PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25592838-6 2015 All-atom unbiased MD simulations of the full D2R-GIPC1-PDZ complex in sphingolipid/cholesterol membranes show that the D2R carboxyl C-terminus samples the region of the conserved GFGL motif located on the carboxylate-binding loop of the GIPC1-PDZ, and the entire complex distances itself from the membrane interface. Cholesterol 83-94 GIPC PDZ domain containing family member 1 Homo sapiens 49-54 33811857-0 2021 The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. Cholesterol 84-95 GIPC PDZ domain containing family member 1 Homo sapiens 20-25 33811857-7 2021 We therefore conclude that GIPC1 plays a key role in the stability and function of SR-B1, and can also effectively regulate hepatic lipid and cholesterol metabolism. Cholesterol 142-153 GIPC PDZ domain containing family member 1 Homo sapiens 27-32 33811857-8 2021 These findings expand our knowledge of the regulatory roles of GIPC1 and suggest that GIPC1 exerts a major effect on cell surface receptors such as SR-B1 and its associated hepatic lipid and cholesterol metabolic processes. Cholesterol 191-202 GIPC PDZ domain containing family member 1 Homo sapiens 86-91