PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28302472-8 2017 Blood cholesterol, triglyceride and insulin concentrations were higher in Erk1-/- obese mice compared to WT obese animals. Cholesterol 6-17 mitogen-activated protein kinase 3 Mus musculus 74-78 28199510-7 2017 In contrast, intravenous injection of oxLDL as well as high cholesterol diet for 6 weeks led to a switch from the Oct-1/SIRT1 signal transduction pathway to the ERK1/2 pathway and in turn to an enhanced thrombotic response with shortened occlusion time. Cholesterol 60-71 mitogen-activated protein kinase 3 Mus musculus 161-167 28104587-9 2017 The available results support involvement of a two-pronged mechanism by which intestine and liver PKCbeta signaling converge on liver ERK1/2 to dictate diet-induced cholesterol and bile acid homeostasis. Cholesterol 165-176 mitogen-activated protein kinase 3 Mus musculus 134-140 27365310-0 2016 MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition. Cholesterol 67-78 mitogen-activated protein kinase 3 Mus musculus 121-127 23643895-6 2013 We have previously shown that cholesterol stimulation leads to PI3K/Akt phosphorylation, and now demonstrated that cholesterol inhibits ERK1/2 phosphorylation; both effects reversed when cholesterol is depleted from lipid rafts using methyl-beta-cyclodextrin (MBCD). Cholesterol 115-126 mitogen-activated protein kinase 3 Mus musculus 136-142 23643895-6 2013 We have previously shown that cholesterol stimulation leads to PI3K/Akt phosphorylation, and now demonstrated that cholesterol inhibits ERK1/2 phosphorylation; both effects reversed when cholesterol is depleted from lipid rafts using methyl-beta-cyclodextrin (MBCD). Cholesterol 115-126 mitogen-activated protein kinase 3 Mus musculus 136-142 23643895-7 2013 In addition, vanadate, an inhibitor of phosphatases, reversed the cholesterol inhibition of ERK1/2 phosphorylation. Cholesterol 66-77 mitogen-activated protein kinase 3 Mus musculus 92-98 22361350-0 2012 Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. Cholesterol 90-101 mitogen-activated protein kinase 3 Mus musculus 148-154 21989075-10 2011 U-0126 inhibited the phosphorylation of ERK1/2 in advanced-glycation-end-product-cholesterol-aggregated-BSA treated mesangial cells. Cholesterol 81-92 mitogen-activated protein kinase 3 Mus musculus 40-46 19028402-6 2010 High cholesterol-diet feeding increases the activity of NADPH oxidase subunits (p47(phox) and Rac), extracellular signal-regulated kinase 1/2, janus kinase 2, signal transducer and activator of transcription 3, nuclear factor-kappaB and the expression of tumor necrosis factor-alpha, interleukin 6, monocyte chemoattactant protein-1 and vascular cell adhesion molecule-1 in the aortas. Cholesterol 5-16 mitogen-activated protein kinase 3 Mus musculus 100-141 19949102-9 2010 Cholesterol accumulation in Abcg1(-/-) CD4 T cells results in enhanced basal phosphorylation levels of ZAP70 and ERK1/2. Cholesterol 0-11 mitogen-activated protein kinase 3 Mus musculus 113-119 19007846-5 2009 We show that StAR protein is a substrate of ERK1/2, and that mitochondrial ERK1/2 is part of a multimeric complex that regulates cholesterol transport. Cholesterol 129-140 mitogen-activated protein kinase 3 Mus musculus 75-81 18816057-5 2008 Moreover, significant increases of phosphorylated AKT, NF-kappaB (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Cholesterol 124-135 mitogen-activated protein kinase 3 Mus musculus 76-82 18816057-5 2008 Moreover, significant increases of phosphorylated AKT, NF-kappaB (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Cholesterol 169-180 mitogen-activated protein kinase 3 Mus musculus 76-82 34355300-10 2021 These findings indicate that p27 plays vital roles in LH-induced testosterone production, providing a novel mechanism that p27 acts as an upstream molecule to elevate ERK1/2 phosphorylation to promote the expression of StAR and other cholesterol-metabolizing enzymes. Cholesterol 234-245 mitogen-activated protein kinase 3 Mus musculus 167-173 34107900-17 2021 CONCLUSIONS: This study demonstrates that ERK1/2 agonists suppress leukemia and possibly other types of cancer through transcriptional stimulation of cholesterol biosynthesis genes. Cholesterol 150-161 mitogen-activated protein kinase 3 Mus musculus 42-48 34975320-10 2022 Furthermore, GPR43 activation increased extracellular regulated protein kinases 1/2 (ERK1/2) activity and EGR1 expression in podocytes, which resulted in an increase in cholesterol influx and autophagy inhibition. Cholesterol 169-180 mitogen-activated protein kinase 3 Mus musculus 85-91 31706303-0 2019 Liraglutide improves lipid metabolism by enhancing cholesterol efflux associated with ABCA1 and ERK1/2 pathway. Cholesterol 51-62 mitogen-activated protein kinase 3 Mus musculus 96-102 22075210-9 2012 On the other hand, destruction of lipid rafts by removal of cholesterol from the PM by methyl-ss-cyclodextrin (MCD) treatment caused disordered signal transductions for osteoclastogenesis, such as hyperactivation of Erk1/2 and insensitivity of Akt to RANKL stimulus. Cholesterol 60-71 mitogen-activated protein kinase 3 Mus musculus 216-222 21660958-6 2011 We first demonstrated that membrane cholesterol depletion with the treatment of methyl-beta-cyclodextrin inhibits oscillatory fluid flow induced intracellular calcium mobilization and ERK1/2 phosphorylation in MC3T3-E1 osteoblastic cells. Cholesterol 36-47 mitogen-activated protein kinase 3 Mus musculus 184-190 18197253-8 2008 As a result of this binding and only in the presence of cholesterol, ERK1/2 phosphorylates StAR at Ser(232). Cholesterol 56-67 mitogen-activated protein kinase 3 Mus musculus 69-75 18197253-11 2008 In summary, here we show that StAR is a novel substrate of ERK1/2, and that mitochondrial ERK1/2 is part of a multimeric protein kinase complex that regulates cholesterol transport. Cholesterol 159-170 mitogen-activated protein kinase 3 Mus musculus 90-96