PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28768165-1 2017 Plasma mannose levels are elevated in subjects with insulin resistance independently of obesity. Mannose 7-14 insulin Homo sapiens 52-59 31682799-0 2020 Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in man. Mannose 0-7 insulin Homo sapiens 14-21 31682799-0 2020 Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in man. Mannose 0-7 insulin Homo sapiens 65-72 31682799-4 2020 However, potential direct effects of mannose on insulin sensitivity in vivo or in vitro are unknown. Mannose 37-44 insulin Homo sapiens 48-55 31682799-7 2020 These data suggest that mannose is a marker, and not a mediator, of insulin resistance. Mannose 24-31 insulin Homo sapiens 68-75 31682799-9 2020 Mannose was reduced by insulin infusion in proportion to whole-body insulin sensitivity. Mannose 0-7 insulin Homo sapiens 23-30 31682799-9 2020 Mannose was reduced by insulin infusion in proportion to whole-body insulin sensitivity. Mannose 0-7 insulin Homo sapiens 68-75 31682799-10 2020 Thus, mannose is a biomarker of insulin resistance which may be useful for the early identification of diabetic individuals with insulin resistance and increased risk of its complications. Mannose 6-13 insulin Homo sapiens 32-39 31682799-10 2020 Thus, mannose is a biomarker of insulin resistance which may be useful for the early identification of diabetic individuals with insulin resistance and increased risk of its complications. Mannose 6-13 insulin Homo sapiens 129-136 30534205-0 2018 Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes. Mannose 15-22 insulin Homo sapiens 50-57 30534205-2 2018 In addition, fasting plasma mannose levels (M0) are associated with insulin resistance independent of BMI. Mannose 28-35 insulin Homo sapiens 68-75 30534205-3 2018 Since the association between mannose and insulin sensitivity (IS) in those with impaired glucose tolerance remains unknown, we aimed to investigate this association in individuals without severe obesity but with varying degrees of glucose tolerance. Mannose 30-37 insulin Homo sapiens 42-49 24198161-6 2014 The up-regulated genes were mainly enriched in the TGF-beta and cell cycle signaling pathways and down-regulated genes were mainly enriched in the insulin-mediated signal pathway, metabolic pathway of fructose and mannose, and glycolysis/gluconeogenesis pathway. Mannose 214-221 insulin Homo sapiens 147-154 27448056-0 2016 Biomarkers: Mannose levels predict insulin resistance. Mannose 12-19 insulin Homo sapiens 35-42 27345421-0 2016 Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. Mannose 66-73 insulin Homo sapiens 85-92 27345421-4 2016 We observed significant correlations between plasma mannose levels, BMI, and insulin resistance (IR). Mannose 52-59 insulin Homo sapiens 77-84 8240280-9 1993 Upon insulin stimulation of fat cells in the presence of 2.5 mM mannose, the release of 3-O-methylglucose-transport-stimulating activity was detected (for purified supernatant of adipocytes without insulin, 6.9 +/- 1.12%; with insulin, 41.0 +/- 3.6%) and lipogenesis-stimulating activity (without insulin, 0.93 +/- 0.17, with insulin 2.96 +/- 0.31 nmol/min per mg). Mannose 64-71 insulin Homo sapiens 5-12 22082268-0 2011 Influence of placental mannose/n-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors. Mannose 23-30 insulin Homo sapiens 91-98 22082268-0 2011 Influence of placental mannose/n-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors. Mannose 23-30 insulin Homo sapiens 103-110 22082268-2 2011 Mannose/N-acetyl-glucosamine (Man/GlcNAc)-binding proteins from placenta were isolated and their reactivity towards placental insulin and insulin-like growth factor receptors (IR and IGF-Rs) was analyzed. Mannose 0-7 insulin Homo sapiens 126-133 22082268-2 2011 Mannose/N-acetyl-glucosamine (Man/GlcNAc)-binding proteins from placenta were isolated and their reactivity towards placental insulin and insulin-like growth factor receptors (IR and IGF-Rs) was analyzed. Mannose 0-7 insulin Homo sapiens 138-145 9972287-2 1998 Glucose, mannose, fructose, glyceraldehyde and dihydroxyacetone all at 8 mM, significantly enhanced the release of insulin elicited by basal concentrations of these carbohydrates (2 mM). Mannose 9-16 insulin Homo sapiens 115-122 8240280-9 1993 Upon insulin stimulation of fat cells in the presence of 2.5 mM mannose, the release of 3-O-methylglucose-transport-stimulating activity was detected (for purified supernatant of adipocytes without insulin, 6.9 +/- 1.12%; with insulin, 41.0 +/- 3.6%) and lipogenesis-stimulating activity (without insulin, 0.93 +/- 0.17, with insulin 2.96 +/- 0.31 nmol/min per mg). Mannose 64-71 insulin Homo sapiens 198-205 8240280-9 1993 Upon insulin stimulation of fat cells in the presence of 2.5 mM mannose, the release of 3-O-methylglucose-transport-stimulating activity was detected (for purified supernatant of adipocytes without insulin, 6.9 +/- 1.12%; with insulin, 41.0 +/- 3.6%) and lipogenesis-stimulating activity (without insulin, 0.93 +/- 0.17, with insulin 2.96 +/- 0.31 nmol/min per mg). Mannose 64-71 insulin Homo sapiens 198-205 8240280-9 1993 Upon insulin stimulation of fat cells in the presence of 2.5 mM mannose, the release of 3-O-methylglucose-transport-stimulating activity was detected (for purified supernatant of adipocytes without insulin, 6.9 +/- 1.12%; with insulin, 41.0 +/- 3.6%) and lipogenesis-stimulating activity (without insulin, 0.93 +/- 0.17, with insulin 2.96 +/- 0.31 nmol/min per mg). Mannose 64-71 insulin Homo sapiens 198-205 8240280-9 1993 Upon insulin stimulation of fat cells in the presence of 2.5 mM mannose, the release of 3-O-methylglucose-transport-stimulating activity was detected (for purified supernatant of adipocytes without insulin, 6.9 +/- 1.12%; with insulin, 41.0 +/- 3.6%) and lipogenesis-stimulating activity (without insulin, 0.93 +/- 0.17, with insulin 2.96 +/- 0.31 nmol/min per mg). Mannose 64-71 insulin Homo sapiens 198-205 1322137-4 1992 A stimulatory effect on preproinsulin mRNA levels was also observed in response to mannose and to 4-methyl-2-oxopentanoate. Mannose 83-90 insulin Homo sapiens 24-37 1322137-12 1992 Other metabolites (mannose, 4-methyl-2-oxopentanoate and leucine plus glutamine) were also able to increase insulin promoter-driven CAT expression, but galactose and arginine were ineffective. Mannose 19-26 insulin Homo sapiens 108-115 1657953-9 1991 The mutation impairs several steps in the post-translational processing of the insulin receptor:dimerization of 190-kDa proreceptors into a disulfide linked species, proteolytic cleavage of the proreceptor into alpha- and beta-subunits, and terminal processing of the high mannose form of N-linked oligosaccharide into complex carbohydrate. Mannose 273-280 insulin Homo sapiens 79-86 1596516-7 1992 The carbohydrate insulin secretagogues mannose and D-glyceraldehyde have also been found to induce islet PGE2 release, but the non-secretagogue carbohydrates L-glucose and lactate do not. Mannose 39-46 insulin Homo sapiens 17-24 2158304-0 1990 Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Mannose 0-7 insulin Homo sapiens 71-78 1673444-3 1991 Glucose and mannose are well-known stimuli of insulin release in mammals and fish. Mannose 12-19 insulin Homo sapiens 46-53 2158304-20 1990 (3) The observation that mannose, inositol monophosphate and glucosamine block the action of insulin of on lipogenesis supports a role of mannose- and glucosamine-containing IP-oligosaccharides as second messengers for this insulin effect. Mannose 25-32 insulin Homo sapiens 93-100 2158304-20 1990 (3) The observation that mannose, inositol monophosphate and glucosamine block the action of insulin of on lipogenesis supports a role of mannose- and glucosamine-containing IP-oligosaccharides as second messengers for this insulin effect. Mannose 25-32 insulin Homo sapiens 224-231 2158304-20 1990 (3) The observation that mannose, inositol monophosphate and glucosamine block the action of insulin of on lipogenesis supports a role of mannose- and glucosamine-containing IP-oligosaccharides as second messengers for this insulin effect. Mannose 138-145 insulin Homo sapiens 93-100 2158304-15 1990 We also found that the effect of insulin on lipogenesis was blocked by mannose, glucosamine and inositol monophosphate, whereas the insulin effects on 3-O-methylglucose, cyclic AMP and lipolysis were unaffected. Mannose 71-78 insulin Homo sapiens 33-40 4031068-3 1985 From 6 to 22 h, there was a progressive increase in the incorporation of [3H]mannose into the insulin proreceptor (190,000 mol wt) and the mature subunits (210,000, 135,000, and 95,000 mol wt). Mannose 77-84 insulin Homo sapiens 94-101 2654926-0 1989 Effects of mannose and fructose on the synthesis and secretion of insulin. Mannose 11-18 insulin Homo sapiens 66-73 3305909-9 1987 Insulin proreceptor, a 210 kDa high-mannose glycopolypeptide, acquires insulin binding function (t1/2 approximately equal to 45 min) then is proteolytically cleaved (t1/2 approximately equal to 3 hr) into subunits of the mature alpha 2 beta 2 receptor. Mannose 36-43 insulin Homo sapiens 0-7 34800594-1 2022 BACKGROUND: High mannose has previously associated with insulin resistance and cardiovascular disease (CVD). Mannose 17-24 insulin Homo sapiens 56-63 3052595-7 1988 Insulin also enhanced mannose metabolism. Mannose 22-29 insulin Homo sapiens 0-7 3296597-6 1987 The result showed that insulin, 200 mU/l, induced a shift in composition of neutral sugars by decreasing the amount of galactose relative to glucose and mannose. Mannose 153-160 insulin Homo sapiens 23-30 3529502-2 1986 Insulin release from the isolated islets was 26.2 microU/5 islets/hr in carbohydrate-free medium and increased by the addition of D-glucose or D-mannose. Mannose 143-152 insulin Homo sapiens 0-7 3899013-1 1985 Homogenates of insulin-producing tumoral cells catalyzed the phosphorylation of glucose, mannose, and fructose. Mannose 89-96 insulin Homo sapiens 15-22 6998814-6 1980 Insulin secretion was also stimulated by mannose, leucine, alpha-ketoisocaproate, dihydroxyacetone and 3-hydroxybutyrate, but not by fructose or N-acetyl-glucosamine. Mannose 41-48 insulin Homo sapiens 0-7 33151749-8 2021 It can be concluded that the improvement in obesity complications including insulin resistance in obese adolescent boys after CRT may be due to decrease in plasma levels of mannose and BCAAs and increase urinary metabolites. Mannose 173-180 insulin Homo sapiens 76-83 389723-2 1979 Insulin release and synthesis were stimulated by glucose or mannose but not by allose, altrose, gulose, idose, galactose or talose. Mannose 60-67 insulin Homo sapiens 0-7 5366873-0 1969 [Effects of mannose on insulin secretion]. Mannose 12-19 insulin Homo sapiens 23-30 32981293-5 2020 For example, increased plasma mannose levels due to decreased uptake in the liver have been identified as a potential biomarker of early insulin resistance by multi-omics approaches. Mannose 30-37 insulin Homo sapiens 137-144