PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31565801-1 2020 A series of broadly neutralizing antibodies called PGT have been shown to be bound directly to human immunodeficiency virus type-1 via high mannose glycans on glycoprotein gp120. Mannose 140-147 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 172-177 32119644-6 2020 Silencing MR or deleting mannose residues on Env rescues Env expression in HIV-1-infected macrophages lacking Vpr. Mannose 25-32 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 45-48 32119644-6 2020 Silencing MR or deleting mannose residues on Env rescues Env expression in HIV-1-infected macrophages lacking Vpr. Mannose 25-32 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 57-60 32119644-8 2020 Together these results reveal a Vpr-Nef-Env axis that hijacks a host mannose-MR response system to facilitate infection while evading MR"s normal role, which is to trap and destroy mannose-expressing pathogens. Mannose 69-76 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 40-43 32119644-8 2020 Together these results reveal a Vpr-Nef-Env axis that hijacks a host mannose-MR response system to facilitate infection while evading MR"s normal role, which is to trap and destroy mannose-expressing pathogens. Mannose 181-188 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 40-43 28994411-3 2017 3.5 and 3.9 A resolution crystal structures of the HIV-1 Env trimer with fully processed and native glycosylation were solved, revealing a glycan shield of high-mannose and complex-type N-glycans that were used to define the complete epitopes of two bNAbs. Mannose 161-168 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 57-60 29738673-1 2018 High-mannose-type N-glycans are an important component of neutralizing epitopes on HIV-1 envelope glycoprotein gp120. Mannose 5-12 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 111-116 29579062-10 2018 In addition, while Env of viruses enriched with mannose-type glycans were sensitive to Endo-H deglycosylation, Env of untreated viruses were partially resistant, indicating that HIV-1 Env glycans are heterogeneously comprised of complex, hybrid, and mannose types. Mannose 48-55 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 19-22 27617431-3 2016 We present 3.5-A- and 3.9-A-resolution crystal structures of the HIV-1 Env trimer with fully processed and native glycosylation, revealing a glycan shield of high-mannose and complex-type N-glycans, which we used to define complete epitopes of two bNAbs. Mannose 163-170 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 71-74 28322582-1 2017 This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env. Mannose 53-60 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 196-199 28249163-7 2017 Thus, HIV-1 Env vaccination induced mannose-dependent antibodies with characteristics of V3-glycan bnAb precursors. Mannose 36-43 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 12-15 24632372-2 2014 HIV-1 gp120 high-mannose has been attributed immunosuppressive roles in human myeloid DCs, but no receptors for high-mannose have so far been reported on human pDCs. Mannose 17-24 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 6-11 27192579-0 2016 Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch. Mannose 129-136 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 120-123 26682982-1 2015 The high-mannose patch on the HIV-1 envelope (Env) glycoprotein is the epicenter for binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for generating such antibodies by vaccination have not been defined. Mannose 9-16 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 46-49 26540494-1 2015 The glycoprotein gp120 of the HIV-1 viral envelope has a high content in mannose residues, particularly alpha-1,2-mannose oligomers. Mannose 73-80 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 17-22 26277072-1 2015 The glycan shield on the human immunodeficiency virus 1 (HIV-1) envelope (Env) glycoprotein has drawn attention as a target for HIV-1 vaccine design given that an increasing number of potent and broadly neutralizing antibodies (bNAbs) recognize epitopes entirely or partially comprised of high mannose type N-linked glycans. Mannose 294-301 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 74-77 25403811-1 2014 The anti-HIV lectin actinohivin (AH) specifically interacts with HMTG (high-mannose-type glycan), which is attached to the glycoprotein gp120 of HIV-1 in a process in which the three branched mannotriose chains (D1, D2, and D3) of HMTG exhibit different binding affinities, it being estimated that that of D1 is the strongest, that of D3 is weaker, and that of D2 is undetectable. Mannose 76-83 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 136-141 22547820-2 2012 Concordant with recent evidence that HIV-1 titers are determined by a race between entry of cell-attached virions and competing inactivation processes, we show that NMAb 2G12, which binds to gp120 N-glycans with alpha (1, 2)-linked mannose termini and inhibits replication after passive transfer into patients, neutralizes by slowing entry of adsorbed virions. Mannose 232-239 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 191-196 22607556-2 2012 We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically against HIV-1, HIV-2, and HIV-1 strains that were selected for resistance against particular CBAs [i.e., 2G12 mAb and microvirin (MVN)]. Mannose 34-41 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 135-140 23221565-1 2013 The highly conserved cluster of high-mannose glycans on the HIV-1 envelope glycoprotein, gp120, has been highlighted as a target for neutralizing antibodies. Mannose 37-44 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 89-94 21715597-0 2011 Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin. Mannose 20-27 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 48-53 22209231-2 2012 The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) inhibit HIV-1 infection by binding to mannose-rich glycans on gp120. Mannose 111-118 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 135-140 21793733-0 2012 Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice. Mannose 14-21 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 70-75 15003531-0 2004 Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120. Mannose 131-138 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 160-165 21694730-2 2011 The cooperative binding of three segments of AH to three high mannose-type glycans (HMTGs) of HIV-1 gp120 generates specific and strong anti-HIV activity. Mannose 62-69 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 100-105 21314946-7 2011 Also, epitope mapping experiments revealed that GNA and the mannose-specific mAb 2G12 can independently bind from GNAmaize to gp120, whereas GNAmaize cannot efficiently bind to gp120 that contained prebound PHA-E (GlcNAcbeta1,2man specific) or SNA (NeuAcalpha2,6X specific). Mannose 60-67 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 126-131 21674342-7 2011 This approach has been applied to the solid-phase synthesis of the N-linked high mannose glycosylated form of peptide T (ASTTTNYT), a fragment of the HIV-1 envelope glycoprotein gp120. Mannose 81-88 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 178-183 18597806-4 2008 Our data demonstrate that Mermaid interacts with high mannose structures present on HIV-1 gp120 and thereby inhibits HIV-1 binding to DC-SIGN on DCs. Mannose 54-61 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 90-95 18198210-1 2008 MAb 2G12 neutralizes HIV-1 by binding with high affinity to a cluster of high-mannose oligosaccharides on the envelope glycoprotein, gp120. Mannose 78-85 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 133-138 17658575-0 2007 High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization. Mannose 5-12 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 47-52 17658575-6 2007 For the first time, our data have collectively defined the high-mannose residues on gp120 affecting CV-N activity, and demonstrated that CBA-escape HIV-1 has increased sensitivity to immunoglobulins and sera from HIV patients, and particularly to V3 loop-directed MAbs. Mannose 64-71 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 84-89 17522223-1 2007 Human immunodeficiency virus type 1 (HIV-1) envelope (gp120) binding to DC-SIGN, a C-type lectin that can facilitate HIV infection in cis and in trans, is largely dependent on high-mannose-content moieties. Mannose 181-188 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 54-59 21697467-0 2011 Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. Mannose 15-22 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 62-67 21799112-2 2011 This antiviral activity is attributed to two homologous carbohydrate binding sites that specifically bind high mannose glycosylation present on envelope glycoproteins such as HIV-1 gp120. Mannose 111-118 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 181-186 19410272-0 2009 Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo. Mannose 21-28 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 80-85 15718224-0 2005 Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis. Mannose 87-94 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 49-54 15367629-9 2004 The nature of these mutations was entirely different from that of mutations that are known to appear in HIV-1 gp120 under the pressure of other viral entry inhibitors such as dextran sulfate, bicyclams (i.e., AMD3100), and chicoric acid, which also explains the lack of cross-resistance of plant lectin-resistant viruses to any other HIV inhibitor including T-20 and the blue-green algae (cyanobacteria)-derived mannose-specific cyanovirin. Mannose 412-419 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 110-115 15003531-8 2004 The above results indicate that high-mannose type saccharide chains of gp120 are molecular targets of AH in its anti-HIV activity. Mannose 37-44 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 71-76 15113002-2 2004 Previous mutational analysis suggested that 2G12 recognized a novel cluster of high-mannose type oligosaccharides on HIV-1 gp120. Mannose 84-91 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 123-128 12565922-0 2003 Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides. Mannose 33-40 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 52-57 7474402-2 1995 Study of the oligosaccharide structures of gp120 suggests that the high mannose type of oligosaccharides are essential for HIV-1 infection. Mannose 72-79 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 43-48 10913359-0 2000 Accessibility of the high-mannose glycans of glycoprotein gp120 from human immunodeficiency virus type 1 probed by in vitro interaction with mannose-binding lectins. Mannose 26-33 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 58-63 12072528-0 2002 The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120. Mannose 4-11 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 113-118 10913359-0 2000 Accessibility of the high-mannose glycans of glycoprotein gp120 from human immunodeficiency virus type 1 probed by in vitro interaction with mannose-binding lectins. Mannose 141-148 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 58-63 10913359-1 2000 The direct interaction of mannose-specific plant lectins with gp120 of HIV-1 was studied by surface plasmon resonance. Mannose 26-33 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 62-67 10913359-5 2000 These results demonstrate that mannose-specific plant lectins are powerful tools to study the accessibility and elucidate the function of the gp120 glycans in the recognition and infection of the host cells by HIV-1. Mannose 31-38 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 142-147 10408727-1 1999 The outer envelope glycoprotein (gp120) from subtypes A-E of HIV-1 was purified using a specific high mannose-binding lectin, Galanthus nivalis agglutinin. Mannose 102-109 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 33-38 21374492-5 1998 Gp120 oligosaccharides are a mixture of high mannose-, hybrid-, and complex-type N-glycans (3-5). Mannose 45-52 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 0-5 8503188-1 1993 We have studied perturbation of the gp120/gp41 envelope complex of HIV-1 in the presence of the mannose-specific lectin succinyl Con A (SC) and compared the effect with that observed in the presence of soluble CD4 (sCD4). Mannose 96-103 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 36-41 2183815-4 1990 Analytical studies suggest that the antibodies are directed against the mannose residues of the HIV-1 glycoprotein (gp) 120 and its precursor gp 160. Mannose 72-79 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 142-148 1874921-2 1991 These are based on the highly specific interaction between gp120 and the mannose-specific lectins from Narcissus pseudonarcissus (NPL) and Galanthus nivalis (GNL). Mannose 73-80 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 59-64