zinc finger 2 Homo sapiens 129-134 21930241-7 2011 Both in the lipid-free form and as part of rHDL, TripA elicited cholesterol efflux from THP1-derived macrophages with similar kinetic parameters and response to liver-X-receptor activation as apoA-I. Cholesterol 64-75 GLI family zinc finger 2 Homo sapiens 88-92 21871057-0 2011 Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 91-96 21994427-5 2011 Furthermore, functionality of HDL with respect to inducing cholesterol efflux from human monocyte cells (THP-1) was determined. Cholesterol 59-70 GLI family zinc finger 2 Homo sapiens 105-110 22108150-5 2011 Cholesterol efflux was expressed as percentage efflux of radioactivity from lipid-laden THP-1 macrophages preincubated with (3)H-cholesterol and then incubated with serum depleted of apolipoprotein B to provide an HDL-enriched acceptor medium. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 88-93 21823057-5 2011 We further investigated the effects of rosuvastatin on cholesterol efflux from AGE-exposed THP-1 cells. Cholesterol 55-66 GLI family zinc finger 2 Homo sapiens 91-96 21823057-10 2011 The results demonstrated that rosuvastatin could inhibit the AGE-induced reduction of THP-1 macrophage cholesterol efflux by suppressing NADPH oxidase activity via inhibition of geranylgeranylation of Rac-1. Cholesterol 103-114 GLI family zinc finger 2 Homo sapiens 86-91 21823057-8 2011 AGE decreased ABCA1 and ABCG1 mRNA levels, and subsequently reduced cholesterol efflux from THP-1 cells, which was prevented by GGPP. Cholesterol 68-79 GLI family zinc finger 2 Homo sapiens 92-97 21336983-0 2011 Receptor mediated elevation in FABP4 levels by advanced glycation end products induces cholesterol and triacylglycerol accumulation in THP-1 macrophages. Cholesterol 87-98 GLI family zinc finger 2 Homo sapiens 135-140 21111593-6 2011 Sitosterol had no effect on cholesterol efflux to Apo AI or HDL, whereas campesterol had a modest but significant reduction in cholesterol efflux to HDL in THP-1 macrophages. Cholesterol 127-138 GLI family zinc finger 2 Homo sapiens 156-161 21181286-9 2011 Oil red O staining revealed a profound increase in foam cell transformation of THP-1 macrophages exposed to either celecoxib or AACOCF3 (both 25 muM), supporting a role for the COX pathway in maintaining macrophage cholesterol homeostasis. Cholesterol 215-226 GLI family zinc finger 2 Homo sapiens 79-84 21151462-0 2010 Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. Cholesterol 46-57 GLI family zinc finger 2 Homo sapiens 73-78 21177161-5 2010 RESULTS: In THP-1-derived macrophages and foam cells, the expression levels of ACAT-1 mRNA and protein and cellular cholesterol content increased significantly in response to ADMA treatment in a time- and concentration-dependent manner. Cholesterol 116-127 GLI family zinc finger 2 Homo sapiens 12-17 20947831-7 2010 Overexpression of human NCEH1 increased the hydrolysis of CE, thereby stimulating cholesterol mobilization from THP-1 macrophages. Cholesterol 82-93 GLI family zinc finger 2 Homo sapiens 112-117 21670559-7 2011 RESULTS: AOPPs significantly decreased the expression of ATP-binding membrane cassette transporter A-1 (ABCA1) and liver X receptor alpha (LXRalpha) and reduced cholesterol efflux from THP-1 macrophage- derived foam cells. Cholesterol 161-172 GLI family zinc finger 2 Homo sapiens 185-190 21670559-11 2011 CONCLUSIONS: AOPPs may first down-regulate the expression of LXRalpha and ABCA1 through JAK/STAT signal pathway activation and then inhibit cholesterol efflux in THP-1-derived foam-like cells; therefore, our study may be useful for understanding the critical effects of AOPPs on the pathogenesis of atherosclerosis. Cholesterol 140-151 GLI family zinc finger 2 Homo sapiens 162-167 20871621-5 2010 RESULTS: Ibrolipim 5 and 50 mumol/L significantly increased cholesterol efflux from THP-1 macrophage-derived foam cells to apoA-I or HDL. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 84-89 20723893-4 2010 METHODS AND RESULTS: We observed that treatment of THP-1 macrophages, human monocyte-derived macrophages, and RAW264.7 cells with cilostazol increased ABCA1 and ABCG1 expression in a concentration-dependent manner, translating into enhanced apoA-I- and HDL-mediated cholesterol efflux from the macrophages. Cholesterol 266-277 GLI family zinc finger 2 Homo sapiens 51-56 20625316-0 2010 Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 45-56 GLI family zinc finger 2 Homo sapiens 67-72 19747856-3 2010 We assessed the expression of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) and adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1), which have been implicated in regulating cellular cholesterol homeostasis and therefore play critical roles in foam cell formation, in THP-1-derived foam cells in the presence of various concentration of ghrelin. Cholesterol 46-57 GLI family zinc finger 2 Homo sapiens 294-299 20979792-9 2010 Rosiglitazone can enhance this procedure in THP-1 macrophages derived foam cells which means that they can promote ABCA1 mediated cholesterol reverse transportation through improve ABCA1 protein expression. Cholesterol 130-141 GLI family zinc finger 2 Homo sapiens 44-49 20625316-10 2010 These results provide evidence that D4-F enhances ABCA1 serine phosphorylation and ABCA1-dependent cholesterol efflux through Cdc42/cAMP/PKA pathway in THP-1 macrophage-derived foam cells. Cholesterol 99-110 GLI family zinc finger 2 Homo sapiens 152-157 20598228-12 2010 There was also an increase of cholesterol content in ER with AcLDL-induced apoptosis in THP-1 macrophages. Cholesterol 30-41 GLI family zinc finger 2 Homo sapiens 88-93 19653192-4 2010 In the present study, the effects of APS on ABCA1 expression, cholesterol effluent rate and total cholesterol content of THP-1 derived foam cells exposed to TNF-alpha were investigated. Cholesterol 98-109 GLI family zinc finger 2 Homo sapiens 121-126 20139031-3 2010 In the present study, we found that the addition of tryptase into THP-1-derived macrophages increased both intracellular lipid accumulation and total cholesterol level. Cholesterol 150-161 GLI family zinc finger 2 Homo sapiens 66-71 19547978-3 2010 We determined whether lupus plasma impacts expression of cholesterol 27-hydroxylase, an anti-atherogenic cholesterol-degrading enzyme that promotes cellular cholesterol efflux, in THP-1 human monocytes and primary human aortic endothelial cells (HAEC). Cholesterol 57-68 GLI family zinc finger 2 Homo sapiens 180-185 19656510-8 2010 In addition, the peptide increased cholesterol efflux from THP-1 cells by an ABCA1 independent mechanism. Cholesterol 35-46 GLI family zinc finger 2 Homo sapiens 59-64 19547978-6 2010 THP-1 macrophages were incubated in 25% lupus plasma or CHP and cholesterol-loaded (50 microg ml(-1) acetylated low density lipoprotein). Cholesterol 64-75 GLI family zinc finger 2 Homo sapiens 0-5 19552907-7 2009 Incubation of macrophages (J774, THP-1 and MPM) with Fe/ascorbate ion, attenuated apoA-1 and HDL(3)-mediated cholesterol efflux whereas resveratrol (0-25microM) significantly redressed this attenuation in a dose-dependent manner (p<0.001). Cholesterol 109-120 GLI family zinc finger 2 Homo sapiens 33-38 19376519-6 2009 HDL-mediated cholesterol efflux was determined using human THP-1-derived macrophages pre-labeled with [(3)H]-cholesterol. Cholesterol 13-24 GLI family zinc finger 2 Homo sapiens 59-64 19770838-4 2009 Clinically relevant concentrations of HAART 3-plex significantly reduced cholesterol efflux in foam cells derived from THP-1 and PBMCs. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 119-124 19533020-3 2009 RESULTS: We demonstrated that LPS enhanced transformation of THP-1 macrophages into foam cells by increased uptake of unmodified LDL as evidenced by Oil Red O staining and direct assay of intracellular cholesterol. Cholesterol 202-213 GLI family zinc finger 2 Homo sapiens 61-66 19376519-8 2009 Glycation of HDL significantly reduced the HDL-mediated cholesterol efflux from THP-1-derived macrophages (87.7+/-4.2% of control, n=9, p<0.0001). Cholesterol 56-67 GLI family zinc finger 2 Homo sapiens 80-85 19781328-14 2009 Exposure of THP-1 macrophages to 100 microg/ml of AcLDL for 24 hours resulted in a significant increase in caspase 3,7 activity, a significant increase in FC and CE mass of 1.5 and 2.4-fold, meanwhile, a significant increase in transcription factor C/EBP homologous protein and a decrease in Bcl-2 both in protein and mRNA levels were observed with an 8-fold rise of free cholesterol in the ER. Cholesterol 372-383 GLI family zinc finger 2 Homo sapiens 12-17 19781328-15 2009 CONCLUSION: ER stress is involved in AcLDL induced apoptosis in THP-1 macrophages with free cholesterol accumulation in the ER. Cholesterol 92-103 GLI family zinc finger 2 Homo sapiens 64-69 18787236-5 2009 In addition, cholesterol efflux from acetyl-LDL-loaded human THP-1 macrophages to individual sera (0.5%) derived from the study subjects was evaluated. Cholesterol 13-24 GLI family zinc finger 2 Homo sapiens 61-66 19281927-9 2009 rHDL increased the capacity of plasma to receive cholesterol from THP-1 macrophages by 1 h up to 72 h post-infusion (by 40% to 60%, p < 0.05). Cholesterol 49-60 GLI family zinc finger 2 Homo sapiens 66-71 18787236-8 2009 Cholesterol efflux from THP-1 foam cells to serum recovered from high-HDL subjects was slightly higher than that to serum from low-HDL subjects (P = 0.046). Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 24-29 18787236-9 2009 Cholesterol efflux from THP-1 macrophages to serum from study subjects correlated with serum apoB (P = 0.033), apoA-I (P = 0.004), apoA-II (P < 0.0001), and the percentage of apoA-I present in the form of prebeta-HDL (P = 0.0001). Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 24-29 18785587-13 2008 Compared with the normal cells, cholesterol efflux of siRNA THP-1 macrophage-derived foam cells was significantly decreased, whereas cholesterol efflux of LXR agonist T0901317-treated THP-1 macrophage-derived foam cells was significantly increased. Cholesterol 32-43 GLI family zinc finger 2 Homo sapiens 60-65 18988890-0 2009 Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages. Cholesterol 55-66 GLI family zinc finger 2 Homo sapiens 77-82 18988890-10 2009 Lysophosphatidylcholine treatment dose-dependently stimulated apoAI-mediated cholesterol efflux in THP-1 macrophages. Cholesterol 77-88 GLI family zinc finger 2 Homo sapiens 99-104 18785587-13 2008 Compared with the normal cells, cholesterol efflux of siRNA THP-1 macrophage-derived foam cells was significantly decreased, whereas cholesterol efflux of LXR agonist T0901317-treated THP-1 macrophage-derived foam cells was significantly increased. Cholesterol 133-144 GLI family zinc finger 2 Homo sapiens 184-189 18096828-2 2008 METHODS AND RESULTS: Human THP-1 monocytes and peripheral blood mononuclear cells (PBMCs) were preincubated with acetylated LDL and [3H]-cholesterol to form foam cells, which were then treated with apolipoprotein A-I (apoA-I) or HDL for cholesterol efflux assay. Cholesterol 137-148 GLI family zinc finger 2 Homo sapiens 27-32 18427282-0 2008 Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway. Cholesterol 43-54 GLI family zinc finger 2 Homo sapiens 65-70 18427282-4 2008 ApoAI-mediated cholesterol efflux was reduced in PMA-stimulated THP-1 cells treated with atorvastatin, this effect was abolished with acetylated low-density lipoprotein (LDL) pretreatment. Cholesterol 15-26 GLI family zinc finger 2 Homo sapiens 64-69 18096828-3 2008 Clinically relevant concentrations of CRP significantly reduced cholesterol efflux from THP-1 and PBMCs to apoA-I or HDL. Cholesterol 64-75 GLI family zinc finger 2 Homo sapiens 88-93 18096828-8 2008 CONCLUSIONS: CRP inhibits cholesterol efflux from human foam cells derived from THP-1 and PBMCs in vitro though oxidative stress, ERK1/2 activation, and downregulation of intracellular cholesterol transport molecules ABCA1 and ABCG1. Cholesterol 26-37 GLI family zinc finger 2 Homo sapiens 80-85 17991739-7 2008 Silencing of ORP8 by RNA interference in THP-1 macrophages increased the expression of ATP binding cassette transporter A1 (ABCA1) and concomitantly cholesterol efflux to lipid-free apolipoprotein A-I but had no significant effect on ABCG1 expression or cholesterol efflux to spherical high density lipoprotein HDL(2). Cholesterol 149-160 GLI family zinc finger 2 Homo sapiens 41-46 17991739-7 2008 Silencing of ORP8 by RNA interference in THP-1 macrophages increased the expression of ATP binding cassette transporter A1 (ABCA1) and concomitantly cholesterol efflux to lipid-free apolipoprotein A-I but had no significant effect on ABCG1 expression or cholesterol efflux to spherical high density lipoprotein HDL(2). Cholesterol 254-265 GLI family zinc finger 2 Homo sapiens 41-46 17681345-3 2007 uPA increased cellular cholesterol content by 44% (mainly unesterified cholesterol) in THP-1 macrophages, and this effect was inhibited by statins. Cholesterol 23-34 GLI family zinc finger 2 Homo sapiens 87-92 17681345-3 2007 uPA increased cellular cholesterol content by 44% (mainly unesterified cholesterol) in THP-1 macrophages, and this effect was inhibited by statins. Cholesterol 71-82 GLI family zinc finger 2 Homo sapiens 87-92 17900150-4 2007 In this study we clarify the role of the two forms of PLTP in cholesterol efflux from [3H]cholesterol oleate-acetyl-LDL-loaded THP-1 macrophages. Cholesterol 62-73 GLI family zinc finger 2 Homo sapiens 127-132 17689273-5 2007 The total cholesterol content in THP-1 macrophage-derived foam cells was detected by the zymochemistry method. Cholesterol 10-21 GLI family zinc finger 2 Homo sapiens 33-38 17689273-6 2007 Results revealed that TNF-alpha could increase cholesterol content by down-regulating ABCA1 expression in a time-dependent manner in THP-1 macrophage-derived foam cells, which may contribute to its pro-atherosclerotic effect. Cholesterol 47-58 GLI family zinc finger 2 Homo sapiens 133-138 17872455-7 2007 The pioglitazone-induced apoA-I lipoprotein particles increased cholesterol efflux from THP-1 macrophages. Cholesterol 64-75 GLI family zinc finger 2 Homo sapiens 88-93 17579831-5 2007 RESULTS: The ability of AGE-modified apoA-I to promote cholesterol efflux from THP-1 macrophages, isolated human monocytes and from ABCA1-transfected HeLa cells was significantly reduced (>70%) compared with unmodified apoA-I. Cholesterol 55-66 GLI family zinc finger 2 Homo sapiens 79-84 17551762-0 2007 Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. Cholesterol 75-86 GLI family zinc finger 2 Homo sapiens 101-106 17591975-4 2007 A clinically relevant concentration of ritonavir (15 mumol/L) significantly reduced cholesterol efflux from THP-1 and peripheral blood mononuclear cells to apolipoprotein A-I by 30 and 29%, respectively, as compared with controls. Cholesterol 84-95 GLI family zinc finger 2 Homo sapiens 108-113 16820149-7 2007 Furthermore, cholesterol efflux from THP-1 macrophages to HDL(3) or apolipoprotein A-I was enhanced by K-604. Cholesterol 13-24 GLI family zinc finger 2 Homo sapiens 37-42 17587765-0 2007 Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 45-50 17348203-1 2006 In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis. Cholesterol 203-214 GLI family zinc finger 2 Homo sapiens 218-223 16971496-0 2007 Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages. Cholesterol 95-106 GLI family zinc finger 2 Homo sapiens 125-129 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol 20-31 GLI family zinc finger 2 Homo sapiens 406-410 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol 50-61 GLI family zinc finger 2 Homo sapiens 406-410 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol 50-61 GLI family zinc finger 2 Homo sapiens 406-410 16971496-2 2007 Since extracellular cholesterol acceptor-mediated cholesterol efflux is the only recognized mechanism of cholesterol removal from foam cells and this process is rate limited at the level of intracellular cholesterol ester hydrolysis, a reaction catalyzed by neutral cholesteryl ester hydrolase (CEH), we examined the hypothesis that CEH overexpression in the human macrophage monocyte/macrophage cell line THP1 results in increased cholesterol efflux, as well as decreased cellular cholesterol ester accumulation. Cholesterol 50-61 GLI family zinc finger 2 Homo sapiens 406-410 16971496-5 2007 Efflux of free or unesterified cholesterol by acetylated LDL-loaded THP1-CEH cells to ApoA-I by an ABCA1-dependent pathway or to HDL by an ABCG1-dependent pathway was significantly higher than that in THP1-WT cells. Cholesterol 31-42 GLI family zinc finger 2 Homo sapiens 68-72 16971496-5 2007 Efflux of free or unesterified cholesterol by acetylated LDL-loaded THP1-CEH cells to ApoA-I by an ABCA1-dependent pathway or to HDL by an ABCG1-dependent pathway was significantly higher than that in THP1-WT cells. Cholesterol 31-42 GLI family zinc finger 2 Homo sapiens 201-205 16971496-6 2007 In addition, THP1-CEH cells accumulated significantly lower amount of esterified cholesterol. Cholesterol 81-92 GLI family zinc finger 2 Homo sapiens 13-17 17045616-0 2006 Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage. Cholesterol 81-92 GLI family zinc finger 2 Homo sapiens 103-108 17045616-4 2006 HDL-mediated cholesterol efflux assay was carried out in human THP-1 macrophages. Cholesterol 13-24 GLI family zinc finger 2 Homo sapiens 63-68 17045616-6 2006 Also, incubation of HDL with AEM significantly increased HDL-mediated cholesterol efflux from THP-1 macrophages implicating an independent ATP binding cassette A1 (ABCA1) pathways. Cholesterol 70-81 GLI family zinc finger 2 Homo sapiens 94-99 17196163-3 2007 The aim of the study is to investigate the influence of AngII on the expression of ABCA1 and the content of cholesterol in THP-1 derived foam cells. Cholesterol 108-119 GLI family zinc finger 2 Homo sapiens 123-128 17158353-3 2007 METHODS AND RESULTS: Cholesterol enrichment of human THP-1 monocytes, alone or in combination with lipopolysaccharide (LPS), tripled their total MV generation, as quantified by flow cytometry based on particle size and PS exposure. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 53-58 17244362-10 2007 Cholesterol-loaded THP-1 macrophages showed significantly increased foam cell transformation in the presence of NS398 versus control (42.7% +/- 6.6% versus 20.1% +/- 3.4%, p = 0.04) as determined by oil red O staining. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 19-24 17070507-0 2006 Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors. Cholesterol 28-39 GLI family zinc finger 2 Homo sapiens 50-55 17348203-1 2006 In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis. Cholesterol 294-305 GLI family zinc finger 2 Homo sapiens 75-80 17348203-3 2006 In the THP-1 monocytes incubated with human IgG, PMA and LDL, the intracellular accumulated total cholesterol (TC), free cholesterol (FC), cholesteryl ester (CE) and the CE/TC increased evidently, and the cholesterol ozonation product 5,6-secosterol was also produced markly, all of that were inhibited by vinylbenzoic acid. Cholesterol 98-109 GLI family zinc finger 2 Homo sapiens 7-12 15951238-2 2005 In THP-1 macrophages lipid loaded with CRLPs and incubated with various cholesterol acceptors for 24 h, the mass of cholesterol and cholesteryl ester found in the cells was not changed by HDL, HDL3 or lipid-free ApoA-I, although it was decreased by 38% by ApoA-I-phosphatidylcholine vesicles (ApoA-I-PC). Cholesterol 72-83 GLI family zinc finger 2 Homo sapiens 3-8 16019008-0 2006 Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophages. Cholesterol 121-132 GLI family zinc finger 2 Homo sapiens 151-156 16019008-8 2006 Incubation of HDL with VAO-PE significantly increased the fluidity of the HDL phospholipidic bilayer (P=0.0004) and HDL-mediated cholesterol efflux from THP-1 macrophages. Cholesterol 129-140 GLI family zinc finger 2 Homo sapiens 153-158 16024919-2 2005 Previous studies with mildly oxidized low density lipoprotein (OxLDL)-treated THP-1 macrophages suggest an initial buildup of free cholesterol (FC), followed by an inhibition of lysosomal cholesteryl ester (CE) hydrolysis and a subsequent lysosomal accumulation of unhydrolyzed lipoprotein CE. Cholesterol 131-142 GLI family zinc finger 2 Homo sapiens 78-83 15951238-2 2005 In THP-1 macrophages lipid loaded with CRLPs and incubated with various cholesterol acceptors for 24 h, the mass of cholesterol and cholesteryl ester found in the cells was not changed by HDL, HDL3 or lipid-free ApoA-I, although it was decreased by 38% by ApoA-I-phosphatidylcholine vesicles (ApoA-I-PC). Cholesterol 116-127 GLI family zinc finger 2 Homo sapiens 3-8 15817453-4 2005 Preincubation of THP-1 macrophages with atorvastatin, dose dependently (1-10 microm) stimulated cholesterol efflux to apolipoprotein AI (apoAI, 10-60%, p < 0.05) and high density lipoprotein (HDL(3)) (2-50%, p < 0.05), despite a significant decrease in cholesterol synthesis (2-90%). Cholesterol 96-107 GLI family zinc finger 2 Homo sapiens 17-22 15817453-4 2005 Preincubation of THP-1 macrophages with atorvastatin, dose dependently (1-10 microm) stimulated cholesterol efflux to apolipoprotein AI (apoAI, 10-60%, p < 0.05) and high density lipoprotein (HDL(3)) (2-50%, p < 0.05), despite a significant decrease in cholesterol synthesis (2-90%). Cholesterol 259-270 GLI family zinc finger 2 Homo sapiens 17-22 15507847-8 2004 RESULTS: IFN-gamma -treated THP-1 macrophages exhibit increased foam cell transformation compared to untreated cells under cholesterol loading conditions. Cholesterol 123-134 GLI family zinc finger 2 Homo sapiens 28-33 15805548-3 2005 The secondary structural properties of the monomeric mutants, their abilities to bind lipid and to promote cholesterol efflux from THP-1 macrophages, and the possibility of antiperoxidation were investigated. Cholesterol 107-118 GLI family zinc finger 2 Homo sapiens 131-136 16013454-0 2005 Cholesterol regulation of genes involved in sterol trafficking in human THP-1 macrophages. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 72-77 16013454-8 2005 These findings indicate that in THP-1 macrophages, the expression of genes for receptors involved in lipoprotein binding and uptake tends to decrease upon cholesterol loading and to increase by cholesterol depletion, while the opposite pattern is found regarding the mRNA levels for proteins involved in cholesterol efflux. Cholesterol 155-166 GLI family zinc finger 2 Homo sapiens 32-37 16013454-8 2005 These findings indicate that in THP-1 macrophages, the expression of genes for receptors involved in lipoprotein binding and uptake tends to decrease upon cholesterol loading and to increase by cholesterol depletion, while the opposite pattern is found regarding the mRNA levels for proteins involved in cholesterol efflux. Cholesterol 194-205 GLI family zinc finger 2 Homo sapiens 32-37 16013454-8 2005 These findings indicate that in THP-1 macrophages, the expression of genes for receptors involved in lipoprotein binding and uptake tends to decrease upon cholesterol loading and to increase by cholesterol depletion, while the opposite pattern is found regarding the mRNA levels for proteins involved in cholesterol efflux. Cholesterol 194-205 GLI family zinc finger 2 Homo sapiens 32-37 15514964-7 2004 Also, cholesterol content was reduced in THP-1 cells and a phospholipid, phosphatidylethanolamine (PE), was reduced in HCP cells. Cholesterol 6-17 GLI family zinc finger 2 Homo sapiens 41-46 15507847-10 2004 IFN-gamma diminishes cholesterol 27-hydroxylase expression in THP-1, and this IFN-gamma -induced downregulation is prevented by pre-treating the cultured cells with either IFN-gamma neutralizing or IFN-gamma receptor blocking antibody. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 62-67 15234191-6 2004 Pitavastatin-induced changes in THP-1 cells were reversed by treatment with 10 microM of mevalonate, the intermediate of cholesterol biosynthesis. Cholesterol 121-132 GLI family zinc finger 2 Homo sapiens 32-37 12832423-7 2003 The effect of cholesterol depletion was confirmed in human THP-1 and Hep3B cells and in primary human peripheral blood monocytes, which naturally express the IL-6R. Cholesterol 14-25 GLI family zinc finger 2 Homo sapiens 59-64 15132822-2 2004 METHODS: After exposing the cultured THP-1 macrophages to ox-LDL for different periods, cholesterol efflux was determined by FJ-2107P type liquid scintillator. Cholesterol 88-99 GLI family zinc finger 2 Homo sapiens 37-42 15132822-4 2004 The cholesterol level in THP-1 macrophage foam cells was detected by high performance liquid chromatography. Cholesterol 4-15 GLI family zinc finger 2 Homo sapiens 25-30 15132822-6 2004 22(R)-hydroxycholesterol and 9-cis-retinoic acid did significantly increase cholesterol efflux in THP-1 macrophage foam cells (P<0.05), respectively. Cholesterol 13-24 GLI family zinc finger 2 Homo sapiens 98-103 15202507-6 2004 Results showed that apoA-I markedly increased ABCA1-mediated cholesterol efflux from THP-1 macrophage-derived foam cells. Cholesterol 61-72 GLI family zinc finger 2 Homo sapiens 85-90 14707038-3 2004 In this study, we investigated the function of adipophilin in lipid accumulation and cholesterol efflux in THP-1 macrophages. Cholesterol 85-96 GLI family zinc finger 2 Homo sapiens 107-112 14673498-0 2003 [Effects of oleate on ATP binding cassette transporter A1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells]. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 95-100 14673498-1 2003 To study the effect of oleate on ATP binding cassette transporter A1 (ABCA1) expression and cholesterol efflux in THP-1 macrophage-derived foam cells, after exposure of the cultured THP-1 macrophage-derived foam cells to oleate for different time, cholesterol efflux was determined by FJ-2107P type liquid scintillator. Cholesterol 92-103 GLI family zinc finger 2 Homo sapiens 114-119 14673498-4 2003 The results showed that oleate markedly inhibited ABCA1-mediated cholesterol efflux from THP-1 macrophage-derived foam cells. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 89-94 12968020-2 2003 The uptake of HOCl-LDL by THP-1 macrophages was not saturable and led to cholesterol/cholesteryl ester accumulation. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 26-31 14555225-2 2003 Examination of cultured human THP-1 macrophages treated with the cholesterol oxide, 7-ketocholesterol, revealed a concentration- and time-dependent increase in formation of cholesterol crystals in the cells. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 30-35 15182357-2 2004 The total lipid content of THP-1 macrophages was markedly higher (x2.2) after 48 h of incubation of THP-1 macrophages with CRLPs containing probucol (pCRLPs) when compared to CRLPs without probucol, and this was because of increases in triacylglycerol (x2.3) and cholesterol (x1.8) levels, while cholesteryl ester concentrations were not significantly changed. Cholesterol 263-274 GLI family zinc finger 2 Homo sapiens 27-32 15202507-0 2004 Effect of apolipoprotein A-I on ATP binding cassette transporter A1 degradation and cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 84-95 GLI family zinc finger 2 Homo sapiens 106-111 15202507-3 2004 This study investigated the effect of apoA-I on ABCA1 degradation and cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 70-81 GLI family zinc finger 2 Homo sapiens 92-97 12883330-9 2003 These data demonstrate that statins have the capacity to reduce the synthesis and secretion of both apoE and apoC-I in THP-1 macrophages loaded or unloaded with cholesterol. Cholesterol 161-172 GLI family zinc finger 2 Homo sapiens 119-124 14499733-0 2003 HDL derived from the different phases of conjugated diene formation reduces membrane fluidity and contributes to a decrease in free cholesterol efflux from human THP-1 macrophages. Cholesterol 132-143 GLI family zinc finger 2 Homo sapiens 162-167 12036961-8 2002 In conclusion, increased hydrolysis of CE by the overexpression of HSL leads to complete elimination of CE from THP-1 foam cells not only by increasing efflux but also by decreasing influx of cholesterol. Cholesterol 192-203 GLI family zinc finger 2 Homo sapiens 112-117 12044893-2 2002 Using a ligand of PPAR gamma, troglitazone or pioglitazone, we have shown that the expression of two genes involved in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase and HMG-CoA reductase, were increased by activation of PPAR gamma through a PPAR response element (PPRE) in THP-1 macrophages. Cholesterol 119-130 GLI family zinc finger 2 Homo sapiens 310-315 12050168-1 2002 A unique property of the extracellular matrix of J774 and THP-1 cells has been identified, which contributes to the ability of these cells to promote cholesterol efflux. Cholesterol 150-161 GLI family zinc finger 2 Homo sapiens 58-63 11478905-0 2001 A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1. Cholesterol 28-39 GLI family zinc finger 2 Homo sapiens 52-57 11907145-0 2002 Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux. Cholesterol 82-93 GLI family zinc finger 2 Homo sapiens 26-31 11785950-3 2002 We show that rolipram and cilomilast, inhibitors of cAMP-specific PDE4, increase apolipoprotein A-I (apoA-I)-mediated cholesterol efflux up to 80 and 140% in human THP-1 and mouse J774.A1 macrophages, respectively, concomitant with an elevation of cAMP levels. Cholesterol 118-129 GLI family zinc finger 2 Homo sapiens 164-169 11755918-2 2002 The expression of IL-8 gene can be induced in cholesterol loaded THP-1 macrophages by oxidized low density lipoprotein. Cholesterol 46-57 GLI family zinc finger 2 Homo sapiens 65-70 11254742-4 2001 We examined whether lysosomal stores of cholesterol from oxLDL are cleared from THP-1 and mouse macrophages. Cholesterol 40-51 GLI family zinc finger 2 Homo sapiens 80-85 12940072-4 2001 CONCLUSIONS: Cell surface apoE of THP-1 macrophage relates to the process of cholesterol loading of macrophage cells and lipid mediated binding of apoA1 to the cell surface. Cholesterol 77-88 GLI family zinc finger 2 Homo sapiens 34-39 11254742-5 2001 As in previous studies, oxLDL-enriched THP-1 macrophages accumulated substantial lysosomal cholesterol. Cholesterol 91-102 GLI family zinc finger 2 Homo sapiens 39-44 9763531-0 1998 Cholesterol metabolism and efflux in human THP-1 macrophages. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 43-48 11108728-0 2000 Involvement of caveolin-1 in cholesterol enrichment of high density lipoprotein during its assembly by apolipoprotein and THP-1 cells. Cholesterol 29-40 GLI family zinc finger 2 Homo sapiens 122-127 11108728-1 2000 High density lipoprotein (HDL) is assembled by interaction of apolipoprotein A-I with human monocytic leukemia cell line THP-1 by removing cellular cholesterol and phospholipid. Cholesterol 148-159 GLI family zinc finger 2 Homo sapiens 121-126 10858438-3 2000 We cloned the 5"-end of the human ABC1 transcript from cholesterol-loaded THP1 macrophages. Cholesterol 55-66 GLI family zinc finger 2 Homo sapiens 74-78 10484611-6 1999 Differentiation of THP-1 cells increased the percent of membrane cholesterol associated with caveolae from 12% +/- 1.9% to 38% +/- 3.1%. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 19-24 10431238-6 1999 We also found a change in ABC1 expression level on cholesterol loading of phorbol ester-treated THP1 macrophages, substantiating the role of ABC1 in cholesterol efflux. Cholesterol 51-62 GLI family zinc finger 2 Homo sapiens 96-100 10431238-6 1999 We also found a change in ABC1 expression level on cholesterol loading of phorbol ester-treated THP1 macrophages, substantiating the role of ABC1 in cholesterol efflux. Cholesterol 149-160 GLI family zinc finger 2 Homo sapiens 96-100 11108735-3 2000 This report demonstrates that human cholesterol-loaded THP-1 macrophages express ALBP/aP2 and that its expression can be stimulated by oxidized low density lipoprotein (oxLDL). Cholesterol 36-47 GLI family zinc finger 2 Homo sapiens 55-60 11015481-5 2000 The following variables did not differ during the diet periods: number of small VLDL (S:(f) 20-100) particles, esterified cholesterol accumulated in THP-1 macrophages incubated with the same number of big and small VLDL particles and particle composition. Cholesterol 122-133 GLI family zinc finger 2 Homo sapiens 149-154 9763531-1 1998 This study has investigated in detail factors regulating accumulation, esterification, and mobilization of cholesterol in human THP-1 macrophages. Cholesterol 107-118 GLI family zinc finger 2 Homo sapiens 128-133 9763531-3 1998 Although THP-1 macrophages accumulated FC and esterified cholesterol (EC), assessed by both mass and radioactivity, cellular EC always demonstrated a much lower specific activity (cpm/ microg) than did cellular FC, and several potential causes of this finding were investigated. Cholesterol 57-68 GLI family zinc finger 2 Homo sapiens 9-14 9763531-10 1998 Kinetics of cholesterol efflux from AcLDL-loaded THP-1 cells were first investigated after loading with only FC, and interactions between efflux and EC hydrolysis were further assessed after loading cells with both EC and FC. Cholesterol 12-23 GLI family zinc finger 2 Homo sapiens 49-54 34332075-0 2021 Eicosapentaenoic acid membrane incorporation stimulates ABCA1-mediated cholesterol efflux from human THP-1 macrophages. Cholesterol 71-82 GLI family zinc finger 2 Homo sapiens 101-106 9684737-7 1998 Consistent with lysosomal accumulation, cholesterol esterification was 75% less in THP-1 macrophages enriched with oxLDL cholesterol compared with acLDL. Cholesterol 40-51 GLI family zinc finger 2 Homo sapiens 83-88 9684737-7 1998 Consistent with lysosomal accumulation, cholesterol esterification was 75% less in THP-1 macrophages enriched with oxLDL cholesterol compared with acLDL. Cholesterol 121-132 GLI family zinc finger 2 Homo sapiens 83-88 9430696-1 1998 Macrophage cells derived from the human monocytic leukemia cell line, THP-1, accumulate esterified cholesterol when cultivated in the presence of acetylated low density lipoprotein (Ac-LDL) through scavenger receptors (ScR). Cholesterol 99-110 GLI family zinc finger 2 Homo sapiens 70-75 8645354-0 1996 Impaired mobilisation of cholesterol from stored cholesteryl esters in human (THP-1) macrophages. Cholesterol 25-36 GLI family zinc finger 2 Homo sapiens 78-83 8645354-3 1996 This study examines the importance of the balance between these two enzymes in determining the efflux of cholesterol from human (THP-1) macrophages. Cholesterol 105-116 GLI family zinc finger 2 Homo sapiens 129-134 7868969-1 1994 Esterified cholesterol (EC) accumulation was induced in THP-1 macrophages after exposure to acetylated LDL (acLDL), and the extent of accumulation was dependent on cell density. Cholesterol 11-22 GLI family zinc finger 2 Homo sapiens 56-61 8257450-0 1993 Effect of hyperapo B LDL on cholesterol esterification in THP-1 macrophages. Cholesterol 28-39 GLI family zinc finger 2 Homo sapiens 58-63 1744079-4 1991 We now report that the induction of scavenger receptor activity (as measured by acetyl-LDL stimulation of intracellular cholesterol esterification) seen in phorbol ester-differentiated THP-1 human macrophages was completely suppressed to the level seen in undifferentiated THP-1 monocytes by picomolar concentrations of transforming growth factor-beta 1 (TGF-beta 1). Cholesterol 120-131 GLI family zinc finger 2 Homo sapiens 185-190 2010692-8 1991 Furthermore, although platelets induced a 90% reduction in cholesterol synthesis in macrophages by day 5, cholesterol synthesis in THP-1 cells and phorbol ester-treated THP-1 cells was inhibited less than 50% by platelets. Cholesterol 106-117 GLI family zinc finger 2 Homo sapiens 131-136 8608733-0 1995 Changes in free cholesterol content, measured by filipin fluorescence and flow cytometry, correlate with changes in cholesterol biosynthesis in THP-1 macrophages. Cholesterol 16-27 GLI family zinc finger 2 Homo sapiens 144-149 8608733-0 1995 Changes in free cholesterol content, measured by filipin fluorescence and flow cytometry, correlate with changes in cholesterol biosynthesis in THP-1 macrophages. Cholesterol 116-127 GLI family zinc finger 2 Homo sapiens 144-149 8608733-2 1995 In a previous study (Hassall: Cytometry 13:381-388, 1992) using THP-1 macrophages, a decrease in filipin fluorescence in response to increasing concentrations of modified lipoprotein was observed, suggesting a reduction in the free cholesterol content of the cells. Cholesterol 232-243 GLI family zinc finger 2 Homo sapiens 64-69 8608733-3 1995 In this study, THP-1 macrophages were treated with a number of agents known to modulate cholesterol biosynthesis and cholesterol esterification. Cholesterol 88-99 GLI family zinc finger 2 Homo sapiens 15-20 8608733-3 1995 In this study, THP-1 macrophages were treated with a number of agents known to modulate cholesterol biosynthesis and cholesterol esterification. Cholesterol 117-128 GLI family zinc finger 2 Homo sapiens 15-20 7624733-0 1995 In vitro reverse cholesterol transport from THP-1-derived macrophage-like cells with synthetic HDL particles consisting of proapolipoprotein A1 or apolipoprotein A1 and phosphatidylcholine. Cholesterol 17-28 GLI family zinc finger 2 Homo sapiens 44-49 8084280-0 1994 Diabetic postprandial triglyceride-rich lipoproteins increase esterified cholesterol accumulation in THP-1 macrophages. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 101-106 34733931-5 2021 Results: It was revealed that ART attenuated oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation from THP-1-derived macrophages by decreasing cholesterol accumulation, and the effect might have occurred via enhanced cholesterol efflux. Cholesterol 160-171 GLI family zinc finger 2 Homo sapiens 120-125 34733931-5 2021 Results: It was revealed that ART attenuated oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation from THP-1-derived macrophages by decreasing cholesterol accumulation, and the effect might have occurred via enhanced cholesterol efflux. Cholesterol 234-245 GLI family zinc finger 2 Homo sapiens 120-125 34733931-7 2021 Conclusions: This study showed that ART attenuated the ox-LDL-induced formation of foam cells from THP-1-derived macrophages by increasing ABCA1 and ABCG1 expression via inhibiting TLR4 expression and reducing TNF-alpha and IL-6 secretion from macrophages induced by ox-LDL, which ultimately decreased the accumulation of cholesterol. Cholesterol 322-333 GLI family zinc finger 2 Homo sapiens 99-104 35618159-5 2022 We incubated THP-1 macrophages with acetylated LDL (acLDL) to obtain cholesterol-laden cells or with mildly oxidized LDL (oxLDL) to generate cholesterol- and oxidized lipids-laden cells. Cholesterol 69-80 GLI family zinc finger 2 Homo sapiens 13-18 34328100-11 2021 The CECs of lipidated HDLs were analyzed by incubating apolipoprotein B (apoB)-depleted plasma with 3H-cholesterol-labeled THP-1 macrophages. Cholesterol 103-114 GLI family zinc finger 2 Homo sapiens 123-128 34217526-0 2021 Editorial expression of concern: "MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages" (Atherosclerosis Volume 234, Issue 1, May 2014, Pages 54-64). Cholesterol 68-79 GLI family zinc finger 2 Homo sapiens 128-133 33865458-5 2021 The CEC was measured using a cell-based cholesterol efflux system of BODIPY-cholesterol-labelled THP-1 macrophages. Cholesterol 40-51 GLI family zinc finger 2 Homo sapiens 97-102 2482322-8 1989 Uptake of Ac-LDL by THP-1 resulted in an 11-fold increase in the rate of cholesterol esterification which was saturable at 50 micrograms/ml. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 20-25 33865458-5 2021 The CEC was measured using a cell-based cholesterol efflux system of BODIPY-cholesterol-labelled THP-1 macrophages. Cholesterol 76-87 GLI family zinc finger 2 Homo sapiens 97-102 33493198-5 2021 Results show that agLDL induce excessive accumulation of free (FC) and esterified cholesterol in THP-1 macrophages and determine mitochondrial dysfunction expressed as decreased mitochondrial membrane potential and diminished intracellular ATP levels, without generating mitochondrial reactive oxygen species (ROS) production. Cholesterol 82-93 GLI family zinc finger 2 Homo sapiens 97-102 32579243-9 2020 KEY RESULTS: We screened the effects on ABCA1 expression, and identified the chalcone derivative, 1m-6, which enhances ABCA1 expression and promotes cholesterol efflux in THP-1 macrophages. Cholesterol 149-160 GLI family zinc finger 2 Homo sapiens 171-176 33952798-0 2021 Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis. Cholesterol 18-29 GLI family zinc finger 2 Homo sapiens 102-107 33952798-1 2021 OBJECTIVE: To seek out the effect of curcumin on cholesterol efflux in THP-1 macrophages and clarify its specific mechanism. Cholesterol 49-60 GLI family zinc finger 2 Homo sapiens 71-76 33952798-8 2021 RESULTS: The optimal dosage of curcumin could reduce foam cell formation and intracellular lipid content, and promote cholesterol efflux in THP-1 macrophages. Cholesterol 118-129 GLI family zinc finger 2 Homo sapiens 140-145 33952798-13 2021 CONCLUSION: urcumin could promote cholesterol efflux of THP-1 macrophages through miR-125a-5p/SIRT6 axis and regulate the expression of ABCA1. Cholesterol 34-45 GLI family zinc finger 2 Homo sapiens 56-61 32485752-11 2020 Functional studies revealed that LT-141A increased cholesterol efflux from THP-1-derived macrophages via enhanced ATP-binding cassette transporter 1 expression. Cholesterol 51-62 GLI family zinc finger 2 Homo sapiens 75-80 32785591-5 2020 A high-performance liquid chromatography assay indicated that cellular cholesterol content was decreased by IL-5 treatment in THP-1-derived macrophages. Cholesterol 71-82 GLI family zinc finger 2 Homo sapiens 126-131 32824555-7 2020 THP-1 MPhi loaded with NBD-labeled cholesterol and treated with the HSP27 IC showed a 22% increase in extracellular vesicles labeled with NBD and a 95% increase in mean fluorescent intensity. Cholesterol 35-46 GLI family zinc finger 2 Homo sapiens 0-5 32417575-9 2020 Results revealed that DBP at 10-7 mol/L prompted THP-1 macrophages lipid accumulation by inhibiting cholesterol efflux via suppressing ABCA1 expression. Cholesterol 100-111 GLI family zinc finger 2 Homo sapiens 49-54 32417575-13 2020 Collectively, these data suggested that DBP at levels relative to human exposure could increase lipid accumulation in THP-1 macrophages by decreasing cholesterol efflux through miR200c-5p-ABCA1, then potentiate the formation of atherosclerosis. Cholesterol 150-161 GLI family zinc finger 2 Homo sapiens 118-123 32437392-0 2020 THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation. Cholesterol 17-28 GLI family zinc finger 2 Homo sapiens 0-5 32043034-4 2020 The ability of total patient serum without any modifications to (i) facilitate efflux of cholesterol from human THP1-macrophage foam cells under physiological conditions (cholesterol efflux capacity [CEC]) and (ii) to deliver this effluxed cholesterol to primary hepatocytes with physiological expression of high-density lipoprotein (HDL) receptor SR-BI (capacity to deliver cholesterol to hepatocytes [CDCH]) was evaluated. Cholesterol 89-100 GLI family zinc finger 2 Homo sapiens 112-116 32293456-3 2020 METHODS: We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 62-67 32319624-13 2020 In summary, knockdown of MALAT1 may promote cholesterol accumulation by regulating the miR-17-5p/ABCA1 axis in ox-LDL-induced THP-1 macrophages. Cholesterol 44-55 GLI family zinc finger 2 Homo sapiens 126-131 31188743-0 2019 Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages. Cholesterol 39-50 GLI family zinc finger 2 Homo sapiens 149-154 31188743-0 2019 Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages. Cholesterol 74-85 GLI family zinc finger 2 Homo sapiens 149-154 31188743-4 2019 In this study, the RCT function of RBCs was assessed using cholesterol efflux capacity (CEC) assays, in which [3H]-labeled cholesterol-loaded human acute monocytic leukemia (THP-1) macrophages were incubated with RBCs as a cholesterol acceptor in the presence or absence of HDL or its main component protein apolipoprotein A-I (apoA-I). Cholesterol 59-70 GLI family zinc finger 2 Homo sapiens 174-179 31188743-4 2019 In this study, the RCT function of RBCs was assessed using cholesterol efflux capacity (CEC) assays, in which [3H]-labeled cholesterol-loaded human acute monocytic leukemia (THP-1) macrophages were incubated with RBCs as a cholesterol acceptor in the presence or absence of HDL or its main component protein apolipoprotein A-I (apoA-I). Cholesterol 123-134 GLI family zinc finger 2 Homo sapiens 174-179 31188743-4 2019 In this study, the RCT function of RBCs was assessed using cholesterol efflux capacity (CEC) assays, in which [3H]-labeled cholesterol-loaded human acute monocytic leukemia (THP-1) macrophages were incubated with RBCs as a cholesterol acceptor in the presence or absence of HDL or its main component protein apolipoprotein A-I (apoA-I). Cholesterol 123-134 GLI family zinc finger 2 Homo sapiens 174-179 31188743-5 2019 The CEC of RBCs was found to be dose dependent, enabling uptake of cholesterol from THP-1 macrophages through apoA-I and HDL, and directly from apoA-I and HDL in medium without the presence THP-1 macrophages. Cholesterol 67-78 GLI family zinc finger 2 Homo sapiens 84-89 31378770-2 2019 Our previous study showed that the AGEs-RAGE axis can reduce the cholesterol efflux of THP-1 macrophages through suppression of the expression of ABCG1 and that statins can inhibit the expression of RAGE. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 87-92 31378770-4 2019 Cholesterol efflux of THP-1 macrophages and murine peritoneal macrophages was tested by fluorescence microplate technique. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 22-27 31378770-8 2019 CONCLUSIONS: This study demonstrated that atorvastatin can recover the deleterious ABCG1-mediated cholesterol efflux induced by AGEs in THP-1 macrophages and murine peritoneal macrophages by downregulating RAGE expression. Cholesterol 98-109 GLI family zinc finger 2 Homo sapiens 136-141 31177468-0 2019 A Low-Molecular-Weight Phenotype of Apolipoprotein(a) as a Factor Provoking Accumulation of Cholesterol by THP-1 Monocyte-Like Cells. Cholesterol 92-103 GLI family zinc finger 2 Homo sapiens 107-112 31026357-2 2019 A decrease in intracellular K+ is essential for inflammasome activation/IL-1beta secretion and, herein, we examined the hypothesis that cellular cholesterol affects K+ -channel activity and K+ -efflux using mouse peritoneal macrophages (MPMs) and human/THP1 macrophages. Cholesterol 145-156 GLI family zinc finger 2 Homo sapiens 253-257 31026357-3 2019 An increase in cellular cholesterol led to a significant increase in K+ currents (> 350% in both MPM and THP1). Cholesterol 24-35 GLI family zinc finger 2 Homo sapiens 108-112 31177468-4 2019 Cholesterol concentration in lysates of THP-1 cells was significantly higher after their incubation with lipoprotein(a)-containing serum samples with low-molecular-weight phenotype of apolipoprotein(a) in comparison with samples with a high-molecular-weight apolipoprotein(a) phenotype irrespective of initial cholesterol level as well as serum concentrations of apoB-100, oxidized LDL, and circulating immune complexes. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 40-45 31177468-4 2019 Cholesterol concentration in lysates of THP-1 cells was significantly higher after their incubation with lipoprotein(a)-containing serum samples with low-molecular-weight phenotype of apolipoprotein(a) in comparison with samples with a high-molecular-weight apolipoprotein(a) phenotype irrespective of initial cholesterol level as well as serum concentrations of apoB-100, oxidized LDL, and circulating immune complexes. Cholesterol 310-321 GLI family zinc finger 2 Homo sapiens 40-45 31177468-5 2019 The presence of the most atherogenic small dense LDL subfractions in examined sera in addition to a low-molecular-weight apolipoprotein(a) phenotype resulted in significant elevation of cholesterol accumulation by THP-1 cells. Cholesterol 186-197 GLI family zinc finger 2 Homo sapiens 214-219 29782965-6 2018 Here, we demonstrate that (i) A549, THP-1 and U937 cells are all susceptible to the Rh2-induced apoptosis but to a differential extent and (ii) the cytotoxic effect inversely correlates with the cell membrane cholesterol content. Cholesterol 209-220 GLI family zinc finger 2 Homo sapiens 36-41 30210053-0 2019 Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells. Cholesterol 24-35 GLI family zinc finger 2 Homo sapiens 102-107 30545366-6 2018 Cholesterol efflux from acetyl-LDL loaded THP-1 macrophages was measured using HDL and plasma as acceptors. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 42-47 29704538-2 2018 Upon oxLDL exposure of THP-1 macrophages, intracellular oxidation of LDL derived-cholesterol as well as endogenous cholesterol was increased. Cholesterol 81-92 GLI family zinc finger 2 Homo sapiens 23-28 29704538-2 2018 Upon oxLDL exposure of THP-1 macrophages, intracellular oxidation of LDL derived-cholesterol as well as endogenous cholesterol was increased. Cholesterol 115-126 GLI family zinc finger 2 Homo sapiens 23-28 29140707-4 2018 Naringenin treatments were also able to promote reverse cholesterol transport in THP-1 cells, which is in line with the increase in the ABCA1 and ABCG1 expression found. Cholesterol 56-67 GLI family zinc finger 2 Homo sapiens 81-86 29596892-0 2018 Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages. Cholesterol 15-26 GLI family zinc finger 2 Homo sapiens 75-80 29596892-9 2018 Betulin effectively suppressed the accumulation of intracellular cholesterol in the SCAP over-expressed THP-1 macrophages, but did not affect the expression of inflammatory cytokines, indicating that the pro-inflammatory effect of SCAP was independent of its routine role in regulating cholesterol homeostasis. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 104-109 29596892-13 2018 In conclusion, the cholesterol sensor SCAP plays a role in regulating the expression of inflammatory factors such as IL-1beta, TNF-alpha, and MCP-1 in THP-1 macrophages. Cholesterol 19-30 GLI family zinc finger 2 Homo sapiens 151-156 29802792-0 2018 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Cholesterol 49-60 GLI family zinc finger 2 Homo sapiens 73-78 29802792-4 2018 METHODS AND RESULTS: We show that 6-dihydroparadol concentration-dependently enhances both apolipoprotein A1- and human plasma-mediated cholesterol efflux from cholesterol-loaded THP-1-derived macrophages using macrophage cholesterol efflux assay. Cholesterol 136-147 GLI family zinc finger 2 Homo sapiens 179-184 29802792-4 2018 METHODS AND RESULTS: We show that 6-dihydroparadol concentration-dependently enhances both apolipoprotein A1- and human plasma-mediated cholesterol efflux from cholesterol-loaded THP-1-derived macrophages using macrophage cholesterol efflux assay. Cholesterol 160-171 GLI family zinc finger 2 Homo sapiens 179-184 29802792-4 2018 METHODS AND RESULTS: We show that 6-dihydroparadol concentration-dependently enhances both apolipoprotein A1- and human plasma-mediated cholesterol efflux from cholesterol-loaded THP-1-derived macrophages using macrophage cholesterol efflux assay. Cholesterol 160-171 GLI family zinc finger 2 Homo sapiens 179-184 29518394-0 2018 Interferon-stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR-17-5p/Beclin-1 pathway in THP-1 macrophage-derived foam cells. Cholesterol 39-50 GLI family zinc finger 2 Homo sapiens 120-125 29518394-3 2018 The present study aimed to examine the effects of ISG15 on autophagy and cholesterol efflux in THP-1 macrophage-derived foam cells and to explore the underlying molecular mechanisms. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 95-100 29518394-9 2018 In conclusion, these findings suggest that ISG15 reduces miR-17-5p levels and thereby promotes Beclin-1-mediated autophagy, resulting in increased cholesterol efflux from THP-1 macrophage-derived foam cells. Cholesterol 147-158 GLI family zinc finger 2 Homo sapiens 171-176 29653102-0 2018 Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-kappaB/miR-33a pathway in THP-1 macropahge-derived foam cells. Cholesterol 70-81 GLI family zinc finger 2 Homo sapiens 160-165 29174964-0 2018 microRNA-212 promotes lipid accumulation and attenuates cholesterol efflux in THP-1 human macrophages by targeting SIRT1. Cholesterol 56-67 GLI family zinc finger 2 Homo sapiens 78-83 30053283-0 2018 Diets Low in Saturated Fat with Different Unsaturated Fatty Acid Profiles Similarly Increase Serum-Mediated Cholesterol Efflux from THP-1 Macrophages in a Population with or at Risk for Metabolic Syndrome: The Canola Oil Multicenter Intervention Trial. Cholesterol 108-119 GLI family zinc finger 2 Homo sapiens 132-137 30053283-11 2018 Results: The 5 diets increased serum-mediated cholesterol efflux capacity from THP-1 macrophages similarly by 39%, 34%, 55%, 49% and 51%, respectively, compared with baseline (P < 0.05 for all). Cholesterol 46-57 GLI family zinc finger 2 Homo sapiens 79-84 29242172-7 2018 Curcumin treatment inhibited cell migration and was also able to promote reverse cholesterol transport in THP-1 cells. Cholesterol 81-92 GLI family zinc finger 2 Homo sapiens 106-111 29242172-8 2018 This enhanced reverse cholesterol transport might be related to the up-regulating of ABCA1 and ABCG1 mRNA expression by activating AMPK-LXRalpha signaling in THP-1 cells. Cholesterol 22-33 GLI family zinc finger 2 Homo sapiens 158-163 29174964-10 2018 Rescue experiments confirmed that co-expression of SIRT1 attenuated lipid accumulation and restored cholesterol efflux in miR-212-overexpressing THP-1 macrophages. Cholesterol 100-111 GLI family zinc finger 2 Homo sapiens 145-150 29321244-2 2018 We recently reported that silencing expression of carboxylesterase 1 (CES1) in human THP-1 macrophages [CES1KD (THP-1 cells with CES1 expression knocked down) macrophages] reduced cholesterol uptake and decreased expression of CD36 and scavenger receptor-A in cells loaded with acetylated low-density lipoprotein (acLDL). Cholesterol 180-191 GLI family zinc finger 2 Homo sapiens 112-117 29241586-3 2018 We used Methyl-beta-cyclodextrin (MbetaCD) to alter the baseline cholesterol in human monocytic cell line THP-1, and evaluated their chemotactic response to MCP-1. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 106-111 29321244-2 2018 We recently reported that silencing expression of carboxylesterase 1 (CES1) in human THP-1 macrophages [CES1KD (THP-1 cells with CES1 expression knocked down) macrophages] reduced cholesterol uptake and decreased expression of CD36 and scavenger receptor-A in cells loaded with acetylated low-density lipoprotein (acLDL). Cholesterol 180-191 GLI family zinc finger 2 Homo sapiens 85-90 28781617-6 2017 The results indicated that IL-32alpha exposure enhanced the lipid deposition and attenuated the cholesterol efflux from ox-LDL-stimulated THP-1 macrophages in a dose-dependent manner. Cholesterol 96-107 GLI family zinc finger 2 Homo sapiens 138-143 28815701-2 2018 THP-1 and RAW264.7 cells were incubated with oxLDL for 48 h to induce the formation of foam cells, and ORO staining was performed and intracellular cholesterol contents were measured by HPLC assay. Cholesterol 148-159 GLI family zinc finger 2 Homo sapiens 0-5 28815701-10 2018 LincRNA-DYNLRB2-2 plays important role in regulating the cholesterol efflux, ABCA1 expression level and anti-inflammatory processes in THP-1 and RAW264.7 cells. Cholesterol 57-68 GLI family zinc finger 2 Homo sapiens 135-140 29122594-4 2018 Inhibition of the NLRP3 inflammasome attenuated foam cell formation, diminished ox-LDL uptake, and promoted cholesterol efflux from THP-1 macrophages. Cholesterol 108-119 GLI family zinc finger 2 Homo sapiens 132-137 29146892-1 2017 BACKGROUND The aim of this study was to explore the role of intermedin and its mechanism in cholesterol efflux of macrophage THP-1 and RAW264.7 cell lines in atherosclerosis (AS). Cholesterol 92-103 GLI family zinc finger 2 Homo sapiens 125-130 29146892-6 2017 In vitro, IMD increased intracellular cAMP concentration in a dose-dependent manner in THP-1 and RAW264.7 cell lines, which enhanced the expression of ABCA1 and increased cholesterol efflux rate. Cholesterol 171-182 GLI family zinc finger 2 Homo sapiens 87-92 28653788-5 2017 Enforced expression of miR-497 promoted lipid accumulation and decreased cholesterol efflux in oxLDL-exposed THP-1 macrophages. Cholesterol 73-84 GLI family zinc finger 2 Homo sapiens 109-114 28653788-9 2017 Interestingly, delivery of a miR-497-resistant variant of apelin significantly inhibited lipid accumulation and enhanced cholesterol efflux in miR-497-overexpressing THP-1 macrophages in response to oxLDL. Cholesterol 121-132 GLI family zinc finger 2 Homo sapiens 166-171 29236764-2 2017 We investigated the possibility that dexamethasone could affect activation of monocytic cells induced by oxygenated derivatives of cholesterol (oxysterols) using THP-1 monocyte/macrophage cells. Cholesterol 131-142 GLI family zinc finger 2 Homo sapiens 162-167 28576406-2 2017 This study was designed to determine whether puerarin decreased lipid accumulation via up-regulation of ABCA1-mediated cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 119-130 GLI family zinc finger 2 Homo sapiens 141-146 28576406-6 2017 Additionally, treatment with miR-7 decreased cholesterol efflux and increased cholesterol levels in THP-1 macrophage-derived foam cells. Cholesterol 78-89 GLI family zinc finger 2 Homo sapiens 100-105 28610841-0 2017 Hsp27 promotes ABCA1 expression and cholesterol efflux through the PI3K/PKCzeta/Sp1 pathway in THP-1 macrophages. Cholesterol 36-47 GLI family zinc finger 2 Homo sapiens 95-100 28610841-8 2017 Taken together, our results revealed that Hsp27 may up-regulate the expression of ABCA1 and promotes cholesterol efflux through activation of the PI3K/PKCzeta/Sp1 signal pathway in THP-1 macrophage-derived foam cells. Cholesterol 101-112 GLI family zinc finger 2 Homo sapiens 181-186 28919859-0 2017 The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability. Cholesterol 46-57 GLI family zinc finger 2 Homo sapiens 70-75 28919859-2 2017 Falcarindiol (3-20 muM) increased cholesterol efflux from THP-1-derived macrophages. Cholesterol 34-45 GLI family zinc finger 2 Homo sapiens 58-63 28781617-8 2017 Addition of the PPARgamma agonist 15d-PGJ2 or overexpression of PPARgamma in THP-1 macrophages abrogated the IL-32alpha-mediated inhibition of cholesterol efflux and reversed the IL-32alpha-mediated downregulation of ABCA1 and LXRalpha. Cholesterol 143-154 GLI family zinc finger 2 Homo sapiens 77-82 28781617-9 2017 In conclusion, IL-32alpha enhances lipid accumulation and inhibits cholesterol efflux from ox-LDL-exposed THP-1 macrophages by regulating the PPARgamma-LXRalpha-ABCA1 pathway. Cholesterol 67-78 GLI family zinc finger 2 Homo sapiens 106-111 28659806-0 2017 Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Cholesterol 85-96 GLI family zinc finger 2 Homo sapiens 109-114 28673011-0 2017 Tribbles homolog 1 enhances cholesterol efflux from oxidized low-density lipoprotein-loaded THP-1 macrophages. Cholesterol 28-39 GLI family zinc finger 2 Homo sapiens 92-97 28207870-4 2017 THP-1 macrophages loaded with acetyl-LDL were used in the assay of cholesterol efflux to total HDL, HDL2, HDL3 or serum. Cholesterol 67-78 GLI family zinc finger 2 Homo sapiens 0-5 28455345-3 2017 METHODS AND RESULTS: Cholesterol efflux from THP-1 macrophages was assessed using plasma obtained from normo- and hyperbilirubinemic (Gilbert syndrome) humans (n=60 per group) or (heterozygote/homozygote Gunn) rats (n=20 per group) as an acceptor. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 45-50 28455345-6 2017 We also showed reduced protein expression of the ATP-binding cassette transporter A1 (ABCA1), a transmembrane cholesterol transporter involved in apolipoprotein A1-mediated cholesterol efflux, in THP-1 macrophages treated with unconjugated bilirubin and in peripheral blood mononuclear cells obtained from hyperbilirubinemic individuals. Cholesterol 110-121 GLI family zinc finger 2 Homo sapiens 196-201 28455345-8 2017 CONCLUSIONS: Cholesterol efflux from THP-1 macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. Cholesterol 13-24 GLI family zinc finger 2 Homo sapiens 37-42 28594401-3 2017 Here, we investigated the effect of PDT mediated by upconversion fluorescent nanoparticles encapsulating chlorin e6 (UCNPs-Ce6) on the cholesterol efflux of THP-1 macrophage-derived foam cells and explored the possible mechanism of this effect. Cholesterol 135-146 GLI family zinc finger 2 Homo sapiens 157-162 28594401-8 2017 Therefore, our findings demonstrate that PDT promotes cholesterol efflux by inducing autophagy, and the autophagy was mediated in part through the ROS/PI3K/Akt/mTOR signaling pathway in THP-1 and peritoneal macrophage-derived foam cells. Cholesterol 54-65 GLI family zinc finger 2 Homo sapiens 186-191 27574949-0 2016 Long Noncoding RNA HOXC-AS1 Suppresses Ox-LDL-Induced Cholesterol Accumulation Through Promoting HOXC6 Expression in THP-1 Macrophages. Cholesterol 54-65 GLI family zinc finger 2 Homo sapiens 117-122 28148911-4 2017 ESRD-HDL (n = 15) were compared to healthy control HDL (n = 15) for their capacity to promote in vitro (i) cholesterol efflux from THP-1 macrophage foam cells and (ii) SR-BI-mediated selective uptake into ldla[SR-BI] cells as well as (iii) in vivo RCT. Cholesterol 107-118 GLI family zinc finger 2 Homo sapiens 131-136 28102849-3 2017 In the present study, berberine-mediated sonodynamic therapy (BBR-SDT) was used to induce autophagy and cholesterol efflux in THP-1 macrophages and derived foam cells. Cholesterol 104-115 GLI family zinc finger 2 Homo sapiens 126-131 29045950-2 2017 This study was designed to investigate the effects of leonurine on cholesterol efflux from THP-1 macrophage-derived foam cells and development of atherosclerotic lesions in apoE-/- mice, and further determine the potential mechanisms. Cholesterol 67-78 GLI family zinc finger 2 Homo sapiens 91-96 28105139-9 2016 It may be concluded that baicalin induced cholesterol efflux from THP-1 macrophages via the PPAR-gamma/LXRalpha/SR-BI pathway. Cholesterol 42-53 GLI family zinc finger 2 Homo sapiens 66-71 27881422-5 2016 We measured the capacity of 40-fold diluted serum to mediate cholesterol efflux from cholesterol-loaded human THP-1 macrophages. Cholesterol 61-72 GLI family zinc finger 2 Homo sapiens 110-115 27881422-5 2016 We measured the capacity of 40-fold diluted serum to mediate cholesterol efflux from cholesterol-loaded human THP-1 macrophages. Cholesterol 85-96 GLI family zinc finger 2 Homo sapiens 110-115 27735019-7 2016 Cellular cholesterol efflux from THP-1 macrophages was analyzed using liquid scintillation counting assays. Cholesterol 9-20 GLI family zinc finger 2 Homo sapiens 33-38 27392709-6 2016 We also found that the levels of oil red O-staining, triglyceride (TG) and total cholesterol (TC) were significantly upregulated in ox-LDL-treated THP1 cells, but inhibited by Lp-PLA2 silencing. Cholesterol 81-92 GLI family zinc finger 2 Homo sapiens 147-151 27220065-1 2016 alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages. Cholesterol 19-30 GLI family zinc finger 2 Homo sapiens 43-48 27221153-0 2016 FABP4-mediated homocysteine-induced cholesterol accumulation in THP-1 monocyte-derived macrophages and the potential epigenetic mechanism. Cholesterol 36-47 GLI family zinc finger 2 Homo sapiens 64-69 27220065-5 2016 Leoligin increases apo A1- as well as 1% human plasma-mediated cholesterol efflux in THP-1 macrophages without affecting cell viability as determined by resazurin conversion. Cholesterol 63-74 GLI family zinc finger 2 Homo sapiens 85-90 27220065-9 2016 Taken together, these results suggest that leoligin induces cholesterol efflux in THP-1-derived macrophages by upregulating ABCA1 and ABCG1 expression. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 82-87 26859197-0 2016 Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells. Cholesterol 58-69 GLI family zinc finger 2 Homo sapiens 80-85 26891591-6 2016 Urolithin C, a combination of urolithins A and B, and ellagic acid also decreased the accumulation of cholesterol in THP-1-derived macrophages, but they were not able to promote cholesterol efflux. Cholesterol 102-113 GLI family zinc finger 2 Homo sapiens 117-122 27012514-6 2016 Consistent with the patient data the ALL (CCRF-CEM and MOLT-3) and AML (KG-1 and THP-1) cell lines also displayed significantly lower intracellular levels of total cholesterol. Cholesterol 164-175 GLI family zinc finger 2 Homo sapiens 81-86 27957343-5 2016 The cholesterol efflux capacity of apoA-I was greatly influenced by the extent of differentiation of THP-1 cells and attenuated by excessive foam cell formation. Cholesterol 4-15 GLI family zinc finger 2 Homo sapiens 101-106 26681758-9 2016 Despite a slight reduction in plasma cholesterol efflux capacity from human THP-1 macrophages, evaluation of global RCT efficacy by combining both ex vivo and in vivo approaches indicate that postprandial HDL particles formed under ERN/LRPT therapy displayed a greater capacity for HDL-mediated RCT to feces. Cholesterol 37-48 GLI family zinc finger 2 Homo sapiens 76-81 26772887-1 2016 This study was designed to evaluate whether CSE/H2S system, which is regulated by miR-216a, regulated ABCA1-mediated cholesterol efflux and cholesterol contents in THP-1 macrophages-derived foam cells. Cholesterol 117-128 GLI family zinc finger 2 Homo sapiens 164-169 26772887-1 2016 This study was designed to evaluate whether CSE/H2S system, which is regulated by miR-216a, regulated ABCA1-mediated cholesterol efflux and cholesterol contents in THP-1 macrophages-derived foam cells. Cholesterol 140-151 GLI family zinc finger 2 Homo sapiens 164-169 26772887-5 2016 Additionally, cholesterol efflux decreased, and cholesterol levels increased in THP-1 macrophage-derived foam cells in response to treatment with miR-216a. Cholesterol 48-59 GLI family zinc finger 2 Homo sapiens 80-85 27331097-6 2016 The present article complements data published in "Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11beta-hydroxysteroid dehydrogenase type 1" Ledda et al. Cholesterol 78-89 GLI family zinc finger 2 Homo sapiens 100-104 26654953-7 2016 Meanwhile, the results of liquid scintillation counter and high performance liquid chromatography (HPLC) showed that miR-486 promoted cholesterol accumulation in THP-1 macrophages. Cholesterol 134-145 GLI family zinc finger 2 Homo sapiens 162-167 26654953-8 2016 CONCLUSION: These data indicated that miR-486 aggravate the cholesterol accumulation in THP-1 cells by targeting HAT1. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 88-93 26721343-0 2016 Imatinib reduces cholesterol uptake and matrix metalloproteinase activity in human THP-1 macrophages. Cholesterol 17-28 GLI family zinc finger 2 Homo sapiens 83-88 27957343-0 2016 Cholesterol Efflux Capacity of Apolipoprotein A-I Varies with the Extent of Differentiation and Foam Cell Formation of THP-1 Cells. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 119-124 26086093-3 2015 Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 13-18 25496323-6 2015 Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux. Cholesterol 114-125 GLI family zinc finger 2 Homo sapiens 136-141 26239480-0 2015 Characterization of fluorescent NBD-cholesterol efflux in THP-1-derived macrophages. Cholesterol 36-47 GLI family zinc finger 2 Homo sapiens 58-63 26239480-4 2015 NBD-cholesterol uptake and metabolism in the THP-1 cells were characterized using fluorescent microscopy and spectrophotometry. Cholesterol 4-15 GLI family zinc finger 2 Homo sapiens 45-50 26239480-6 2015 The uptake of NBD-cholesterol in the THP-1 macrophages was concentration- and time-dependent, and reached a plateau following 4 h incubation. Cholesterol 18-29 GLI family zinc finger 2 Homo sapiens 37-42 26239480-8 2015 The results demonstrated that the percentage of efflux of NBD-cholesterol in the THP-1 cells was significantly correlated with that of [3H]-cholesterol, at various concentrations of HDL or apoA-1 as lipid acceptors (R2=0.876 for HDL; R2=0.837 for apoA-1; P<0.001). Cholesterol 62-73 GLI family zinc finger 2 Homo sapiens 81-86 26239480-8 2015 The results demonstrated that the percentage of efflux of NBD-cholesterol in the THP-1 cells was significantly correlated with that of [3H]-cholesterol, at various concentrations of HDL or apoA-1 as lipid acceptors (R2=0.876 for HDL; R2=0.837 for apoA-1; P<0.001). Cholesterol 140-151 GLI family zinc finger 2 Homo sapiens 81-86 26239480-10 2015 Furthermore, NBD-cholesterol efflux in the THP-1 cells exhibited a similar trend to that obseved in the PBMCs. Cholesterol 17-28 GLI family zinc finger 2 Homo sapiens 43-48 26239480-11 2015 In conclusion, the results of the present study suggested that fluorescent NBD-cholesterol can be used as a sensitive and specific probe in cholesterol efflux assays in THP-1-derived macrophages. Cholesterol 79-90 GLI family zinc finger 2 Homo sapiens 169-174 26239480-11 2015 In conclusion, the results of the present study suggested that fluorescent NBD-cholesterol can be used as a sensitive and specific probe in cholesterol efflux assays in THP-1-derived macrophages. Cholesterol 140-151 GLI family zinc finger 2 Homo sapiens 169-174 26102194-0 2015 Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells. Cholesterol 18-29 GLI family zinc finger 2 Homo sapiens 111-116 26102194-3 2015 In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels. Cholesterol 138-149 GLI family zinc finger 2 Homo sapiens 162-167 26086093-3 2015 Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 242-247 26223891-6 2015 RESULTS: We demonstrated that the accumulation of cholesterol was decreased after FGF21 treatment in THP1 macrophage derived foam cells. Cholesterol 50-61 GLI family zinc finger 2 Homo sapiens 101-105 25779847-0 2015 Angiotensin-(1-7) stimulates cholesterol efflux from angiotensin II-treated cholesterol-loaded THP-1 macrophages through the suppression of p38 and c-Jun N-terminal kinase signaling. Cholesterol 29-40 GLI family zinc finger 2 Homo sapiens 95-100 25956064-11 2015 CONCLUSION: These results demonstrate that Sal B promotes cholesterol efflux in THP-1 macrophages through ABCA1/PPAR-gamma/LXRalpha pathway. Cholesterol 58-69 GLI family zinc finger 2 Homo sapiens 80-85 25956064-3 2015 Here, we sought to investigate the effects of Sal B on the cholesterol efflux in THP-1 macrophages. Cholesterol 59-70 GLI family zinc finger 2 Homo sapiens 81-86 25779847-0 2015 Angiotensin-(1-7) stimulates cholesterol efflux from angiotensin II-treated cholesterol-loaded THP-1 macrophages through the suppression of p38 and c-Jun N-terminal kinase signaling. Cholesterol 76-87 GLI family zinc finger 2 Homo sapiens 95-100 25779847-5 2015 The results demonstrated that Ang II significantly inhibited the cholesterol efflux from cholesterol-loaded THP-1 macrophages. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 108-113 25573889-0 2015 Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients: impact of HAART. Cholesterol 7-18 GLI family zinc finger 2 Homo sapiens 46-51 25779847-5 2015 The results demonstrated that Ang II significantly inhibited the cholesterol efflux from cholesterol-loaded THP-1 macrophages. Cholesterol 89-100 GLI family zinc finger 2 Homo sapiens 108-113 25779847-12 2015 In conclusion, the data demonstrated that treatment with Ang-(1-7) promoted cholesterol efflux in Ang II-treated THP-1 macrophages, partly through inactivation of p38 and JNK signaling and by inducing the expression of PPARgamma and LXRalpha. Cholesterol 76-87 GLI family zinc finger 2 Homo sapiens 113-118 25989518-0 2015 The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 122-127 25989518-3 2015 Here, we analyzed the effects of PLPEs on cholesterol efflux in oxidized low-density lipoprotein (ox-LDL)-loaded THP-1 (human acute monocytic leukemia cell line) macrophages. Cholesterol 42-53 GLI family zinc finger 2 Homo sapiens 113-118 25989518-9 2015 However, high dose of PLPEs (100 mug/mL) inhibited cholesterol efflux to ApoA-I from ox-LDL-loaded THP-1 macrophages, enhanced the production of superoxide anion, decreased mitochondrial membrane potential and ATP levels, and raised nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate oxidase subunits. Cholesterol 51-62 GLI family zinc finger 2 Homo sapiens 99-104 25989518-10 2015 Thus, these results indicate that low and high doses of PLPEs exhibit opposite effects on cholesterol efflux from ox-LDL-loaded THP-1 cells. Cholesterol 90-101 GLI family zinc finger 2 Homo sapiens 128-133 25742736-0 2015 THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL. Cholesterol 26-37 GLI family zinc finger 2 Homo sapiens 0-4 25742736-5 2015 Using both radiochemical and mass analyzes, we showed that THP1 macrophages promote the intracellular oxidation of LDL derived-cholesterol as well as intracellular cholesterol, this later mechanism being enhanced by exposure with native or oxLDL. Cholesterol 127-138 GLI family zinc finger 2 Homo sapiens 59-63 25742736-5 2015 Using both radiochemical and mass analyzes, we showed that THP1 macrophages promote the intracellular oxidation of LDL derived-cholesterol as well as intracellular cholesterol, this later mechanism being enhanced by exposure with native or oxLDL. Cholesterol 164-175 GLI family zinc finger 2 Homo sapiens 59-63 25742736-9 2015 Both oxysterols derived from LDL cholesterol and cellular cholesterol were readily exported to HDL whereas apoA1 was inefficient, showing that HDL plays a major role in the removal of excess oxysterols in THP1 macrophages. Cholesterol 58-69 GLI family zinc finger 2 Homo sapiens 205-209 25997555-0 2015 Zerumbone, A Natural Cyclic Sesquiterpene, Promotes ABCA1-Dependent Cholesterol Efflux from Human THP-1 Macrophages. Cholesterol 68-79 GLI family zinc finger 2 Homo sapiens 98-103 25334019-0 2015 Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 37-48 GLI family zinc finger 2 Homo sapiens 59-64 25997555-1 2015 This study was conducted to explore the effect of zerumbone, isolated from Zingiberzerumbet Smith, on apolipoprotein A-I (apoA-I)-mediated cholesterol efflux from THP-1 macrophages. Cholesterol 139-150 GLI family zinc finger 2 Homo sapiens 163-168 25329888-0 2014 Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages. Cholesterol 43-54 GLI family zinc finger 2 Homo sapiens 91-96 25225013-4 2014 Ang-(1-7) increased ABCA1 and ABCG1 expression in a concentration-dependent manner at both the mRNA and protein levels, promoted cholesterol efflux, and decreased cholesterol content in THP-1 macrophages treated with AngII. Cholesterol 163-174 GLI family zinc finger 2 Homo sapiens 186-191 25329888-9 2014 This study indicated that inflammatory cytokines inhibited ABCA1/ABCG1-mediated cholesterol efflux by up-regulating miR-33a-5P in THP-1 macrophages. Cholesterol 80-91 GLI family zinc finger 2 Homo sapiens 130-135 25329888-1 2014 The present study is to investigate whether inflammatory cytokines inhibit ABCA1/ABCG1-mediated cholesterol efflux by regulating miR-33a-5P in THP-1 macrophages. Cholesterol 96-107 GLI family zinc finger 2 Homo sapiens 143-148 25130461-7 2014 Finally, we tested the efflux of cholesterol from THP-1 macrophages to apolipoprotein A-I, and we found that the treatment of THP-1 macrophages with the FFA mixture significantly attenuated cholesterol efflux. Cholesterol 33-44 GLI family zinc finger 2 Homo sapiens 50-55 25130461-7 2014 Finally, we tested the efflux of cholesterol from THP-1 macrophages to apolipoprotein A-I, and we found that the treatment of THP-1 macrophages with the FFA mixture significantly attenuated cholesterol efflux. Cholesterol 33-44 GLI family zinc finger 2 Homo sapiens 126-131 25130461-0 2014 Cholesterol efflux from THP-1 macrophages is impaired by the fatty acid component from lipoprotein hydrolysis by lipoprotein lipase. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 24-29 25130461-7 2014 Finally, we tested the efflux of cholesterol from THP-1 macrophages to apolipoprotein A-I, and we found that the treatment of THP-1 macrophages with the FFA mixture significantly attenuated cholesterol efflux. Cholesterol 190-201 GLI family zinc finger 2 Homo sapiens 126-131 25072708-5 2014 Administration of 25HCDS to human THP-1-derived macrophages or HepG2 cells significantly inhibited cholesterol synthesis and markedly decreased lipid levels in vivo in NAFLD mouse models. Cholesterol 99-110 GLI family zinc finger 2 Homo sapiens 34-39 25035925-3 2014 In the present study we examined the effects of IL-10 on cholesterol efflux mechanism in lipid-loaded THP-1 macrophages. Cholesterol 57-68 GLI family zinc finger 2 Homo sapiens 102-107 24953492-2 2014 This study was to determine the effects and potential mechanisms of Chlamydia pneumoniae (C. pneumoniae) on ABCA1 expression and cellular cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 138-149 GLI family zinc finger 2 Homo sapiens 160-165 24735204-0 2014 FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARgamma-LXRalpha pathway in THP1 macrophage-derived foam cells. Cholesterol 16-27 GLI family zinc finger 2 Homo sapiens 106-110 24735204-4 2014 In this study, the effects of FGF21 on cholesterol efflux in THP1 macrophage-derived foam cells and the underlying mechanisms were investigated. Cholesterol 39-50 GLI family zinc finger 2 Homo sapiens 61-65 24735204-10 2014 These results demonstrate that FGF21 can promote cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARgamma-LXRalpha pathway in THP1 macrophage-derived foam cells. Cholesterol 49-60 GLI family zinc finger 2 Homo sapiens 139-143 24746987-7 2014 Moreover, exposure to ZnO particles, but not TiO2 particles, upregulated the expression of membrane scavenger receptors of modified LDL and increased cholesterol uptake in THP-1 monocytes/macrophages. Cholesterol 150-161 GLI family zinc finger 2 Homo sapiens 172-177 24751522-0 2014 miR-613 regulates cholesterol efflux by targeting LXRalpha and ABCA1 in PPARgamma activated THP-1 macrophages. Cholesterol 18-29 GLI family zinc finger 2 Homo sapiens 92-97 24751522-5 2014 Furthermore, downregulation of LXRalpha and ABCA1 by miR-613 inhibited cholesterol efflux from PPARgamma activated THP-1 macrophages. Cholesterol 71-82 GLI family zinc finger 2 Homo sapiens 115-120 24297394-16 2014 Inflammatory stress disrupts LDL receptor negative feedback regulation induced by intracellular cholesterol in both cell types, to a greater degree in THP-1 macrophages, which could be one reason why THP-1 macrophages are more prone to become foam cells under inflammatory stress. Cholesterol 96-107 GLI family zinc finger 2 Homo sapiens 200-205 24608080-0 2014 MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Cholesterol 34-45 GLI family zinc finger 2 Homo sapiens 94-99 24608080-8 2014 Treatment with miR-27a and miR-27b mimics reduced apoA1-mediated cholesterol efflux by 33.08% and 44.61% in THP-1 cells, respectively. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 108-113 24608080-9 2014 miR-27a/b also regulated HDL-mediated cholesterol efflux in THP-1 macrophages and affected the expression of apoA1 in HepG2 cells. Cholesterol 38-49 GLI family zinc finger 2 Homo sapiens 60-65 24674903-2 2014 METHODS: We measured cholesterol efflux from human THP-1 macrophages to total plasma or to isolated HDL subfractions in patients with HALP carrying molecular defect in either the CETP or LIPC gene. Cholesterol 21-32 GLI family zinc finger 2 Homo sapiens 51-56 24500716-5 2014 Cell cholesterol loading similarly regulates degradation of endogenously expressed ABCA1 and ABCG1 in human THP-1 macrophages. Cholesterol 5-16 GLI family zinc finger 2 Homo sapiens 108-113 24463979-9 2014 Taken together, our results indicate that IL-8 exerts negative regulatory effects on cholesterol efflux from THP-1 cells and may thus represent a potential target for prevention and treatment of atherosclerosis. Cholesterol 85-96 GLI family zinc finger 2 Homo sapiens 109-114 24463979-0 2014 Interleukin 8 inhibition enhanced cholesterol efflux in acetylated low-density lipoprotein-stimulated THP-1 macrophages. Cholesterol 34-45 GLI family zinc finger 2 Homo sapiens 102-107 24092747-5 2013 Key biological activities of HDL subpopulations, notably cholesterol efflux capacity from human THP-1 macrophages, antioxidative activity toward low-density lipoprotein oxidation, antithrombotic activity in human platelets, cell-free anti-inflammatory activity, and antiapoptotic activity in endothelial cells, were predominantly associated with small, dense, protein-rich HDL3. Cholesterol 57-68 GLI family zinc finger 2 Homo sapiens 96-101 24463979-4 2014 Here, we used human IL-8-neutralizing antibody to inhibit IL-8 and analyze the function of IL-8 in cholesterol efflux from acetylated low-density lipoprotein-loaded THP-1 macrophages. Cholesterol 99-110 GLI family zinc finger 2 Homo sapiens 165-170 24463979-6 2014 Five and 10 microg/mL of human IL-8-neutralizing antibody enhanced cholesterol efflux from THP-1-derived macrophages by 1.2- and 1.4-fold, respectively. Cholesterol 67-78 GLI family zinc finger 2 Homo sapiens 91-96 24325778-4 2014 Cholesterol efflux was determined using human THP-1 monocyte-derived macrophages, HDL antioxidative capacity was measured as inhibition of low-density lipoprotein oxidation in vitro, and HDL anti-inflammatory capacity was assessed as suppression of thrombin-induced monocyte chemotactic protein 1 expression in human umbilical vein endothelial cells. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 46-51 24942406-4 2014 METHODS: We measured the capacity of whole serum to mediate cholesterol efflux from human THP-1 macrophages in a cohort of 439 Japanese-Americans who underwent 75-g OGTTs. Cholesterol 60-71 GLI family zinc finger 2 Homo sapiens 90-95 24314365-8 2013 METHODS: Cholesterol efflux (MCE) from THP-1 macrophages to plasma from NL controls and to obese patients with MetS before and after weight loss was measured. Cholesterol 9-20 GLI family zinc finger 2 Homo sapiens 39-44 23649042-5 2013 The cholesterol efflux capacity of serum from cultured human macrophages (THP-1) was measured. Cholesterol 4-15 GLI family zinc finger 2 Homo sapiens 74-79 23883163-10 2013 In Pcsk9 knockout males, THP-1 macrophage cholesterol efflux capacity of serum was reduced and the fatty streak lesion volume was similar to wild-type controls. Cholesterol 42-53 GLI family zinc finger 2 Homo sapiens 25-30 23879935-0 2013 Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. Cholesterol 48-59 GLI family zinc finger 2 Homo sapiens 71-76 23564066-5 2013 Neopterin decreased ABCA1 expression and cholesterol efflux in a time- and concentration-dependent manner in THP-1 macrophage-derived foam cells, and the LXRalpha siRNA can reverse the inhibitory effects induced by neopterin. Cholesterol 41-52 GLI family zinc finger 2 Homo sapiens 109-114 24396573-0 2013 The Effect of Unsaturated Fatty Acids on Molecular Markers of Cholesterol Homeostasis in THP-1 Macrophages. Cholesterol 62-73 GLI family zinc finger 2 Homo sapiens 89-94 24396573-4 2013 Alpha Linolenic Acid (LA), and Eicosapentaenoic Acid (EPA) on the PPARalpha and ACAT1 mRNA expression by Real time PCR and cholesterol homeostasis in THP-1 macrophages derived foam cells. Cholesterol 123-134 GLI family zinc finger 2 Homo sapiens 150-155 23305793-6 2013 Cholesterol contents of THP-1 macrophages incubated with Acro-LDL were determined by enzymatic method. Cholesterol 0-11 GLI family zinc finger 2 Homo sapiens 24-29 23658787-4 2013 Whilst direct PPARgamma-agonism promoted cholesterol efflux from THP-1 derived foam cells by 37.7+-3.1% (P<0.01) and stimulated transcription of LXRalpha by 87.9+-9.5% (P<0.001) and ABCG1 by 101.2+-15.5% (P<0.01), NA showed no effect in foam cells on either cholesterol efflux or key RCT genes transcription. Cholesterol 41-52 GLI family zinc finger 2 Homo sapiens 65-70 23372063-2 2013 APPROACH AND RESULTS: The capacity of whole-plasma to mediate cholesterol efflux from cholesterol-loaded human THP-1 macrophages was measured in 846 individuals (450 men and 396 women). Cholesterol 62-73 GLI family zinc finger 2 Homo sapiens 111-116 23372063-2 2013 APPROACH AND RESULTS: The capacity of whole-plasma to mediate cholesterol efflux from cholesterol-loaded human THP-1 macrophages was measured in 846 individuals (450 men and 396 women). Cholesterol 86-97 GLI family zinc finger 2 Homo sapiens 111-116 23305686-0 2013 Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Cholesterol 22-33 GLI family zinc finger 2 Homo sapiens 80-85 23840542-5 2013 We demonstrated that cellular cholesterol content was significantly decreased while apoA1-mediated cholesterol efflux was significantly increased following treatment with DHC in THP-1 macrophage-derived foam cells. Cholesterol 99-110 GLI family zinc finger 2 Homo sapiens 178-183 23305793-10 2013 Acrolein interacted with apolipoprotein B in LDL and Acro-LDL uptake by THP-1 macrophage was a more effective inducer of cholesterol accumulation than oxidized LDL uptake. Cholesterol 121-132 GLI family zinc finger 2 Homo sapiens 72-77 23290264-4 2013 The results showed that apelin-13 dramatically increased cholesterol efflux from THP-1 macrophage-derived foam cells and reduced cellular cholesterol levels. Cholesterol 57-68 GLI family zinc finger 2 Homo sapiens 81-86 23168167-4 2013 THP-1 human monocytes/macrophages and HAEC exposed to the A(2A)R-specific agonist ATL313 exhibited upregulation of proteins responsible for cholesterol efflux: the ABCA1 and G1 transporters. Cholesterol 140-151 GLI family zinc finger 2 Homo sapiens 0-5 23399664-2 2013 We hypothesized that quercetin could lower the content of cholesterol in macrophages by regulating the expression of the ATP binding cassette transporter A1 (ABCA1) gene in differentiated human acute monocyte leukemia cell line (THP-1) cells and thereby reducing the chance of forming foam cells. Cholesterol 58-69 GLI family zinc finger 2 Homo sapiens 229-234 23399664-7 2013 Furthermore, quercetin-enhanced cholesterol efflux from differentiated THP-1 cells to both high-density lipoprotein (HDL) and apolipoprotein A1. Cholesterol 32-43 GLI family zinc finger 2 Homo sapiens 71-76 23399664-10 2013 Our data demonstrated that quercetin increased the expressions of PPARgamma, LXRalpha, and ABCA1 genes and cholesterol efflux from THP-1 macrophages. Cholesterol 107-118 GLI family zinc finger 2 Homo sapiens 131-136 23041272-5 2013 We analyzed the effect of resveratrol on apoA-1-and HDL-mediated cholesterol efflux in human THP-1 macrophages. Cholesterol 65-76 GLI family zinc finger 2 Homo sapiens 93-98 23739547-4 2013 METHODS AND RESULTS: tBHQ increased ABCA1 protein levels and markedly enhanced cholesterol efflux from THP-1 macrophage-derived foam cells. Cholesterol 79-90 GLI family zinc finger 2 Homo sapiens 103-108 23137417-5 2013 Concentration adjusted HDL fraction was used to determine HDL-mediated cholesterol efflux (Efflux-hdl) from THP-1 derived macrophages. Cholesterol 71-82 GLI family zinc finger 2 Homo sapiens 108-113