PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29251770-0	2018	Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.	Cholesterol	78-89	radical S-adenosyl methionine domain containing 2	Homo sapiens	6-13	
34029588-0	2021	The antiviral enzyme viperin inhibits cholesterol biosynthesis.	Cholesterol	38-49	radical S-adenosyl methionine domain containing 2	Homo sapiens	21-28	
34029588-5	2021	Here, we investigated the effect of viperin expression on cholesterol biosynthesis using transiently expressed genes in the human cell line HEK293T.	Cholesterol	58-69	radical S-adenosyl methionine domain containing 2	Homo sapiens	36-43	
34029588-6	2021	We found that viperin expression reduces cholesterol levels by 20% - 30% in these cells.	Cholesterol	41-52	radical S-adenosyl methionine domain containing 2	Homo sapiens	14-21	
34029588-7	2021	Following this observation, a proteomic screen of the viperin interactome identified several cholesterol biosynthetic enzymes among the top hits, including lanosterol synthase (LS) and squalene monooxygenase (MS), which are enzymes that catalyze key steps in establishing the sterol carbon skeleton.	Cholesterol	93-104	radical S-adenosyl methionine domain containing 2	Homo sapiens	54-61	
34029588-11	2021	Our results establish a link between viperin expression and downregulation of cholesterol biosynthesis that helps explain viperin"s antiviral effects against enveloped viruses.	Cholesterol	78-89	radical S-adenosyl methionine domain containing 2	Homo sapiens	37-44	
34029588-11	2021	Our results establish a link between viperin expression and downregulation of cholesterol biosynthesis that helps explain viperin"s antiviral effects against enveloped viruses.	Cholesterol	78-89	radical S-adenosyl methionine domain containing 2	Homo sapiens	122-129	
29251770-2	2018	Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis.	Cholesterol	157-168	radical S-adenosyl methionine domain containing 2	Homo sapiens	40-47	
29251770-3	2018	We postulate that the radical modification of these two molecules by viperin might lead to defects in cholesterol synthesis, thereby affecting the composition of lipid rafts and subsequent enveloped virus budding.	Cholesterol	102-113	radical S-adenosyl methionine domain containing 2	Homo sapiens	69-76	
27834682-4	2016	Numerous enveloped viruses utilize cholesterol-rich lipid rafts to bud from the host cell membrane, and it is thought that by inhibiting FPPS activity (and therefore cholesterol synthesis), viperin retards viral budding from infected cells.	Cholesterol	35-46	radical S-adenosyl methionine domain containing 2	Homo sapiens	190-197	
27834682-4	2016	Numerous enveloped viruses utilize cholesterol-rich lipid rafts to bud from the host cell membrane, and it is thought that by inhibiting FPPS activity (and therefore cholesterol synthesis), viperin retards viral budding from infected cells.	Cholesterol	166-177	radical S-adenosyl methionine domain containing 2	Homo sapiens	190-197