PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7036172-1 1981 Serum vitamin A levels were high in haemodialysis patients, and were found to correlate with plasma calcium, triglyceride, cholesterol and insulin levels. Vitamin A 6-15 insulin Homo sapiens 139-146 35425797-8 2022 Mediation analysis showed that increased homeostasis model assessment - insulin resistance HOMA-IR, triglycerides (TG), and serum xanthine oxidase (XO) activity could account for 8.5, 14.7, and 12.1% of the total effects of serum retinol on type 2 diabetes, respectively. Vitamin A 230-237 insulin Homo sapiens 72-79 35425797-11 2022 Overall, elevated serum retinol might increase the risk of type 2 diabetes which is mainly mediated by increased insulin resistance, TG, or serum XO activity. Vitamin A 24-31 insulin Homo sapiens 113-120 35015002-8 2022 Path analyses showed that vitamin A was positively associated with the serum retinol-binding protein 4, triglycerides, insulin resistance, and body mass index (standardized beta 0.065-0.304, all p < 0.001), and all of these factors positively correlated with the prevalence and progression of NAFLD (standardized beta 0.045-0.384, all p < 0.01). Vitamin A 26-35 insulin Homo sapiens 119-126 35015002-9 2022 Conclusions: A higher serum vitamin A concentration was associated with NAFLD progression, which might be mediated by increases in the serum retinol-binding protein 4, triglycerides, insulin resistance, and body mass index. Vitamin A 28-37 insulin Homo sapiens 183-190 30773418-10 2019 These results indicate that a low saturation of RBP4 with retinol, which implies a higher concentration of free-RBP4, may preserve the antilipolytic function of insulin in adipose tissue in children with obesity. Vitamin A 58-65 insulin Homo sapiens 161-168 31956345-0 2020 Changes of serum retinol-binding protein 4 associated with improved insulin resistance after laparoscopic sleeve gastrectomy in Chinese obese patients. Vitamin A 17-24 insulin Homo sapiens 68-75 31956345-1 2020 Background: Serum retinol-binding protein 4 (RBP4) plays a critical role in insulin resistance. Vitamin A 18-25 insulin Homo sapiens 76-83 30882700-1 2019 Cell and animal experiments have found that in addition to being a retinol transporter, Stimulated by Retinoic Acid 6 (STRA6) also functions as a surface signaling receptor by which retinol regulates insulin responses. Vitamin A 67-74 insulin Homo sapiens 200-207 376383-1 1979 Effects of retinol on insulin release and islet ultrastructure. Vitamin A 11-18 insulin Homo sapiens 22-29 33499915-13 2021 CONCLUSIONS: Present study showed that high adherence to a nutrient pattern rich in vitamin A, vitamin C, pyridoxine, potassium, and fructose is inversely associated with 3-years changes in insulin, HOMA-IR, and directly associated with HOMA-S. Vitamin A 84-93 insulin Homo sapiens 190-197 33364042-8 2021 Although vitamin A needs dose moderation, these results suggest that, high-dose vitamin A plus E supplementation combined with zinc may improve glycemic control, beta-cell function, and insulin secretion in adults with T2DM. Vitamin A 80-89 insulin Homo sapiens 186-193 31697447-6 2019 Vitamin A modulates activities at the cellular level and, via its interrelationship with hormones such as thyroid, insulin, and corticosteroids, has diffuse metabolic effects on the body. Vitamin A 0-9 insulin Homo sapiens 115-122 30773418-11 2019 CONCLUSION: Our findings suggest that, in prepubertal children with obesity and insulin resistance, the amount of RBP4/retinol correlates with the antilipolytic response of the adipose tissue to insulin rather than the total RBP4 concentration. Vitamin A 119-126 insulin Homo sapiens 80-87 30773418-11 2019 CONCLUSION: Our findings suggest that, in prepubertal children with obesity and insulin resistance, the amount of RBP4/retinol correlates with the antilipolytic response of the adipose tissue to insulin rather than the total RBP4 concentration. Vitamin A 119-126 insulin Homo sapiens 195-202 28651670-0 2017 Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance. Vitamin A 15-24 insulin Homo sapiens 79-86 23936766-0 2013 Serum Retinol and Carotenoids in Association with Biomarkers of Insulin Resistance among Premenopausal Women. Vitamin A 6-13 insulin Homo sapiens 64-71 26962819-1 2016 Insulin resistance (IR) is found in chronic hepatitis C (CHC) more frequently than in other chronic liver diseases.Prospective cross-sectional study to evaluate a wide multitest panel to identify factors related with IR in CHC and their possible interactions.In 76 patients with CHC we performed a series of routine laboratory analysis as well as specifically designed serum biochemical tests [retinol, retinol-binding protein 4 (RBP4), 25-OH vitamin D, Vitamin E, lipopolysaccharide-binding protein (LBP), interleukin-6 (IL-6), and cystatin C]. Vitamin A 394-401 insulin Homo sapiens 0-7 24906472-9 2015 CONCLUSION: These results suggest the existence of a favourable effect of beta-carotene on insulin sensitivity in obese individuals that could involve a positive regulation of adiponectin, either directly or via its pro-vitamin A activity. Vitamin A 220-229 insulin Homo sapiens 91-98 26729422-0 2016 Vitamin A in regulation of insulin responsiveness: mini review. Vitamin A 0-9 insulin Homo sapiens 27-34 26059371-2 2015 The aim of this study was to examine the associations of serum beta-carotene and retinol concentrations with glucose and insulin concentrations. Vitamin A 81-88 insulin Homo sapiens 121-128 27335827-0 2013 Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance. Vitamin A 9-18 insulin Homo sapiens 60-67 23936766-1 2013 OBJECTIVE: The aim of this study was to investigate how serum retinol and carotenoids (beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, lycopene) are associated with biomarkers of insulin resistance. Vitamin A 62-69 insulin Homo sapiens 185-192 23936766-6 2013 RESULTS: Retinol was positively associated with HOMA-IR (beta = 0.19 (95% CI: 0.07, 0.32)) units per ug/mL increase in retinol; the relationship was driven by insulin (beta = 0.20 (95% CI: 0.08, 0.31)). Vitamin A 9-16 insulin Homo sapiens 159-166 23833574-1 2012 BACKGROUND: Retinol binding protein-4 (BP-4) a new adipocytokine, specifically binds to retinol, through experimental studies, reported its link between obesity and insulin resistance (IR). Vitamin A 88-95 insulin Homo sapiens 165-172 22431523-0 2012 Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Vitamin A 194-201 insulin Homo sapiens 35-42 18641048-1 2008 Elevated serum retinol-binding protein (RBP) concentration has been associated with obesity and insulin resistance, but accompanying retinol values have not been reported. Vitamin A 15-22 insulin Homo sapiens 96-103 21368206-0 2011 Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Vitamin A 13-22 insulin Homo sapiens 88-95 21173508-3 2011 Recently, retinol-binding protein 4 (RBP4), which carries retinol in circulation, has been shown to be a potential regulator of insulin resistance originating from adipose tissue. Vitamin A 10-17 insulin Homo sapiens 128-135 19082851-6 2009 Serum retinol binding protein 4 has been linked to insulin-resistant states, and only the CRD decreased this marker (-20%). Vitamin A 6-13 insulin Homo sapiens 51-58 19215278-10 2009 Hence, the previously reported insulin resistance in mice induced by overexpression or injection of RBP could be because of higher levels of RBP relative to retinol rather than higher total levels of RBP. Vitamin A 157-164 insulin Homo sapiens 31-38 22128213-0 2011 Correlation between vitamin A, E, coenzyme Q(10) and degree of insulin resistance in obese and non-obese subjects. Vitamin A 20-29 insulin Homo sapiens 63-70 22128213-1 2011 The aim of the present study was to investigate correlation between plasma vitamin A, vitamin E, serum coenzyme Q(10) levels and degree of insulin resistance in obese and normal weight people. Vitamin A 75-84 insulin Homo sapiens 139-146 21442217-1 2011 BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Vitamin A 90-97 insulin Homo sapiens 155-162 21368206-5 2011 The RBP-retinol/STRA6/JAK2/STAT5 signaling cascade induces the expression of STAT target genes, including suppressor of cytokine signaling 3 (SOCS3), which inhibits insulin signaling, and peroxisome proliferator-activated receptor gamma (PPARgamma), which enhances lipid accumulation. Vitamin A 8-15 insulin Homo sapiens 165-172 21368206-6 2011 These observations establish that the parental vitamin A molecule is a transcriptional regulator in its own right, reveal that the scope of biological functions of the vitamin is broader than previously suspected, and provide a rationale for understanding how RBP and retinol regulate energy homeostasis and insulin responses. Vitamin A 47-56 insulin Homo sapiens 308-315 20832065-8 2010 Changes in RBP4 saturation with retinol may link renal dysfunction and insulin resistance to atherosclerosis. Vitamin A 32-39 insulin Homo sapiens 71-78 20151940-0 2010 Effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar, insulin, apoprotein B and apoprotein A-I in patients with type I diabetes. Vitamin A 35-44 insulin Homo sapiens 91-98 19900011-1 2010 OBJECTIVE: Retinol binding protein 4 (RBP4), a specific carrier for retinol in the blood, is a novel adipokine that has been implicated in the pathophysiology of insulin resistance, and its gene expression has been associated with adipose tissue inflammation. Vitamin A 68-75 insulin Homo sapiens 162-169 19786482-0 2009 Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance. Vitamin A 74-81 insulin Homo sapiens 106-113 19786482-7 2009 This analysis reveals RetSat as a widely shared component of mechanisms involved in insulin resistance and sensitivity and adds to the growing importance of the retinol pathway in diabetes, adipogenesis and insulin resistance. Vitamin A 161-168 insulin Homo sapiens 84-91 19786482-7 2009 This analysis reveals RetSat as a widely shared component of mechanisms involved in insulin resistance and sensitivity and adds to the growing importance of the retinol pathway in diabetes, adipogenesis and insulin resistance. Vitamin A 161-168 insulin Homo sapiens 207-214 9536928-7 1998 Insulin-dependent diabetes mellitus was associated with lower retinol levels and higher levels of beta-carotene, alpha-carotene and beta-cryptoxanthin than sex-matched, first-degree relatives. Vitamin A 62-69 insulin Homo sapiens 0-7 18496666-1 2008 AIMS/HYPOTHESIS: Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. Vitamin A 72-79 insulin Homo sapiens 141-148 18430770-0 2008 Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance. Vitamin A 6-13 insulin Homo sapiens 46-53 17785917-9 2007 Retinoid, metabolities of vitamin A, and synthetic peroxisome proliferator-activated receptor (PPAR) gamma ligands, which have been used for the treatment of insulin resistance in type II diabetes mellitus, may be the important candidates as drugs not only for prevention but also for possible endocrine treatment of endometrial carcinoma. Vitamin A 26-35 insulin Homo sapiens 158-165 12591543-0 2003 Retinol and alpha-tocopherol in serum of type 1 diabetic patients with intensive insulin therapy: a long term follow-up study. Vitamin A 0-7 insulin Homo sapiens 81-88 12591543-5 2003 RESULTS: At entrance, serum retinol concentrations, but not the ratio of alpha-tocopherol to cholesterol, showed a negative correlation with increasing values of HbA1c and insulin dose, neither of which was significant in multiple regression models. Vitamin A 28-35 insulin Homo sapiens 172-179 8407170-7 1993 In conclusion, according to our findings, plasma retinol is significantly decreased in younger insulin-dependent diabetic patients while alpha-tocopherol is significantly altered in diabetic patients with nephropathy. Vitamin A 49-56 insulin Homo sapiens 95-102 8482050-0 1993 Effect of posture and acute glycaemic control on the excretion of retinol-binding protein in normoalbuminuric insulin-dependent diabetic patients. Vitamin A 66-73 insulin Homo sapiens 110-117 9437541-4 1997 There was a univariate association between vitamin A levels and insulin resistance (r = 0.164; P = 0.02) and in multivariate logistic regression analysis the relative risk of subjects with high vitamin A concentrations having IGT was 3.8 (P = 0.002). Vitamin A 43-52 insulin Homo sapiens 64-71 8644691-3 1996 An independent relation between increased intake of vitamin A and insulin action was shown, ie, the greater the intake of vitamin A, the more effective was insulin in stimulating glucose disposal. Vitamin A 52-61 insulin Homo sapiens 66-73 8644691-3 1996 An independent relation between increased intake of vitamin A and insulin action was shown, ie, the greater the intake of vitamin A, the more effective was insulin in stimulating glucose disposal. Vitamin A 52-61 insulin Homo sapiens 156-163 8644691-3 1996 An independent relation between increased intake of vitamin A and insulin action was shown, ie, the greater the intake of vitamin A, the more effective was insulin in stimulating glucose disposal. Vitamin A 122-131 insulin Homo sapiens 66-73 8644691-3 1996 An independent relation between increased intake of vitamin A and insulin action was shown, ie, the greater the intake of vitamin A, the more effective was insulin in stimulating glucose disposal. Vitamin A 122-131 insulin Homo sapiens 156-163 8644691-5 1996 These results suggest that vitamin A intake, but not intakes of vitamin C and E, fiber, fat, or carbohydrate is associated with enhanced insulin-mediated glucose disposal. Vitamin A 27-36 insulin Homo sapiens 137-144 34431270-0 2021 Serum Retinol Binding Protein-4 Levels in Prediabetics - Novel Biomarker of Insulin Resistance and Atherosclerosis. Vitamin A 6-13 insulin Homo sapiens 76-83 34440929-0 2021 The Interactions of Insulin and Vitamin A Signaling Systems for the Regulation of Hepatic Glucose and Lipid Metabolism. Vitamin A 32-41 insulin Homo sapiens 20-27 35634391-1 2022 Background: As a fat-soluble vitamin, vitamin A plays a crucial role in adipogenesis, lipolysis, insulin resistance, and obesity. Vitamin A 38-47 insulin Homo sapiens 97-104