PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34903070-1 2022 BACKGROUND: The study aimed to identify two beta-carotene 15,15"-monooxygenase (BCMO1) mutations, namely R267S and A379V, and determine their association with vitamin A status among Filipinos 6 to 19 years old respondents of the 2013 Philippine National Nutrition Survey living in the National Capital Region. Vitamin A 159-168 beta-carotene oxygenase 1 Homo sapiens 80-85 16186334-0 2005 beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells. Vitamin A 30-39 beta-carotene oxygenase 1 Homo sapiens 0-4 16186334-2 2005 The key step in the vitamin A biosynthetic pathway is the oxidative cleavage of beta-carotene into retinal by the enzyme beta,beta-carotene-15,15"-monooxygenase (BCO). Vitamin A 20-29 beta-carotene oxygenase 1 Homo sapiens 80-84 16186334-2 2005 The key step in the vitamin A biosynthetic pathway is the oxidative cleavage of beta-carotene into retinal by the enzyme beta,beta-carotene-15,15"-monooxygenase (BCO). Vitamin A 20-29 beta-carotene oxygenase 1 Homo sapiens 121-160 16186334-2 2005 The key step in the vitamin A biosynthetic pathway is the oxidative cleavage of beta-carotene into retinal by the enzyme beta,beta-carotene-15,15"-monooxygenase (BCO). Vitamin A 20-29 beta-carotene oxygenase 1 Homo sapiens 162-165 16504037-2 2006 beta, beta-carotene 15,15"-monooxygenase 1 (BCMO1) catalyzes the central cleavage of beta-carotene to all-trans retinal and is the key enzyme in the intestinal metabolism of carotenes to vitamin A. Vitamin A 187-196 beta-carotene oxygenase 1 Homo sapiens 0-42 16504037-2 2006 beta, beta-carotene 15,15"-monooxygenase 1 (BCMO1) catalyzes the central cleavage of beta-carotene to all-trans retinal and is the key enzyme in the intestinal metabolism of carotenes to vitamin A. Vitamin A 187-196 beta-carotene oxygenase 1 Homo sapiens 44-49 15983114-1 2005 The symmetrically cleaving beta-carotene 15,15"-monooxygenase (BCO1) catalyzes the first step in the conversion of provitamin A carotenoids to vitamin A in the mucosa of the small intestine. Vitamin A 118-127 beta-carotene oxygenase 1 Homo sapiens 63-67 16186334-6 2005 The conversion of beta-carotene to retinoids was determined by measuring retinol levels in D407 cells on beta-carotene supplementation. Vitamin A 73-80 beta-carotene oxygenase 1 Homo sapiens 18-22 16186334-13 2005 Furthermore, D407 cells took up beta-carotene in a time-dependent manner and converted it to retinol. Vitamin A 93-100 beta-carotene oxygenase 1 Homo sapiens 32-36 16186334-14 2005 CONCLUSIONS: The results suggest that BCO is expressed in the RPE and that beta-carotene can be metabolized into retinol. Vitamin A 113-120 beta-carotene oxygenase 1 Homo sapiens 75-79 15034000-3 2004 Epithelia in general are structures that are very sensitive to vitamin A deficiency, and although the extraintestinal function of BCO1 is unclear, the finding that the enzyme is expressed in all epithelia examined thus far leads us to suggest that BCO1 may be important for local synthesis of vitamin A, constituting a back-up pathway of vitamin A synthesis during times of insufficient dietary intake of vitamin A. Vitamin A 293-302 beta-carotene oxygenase 1 Homo sapiens 248-252 15034000-3 2004 Epithelia in general are structures that are very sensitive to vitamin A deficiency, and although the extraintestinal function of BCO1 is unclear, the finding that the enzyme is expressed in all epithelia examined thus far leads us to suggest that BCO1 may be important for local synthesis of vitamin A, constituting a back-up pathway of vitamin A synthesis during times of insufficient dietary intake of vitamin A. Vitamin A 293-302 beta-carotene oxygenase 1 Homo sapiens 248-252 11960992-1 2002 Beta-carotene 15,15"-monooxygenase (BCO), formerly known as beta-carotene 15,15"-dioxygenase, catalyzes the first step in the synthesis of vitamin A from dietary carotenoids. Vitamin A 139-148 beta-carotene oxygenase 1 Homo sapiens 0-34 11960992-1 2002 Beta-carotene 15,15"-monooxygenase (BCO), formerly known as beta-carotene 15,15"-dioxygenase, catalyzes the first step in the synthesis of vitamin A from dietary carotenoids. Vitamin A 139-148 beta-carotene oxygenase 1 Homo sapiens 36-39 11960992-7 2002 The current data suggest that the human BCO enzyme may, in addition to its well established role in the digestive system, also play a role in peripheral vitamin A synthesis from plasma-borne provitamin A carotenoids. Vitamin A 153-162 beta-carotene oxygenase 1 Homo sapiens 40-43 34742949-3 2022 Cell culture and in vitro studies show that fenretinide binds and inhibits the activity of beta-carotene oxygenase 1 (BCO1), the enzyme responsible for endogenous vitamin A formation. Vitamin A 163-172 beta-carotene oxygenase 1 Homo sapiens 118-122 31048207-2 2019 beta-carotene 15,15"-oxygenase (BCO1) is the main enzyme that catalyzes the first step in vitamin A biosynthesis from pro-vitamin A carotenoids. Vitamin A 90-99 beta-carotene oxygenase 1 Homo sapiens 0-30 34836244-4 2021 Specifically, once absorbed, carotenoids are cleaved by carotenoid cleavage oxygenases (CCOs), such as Beta-carotene 15,15"-monooxygenase (BCO1), to produce all-trans retinal that subsequently gets converted into all-trans retinol. Vitamin A 223-230 beta-carotene oxygenase 1 Homo sapiens 103-137 34836244-4 2021 Specifically, once absorbed, carotenoids are cleaved by carotenoid cleavage oxygenases (CCOs), such as Beta-carotene 15,15"-monooxygenase (BCO1), to produce all-trans retinal that subsequently gets converted into all-trans retinol. Vitamin A 223-230 beta-carotene oxygenase 1 Homo sapiens 139-143 35464265-2 2022 BCX can be metabolized through beta-carotene-15,15"-oxygenase (BCO1) and beta-carotene-9",10"-oxygenase (BCO2) cleavage pathways to produce both vitamin A and apo-carotenoids, respectively, which are considered important signaling molecules in a variety of biological processes. Vitamin A 145-154 beta-carotene oxygenase 1 Homo sapiens 63-67 35306905-2 2022 BCMO1 is expressed in various human tissues and is considered to be a key enzyme that converts BC into vitamin A. Vitamin A 103-112 beta-carotene oxygenase 1 Homo sapiens 0-5 33795317-6 2021 We also found some evidence for modification of the associations between preformed vitamin A intake and lung function by BCMO1, NCOR2 and CC16 gene polymorphisms.A higher intake of preformed vitamin A, but not beta-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma. Vitamin A 83-92 beta-carotene oxygenase 1 Homo sapiens 121-126 32963037-3 2020 Strong epidemiological data find an inverse association between plasma beta-carotene with atherosclerosis, and we recently showed that beta-carotene oxygenase 1 (BCO1) activity, responsible for beta-carotene cleavage to vitamin A, is associated with reduced plasma cholesterol in humans and mice. Vitamin A 220-229 beta-carotene oxygenase 1 Homo sapiens 135-160 32963037-3 2020 Strong epidemiological data find an inverse association between plasma beta-carotene with atherosclerosis, and we recently showed that beta-carotene oxygenase 1 (BCO1) activity, responsible for beta-carotene cleavage to vitamin A, is associated with reduced plasma cholesterol in humans and mice. Vitamin A 220-229 beta-carotene oxygenase 1 Homo sapiens 162-166 32433733-4 2020 OBJECTIVE: The objective of this study was to determine the impact of dietary beta-carotene and the activity of beta-carotene oxygenase 1 (BCO1), which is the enzyme responsible for the conversion of beta-carotene to vitamin A, on circulating cholesterol concentration. Vitamin A 217-226 beta-carotene oxygenase 1 Homo sapiens 139-143 31048207-2 2019 beta-carotene 15,15"-oxygenase (BCO1) is the main enzyme that catalyzes the first step in vitamin A biosynthesis from pro-vitamin A carotenoids. Vitamin A 90-99 beta-carotene oxygenase 1 Homo sapiens 32-36 24106281-9 2013 We also show that a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production. Vitamin A 177-186 beta-carotene oxygenase 1 Homo sapiens 50-54 29892071-4 2018 Another cleavage enzyme, beta-carotene 9",10"-oxygenase (BCO2), asymmetrically cleaves beta-carotene in adult tissues to prevent its mitochondrial toxicity, generating beta-apo-10"-carotenal, which can be converted to retinoids (vitamin A and its metabolites) by BCO1. Vitamin A 229-238 beta-carotene oxygenase 1 Homo sapiens 263-267 28732066-1 2017 beta-carotene 15,15"-oxygenase (BCO1) catalyzes the first step in the conversion of dietary provitamin A carotenoids to vitamin A. Vitamin A 95-104 beta-carotene oxygenase 1 Homo sapiens 0-30 28732066-1 2017 beta-carotene 15,15"-oxygenase (BCO1) catalyzes the first step in the conversion of dietary provitamin A carotenoids to vitamin A. Vitamin A 95-104 beta-carotene oxygenase 1 Homo sapiens 32-36 28732066-6 2017 Consequently, we investigated if GCs counteract retinoid effects in alveolar epithelial cells by mechanisms involving BCO1-dependent local vitamin A metabolism. Vitamin A 139-148 beta-carotene oxygenase 1 Homo sapiens 118-122 28732066-12 2017 Taken together, these findings provide the first evidence that GCs regulate vitamin A (retinoid) signaling via inhibition of bco1 gene expression in a PPARalpha-dependent manner. Vitamin A 76-85 beta-carotene oxygenase 1 Homo sapiens 125-129 25701869-4 2015 The BCO1 gene encodes an enzyme that is expressed in the intestine and converts provitamin A carotenoids to vitamin A-aldehyde. Vitamin A 83-92 beta-carotene oxygenase 1 Homo sapiens 4-8 25701869-7 2015 In this process, conversion of beta-carotene to vitamin A by BCO1 induces via retinoid signaling the expression of the intestinal homeobox transcription factor ISX. Vitamin A 48-57 beta-carotene oxygenase 1 Homo sapiens 61-65 25002123-2 2014 Vitamin A is produced from dietary carotenoids such as beta-carotene by centric cleavage via the enzyme BCO1. Vitamin A 0-9 beta-carotene oxygenase 1 Homo sapiens 104-108 24187135-2 2013 beta-Carotene 15,15"-oxygenase (BCO1) catalyzes the oxidative cleavage of provitamin A carotenoids at the central 15-15" double bond to yield retinal (vitamin A). Vitamin A 77-86 beta-carotene oxygenase 1 Homo sapiens 0-30 24187135-2 2013 beta-Carotene 15,15"-oxygenase (BCO1) catalyzes the oxidative cleavage of provitamin A carotenoids at the central 15-15" double bond to yield retinal (vitamin A). Vitamin A 77-86 beta-carotene oxygenase 1 Homo sapiens 32-36 24071514-1 2013 beta-Carotene 15,15"-monooxygenase (CMO1, BCMO1) converts beta-carotene to retinaldehyde (retinal) and is a key enzyme in vitamin A metabolism. Vitamin A 122-131 beta-carotene oxygenase 1 Homo sapiens 42-47 27402843-2 2016 In mammalian tissues, beta-carotene 15,15"-oxygenase (BCO1) converts beta-carotene to retinaldehyde, which is then oxidized to retinoic acid, the biologically active form of vitamin A that acts as a transcription factor ligand to regulate gene expression. Vitamin A 174-183 beta-carotene oxygenase 1 Homo sapiens 54-58 25445224-2 2014 beta-Carotene 15,15"-monooxygenase 1 (BCMO1) is a critical enzyme involved in the conversion of beta-carotene into vitamin A (retinal) in the small intestine of many vertebrates. Vitamin A 115-124 beta-carotene oxygenase 1 Homo sapiens 0-36 25445224-2 2014 beta-Carotene 15,15"-monooxygenase 1 (BCMO1) is a critical enzyme involved in the conversion of beta-carotene into vitamin A (retinal) in the small intestine of many vertebrates. Vitamin A 115-124 beta-carotene oxygenase 1 Homo sapiens 38-43 23727499-1 2013 The formal first step in in vitamin A metabolism is the conversion of its natural precursor beta,beta-carotene (C40) to retinaldehyde (C20). Vitamin A 28-37 beta-carotene oxygenase 1 Homo sapiens 92-96 23727499-1 2013 The formal first step in in vitamin A metabolism is the conversion of its natural precursor beta,beta-carotene (C40) to retinaldehyde (C20). Vitamin A 28-37 beta-carotene oxygenase 1 Homo sapiens 97-101 23727499-11 2013 Establishment of a protocol that yields highly active homogenous BCMO1 is an important step towards clarifying the lipophilic substrate interaction, reaction mechanism and structure of this vitamin A forming enzyme. Vitamin A 190-199 beta-carotene oxygenase 1 Homo sapiens 65-70 21106934-3 2011 The roles of the family members BCMO1 and RPE65 for vitamin A production and vision have been well established. Vitamin A 52-61 beta-carotene oxygenase 1 Homo sapiens 32-37 23515144-2 2013 Single-nucleotide polymorphisms (SNPs) in beta-carotene 15,15"-monooxygenase 1 (BCMO1), a gene encoding the enzyme involved in the first step of synthesizing vitamin A from dietary carotenoids, have been associated with circulating carotenoid concentrations and may serve as unconfounded surrogates for those biomarkers. Vitamin A 158-167 beta-carotene oxygenase 1 Homo sapiens 42-78 23515144-2 2013 Single-nucleotide polymorphisms (SNPs) in beta-carotene 15,15"-monooxygenase 1 (BCMO1), a gene encoding the enzyme involved in the first step of synthesizing vitamin A from dietary carotenoids, have been associated with circulating carotenoid concentrations and may serve as unconfounded surrogates for those biomarkers. Vitamin A 158-167 beta-carotene oxygenase 1 Homo sapiens 80-85 23393141-2 2013 beta-Carotene is converted to vitamin A in the intestine by the enzyme beta-carotene-15,15"-monoxygenase (BCMO1) to support vision, reproduction, immune function, and cell differentiation. Vitamin A 30-39 beta-carotene oxygenase 1 Homo sapiens 106-111 23134893-0 2012 beta-Carotene 15,15"-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of European descent. Vitamin A 106-113 beta-carotene oxygenase 1 Homo sapiens 0-36 23134893-4 2012 DESIGN: We assessed the associations between 224 SNPs in BCMO1 +- 20 kb imputed from the 1000 Genomes Project EUR reference panel with plasma carotenoid and retinol concentrations by using 7 case-control data sets (n = 2344) within the Nurses" Health Study, randomly divided into training (n = 1563) and testing (n = 781) data sets. Vitamin A 157-164 beta-carotene oxygenase 1 Homo sapiens 57-62 19103647-2 2009 Since it has been reported that the conversion of beta-carotene into vitamin A is highly variable in up to 45% of healthy individuals, we hypothesized that genetic polymorphisms in the BCMO1 gene could contribute to the occurrence of the poor converter phenotype. Vitamin A 69-78 beta-carotene oxygenase 1 Homo sapiens 185-190 20599666-1 2010 beta,beta-Carotene 15,15"-monooxygenase-1 (BCMO1) is a key enzyme in vitamin A metabolism in mammals. Vitamin A 69-78 beta-carotene oxygenase 1 Homo sapiens 0-41 20599666-1 2010 beta,beta-Carotene 15,15"-monooxygenase-1 (BCMO1) is a key enzyme in vitamin A metabolism in mammals. Vitamin A 69-78 beta-carotene oxygenase 1 Homo sapiens 43-48 20599666-3 2010 Furthermore, vitamin A deficiency has been shown to induce BCMO1 expression, whereas supplementation with vitamin A or its active metabolites, all-trans and 9-cis retinoic acid, dose-dependently reverse these effects. Vitamin A 13-22 beta-carotene oxygenase 1 Homo sapiens 59-64