PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28334053-12	2017	An inverse relationship was observed between total cholesterol and aberrant behaviour as determined by ABC-C total score.	Cholesterol	51-62	ATP binding cassette subfamily C member 1	Homo sapiens	103-108	
28383515-4	2017	Subsequently, further ABC transporters, i.e., ABCG1, ABCG4, ABCB6, ABCC1, ABCC6 or ABCC9, have been shown to directly or indirectly affect cellular cholesterol efflux, the inflammatory response in macrophages, megakaryocyte proliferation and thrombus formation, as well as vascular function and blood pressure, and may thereby contribute to the pathogenesis of CVD and its complications.	Cholesterol	148-159	ATP binding cassette subfamily C member 1	Homo sapiens	67-72	
22982209-6	2012	The mRNA levels of cholesterol transport regulators ABCA1 and ABCG1 were markedly downregulated by UVB, parallel to the lamellar ichthyosis related glucosylceramide transporter ABCA12 and the suspected sphingosine-1-phosphate and cholesterol sulfate transporter ABCC1.	Cholesterol	19-30	ATP binding cassette subfamily C member 1	Homo sapiens	262-267	
24225025-1	2013	BACKGROUND: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol in plasma membrane and detergent resistant membranes (DRMs).	Cholesterol	208-219	ATP binding cassette subfamily C member 1	Homo sapiens	53-91	
24225025-1	2013	BACKGROUND: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol in plasma membrane and detergent resistant membranes (DRMs).	Cholesterol	208-219	ATP binding cassette subfamily C member 1	Homo sapiens	93-97	
24225025-4	2013	RESULTS: MDR cells, which overexpressed Pgp and MRP1, had a dysregulated cholesterol metabolism, due to the lower expression of ubiquitin E3 ligase Trc8: this produced lower ubiquitination rate of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCoAR), higher cholesterol synthesis, higher cholesterol content in MDR cells.	Cholesterol	73-84	ATP binding cassette subfamily C member 1	Homo sapiens	48-52	
24225025-4	2013	RESULTS: MDR cells, which overexpressed Pgp and MRP1, had a dysregulated cholesterol metabolism, due to the lower expression of ubiquitin E3 ligase Trc8: this produced lower ubiquitination rate of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCoAR), higher cholesterol synthesis, higher cholesterol content in MDR cells.	Cholesterol	263-274	ATP binding cassette subfamily C member 1	Homo sapiens	48-52	
18851956-10	2009	In conclusion, ABCB1 and ABCC1 mRNA levels in PBMC are modulated by atorvastatin and ABCB1 G2677T/A polymorphism and ABCB1 baseline expression is related to differences in serum LDL cholesterol and apoB in response to atorvastatin.	Cholesterol	182-193	ATP binding cassette subfamily C member 1	Homo sapiens	25-30	
19651114-5	2009	Two of these transporters are relevant to multidrug resistance in tumor cells (Pgp/ABCB1 and MRP1/ABCC1), while the third (ABCA1) is extensively studied in relation to the reverse cholesterol pathway and cellular cholesterol homeostasis.	Cholesterol	180-191	ATP binding cassette subfamily C member 1	Homo sapiens	93-97	
19651114-5	2009	Two of these transporters are relevant to multidrug resistance in tumor cells (Pgp/ABCB1 and MRP1/ABCC1), while the third (ABCA1) is extensively studied in relation to the reverse cholesterol pathway and cellular cholesterol homeostasis.	Cholesterol	180-191	ATP binding cassette subfamily C member 1	Homo sapiens	98-103	
19651114-5	2009	Two of these transporters are relevant to multidrug resistance in tumor cells (Pgp/ABCB1 and MRP1/ABCC1), while the third (ABCA1) is extensively studied in relation to the reverse cholesterol pathway and cellular cholesterol homeostasis.	Cholesterol	213-224	ATP binding cassette subfamily C member 1	Homo sapiens	98-103	
17489102-8	2007	Further cholesterol depletion below 40% yielded both a partial shift of MRP1 to the high-density fraction and a decrease of its functionality.	Cholesterol	8-19	ATP binding cassette subfamily C member 1	Homo sapiens	72-76	
17489102-9	2007	Taken together, these data suggest that MRP1 functionality depends on its localization in cholesterol-rich membrane microdomains.	Cholesterol	90-101	ATP binding cassette subfamily C member 1	Homo sapiens	40-44	
17213331-8	2007	Similar but less pronounced alterations in intracellular cholesterol distribution are observed on expression of a temperature-rescued mutant variant of the related ATP-binding cassette (ABC) protein multidrug resistance-associated protein 1 (MRP1).	Cholesterol	57-68	ATP binding cassette subfamily C member 1	Homo sapiens	199-240	
17213331-8	2007	Similar but less pronounced alterations in intracellular cholesterol distribution are observed on expression of a temperature-rescued mutant variant of the related ATP-binding cassette (ABC) protein multidrug resistance-associated protein 1 (MRP1).	Cholesterol	57-68	ATP binding cassette subfamily C member 1	Homo sapiens	242-246	
11118294-1	2000	The aim of the present paper is to reinvestigate the role of multidrug resistance P-glycoprotein MDR1 and MDR-associated protein (MRP1) in cholesterol esterification using well-characterized inhibitors.	Cholesterol	139-150	ATP binding cassette subfamily C member 1	Homo sapiens	130-134	
34822764-5	2021	MRP demonstrates an ability to recover signals such as associations between PCSK9 and LDL cholesterol levels.	Cholesterol	90-101	ATP binding cassette subfamily C member 1	Homo sapiens	0-3