PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8900159-1 1996 Disregulation of vitamin A metabolism is able to generate different immunological effects, including altered response to infection, reduced IgG production, and differential regulation of cytokine gene expression (including interleukin-2 and -4 and interferon-gamma (IFN-gamma)). Vitamin A 17-26 interferon gamma Homo sapiens 248-264 8900159-1 1996 Disregulation of vitamin A metabolism is able to generate different immunological effects, including altered response to infection, reduced IgG production, and differential regulation of cytokine gene expression (including interleukin-2 and -4 and interferon-gamma (IFN-gamma)). Vitamin A 17-26 interferon gamma Homo sapiens 266-275 8900159-2 1996 In particular, IFN-gamma gene expression is significantly affected by vitamin A and/or its derivatives (e.g. retinoic acid (RA)). Vitamin A 70-79 interferon gamma Homo sapiens 15-24 30473441-6 2019 RESULTS: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-gamma and T-bet) and anti-inflammatory (TGF-beta and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases. Vitamin A 260-269 interferon gamma Homo sapiens 141-150 2465168-8 1989 Furthermore, the simultaneous addition of 10(-6) M retinol partially reversed the inhibitory action of IFN-gamma on the NAP induction by G-CSF. Vitamin A 51-58 interferon gamma Homo sapiens 103-112 33377367-8 2020 Zinc supplementation increased ex-vivo IFN-gamma production, greatest amongst boys, younger (<3.5 years), normal weight and children with low baseline retinol concentration. Vitamin A 151-158 interferon gamma Homo sapiens 39-48 33377367-9 2020 Vitamin A supplementation increased IFN-gamma only in those with low baseline retinol, with no effect on serum IgG and salivary IgA. Vitamin A 0-9 interferon gamma Homo sapiens 36-45 17425177-2 2006 The objective of the present study was to analyze the serum concentration of IFN-gamma and IL-10 in anemic and non anemic children according to vitamin A nutritional status. Vitamin A 144-153 interferon gamma Homo sapiens 77-86 28730424-7 2018 After retinol stimulation, the concentration of IL-17 and IFN-gamma increased significantly in both groups. Vitamin A 6-13 interferon gamma Homo sapiens 58-67 25496023-0 2015 Whether vitamin A supplementation is effective in T-bet and IFN-gamma gene expression reduction? Vitamin A 8-17 interferon gamma Homo sapiens 60-69 25496023-1 2015 BACKGROUND: The aim of present study is evaluation of vitamin A supplementation efficacy on IFN-gamma and T-bet gene expression in atherosclerotic patients. Vitamin A 54-63 interferon gamma Homo sapiens 92-101 25496023-6 2015 RESULTS: IFN-gamma gene expression in fresh cells of patients taking vitamin A declined slightly (0.85-fold, p = 0.068), whereas the expression of this gene was increased in patients taking placebo, and in healthy control subjects 1.2-fold (p = 0.267) and 1.7-fold (p = 0.580), respectively. Vitamin A 69-78 interferon gamma Homo sapiens 9-18 25496023-10 2015 IFN-gamma gene expression in cells activated with ox-LDL in healthy control subjects and patients taking vitamin A, was reduced 0.43 (p = 0.0001) and 0.41 (p = 0.001) respectively, but in placebo patients was increased 2.2-fold (p = 0.959). Vitamin A 105-114 interferon gamma Homo sapiens 0-9 17377406-4 2007 The aim of the study was to compare the in vitro effect of vitamin A on the production of pro-inflammatory (IL-1beta and IL-6) and anti-inflammatory (IL-1 receptor antagonist (ra) and IL-10) cytokines, as well as IL-2 and IFNgamma by cord blood mononuclear cells (CBMC) of preterm newborns to that of peripheral blood mononuclear cells (PBMC) from adults. Vitamin A 59-68 interferon gamma Homo sapiens 222-230 17377406-7 2007 RESULTS: Vitamin A exerted an in vitro inhibitory effect on the production of the anti-inflammatory cytokine IL-1ra by MC of preterm newborns and adults, but did not affect the secretion of the pro-inflammatory cytokines IL-1beta, IL-6 and IFNgamma. Vitamin A 9-18 interferon gamma Homo sapiens 240-248 31084433-6 2019 Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues. Vitamin A 26-35 interferon gamma Homo sapiens 130-139 29256181-10 2018 Retinol reduced IFNgamma in GO and control fibroblasts. Vitamin A 0-7 interferon gamma Homo sapiens 16-24 28235040-11 2017 In gene expression analyses, 25(OH)D was associated with higher IL-37, vitamin A with higher IFN-gamma and vitamin E with less IL-28 (P < 0.05). Vitamin A 71-80 interferon gamma Homo sapiens 93-102 26909479-1 2016 OBJECTIVE: The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNgamma) and Treg (TGF-beta, IL-10) related cytokines in obese and non-obese women. Vitamin A 79-88 interferon gamma Homo sapiens 133-141 16734607-8 2006 Furthermore, vitamin A supplementation was significantly associated with an increased ratio of mitogen-induced proinflammatory cytokine (IFN-gamma) to anti-inflammatory cytokine (IL-10) during pregnancy and in the postpartum period. Vitamin A 13-22 interferon gamma Homo sapiens 137-146 16614431-8 2006 Vitamin A-supplemented children infected with enteropathogenic E. coli (EPEC) had reduced IL-4 and IFN-gamma levels [odds ratio (OR) = 0.3, 95% CI 0.13-0.67 and OR = 0.34, 95% CI 0.14-0.83, respectively] compared with children in the placebo group. Vitamin A 0-9 interferon gamma Homo sapiens 99-108 16614431-10 2006 In contrast, IL-4 levels increased (OR = 2.14, 95% CI 0.94-4.87) and IFN-gamma levels decreased (OR = 0.51, 95% CI 0.26-0.99) among vitamin A-supplemented children with diarrhea compared with children in the placebo group. Vitamin A 132-141 interferon gamma Homo sapiens 69-78 15162133-6 2004 Vitamin-A deficient infants had significantly reduced ex vivo production of IFN-gamma, but also significantly higher circulating neopterin concentrations. Vitamin A 0-9 interferon gamma Homo sapiens 76-85 12766968-9 2003 Using this assay, we identified several new Pgp substrates, including monensin and retinol, and confirmed that interleukin-2 and interferon-gamma can be transported by Pgp. Vitamin A 83-90 interferon gamma Homo sapiens 129-145 15719622-6 2003 After surgery, chemotherapy for 3 cycles and oral vitamin-A, a sharp reduction in telomerase activity and serum IFN-gamma levels was observed in all groups of patients compared to the controls. Vitamin A 50-59 interferon gamma Homo sapiens 112-121 15719622-10 2003 In contrast, negative correlations were observed between serum levels of vitamin-A and telomerase activity and serum levels of IFN-gamma (P < 0.01). Vitamin A 73-82 interferon gamma Homo sapiens 127-136 9797646-1 1998 Excessive interferon-gamma (IFN-gamma) production appears to be a primary immunological lesion in vitamin A-deficient experimental animals but comparable data from humans is lacking. Vitamin A 98-107 interferon gamma Homo sapiens 10-26 9797646-1 1998 Excessive interferon-gamma (IFN-gamma) production appears to be a primary immunological lesion in vitamin A-deficient experimental animals but comparable data from humans is lacking. Vitamin A 98-107 interferon gamma Homo sapiens 28-37 9649586-0 1998 Vitamin A is required for regulation of polymeric immunoglobulin receptor (pIgR) expression by interleukin-4 and interferon-gamma in a human intestinal epithelial cell line. Vitamin A 0-9 interferon gamma Homo sapiens 113-129 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Vitamin A 39-48 interferon gamma Homo sapiens 181-197 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Vitamin A 39-48 interferon gamma Homo sapiens 199-208