PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34742949-3 2022 Cell culture and in vitro studies show that fenretinide binds and inhibits the activity of beta-carotene oxygenase 1 (BCO1), the enzyme responsible for endogenous vitamin A formation. Vitamin A 163-172 beta-carotene oxygenase 1 Mus musculus 91-116 33631212-4 2021 The homeodomain transcription factor ISX controls the activity of the vitamin A-forming enzyme BCO1 in intestinal enterocytes in response to increasing concentration of the vitamin A metabolite retinoic acid. Vitamin A 70-79 beta-carotene oxygenase 1 Mus musculus 95-99 33631212-4 2021 The homeodomain transcription factor ISX controls the activity of the vitamin A-forming enzyme BCO1 in intestinal enterocytes in response to increasing concentration of the vitamin A metabolite retinoic acid. Vitamin A 173-182 beta-carotene oxygenase 1 Mus musculus 95-99 32433733-4 2020 OBJECTIVE: The objective of this study was to determine the impact of dietary beta-carotene and the activity of beta-carotene oxygenase 1 (BCO1), which is the enzyme responsible for the conversion of beta-carotene to vitamin A, on circulating cholesterol concentration. Vitamin A 217-226 beta-carotene oxygenase 1 Mus musculus 112-137 32433733-8 2020 Our results in the UP AMIGOS cohort show that the rs6564851 allele of BCO1, which has been linked to BCO1 enzymatic activity, was associated with a reduction in 10 mg/dL total cholesterol concentrations (P = 0.009) when adjusted for vitamin A and carotenoid intakes. Vitamin A 233-242 beta-carotene oxygenase 1 Mus musculus 70-74 32433733-8 2020 Our results in the UP AMIGOS cohort show that the rs6564851 allele of BCO1, which has been linked to BCO1 enzymatic activity, was associated with a reduction in 10 mg/dL total cholesterol concentrations (P = 0.009) when adjusted for vitamin A and carotenoid intakes. Vitamin A 233-242 beta-carotene oxygenase 1 Mus musculus 101-105 32433733-10 2020 CONCLUSIONS: Overall, our results in mice and young adults show that BCO1 activity impacts circulating cholesterol concentration, linking vitamin A formation with the risk of developing ASCVD. Vitamin A 138-147 beta-carotene oxygenase 1 Mus musculus 69-73 25602705-1 2015 In mammals, beta-carotene-15,15"-oxygenase (BCO1) is the main enzyme that cleaves beta-carotene, the most abundant vitamin A precursor, to generate retinoids (vitamin A derivatives), both in adult and developing tissues. Vitamin A 115-124 beta-carotene oxygenase 1 Mus musculus 12-42 31212314-1 2019 BACKGROUND: beta-Cryptoxanthin (BCX), a provitamin A carotenoid shown to protect against nonalcoholic fatty liver disease (NAFLD), can be cleaved by beta-carotene-15,15"-oxygenase (BCO1) to generate vitamin A, and by beta-carotene-9",10"-oxygenase (BCO2) to produce bioactive apo-carotenoids. Vitamin A 43-52 beta-carotene oxygenase 1 Mus musculus 181-185 31891208-1 2020 SCOPE: beta-Cryptoxanthin (BCX) can be cleaved by both beta-carotene 15,15"-oxygenase (BCO1) and beta-carotene 9",10"-oxygenase (BCO2), generating biological active vitamin A and apocarotenoids. Vitamin A 165-174 beta-carotene oxygenase 1 Mus musculus 87-91 25602705-1 2015 In mammals, beta-carotene-15,15"-oxygenase (BCO1) is the main enzyme that cleaves beta-carotene, the most abundant vitamin A precursor, to generate retinoids (vitamin A derivatives), both in adult and developing tissues. Vitamin A 115-124 beta-carotene oxygenase 1 Mus musculus 44-48 25602705-1 2015 In mammals, beta-carotene-15,15"-oxygenase (BCO1) is the main enzyme that cleaves beta-carotene, the most abundant vitamin A precursor, to generate retinoids (vitamin A derivatives), both in adult and developing tissues. Vitamin A 159-168 beta-carotene oxygenase 1 Mus musculus 12-42 25602705-1 2015 In mammals, beta-carotene-15,15"-oxygenase (BCO1) is the main enzyme that cleaves beta-carotene, the most abundant vitamin A precursor, to generate retinoids (vitamin A derivatives), both in adult and developing tissues. Vitamin A 159-168 beta-carotene oxygenase 1 Mus musculus 44-48 25260612-4 2014 Surprisingly, Bco1(-/-) mice had an increase in heart levels of retinol, nonesterified fatty acids, and ceramides and a decrease in heart triglycerides. Vitamin A 64-71 beta-carotene oxygenase 1 Mus musculus 14-18 18093975-0 2008 Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15"-monooxygenase (Bcmo1) expression. Vitamin A 39-48 beta-carotene oxygenase 1 Mus musculus 77-111 20372966-6 2010 Supported by metabolite and gene-expression data, we hypothesize that the increased inflammatory response is due to an altered BC metabolism, resulting in an increased vitamin A requirement in Bcmo1 (-/-) mice. Vitamin A 168-177 beta-carotene oxygenase 1 Mus musculus 193-198 18295589-4 2008 Our studies suggest that cellular retinol-binding protein, type I (RBP1) acts as an intracellular sensor of retinoid status that, when present as apo-RBP1, stimulates BCMO1 activity and the conversion of carotenoids to retinoids. Vitamin A 34-41 beta-carotene oxygenase 1 Mus musculus 167-172 18093975-4 2008 Quantitative mRNA expression profiling of duodenum and jejunum showed that beta-carotene 15,15"-monooxygenase (EC1.14.99.36 Bcmo1) and the class B type I scavenger receptor, which are involved in vitamin A synthesis and carotenoid uptake, respectively, were drastically increased in IsxLacZ/LacZ mice. Vitamin A 196-205 beta-carotene oxygenase 1 Mus musculus 75-109 18093975-8 2008 These data suggest that Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine. Vitamin A 63-72 beta-carotene oxygenase 1 Mus musculus 98-103 21285397-9 2011 Finally, we demonstrate unequivocally that beta-carotene can serve as an alternative vitamin A source for the in situ synthesis of retinoids in developing tissues by the action of CMOI. Vitamin A 85-94 beta-carotene oxygenase 1 Mus musculus 180-184 20962153-2 2010 Carotene-15,15"-monooxygenase (CMO-I) primarily centrally cleaves beta,beta-carotene to form vitamin A. Vitamin A 93-102 beta-carotene oxygenase 1 Mus musculus 31-36 20003456-1 2009 BACKGROUND: beta-carotene 15,15"-monooxygenase (BCMO1) catalyzes the crucial first step in vitamin A biosynthesis in animals. Vitamin A 91-100 beta-carotene oxygenase 1 Mus musculus 12-46 20003456-1 2009 BACKGROUND: beta-carotene 15,15"-monooxygenase (BCMO1) catalyzes the crucial first step in vitamin A biosynthesis in animals. Vitamin A 91-100 beta-carotene oxygenase 1 Mus musculus 48-53 19022959-1 2008 15,15"-carotenoid monooxygenase (CMO I) is generally recognized as the central carotenoid cleavage enzyme responsible for converting provitamin A carotenoids to vitamin A, while having little affinity for nonprovitamin A carotenoids, such as lycopene. Vitamin A 136-145 beta-carotene oxygenase 1 Mus musculus 33-38 19022959-5 2008 CMO I KO mice fed beta-carotene (betaC-KO) had significantly lower hepatic vitamin A concentrations (17% of WT mice fed beta-carotene [betaC-WT]). Vitamin A 75-84 beta-carotene oxygenase 1 Mus musculus 0-5 19022959-8 2008 In conclusion, CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels. Vitamin A 47-56 beta-carotene oxygenase 1 Mus musculus 15-20 18093975-0 2008 Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15"-monooxygenase (Bcmo1) expression. Vitamin A 39-48 beta-carotene oxygenase 1 Mus musculus 113-118 17855355-8 2007 Even on a vitamin A-sufficient chow, CMO1(-/-) mice developed a fatty liver and displayed altered serum lipid levels with elevated serum unesterified fatty acids. Vitamin A 10-19 beta-carotene oxygenase 1 Mus musculus 37-41 12759335-1 2003 Beta-carotene 15,15"-monooxygenase (BCM) catalyzes the first step of vitamin A biosynthesis from provitamin A carotenoids. Vitamin A 69-78 beta-carotene oxygenase 1 Mus musculus 0-34 12759335-1 2003 Beta-carotene 15,15"-monooxygenase (BCM) catalyzes the first step of vitamin A biosynthesis from provitamin A carotenoids. Vitamin A 69-78 beta-carotene oxygenase 1 Mus musculus 36-39 12759335-1 2003 Beta-carotene 15,15"-monooxygenase (BCM) catalyzes the first step of vitamin A biosynthesis from provitamin A carotenoids. Vitamin A 97-109 beta-carotene oxygenase 1 Mus musculus 0-34 12759335-1 2003 Beta-carotene 15,15"-monooxygenase (BCM) catalyzes the first step of vitamin A biosynthesis from provitamin A carotenoids. Vitamin A 97-109 beta-carotene oxygenase 1 Mus musculus 36-39 12506054-1 2003 PURPOSE: Beta-carotene 15,15" monooxygenase (beta-CM) catalyzes the central cleavage of beta-carotene to all-trans-retinal, the first step in vitamin A synthesis. Vitamin A 142-151 beta-carotene oxygenase 1 Mus musculus 45-52 17855355-11 2007 Thus, our study identifies CMO1 as the key enzyme for vitamin A production and provides evidence for a role of carotenoids as more general regulators of lipid metabolism. Vitamin A 54-63 beta-carotene oxygenase 1 Mus musculus 27-31 12506054-1 2003 PURPOSE: Beta-carotene 15,15" monooxygenase (beta-CM) catalyzes the central cleavage of beta-carotene to all-trans-retinal, the first step in vitamin A synthesis. Vitamin A 142-151 beta-carotene oxygenase 1 Mus musculus 9-43