PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11959987-5 2002 Adh3 null mutant mice exhibit reduced RA generation in vivo, growth deficiency that can be rescued by retinol supplementation, and completely penetrant postnatal lethality during vitamin A deficiency. Vitamin A 102-109 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 0-4 12604205-3 2003 Mouse genetic studies support a role for cytosolic alcohol dehydrogenases (ADH) in the first step (oxidation of retinol to retinaldehyde) and a role for cytosolic retinaldehyde dehydrogenases (RALDH) in the second step (oxidation of retinaldehyde to RA). Vitamin A 112-119 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 75-78 12604205-4 2003 Mice lacking ADH3 have reduced survival and a growth defect that can be rescued by dietary retinol supplementation, whereas the effect of a loss of ADH1 or ADH4 is noticed only in mice subjected to vitamin A excess or deficiency, respectively. Vitamin A 91-98 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 13-17 12604205-8 2003 Collectively, these genetic findings indicate that metabolism of retinol to retinaldehyde is not tissue-restricted as it is catalyzed by ubiquitously-expressed ADH3 (a low activity form) as well as by tissue-specifically expressed ADH1 and ADH4 (high activity forms). Vitamin A 65-72 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 160-164 12027900-0 2002 Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3. Vitamin A 10-19 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 99-103 12027900-3 2002 Following an acute dose of retinol (50 mg.kg(-1)), metabolism of retinol to retinoic acid in liver was reduced 10-fold in Adh1 mutants and 3.8-fold in Adh3 mutants, but was not significantly reduced in Adh4 mutants. Vitamin A 27-34 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 151-155 12027900-3 2002 Following an acute dose of retinol (50 mg.kg(-1)), metabolism of retinol to retinoic acid in liver was reduced 10-fold in Adh1 mutants and 3.8-fold in Adh3 mutants, but was not significantly reduced in Adh4 mutants. Vitamin A 65-72 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 151-155 12027900-4 2002 Acute retinol toxicity, assessed by determination of the LD(50) value, was greatly increased in Adh1 mutants and moderately increased in Adh3 mutants, but only a minor effect was observed in Adh4 mutants. Vitamin A 6-13 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 137-141 12027900-5 2002 When mice were propagated for one generation on a retinol-supplemented diet containing 10-fold higher vitamin A than normal, Adh3 and Adh4 mutants had essentially the same postnatal survival to adulthood as wild-type (92-95%), but only 36% of Adh1 mutants survived to adulthood with the remainder dying by postnatal day 3. Vitamin A 50-57 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 125-129 11959987-6 2002 ADH3 was also shown to have in vitro retinol oxidation activity. Vitamin A 37-44 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 0-4 10402668-1 1999 Adh4, a member of the mouse alcohol dehydrogenase (ADH) gene family, encodes an enzyme that functions in vitro as a retinol dehydrogenase in the conversion of retinol to retinoic acid, an important developmental signaling molecule. Vitamin A 116-123 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 51-54 10358022-2 1999 Targeting of mouse alcohol dehydrogenase genes Adh1, Adh3, and Adh4 resulted in null mutant mice that all developed and reproduced apparently normally but differed markedly in clearance of ethanol and formaldehyde plus metabolism of retinol to the signaling molecule retinoic acid. Vitamin A 233-240 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 53-57 10402668-9 1999 These findings demonstrate that another retinol dehydrogenase can compensate for a lack of Adh4 when vitamin A is sufficient, but that Adh4 helps optimize retinol utilization under conditions of both retinol deficiency and excess. Vitamin A 101-110 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 40-61 9097017-3 1997 Previous studies in mouse skin have shown that retinol oxidation is catalyzed by a cytosolic retinol dehydrogenase that may be a member of the alcohol dehydrogenase (ADH) enzyme family. Vitamin A 47-54 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 93-114 9202249-1 1997 Retinoid signaling requires the conversion of retinol to retinoic acid by a two-step process, the first of which can be catalyzed in vitro by class I and class IV alcohol dehydrogenases (ADH). Vitamin A 46-53 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 187-190 9733106-2 1998 Alcohol dehydrogenases ADH1 (class I ADH) and ADH4 (class IV ADH) function as retinol dehydrogenases in the oxidation of retinol, a necessary step in the synthesis of retinoic acid from vitamin A. Vitamin A 78-85 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 58-64 9733106-2 1998 Alcohol dehydrogenases ADH1 (class I ADH) and ADH4 (class IV ADH) function as retinol dehydrogenases in the oxidation of retinol, a necessary step in the synthesis of retinoic acid from vitamin A. Vitamin A 186-195 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 58-64 9097017-3 1997 Previous studies in mouse skin have shown that retinol oxidation is catalyzed by a cytosolic retinol dehydrogenase that may be a member of the alcohol dehydrogenase (ADH) enzyme family. Vitamin A 47-54 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 166-169 9097017-4 1997 Analysis of the ADH family has shown that class IV ADH is the most efficient isozyme for retinol oxidation but that other isozymes can catalyze this reaction. Vitamin A 89-96 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 16-19 9097017-4 1997 Analysis of the ADH family has shown that class IV ADH is the most efficient isozyme for retinol oxidation but that other isozymes can catalyze this reaction. Vitamin A 89-96 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 48-54 9002638-3 1997 Here we have examined mouse testis and epididymis for the presence of endogenous retinoic acid and for the expression of genes encoding class I and class IV alcohol dehydrogenases (ADH), both of which catalyze retinol oxidation, the rate-limiting step in the conversion of retinol to retinoic acid. Vitamin A 210-217 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 181-184 9002638-3 1997 Here we have examined mouse testis and epididymis for the presence of endogenous retinoic acid and for the expression of genes encoding class I and class IV alcohol dehydrogenases (ADH), both of which catalyze retinol oxidation, the rate-limiting step in the conversion of retinol to retinoic acid. Vitamin A 273-280 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 181-184 8621625-2 1996 Some members of the alcohol dehydrogenase (ADH) family catalyze retinol oxidation, the rate-limiting step in RA synthesis. Vitamin A 64-71 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 43-46 8801166-2 1996 The rate-limiting step in RA synthesis is the oxidation of retinol, a reaction that can be catalyzed by alcohol dehydrogenase (ADH). Vitamin A 59-66 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 127-130 8801166-3 1996 Ethanol is also a substrate for ADH, and high levels of ethanol inhibit ADH-catalyzed retinol oxidation. Vitamin A 86-93 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 32-35 8801166-3 1996 Ethanol is also a substrate for ADH, and high levels of ethanol inhibit ADH-catalyzed retinol oxidation. Vitamin A 86-93 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 72-75 8801166-8 1996 Thus, the observed ethanol-induced reduction in RA may be caused by ethanol inhibition of retinol oxidation catalyzed by class IV ADH. Vitamin A 90-97 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 127-133 21515404-2 2012 The first step of RA synthesis is controlled by enzymes of the alcohol dehydrogenase (ADH) and retinol dehydrogenase (RDH) families that catalyze oxidation of retinol to retinaldehyde. Vitamin A 95-102 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 118-121 26024318-5 2015 To inhibit ADH3-mediated retinol metabolism, 10 mug 4-methylpyrazole (4-MP)/g of body weight was administered to mice treated with CCl4 or subjected to BDL. Vitamin A 25-32 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 11-15 26024318-14 2015 Therefore, retinol and its metabolizing enzyme, ADH3, might be potential targets for therapeutic intervention of liver fibrosis. Vitamin A 11-18 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 48-52 24668648-4 2014 Among several retinol metabolizing enzymes, only alcohol dehydrogenase (ADH) 3 expression was detected in isolated HSCs and NK cells, whereas hepatocytes express all of them. Vitamin A 14-21 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 49-78 26537191-1 2015 Retinols are metabolized into retinoic acids by alcohol dehydrogenase (ADH) and retinaldehyde dehydrogenase (Raldh). Vitamin A 0-8 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 71-74 26537191-6 2015 Blockade of retinol metabolism in mice given 4-methylpyrazole, an inhibitor of ADH, and ablated Raldh1 gene manifested increased migration of Tregs, eventually protected against Con A-mediated hepatitis by decreasing interferon-gamma in T cells. Vitamin A 12-19 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 79-82 23765990-2 2013 RA is produced from metabolism of retinol to retinaldehyde by retinol dehydrogenase (RDH), followed by metabolism of retinaldehyde to RA by retinaldehyde dehydrogenase (RALDH). Vitamin A 34-41 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 62-83 23765990-2 2013 RA is produced from metabolism of retinol to retinaldehyde by retinol dehydrogenase (RDH), followed by metabolism of retinaldehyde to RA by retinaldehyde dehydrogenase (RALDH). Vitamin A 34-41 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 85-88 21515404-6 2012 ADH knockouts have demonstrated a postnatal role for this enzyme family in clearance of excess retinol to prevent vitamin A toxicity and in generation of RA for postnatal survival during vitamin A deficiency. Vitamin A 95-102 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 0-3 21515404-6 2012 ADH knockouts have demonstrated a postnatal role for this enzyme family in clearance of excess retinol to prevent vitamin A toxicity and in generation of RA for postnatal survival during vitamin A deficiency. Vitamin A 114-123 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 0-3 21515404-6 2012 ADH knockouts have demonstrated a postnatal role for this enzyme family in clearance of excess retinol to prevent vitamin A toxicity and in generation of RA for postnatal survival during vitamin A deficiency. Vitamin A 187-196 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 0-3 17197514-9 2007 However, all-trans retinol, which is the product of action by the enzyme retinol dehydrogenase on all-trans retinal, was not toxic. Vitamin A 19-26 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 73-94 22319578-5 2012 The first requires retinol dehydrogenase (RDH) activity to oxidize Vitamin A (retinol) to retinal, and the second requires retinaldehyde activity (RALDH) to oxidize retinal into RA. Vitamin A 67-76 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 19-40 22319578-5 2012 The first requires retinol dehydrogenase (RDH) activity to oxidize Vitamin A (retinol) to retinal, and the second requires retinaldehyde activity (RALDH) to oxidize retinal into RA. Vitamin A 67-76 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 42-45 22319578-5 2012 The first requires retinol dehydrogenase (RDH) activity to oxidize Vitamin A (retinol) to retinal, and the second requires retinaldehyde activity (RALDH) to oxidize retinal into RA. Vitamin A 19-26 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 42-45 22319578-14 2012 These data demonstrate that RDH10 plays a critical role in mediating the rate limiting RDH step of Vitamin A metabolism and functions as a nodal point in feedback regulation of RA synthesis. Vitamin A 99-108 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Mus musculus 28-31