PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20552430-1 2010 The retinol carrier retinol-binding protein (RBP) forms in blood a complex with the thyroid hormone carrier transthyretin (TTR). Vitamin A 4-11 transthyretin Homo sapiens 108-121 20552431-2 2010 In this assay, the intrinsic fluorescence from the RBP-retinol complex excites a probe molecule which is covalently coupled to TTR. Vitamin A 55-62 transthyretin Homo sapiens 127-130 20552431-3 2010 Generation of an emission signal from the TTR probe indicates interaction between RBP-retinol and TTR. Vitamin A 86-93 transthyretin Homo sapiens 42-45 20552431-3 2010 Generation of an emission signal from the TTR probe indicates interaction between RBP-retinol and TTR. Vitamin A 86-93 transthyretin Homo sapiens 98-101 20552431-5 2010 Thus, compounds which bind to RBP must compete with retinol in order to affect RBP-TTR interaction. Vitamin A 52-59 transthyretin Homo sapiens 83-86 20552430-1 2010 The retinol carrier retinol-binding protein (RBP) forms in blood a complex with the thyroid hormone carrier transthyretin (TTR). Vitamin A 4-11 transthyretin Homo sapiens 123-126 20552430-5 2010 The addition of TTR to the retinol-RBP complex (holoRBP) causes a marked increase in the fluorescence anisotropy of the RBP-bound retinol within the system, due to the formation of the holoRBP-TTR complex, which allows the interaction between the two proteins to be monitored. Vitamin A 27-34 transthyretin Homo sapiens 16-19 20552430-5 2010 The addition of TTR to the retinol-RBP complex (holoRBP) causes a marked increase in the fluorescence anisotropy of the RBP-bound retinol within the system, due to the formation of the holoRBP-TTR complex, which allows the interaction between the two proteins to be monitored. Vitamin A 27-34 transthyretin Homo sapiens 193-196 19665514-1 2009 Transthyretin (TTR) is a plasma protein mostly known for being the transporter of thyroxine and retinol. Vitamin A 96-103 transthyretin Homo sapiens 0-13 19922331-1 2009 Transthyretin (TTR) is a homotetrameric protein involved in thyroid hormone transport in blood and in retinol binding in the central nervous system. Vitamin A 102-109 transthyretin Homo sapiens 0-13 19922331-1 2009 Transthyretin (TTR) is a homotetrameric protein involved in thyroid hormone transport in blood and in retinol binding in the central nervous system. Vitamin A 102-109 transthyretin Homo sapiens 15-18 19665514-1 2009 Transthyretin (TTR) is a plasma protein mostly known for being the transporter of thyroxine and retinol. Vitamin A 96-103 transthyretin Homo sapiens 15-18 19401362-1 2009 CONTEXT: The serum protein transthyretin (TTR) plays an important role in the transport of thyroid hormone and retinol, which are critical for normal development of the human fetus. Vitamin A 111-118 transthyretin Homo sapiens 27-40 19401362-1 2009 CONTEXT: The serum protein transthyretin (TTR) plays an important role in the transport of thyroid hormone and retinol, which are critical for normal development of the human fetus. Vitamin A 111-118 transthyretin Homo sapiens 42-45 16702331-1 2006 The ratio of retinol-binding protein (RBP) to transthyretin (TTR) has been proposed as an indirect method with which to assess vitamin A status in the context of inflammation. Vitamin A 127-136 transthyretin Homo sapiens 43-59 18952041-6 2009 We show that retinol increases the affinity of RBP4 for TTR by a factor of 4 and determine the affinity constants of fenretinide and retinyl acetate. Vitamin A 13-20 transthyretin Homo sapiens 56-59 19682646-1 2009 Transthyretin (TTR), a plasma and cerebrospinal fluid protein secreted by the liver and choroid plexus, is mainly known as the physiological carrier of thyroxine (T(4)) and retinol. Vitamin A 173-180 transthyretin Homo sapiens 0-13 19682646-1 2009 Transthyretin (TTR), a plasma and cerebrospinal fluid protein secreted by the liver and choroid plexus, is mainly known as the physiological carrier of thyroxine (T(4)) and retinol. Vitamin A 173-180 transthyretin Homo sapiens 15-18 19183833-5 2009 Transthyretin at postoperative 28 days in group I was 15.6 +/- 6.2, higher than that in group E. Retinol-binding protein at postoperative 28 days in group I was 2.6 +/- 1.0 and also higher than that in group E. CONCLUSION: HJ with no-stented internal biliary drainage was not associated with systemic infections and mortality, but showed the possibility of improving nutritional status. Vitamin A 97-104 transthyretin Homo sapiens 0-13 19021760-1 2008 Transthyretin is a tetrameric binding protein involved in the transport of thyroid hormones and in the cotransport of retinol by forming a complex in plasma with retinol-binding protein. Vitamin A 118-125 transthyretin Homo sapiens 0-13 19021760-1 2008 Transthyretin is a tetrameric binding protein involved in the transport of thyroid hormones and in the cotransport of retinol by forming a complex in plasma with retinol-binding protein. Vitamin A 162-169 transthyretin Homo sapiens 0-13 19021760-3 2008 The main interactions, both polar and apolar, between retinol-binding protein and transthyretin involve the retinol hydroxyl group and a limited number of solvent exposed residues. Vitamin A 54-61 transthyretin Homo sapiens 82-95 19021760-6 2008 The effect is particularly evident when the mutation affects an interacting residue present in two distinct subunits of transthyretin participating simultaneously in two interactions with a retinol-binding protein molecule. Vitamin A 190-197 transthyretin Homo sapiens 120-133 19021760-8 2008 Remarkably, some of the residues in mutated human transthyretin that weaken or abolish the interaction with retinol-binding protein are present in piscine transthyretin, consistent with the lack of interaction between retinol-binding protein and transthyretin in fish. Vitamin A 108-115 transthyretin Homo sapiens 50-63 19021760-8 2008 Remarkably, some of the residues in mutated human transthyretin that weaken or abolish the interaction with retinol-binding protein are present in piscine transthyretin, consistent with the lack of interaction between retinol-binding protein and transthyretin in fish. Vitamin A 108-115 transthyretin Homo sapiens 155-168 19021760-8 2008 Remarkably, some of the residues in mutated human transthyretin that weaken or abolish the interaction with retinol-binding protein are present in piscine transthyretin, consistent with the lack of interaction between retinol-binding protein and transthyretin in fish. Vitamin A 108-115 transthyretin Homo sapiens 155-168 19021760-8 2008 Remarkably, some of the residues in mutated human transthyretin that weaken or abolish the interaction with retinol-binding protein are present in piscine transthyretin, consistent with the lack of interaction between retinol-binding protein and transthyretin in fish. Vitamin A 218-225 transthyretin Homo sapiens 50-63 16702331-10 2006 Serum retinol increased with vitamin A supplementation among those with a low RBP:TTR ratio, although the effect was small and was not present among those with concurrent inflammation. Vitamin A 6-13 transthyretin Homo sapiens 82-85 16702331-10 2006 Serum retinol increased with vitamin A supplementation among those with a low RBP:TTR ratio, although the effect was small and was not present among those with concurrent inflammation. Vitamin A 29-38 transthyretin Homo sapiens 82-85 18682830-3 2008 The known physiological functions of TTR are the transport of thyroid hormone T(4) and retinol, through binding to the retinol binding protein. Vitamin A 87-94 transthyretin Homo sapiens 37-40 18682830-3 2008 The known physiological functions of TTR are the transport of thyroid hormone T(4) and retinol, through binding to the retinol binding protein. Vitamin A 119-126 transthyretin Homo sapiens 37-40 18237193-1 2008 Transthyretin (TTR) is a 55 kDa homotetrameric protein known for the transport of thyroxine and the indirect transportation of retinol. Vitamin A 127-134 transthyretin Homo sapiens 0-13 18237193-1 2008 Transthyretin (TTR) is a 55 kDa homotetrameric protein known for the transport of thyroxine and the indirect transportation of retinol. Vitamin A 127-134 transthyretin Homo sapiens 15-18 18786882-2 2008 TTR is a normal plasma protein (previously called prealbumin) that functions as a transport protein binding tiroxine and retinol. Vitamin A 121-128 transthyretin Homo sapiens 0-3 17203960-5 2007 Besides the implementation of the previously published AF proteomic maps, our results show that transthyretin (TTR), the protein responsible for transporting both the thyroid hormone tyroxine and the retinol binding protein, is present in the AF of both preeclamptic and control women as a mixture of dimeric and post-translationally modified monomeric forms. Vitamin A 200-207 transthyretin Homo sapiens 96-109 17203960-5 2007 Besides the implementation of the previously published AF proteomic maps, our results show that transthyretin (TTR), the protein responsible for transporting both the thyroid hormone tyroxine and the retinol binding protein, is present in the AF of both preeclamptic and control women as a mixture of dimeric and post-translationally modified monomeric forms. Vitamin A 200-207 transthyretin Homo sapiens 111-114 16702331-1 2006 The ratio of retinol-binding protein (RBP) to transthyretin (TTR) has been proposed as an indirect method with which to assess vitamin A status in the context of inflammation. Vitamin A 127-136 transthyretin Homo sapiens 61-64 15082720-1 2004 Transthyretin (TTR) is an extracellular transport protein involved in the distribution of thyroid hormones and vitamin A. Vitamin A 111-120 transthyretin Homo sapiens 15-18 16157297-1 2005 Retinol-binding protein (RBP) is the retinol-specific carrier protein present in plasma, where it circulates almost entirely bound to thyroxine-binding transthyretin (TTR). Vitamin A 37-44 transthyretin Homo sapiens 167-170 16317126-1 2005 Free holo-retinol binding protein (RBP) [i.e., unbound to transthyretin (TTR)] plays a role in transporting vitamin A across the placenta during pregnancy. Vitamin A 108-117 transthyretin Homo sapiens 73-76 16286652-1 2005 Transthyretin (TTR) is a transport protein for thyroxine and, in association with retinol-binding protein, for retinol, mainly existing as a tetramer in vivo. Vitamin A 82-89 transthyretin Homo sapiens 0-13 16286652-1 2005 Transthyretin (TTR) is a transport protein for thyroxine and, in association with retinol-binding protein, for retinol, mainly existing as a tetramer in vivo. Vitamin A 82-89 transthyretin Homo sapiens 15-18 15951260-4 2005 Results showed that 96 children (36.6%) presented a vitamin A deficiency (vitamin A < 200 microg/L with a retinol binding protein/transthyretin molar ratio = 0.29 +/- 0.06) while 166 (63.3%) children presented normal blood concentrations of vitamin A (vitamin A > or = 200 microg/L with a Retinol Binding Protein/Transthyretin molar ratio = 0.40 +/- 0.08). Vitamin A 74-83 transthyretin Homo sapiens 133-146 15951260-4 2005 Results showed that 96 children (36.6%) presented a vitamin A deficiency (vitamin A < 200 microg/L with a retinol binding protein/transthyretin molar ratio = 0.29 +/- 0.06) while 166 (63.3%) children presented normal blood concentrations of vitamin A (vitamin A > or = 200 microg/L with a Retinol Binding Protein/Transthyretin molar ratio = 0.40 +/- 0.08). Vitamin A 74-83 transthyretin Homo sapiens 133-146 15588697-0 2004 Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis. Vitamin A 102-111 transthyretin Homo sapiens 53-66 15588697-1 2004 Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T(4)) in the human plasma. Vitamin A 0-7 transthyretin Homo sapiens 74-87 15588697-1 2004 Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T(4)) in the human plasma. Vitamin A 0-7 transthyretin Homo sapiens 89-92 15588697-1 2004 Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T(4)) in the human plasma. Vitamin A 40-47 transthyretin Homo sapiens 89-92 15588697-1 2004 Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T(4)) in the human plasma. Vitamin A 135-144 transthyretin Homo sapiens 74-87 15588697-1 2004 Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T(4)) in the human plasma. Vitamin A 135-144 transthyretin Homo sapiens 89-92 15588697-9 2004 Thus, interactions amongst multiple components of retinol transport play critical roles in vitamin A homeostasis and TTR amyloidosis. Vitamin A 50-57 transthyretin Homo sapiens 117-120 15033978-1 2004 Transthyretin (TTR) is a plasma homotetrameric protein that acts physiologically as a transporter of thyroxine (T(4)) and retinol, in the latter case through binding to retinol-binding protein (RBP). Vitamin A 122-129 transthyretin Homo sapiens 0-13 15033978-1 2004 Transthyretin (TTR) is a plasma homotetrameric protein that acts physiologically as a transporter of thyroxine (T(4)) and retinol, in the latter case through binding to retinol-binding protein (RBP). Vitamin A 122-129 transthyretin Homo sapiens 15-18 14644428-1 2003 The thyroid hormone binding protein transthyretin (TTR) forms a macromolecular complex with the retinol-specific carrier retinol binding protein (RBP) in the blood of higher vertebrates. Vitamin A 96-103 transthyretin Homo sapiens 51-54 15196886-0 2004 Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin. Vitamin A 7-14 transthyretin Homo sapiens 88-101 15196886-5 2004 The stability of the retinol-RBP complex appears to be further enhanced when holo-RBP is bound to TTR. Vitamin A 21-28 transthyretin Homo sapiens 98-101 12593674-1 2003 Retinol is transported in the blood bound to a specific carrier protein called retinol-binding protein (RBP), which in turn binds to another protein, transthyretin (TTR), a homotetrameric, thyroid-hormone-transporting protein. Vitamin A 0-7 transthyretin Homo sapiens 150-163 12593674-1 2003 Retinol is transported in the blood bound to a specific carrier protein called retinol-binding protein (RBP), which in turn binds to another protein, transthyretin (TTR), a homotetrameric, thyroid-hormone-transporting protein. Vitamin A 0-7 transthyretin Homo sapiens 165-168 12553418-5 2002 Late in the 1960s it was learned that TBPA also carries vitamin A in the circulation by interacting with retinol-binding protein (RBP). Vitamin A 56-65 transthyretin Homo sapiens 38-42 12697331-1 2003 The human transthyretin (TTR) gene encodes a protein composed of four identical subunits with an important role in the plasma transport of thyroid hormone T4 and retinol. Vitamin A 162-169 transthyretin Homo sapiens 10-23 12697331-1 2003 The human transthyretin (TTR) gene encodes a protein composed of four identical subunits with an important role in the plasma transport of thyroid hormone T4 and retinol. Vitamin A 162-169 transthyretin Homo sapiens 25-28 12553418-6 2002 TBPA then was renamed transthyretin (TTR), in recognition of its dual transport function, and it was shown that retinol-RBP-TTR interactions are mutually enhancing. Vitamin A 112-119 transthyretin Homo sapiens 0-4 12553418-6 2002 TBPA then was renamed transthyretin (TTR), in recognition of its dual transport function, and it was shown that retinol-RBP-TTR interactions are mutually enhancing. Vitamin A 112-119 transthyretin Homo sapiens 124-127 12553422-1 2002 Transthyretin (TTR) is a 55 kDa protein responsible for the transport of thyroid hormones and retinol in human serum. Vitamin A 94-101 transthyretin Homo sapiens 0-13 12553422-1 2002 Transthyretin (TTR) is a 55 kDa protein responsible for the transport of thyroid hormones and retinol in human serum. Vitamin A 94-101 transthyretin Homo sapiens 15-18 12553423-1 2002 Transthyretin (TTR), formerly called prealbumin, one of the transporters of the hormone thyroxine and retinol-binding protein (RBP), the specific carrier of vitamin A, forms, under physiological conditions, a macromolecular complex that prevents glomerular filtration of the low-molecular-weight RBP in the kidneys. Vitamin A 157-166 transthyretin Homo sapiens 0-13 12553423-1 2002 Transthyretin (TTR), formerly called prealbumin, one of the transporters of the hormone thyroxine and retinol-binding protein (RBP), the specific carrier of vitamin A, forms, under physiological conditions, a macromolecular complex that prevents glomerular filtration of the low-molecular-weight RBP in the kidneys. Vitamin A 157-166 transthyretin Homo sapiens 15-18 12553430-5 2002 The discovery of the role of prealbumin in retinol binding led to a change in its name, prealbumin becoming transthyretin. Vitamin A 43-50 transthyretin Homo sapiens 108-121 12553436-2 2002 Elevated serum transthyretin during renal insufficiency is secondary to the lack of retinol-binding protein degradation in renal tubules and to the subsequent increase in the fraction of transthyretin bound to retinol-binding protein. Vitamin A 84-91 transthyretin Homo sapiens 15-28 12553436-2 2002 Elevated serum transthyretin during renal insufficiency is secondary to the lack of retinol-binding protein degradation in renal tubules and to the subsequent increase in the fraction of transthyretin bound to retinol-binding protein. Vitamin A 210-217 transthyretin Homo sapiens 15-28 12553436-2 2002 Elevated serum transthyretin during renal insufficiency is secondary to the lack of retinol-binding protein degradation in renal tubules and to the subsequent increase in the fraction of transthyretin bound to retinol-binding protein. Vitamin A 210-217 transthyretin Homo sapiens 187-200 12468608-0 2002 Determination of a cut-off value for the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) in Bangladeshi patients with low hepatic vitamin A stores. Vitamin A 148-157 transthyretin Homo sapiens 102-105 12468608-1 2002 The purpose of this study was to determine a cut-off value of the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) to indicate marginal vitamin A (VA) deficiency. Vitamin A 153-162 transthyretin Homo sapiens 127-130 12468608-1 2002 The purpose of this study was to determine a cut-off value of the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) to indicate marginal vitamin A (VA) deficiency. Vitamin A 164-166 transthyretin Homo sapiens 127-130 14987380-1 2002 Transthyretin (TTR) is a transport protein for thyroid hormones and vitamin A and might have an important role in the nervous system. Vitamin A 68-77 transthyretin Homo sapiens 0-13 12440486-3 2002 In plasma, TTR circulates as a homotetramer and transports the hormone thyroxine and the retinol-binding protein-vitamin A complex. Vitamin A 113-122 transthyretin Homo sapiens 11-14 14987380-1 2002 Transthyretin (TTR) is a transport protein for thyroid hormones and vitamin A and might have an important role in the nervous system. Vitamin A 68-77 transthyretin Homo sapiens 15-18 11866053-2 2002 In plasma, TTR exists as a tetramer and binds the hormone thyroxine and the retinol-binding protein-vitamin A complex. Vitamin A 76-83 transthyretin Homo sapiens 11-14 11866053-2 2002 In plasma, TTR exists as a tetramer and binds the hormone thyroxine and the retinol-binding protein-vitamin A complex. Vitamin A 100-109 transthyretin Homo sapiens 11-14 11036082-8 2001 However, human retinol-RBP injected intravenously was more rapidly cleared from the circulation (t(12) = 0.5 h for TTR(-) versus t(12) >6 h for WT) and accumulated faster in the kidneys of TTR(-) compared with WT mice. Vitamin A 15-22 transthyretin Homo sapiens 115-118 11409037-1 2001 Transthyretin (TTR) is a plasma protein that transports thyroid hormone and retinol binding protein-vitamin A complex. Vitamin A 100-109 transthyretin Homo sapiens 0-13 11409037-1 2001 Transthyretin (TTR) is a plasma protein that transports thyroid hormone and retinol binding protein-vitamin A complex. Vitamin A 100-109 transthyretin Homo sapiens 15-18 11352912-1 2001 Transthyretin is an essential protein responsible for the transport of thyroid hormones and retinol in human serum and is also implicated in the amyloid diseases familial amyloidotic polyneuropathy and senile systemic amyloidosis. Vitamin A 92-99 transthyretin Homo sapiens 0-13 11036082-8 2001 However, human retinol-RBP injected intravenously was more rapidly cleared from the circulation (t(12) = 0.5 h for TTR(-) versus t(12) >6 h for WT) and accumulated faster in the kidneys of TTR(-) compared with WT mice. Vitamin A 15-22 transthyretin Homo sapiens 192-195 10953676-1 2000 The ratio plasma retinol-binding protein (RBP):transthyretin (TTR) has been proposed as a means to improve the assessment of vitamin A status of individuals with concurrent infection or inflammation. Vitamin A 125-134 transthyretin Homo sapiens 62-65 10982792-3 2000 In the present study we observed that TTR, the transporter of both T(4) and retinol-binding protein, binds to megalin, the multiligand receptor expressed on the luminal surface of various epithelia including the renal proximal tubules. Vitamin A 76-83 transthyretin Homo sapiens 38-41 10982792-6 2000 Radiolabeled TTR, free as well as in complex with thyroxine or retinol-binding protein, was rapidly taken up by the cells, and the uptake was strongly inhibited by a polyclonal megalin antibody and by the receptor-associated protein, a chaperone-like protein inhibiting ligand binding to megalin. Vitamin A 63-70 transthyretin Homo sapiens 13-16 11017772-2 2000 TTR is also indirectly implicated in the carriage of vitamin A through the mediation of retinol-binding protein (RBP). Vitamin A 53-62 transthyretin Homo sapiens 0-3 10953676-6 2000 The RBP:TTR value was significantly decreased by both illness and low liver retinol stores. Vitamin A 76-83 transthyretin Homo sapiens 8-11 10953676-12 2000 Overall, although a trend supporting the theory behind the use of the RBP:TTR for assessment of vitamin A status in infection was observed in the current study, the ratio did not provide adequate sensitivity and specificity to be a useful assessment tool. Vitamin A 96-105 transthyretin Homo sapiens 74-77 8612621-8 1996 Compared with wild-type human transthyretin the avian transthyretin shows quite large differences in the region known to be involved in binding to retinol-binding protein, it has a much shorter helical component than the human protein and some of the monomer-monomer interactions are different. Vitamin A 147-154 transthyretin Homo sapiens 54-67 10089423-3 1999 Based on a 2:2:1 stoichiometry for the Fab-retinol-binding-protein-transthyretin complex and the presence of one such complex per asymmetric unit, a reasonable Vm coefficient of 2.74 A3 Da-1 could be estimated. Vitamin A 43-50 transthyretin Homo sapiens 67-80 9178822-11 1997 When the medium from cells incubated with either 4-HPR or retinol was applied to a TTR affinity column, we found that RBP from cells incubated with 4-HPR had a considerably reduced affinity for TTR. Vitamin A 58-65 transthyretin Homo sapiens 83-86 9178822-11 1997 When the medium from cells incubated with either 4-HPR or retinol was applied to a TTR affinity column, we found that RBP from cells incubated with 4-HPR had a considerably reduced affinity for TTR. Vitamin A 58-65 transthyretin Homo sapiens 194-197 10551861-4 1999 In certain forms of FAP, the amyloid fibrils are mostly constituted by variants of transthyretin (TTR), a homotetrameric plasma protein implicated in the transport of thyroxine and retinol. Vitamin A 181-188 transthyretin Homo sapiens 83-96 10551861-4 1999 In certain forms of FAP, the amyloid fibrils are mostly constituted by variants of transthyretin (TTR), a homotetrameric plasma protein implicated in the transport of thyroxine and retinol. Vitamin A 181-188 transthyretin Homo sapiens 98-101 10319365-6 1999 Cytokines stimulate liver 5"-DA and suppress the synthesis of transthyretin (TTR), causing the drop of retinol-binding protein (RBP) and the leakage of increased amounts of T4 and retinol in free form. Vitamin A 103-110 transthyretin Homo sapiens 62-75 10319365-6 1999 Cytokines stimulate liver 5"-DA and suppress the synthesis of transthyretin (TTR), causing the drop of retinol-binding protein (RBP) and the leakage of increased amounts of T4 and retinol in free form. Vitamin A 103-110 transthyretin Homo sapiens 77-80 16130282-1 1999 PURPOSE: To evaluate the presence of transthyretin (TTR, prealbumin) a protein which binds retinol to retinol-binding protein in various ocular tissues and to study its quantitative changes in the vitreous humor in various diseases. Vitamin A 91-98 transthyretin Homo sapiens 37-50 16130282-1 1999 PURPOSE: To evaluate the presence of transthyretin (TTR, prealbumin) a protein which binds retinol to retinol-binding protein in various ocular tissues and to study its quantitative changes in the vitreous humor in various diseases. Vitamin A 91-98 transthyretin Homo sapiens 52-55 16130282-1 1999 PURPOSE: To evaluate the presence of transthyretin (TTR, prealbumin) a protein which binds retinol to retinol-binding protein in various ocular tissues and to study its quantitative changes in the vitreous humor in various diseases. Vitamin A 102-109 transthyretin Homo sapiens 37-50 16130282-1 1999 PURPOSE: To evaluate the presence of transthyretin (TTR, prealbumin) a protein which binds retinol to retinol-binding protein in various ocular tissues and to study its quantitative changes in the vitreous humor in various diseases. Vitamin A 102-109 transthyretin Homo sapiens 52-55 9772136-5 1998 The ratio of RBP:TTR was selectively reduced in children in the placebo group with low plasma retinol (<0.35 micromol/L) and elevated CRP (>40 mg/L). Vitamin A 94-101 transthyretin Homo sapiens 17-20 9694837-7 1998 High pressure liquid chromatography fractionation of the CHYLO infranate proteins identified the critical protein as transthyretin (TTR), which binds retinol-binding protein and complexes thyroxine and retinol. Vitamin A 150-157 transthyretin Homo sapiens 117-130 9694837-7 1998 High pressure liquid chromatography fractionation of the CHYLO infranate proteins identified the critical protein as transthyretin (TTR), which binds retinol-binding protein and complexes thyroxine and retinol. Vitamin A 150-157 transthyretin Homo sapiens 132-135 9307034-1 1997 Transthyretin is one of two specific proteins involved in the transport of thyroid hormones in plasma; it possesses two binding sites for serum retinol-binding protein. Vitamin A 144-151 transthyretin Homo sapiens 0-13 9095004-7 1997 The introduction of 6.0-hMet 30 into the ttr-/- mice significantly increased their depressed serum levels of T4 and retinol-binding protein, suggesting that human TTR Met 30 binds T4 and retinol-binding protein in vivo. Vitamin A 116-123 transthyretin Homo sapiens 163-166 8639713-1 1996 The retinol carrier retinol-binding protein (RBP) forms a complex with the thyroid hormone binding protein transthyretin in the plasma of a number of vertebrate species. Vitamin A 4-11 transthyretin Homo sapiens 107-120 8639713-4 1996 Although the natural ligand retinol participates in the interaction between retinol-RBP and transthyretin, its binding to RBP is not a prerequisite for protein-protein interaction. Vitamin A 28-35 transthyretin Homo sapiens 92-105 8639713-7 1996 The replacement of RBP-bound retinol with synthetic retinoids affects RBP-transthyretin recognition to an extent that appears to be well correlated with the nature and steric hindrance of the groups substituting the retinol hydroxyl group, consistent with their location at the interface between the contact areas of RBP and transthyretin. Vitamin A 29-36 transthyretin Homo sapiens 74-87 8639713-7 1996 The replacement of RBP-bound retinol with synthetic retinoids affects RBP-transthyretin recognition to an extent that appears to be well correlated with the nature and steric hindrance of the groups substituting the retinol hydroxyl group, consistent with their location at the interface between the contact areas of RBP and transthyretin. Vitamin A 29-36 transthyretin Homo sapiens 325-338 8549676-1 1996 Retinol binding protein (RBP), the retinol-specific carrier, circulates in blood as a 1:1 complex with the homotetrameric protein transthyretin (TTR). Vitamin A 35-42 transthyretin Homo sapiens 130-143 8549676-1 1996 Retinol binding protein (RBP), the retinol-specific carrier, circulates in blood as a 1:1 complex with the homotetrameric protein transthyretin (TTR). Vitamin A 35-42 transthyretin Homo sapiens 145-148 8089102-1 1994 In plasma the thyroid hormone-binding protein transthyretin (TTR) forms a tight complex with the specific retinol carrier retinol-binding protein (RBP). Vitamin A 106-113 transthyretin Homo sapiens 46-59 7656439-1 1995 Retinol-binding protein (RBP), the principal carrier for vitamin A, is known to form a complex with transthyretin (TTR) for transport in plasma. Vitamin A 57-66 transthyretin Homo sapiens 100-113 7656439-1 1995 Retinol-binding protein (RBP), the principal carrier for vitamin A, is known to form a complex with transthyretin (TTR) for transport in plasma. Vitamin A 57-66 transthyretin Homo sapiens 115-118 7814033-9 1995 TTR transports both thyroxine and retinol and is therefore important for normal fetal development. Vitamin A 34-41 transthyretin Homo sapiens 0-3 7966314-2 1994 Transthyretin is a carrier of the hormone thyroxine in plasma whereas retinol-binding protein is the specific transporter of the alcohol form of vitamin A in the same medium. Vitamin A 145-154 transthyretin Homo sapiens 0-13 8089102-1 1994 In plasma the thyroid hormone-binding protein transthyretin (TTR) forms a tight complex with the specific retinol carrier retinol-binding protein (RBP). Vitamin A 106-113 transthyretin Homo sapiens 61-64 1386578-3 1992 The remarkable early reduction in plasma retinol level induced by fenretinide administration may be associated with the high binding affinity of this retinoid to RBP and to its interference with the RBP-TTR complex formation. Vitamin A 41-48 transthyretin Homo sapiens 203-206 7946531-2 1994 TTR is one of three specific carrier proteins involved in the transport of both thyroid hormones and of retinol through the mediation of RBP. Vitamin A 104-111 transthyretin Homo sapiens 0-3 8260484-5 1993 Hb was strongly correlated with retinol, ferritin, MCHC, MCH, packed cell volume and erythrocyte count while retinol formed a triad with transthyretin (TTR) and retinol-binding protein (RBP) which were all correlated with one another. Vitamin A 109-116 transthyretin Homo sapiens 137-150 8260484-5 1993 Hb was strongly correlated with retinol, ferritin, MCHC, MCH, packed cell volume and erythrocyte count while retinol formed a triad with transthyretin (TTR) and retinol-binding protein (RBP) which were all correlated with one another. Vitamin A 109-116 transthyretin Homo sapiens 152-155 1445851-0 1992 Interactions of retinol with binding proteins: studies with retinol-binding protein and with transthyretin. Vitamin A 16-23 transthyretin Homo sapiens 93-106 1445851-5 1992 At 0.15 M NaCl, binding of RBP to TTR showed an absolute requirement for the native ligand, retinol. Vitamin A 92-99 transthyretin Homo sapiens 34-37 1445851-13 1992 The rate of dissociation is slow (k = 0.055/h), however, indicating that the complex apo-RBP-TTR will be an important factor in regulating serum levels of retinol. Vitamin A 155-162 transthyretin Homo sapiens 93-96 1909468-8 1991 There is an alternative explanation for low plasma retinol levels in malaria patients because retinol is bound to the negative acute phase proteins, retinol binding protein and transthyretin. Vitamin A 94-101 transthyretin Homo sapiens 177-190 1915658-0 1991 Retinol-binding protein and transthyretin expressed in HeLa cells form a complex in the endoplasmic reticulum in both the absence and the presence of retinol. Vitamin A 150-157 transthyretin Homo sapiens 28-41 1915658-7 1991 The effect of the vitamin A status on the secretion of TTR and RBP was examined. Vitamin A 18-27 transthyretin Homo sapiens 55-58 1915658-8 1991 While TTR expressed alone was not retained intracellularly, TTR was retained in vitamin A-deficient cells when co-expressed with RBP. Vitamin A 80-89 transthyretin Homo sapiens 60-63 1666289-8 1991 After sequencing of the clone of 572 bp, it was unexpectedly found that pG8 was completely homologous to the coding sequence of transthyretin, TTR gene, as TTR (or prealbumin) gene has been known to be linked to a hereditary disorder, familial amyloidosis (FAP), and related to thyroxine transport and binding to retinol-RBP (the retinol binding protein) complex. Vitamin A 313-320 transthyretin Homo sapiens 128-141 1666289-8 1991 After sequencing of the clone of 572 bp, it was unexpectedly found that pG8 was completely homologous to the coding sequence of transthyretin, TTR gene, as TTR (or prealbumin) gene has been known to be linked to a hereditary disorder, familial amyloidosis (FAP), and related to thyroxine transport and binding to retinol-RBP (the retinol binding protein) complex. Vitamin A 313-320 transthyretin Homo sapiens 143-146 1666289-8 1991 After sequencing of the clone of 572 bp, it was unexpectedly found that pG8 was completely homologous to the coding sequence of transthyretin, TTR gene, as TTR (or prealbumin) gene has been known to be linked to a hereditary disorder, familial amyloidosis (FAP), and related to thyroxine transport and binding to retinol-RBP (the retinol binding protein) complex. Vitamin A 313-320 transthyretin Homo sapiens 156-159 1666289-8 1991 After sequencing of the clone of 572 bp, it was unexpectedly found that pG8 was completely homologous to the coding sequence of transthyretin, TTR gene, as TTR (or prealbumin) gene has been known to be linked to a hereditary disorder, familial amyloidosis (FAP), and related to thyroxine transport and binding to retinol-RBP (the retinol binding protein) complex. Vitamin A 330-337 transthyretin Homo sapiens 128-141 1666289-8 1991 After sequencing of the clone of 572 bp, it was unexpectedly found that pG8 was completely homologous to the coding sequence of transthyretin, TTR gene, as TTR (or prealbumin) gene has been known to be linked to a hereditary disorder, familial amyloidosis (FAP), and related to thyroxine transport and binding to retinol-RBP (the retinol binding protein) complex. Vitamin A 330-337 transthyretin Homo sapiens 143-146 1666289-8 1991 After sequencing of the clone of 572 bp, it was unexpectedly found that pG8 was completely homologous to the coding sequence of transthyretin, TTR gene, as TTR (or prealbumin) gene has been known to be linked to a hereditary disorder, familial amyloidosis (FAP), and related to thyroxine transport and binding to retinol-RBP (the retinol binding protein) complex. Vitamin A 330-337 transthyretin Homo sapiens 156-159 1652460-1 1991 Transthyretin (TTR) is a circulatory protein which plays an important role in the transport of both thyroid hormone and retinol. Vitamin A 120-127 transthyretin Homo sapiens 15-18 1939470-1 1991 We describe a reversed-phase high-performance liquid chromatographic method for the determination of vitamin A-transporting (holo) transthyretin-bound (TTR) retinol-binding protein (RBP) concentrations in serum or plasma. Vitamin A 101-110 transthyretin Homo sapiens 152-155 1939470-5 1991 The percentage of RBP circulating as holo-TTR-RBP decreased significantly as the total concentration of RBP or retinol increased. Vitamin A 111-118 transthyretin Homo sapiens 42-45 1649243-4 1991 Comparing equal concentrations of the [3H]retinol donors, cell uptake and esterification was greatest from the dispersed form and least from that bound to RBP-TTR. Vitamin A 42-49 transthyretin Homo sapiens 159-162 1909468-8 1991 There is an alternative explanation for low plasma retinol levels in malaria patients because retinol is bound to the negative acute phase proteins, retinol binding protein and transthyretin. Vitamin A 94-101 transthyretin Homo sapiens 177-190 2356863-5 1990 The authors have reported that the CP is the unique site of synthesis within the brain of transthyretin (TTR, prealbumin), a transport protein for thyroxine and retinol. Vitamin A 161-168 transthyretin Homo sapiens 90-103 2279702-1 1990 HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the genes for transthyretin (TTR), the carrier protein in the serum for vitamin A and thyroid hormone, and for apolipoprotein CIII (apoCIII), a major constituent of chylomicrons and very low-density lipoproteins (VLDL). Vitamin A 202-211 transthyretin Homo sapiens 144-157 2279702-1 1990 HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the genes for transthyretin (TTR), the carrier protein in the serum for vitamin A and thyroid hormone, and for apolipoprotein CIII (apoCIII), a major constituent of chylomicrons and very low-density lipoproteins (VLDL). Vitamin A 202-211 transthyretin Homo sapiens 159-162 2356863-5 1990 The authors have reported that the CP is the unique site of synthesis within the brain of transthyretin (TTR, prealbumin), a transport protein for thyroxine and retinol. Vitamin A 161-168 transthyretin Homo sapiens 105-108 34207092-2 2021 TTR is a plasma protein that functions as a carrier for thyroxine (T4) and retinol (vitamin A). Vitamin A 75-82 transthyretin Homo sapiens 0-3 34297165-1 2021 Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body and brain. Vitamin A 158-165 transthyretin Homo sapiens 0-13 34297165-1 2021 Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body and brain. Vitamin A 158-165 transthyretin Homo sapiens 15-18 34225167-1 2021 Transthyretin is a tetrameric protein which functions as a transporter of thyroxine and retinol-binding protein. Vitamin A 88-95 transthyretin Homo sapiens 0-13 2354158-9 1990 The calculated value was 7.5 X 10(-8) M. Kd was also measured directly by fluorometric titration and was found to be 7 X 10(-8) M. The relative avidities of retinol for RBP, the complex RBP-transthyretin (RBP-TTR), and serum albumin were also studied. Vitamin A 157-164 transthyretin Homo sapiens 209-212 2354158-10 1990 It was found that binding of RBP to TTR increased its avidity for retinol by about 2-fold. Vitamin A 66-73 transthyretin Homo sapiens 36-39 34562536-1 2021 Wild-type human transthyretin (TTR) is a tetrameric protein that transports thyroxine and retinol in the blood and brain. Vitamin A 90-97 transthyretin Homo sapiens 16-29 34562536-1 2021 Wild-type human transthyretin (TTR) is a tetrameric protein that transports thyroxine and retinol in the blood and brain. Vitamin A 90-97 transthyretin Homo sapiens 31-34 34089308-6 2021 Transthyretin (TTR) is a protein that is produced by the liver and is involved in the transportation of thyroid hormones, especially thyroxine and retinol binding protein. Vitamin A 147-154 transthyretin Homo sapiens 0-13 34089308-6 2021 Transthyretin (TTR) is a protein that is produced by the liver and is involved in the transportation of thyroid hormones, especially thyroxine and retinol binding protein. Vitamin A 147-154 transthyretin Homo sapiens 15-18 34207092-2 2021 TTR is a plasma protein that functions as a carrier for thyroxine (T4) and retinol (vitamin A). Vitamin A 84-93 transthyretin Homo sapiens 0-3 2492196-1 1989 Two non-amino acid components as well as the glutathione constituents in labile associations with transthyretin (TTR) have been detected by preparative polyacrylamide gel electrophoresis from preparations isolated by affinity chromatography on Sepharose-bound retinol-binding protein (RBP). Vitamin A 260-267 transthyretin Homo sapiens 98-111 2492196-1 1989 Two non-amino acid components as well as the glutathione constituents in labile associations with transthyretin (TTR) have been detected by preparative polyacrylamide gel electrophoresis from preparations isolated by affinity chromatography on Sepharose-bound retinol-binding protein (RBP). Vitamin A 260-267 transthyretin Homo sapiens 113-116 3207418-2 1988 In the plasma, retinol is transported by retinol-binding protein (RBP) in complex with transthyretin (TTR, prealbumin). Vitamin A 15-22 transthyretin Homo sapiens 87-100 2512001-5 1989 Since TT levels are strongly influenced by the nutritional status of patients, our results suggest that the decreased blood levels of vitamin A and its carriers observed in digestive cancer are the consequence of nutritional alterations evoked by the disease. Vitamin A 134-143 transthyretin Homo sapiens 6-8 3207418-2 1988 In the plasma, retinol is transported by retinol-binding protein (RBP) in complex with transthyretin (TTR, prealbumin). Vitamin A 15-22 transthyretin Homo sapiens 102-105 3207418-7 1988 We postulate that ocular RBP and TTR are involved in the intraocular translocation of retinol. Vitamin A 86-93 transthyretin Homo sapiens 33-36 2849421-10 1988 Transthyretin decreased the rate of uptake of [3H]retinol from RBP without substantially altering the steady-state uptake levels, suggesting that membranes take up retinol from uncomplexed RBP. Vitamin A 50-57 transthyretin Homo sapiens 0-13 2849421-10 1988 Transthyretin decreased the rate of uptake of [3H]retinol from RBP without substantially altering the steady-state uptake levels, suggesting that membranes take up retinol from uncomplexed RBP. Vitamin A 164-171 transthyretin Homo sapiens 0-13 3354492-2 1988 The purpose of this work was to study the role of TBPA-retinol-binding-protein (RBP)-retinol complex changes in the elevation of serum TBPA in HD patients. Vitamin A 55-62 transthyretin Homo sapiens 50-54 34040908-4 2021 In elderly patients, as with this study, cardiac amyloidosis most often results from abnormalities in the liver protein transthyretin (TTR), a thyroxine and retinol-retinol binding complex transporter in blood. Vitamin A 157-164 transthyretin Homo sapiens 120-133 3936007-1 1985 Thyroxin binding prealbumin (TBPA) and retinol binding protein (RBP) are associated in a complex responsible for the transport of vitamin A and of about 10% of the thyroid hormones T3 and T4. Vitamin A 130-139 transthyretin Homo sapiens 0-27 3936007-1 1985 Thyroxin binding prealbumin (TBPA) and retinol binding protein (RBP) are associated in a complex responsible for the transport of vitamin A and of about 10% of the thyroid hormones T3 and T4. Vitamin A 130-139 transthyretin Homo sapiens 29-33 3559267-2 1987 Retinol is distributed to target cells by the retinol-binding protein (RBP), which circulates in the plasma in complex with transthyretin (TTR). Vitamin A 0-7 transthyretin Homo sapiens 124-137 3559267-2 1987 Retinol is distributed to target cells by the retinol-binding protein (RBP), which circulates in the plasma in complex with transthyretin (TTR). Vitamin A 0-7 transthyretin Homo sapiens 139-142 3559267-4 1987 Retinol radiobinding assays, affinity chromatography with TTR coupled to Sepharose beads, polyacrylamide gel electrophoresis, and immunoblotting techniques were used to show that epidermal extracts contain retinol binding sites with no affinity for TTR. Vitamin A 206-213 transthyretin Homo sapiens 249-252 3094194-0 1986 Binding of a metabolite of 3,4,3",4"-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Vitamin A 88-97 transthyretin Homo sapiens 60-73 3094194-0 1986 Binding of a metabolite of 3,4,3",4"-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Vitamin A 173-180 transthyretin Homo sapiens 60-73 3094194-2 1986 Analysis of [3H]retinol-labeled serum proteins by polyacrylamide gel electrophoresis (PAGE) showed association of retinol with two proteins that were identified as retinol binding protein (RBP) and the RBP complex with transthyretin (TTR). Vitamin A 114-121 transthyretin Homo sapiens 219-232 3094194-2 1986 Analysis of [3H]retinol-labeled serum proteins by polyacrylamide gel electrophoresis (PAGE) showed association of retinol with two proteins that were identified as retinol binding protein (RBP) and the RBP complex with transthyretin (TTR). Vitamin A 114-121 transthyretin Homo sapiens 234-237 3094194-8 1986 These data indicate a direct interaction of a metabolite of TCB with TTR leading to an inhibition of formation of the serum transport protein complex carrying both retinol and thyroxin. Vitamin A 164-171 transthyretin Homo sapiens 69-72 3714052-2 1986 Plasma transthyretin (TTR, formerly called prealbumin) is a 55-kd protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Vitamin A 138-145 transthyretin Homo sapiens 7-20 3714052-2 1986 Plasma transthyretin (TTR, formerly called prealbumin) is a 55-kd protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Vitamin A 138-145 transthyretin Homo sapiens 22-25 3714052-2 1986 Plasma transthyretin (TTR, formerly called prealbumin) is a 55-kd protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Vitamin A 147-156 transthyretin Homo sapiens 7-20 3714052-2 1986 Plasma transthyretin (TTR, formerly called prealbumin) is a 55-kd protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Vitamin A 147-156 transthyretin Homo sapiens 22-25 34040908-4 2021 In elderly patients, as with this study, cardiac amyloidosis most often results from abnormalities in the liver protein transthyretin (TTR), a thyroxine and retinol-retinol binding complex transporter in blood. Vitamin A 157-164 transthyretin Homo sapiens 135-138 34040908-4 2021 In elderly patients, as with this study, cardiac amyloidosis most often results from abnormalities in the liver protein transthyretin (TTR), a thyroxine and retinol-retinol binding complex transporter in blood. Vitamin A 165-172 transthyretin Homo sapiens 120-133 34040908-4 2021 In elderly patients, as with this study, cardiac amyloidosis most often results from abnormalities in the liver protein transthyretin (TTR), a thyroxine and retinol-retinol binding complex transporter in blood. Vitamin A 165-172 transthyretin Homo sapiens 135-138 33001386-2 2020 TTR transports the thyroid hormone thyroxine and the retinol-binding protein (RBP) bound to retinol (vitamin A). Vitamin A 53-60 transthyretin Homo sapiens 0-3 33129902-1 2021 Tetrameric transthyretin (TTR) transports thyroid hormones and retinol in plasma and cerebrospinal fluid and performs protective functions under stress conditions. Vitamin A 63-70 transthyretin Homo sapiens 11-24 33129902-1 2021 Tetrameric transthyretin (TTR) transports thyroid hormones and retinol in plasma and cerebrospinal fluid and performs protective functions under stress conditions. Vitamin A 63-70 transthyretin Homo sapiens 26-29 32419519-3 2020 TTR is a transporter protein that under physiological condition carries thyroxine (T4) and retinol in plasma and in cerebrospinal fluid (CSF); it also has a neuroprotective role against Alzheimer"s disease (AD). Vitamin A 91-98 transthyretin Homo sapiens 0-3 33790810-4 2021 After associating with transthyretin (TTR), the retinol/RBP4/TTR complex is released into the bloodstream and delivers retinol to tissues via binding to specific membrane receptors. Vitamin A 48-55 transthyretin Homo sapiens 23-36 33790810-4 2021 After associating with transthyretin (TTR), the retinol/RBP4/TTR complex is released into the bloodstream and delivers retinol to tissues via binding to specific membrane receptors. Vitamin A 48-55 transthyretin Homo sapiens 38-41 33790810-4 2021 After associating with transthyretin (TTR), the retinol/RBP4/TTR complex is released into the bloodstream and delivers retinol to tissues via binding to specific membrane receptors. Vitamin A 48-55 transthyretin Homo sapiens 61-64 33348885-1 2020 Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyloidotic cardiomyopathy, and central nervous system selective amyloidosis. Vitamin A 98-105 transthyretin Homo sapiens 6-19 33348885-1 2020 Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyloidotic cardiomyopathy, and central nervous system selective amyloidosis. Vitamin A 98-105 transthyretin Homo sapiens 21-25 33348885-1 2020 Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyloidotic cardiomyopathy, and central nervous system selective amyloidosis. Vitamin A 129-136 transthyretin Homo sapiens 6-19 33348885-1 2020 Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyloidotic cardiomyopathy, and central nervous system selective amyloidosis. Vitamin A 129-136 transthyretin Homo sapiens 21-25 33001386-2 2020 TTR transports the thyroid hormone thyroxine and the retinol-binding protein (RBP) bound to retinol (vitamin A). Vitamin A 101-110 transthyretin Homo sapiens 0-3 33212973-1 2020 Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol (vitamin A). Vitamin A 171-178 transthyretin Homo sapiens 0-13 33212973-1 2020 Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol (vitamin A). Vitamin A 171-178 transthyretin Homo sapiens 15-18 33212973-1 2020 Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol (vitamin A). Vitamin A 180-189 transthyretin Homo sapiens 0-13 33212973-1 2020 Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol (vitamin A). Vitamin A 180-189 transthyretin Homo sapiens 15-18 32878437-2 2020 Retinal bisretinoid synthesis depends on influx of serum all-trans-retinol (1) delivered via a tertiary retinol-binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. Vitamin A 57-74 transthyretin Homo sapiens 137-150 32791384-1 2020 Transthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine and retinol in blood and cerebrospinal fluid. Vitamin A 96-103 transthyretin Homo sapiens 0-13 32791384-1 2020 Transthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine and retinol in blood and cerebrospinal fluid. Vitamin A 96-103 transthyretin Homo sapiens 15-18 32828431-1 2020 Transthyretin (TTR) is a ss-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. Vitamin A 97-104 transthyretin Homo sapiens 0-13 32828431-1 2020 Transthyretin (TTR) is a ss-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. Vitamin A 97-104 transthyretin Homo sapiens 15-18 32878437-2 2020 Retinal bisretinoid synthesis depends on influx of serum all-trans-retinol (1) delivered via a tertiary retinol-binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. Vitamin A 57-74 transthyretin Homo sapiens 152-155 32878437-2 2020 Retinal bisretinoid synthesis depends on influx of serum all-trans-retinol (1) delivered via a tertiary retinol-binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. Vitamin A 67-74 transthyretin Homo sapiens 137-150 32878437-2 2020 Retinal bisretinoid synthesis depends on influx of serum all-trans-retinol (1) delivered via a tertiary retinol-binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. Vitamin A 67-74 transthyretin Homo sapiens 152-155 32878437-3 2020 We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. Vitamin A 89-96 transthyretin Homo sapiens 85-88 32241558-1 2020 BACKGROUND: Transthyretin functions as a serum transport protein for retinol. Vitamin A 69-76 transthyretin Homo sapiens 12-25 32197355-1 2020 Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has been specially acknowledged for its functions as a transporter protein of thyroxine and retinol (the latter through binding to the retinol-binding protein), in these fluids. Vitamin A 266-273 transthyretin Homo sapiens 0-13 32197355-1 2020 Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has been specially acknowledged for its functions as a transporter protein of thyroxine and retinol (the latter through binding to the retinol-binding protein), in these fluids. Vitamin A 266-273 transthyretin Homo sapiens 15-18 31358790-1 2019 We have studied the intrinsic fluorescence spectra of a monomeric variant of human transthyretin (M-TTR), a protein involved in the transport of the thyroid hormone and retinol and associated with various forms of amyloidosis, extending our analysis to the second order derivative of the spectra. Vitamin A 169-176 transthyretin Homo sapiens 83-96 31762320-1 2020 Purpose: Transthyretin (TTR) is a protein with a growing number of biological functions in addition to its well-established binding and circulatory transport of thyroxine, and indirect retinoid transport through interaction with retinol-binding protein. Vitamin A 229-236 transthyretin Homo sapiens 9-22 31762320-1 2020 Purpose: Transthyretin (TTR) is a protein with a growing number of biological functions in addition to its well-established binding and circulatory transport of thyroxine, and indirect retinoid transport through interaction with retinol-binding protein. Vitamin A 229-236 transthyretin Homo sapiens 24-27 31397996-12 2019 This disease is characterized by a mutation in the gene encoding TTR, a serum protein that transports retinol in circulation following secretion by the liver. Vitamin A 102-109 transthyretin Homo sapiens 65-68 31358790-1 2019 We have studied the intrinsic fluorescence spectra of a monomeric variant of human transthyretin (M-TTR), a protein involved in the transport of the thyroid hormone and retinol and associated with various forms of amyloidosis, extending our analysis to the second order derivative of the spectra. Vitamin A 169-176 transthyretin Homo sapiens 100-103 30213975-1 2018 Transthyretin (TTR), a homotetrameric protein that transports thyroxine and retinol both in plasma and in cerebrospinal (CSF) fluid provides a natural protective response against Alzheimer"s disease (AD), modulates amyloid-beta (Abeta) deposition by direct interaction and co-localizes with Abeta in plaques. Vitamin A 76-83 transthyretin Homo sapiens 0-13 30733338-1 2019 The tetrameric protein transthyretin is a transporter of retinol and thyroxine in blood, cerebrospinal fluid, and the eye, and is secreted by the liver, choroid plexus, and retinal epithelium, respectively. Vitamin A 57-64 transthyretin Homo sapiens 23-36 30394286-1 2019 Human transthyretin (TTR) is a homotetramer that transports thyroid hormones and retinol in the serum and cerebrospinal fluid. Vitamin A 81-88 transthyretin Homo sapiens 6-19 30394286-1 2019 Human transthyretin (TTR) is a homotetramer that transports thyroid hormones and retinol in the serum and cerebrospinal fluid. Vitamin A 81-88 transthyretin Homo sapiens 21-24 29534342-4 2018 RESULTS: The serum TTR levels exhibited a statistically significant inverse correlation with interleukin-6 (r = -0.412, P = 0.041), and showed statistically significant correlations with retinol-binding protein (r = 0.919, P < 0.001) and albumin (r = 0.442, P = 0.027). Vitamin A 187-194 transthyretin Homo sapiens 19-22 30233492-3 2018 The retinol circulating complex is transported in the bloodstream in the form of a trimolecular edifice made up of transthyretin (TTR), retinol-binding protein (RBP) and its retinol ligand. Vitamin A 4-11 transthyretin Homo sapiens 115-128 30233492-3 2018 The retinol circulating complex is transported in the bloodstream in the form of a trimolecular edifice made up of transthyretin (TTR), retinol-binding protein (RBP) and its retinol ligand. Vitamin A 4-11 transthyretin Homo sapiens 130-133 30233492-6 2018 The steep drop in TTR and RBP plasma values releases thyroxine and retinol ligands in their physiologically active forms, creating free pools estimated to be 10-20 times larger than those described in healthy subjects. Vitamin A 67-74 transthyretin Homo sapiens 18-21 30213975-1 2018 Transthyretin (TTR), a homotetrameric protein that transports thyroxine and retinol both in plasma and in cerebrospinal (CSF) fluid provides a natural protective response against Alzheimer"s disease (AD), modulates amyloid-beta (Abeta) deposition by direct interaction and co-localizes with Abeta in plaques. Vitamin A 76-83 transthyretin Homo sapiens 15-18 29226076-1 2017 Transthyretin (TTR) is a transporter for thyroid hormone (TH) and retinol, the latter via binding with retinol binding protein (RBP). Vitamin A 66-73 transthyretin Homo sapiens 15-18 29626847-4 2018 TTR is a transporter of thyroxine and retinol in the blood and cerebrospinal fluid. Vitamin A 38-45 transthyretin Homo sapiens 0-3 29607936-1 2018 Transthyretin (TTR) is a tetrameric beta-sheet-rich protein that is important in the plasma transport of thyroxine and retinol. Vitamin A 119-126 transthyretin Homo sapiens 0-13 29607936-1 2018 Transthyretin (TTR) is a tetrameric beta-sheet-rich protein that is important in the plasma transport of thyroxine and retinol. Vitamin A 119-126 transthyretin Homo sapiens 15-18 29804846-4 2018 The transthyretin levels exhibited statistically significant correlations with total protein (r = 0.598, P < 0.001), albumin (r = 0.626, P < 0.001), and retinol binding protein (r = 0.753, P < 0.001). Vitamin A 159-166 transthyretin Homo sapiens 4-17 27402536-1 2016 Transthyretin (TTR) is a 54 kDa homotetrameric serum protein that transports thyroxine (T4) and retinol. Vitamin A 96-103 transthyretin Homo sapiens 0-13 28688921-0 2017 Plasma Retinol Concentration Is Mainly Driven by Transthyretin in Hemodialysis Patients. Vitamin A 7-14 transthyretin Homo sapiens 49-62 28688921-7 2017 MAIN OUTCOME MEASURE: Plasma concentration of lipophilic micronutrients retinol and its two co-transporters transthyretin and retinol-binding protein 4, tocopherol, and carotenoids (alpha-carotene and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin), and all factors associated with 1-year mortality. Vitamin A 72-79 transthyretin Homo sapiens 108-121 28688921-12 2017 Nevertheless, the correlation between retinol and mortality disappeared as soon as transthyretin was added in the statistical model, suggesting an effect of transthyretin as confusing bias. Vitamin A 38-45 transthyretin Homo sapiens 83-96 28688921-12 2017 Nevertheless, the correlation between retinol and mortality disappeared as soon as transthyretin was added in the statistical model, suggesting an effect of transthyretin as confusing bias. Vitamin A 38-45 transthyretin Homo sapiens 157-170 28454241-4 2017 Transthyretin (TTR) is a 56-kDa homotetrameric protein that binds thyroid hormone and retinol binding protein. Vitamin A 86-93 transthyretin Homo sapiens 0-13 28454241-4 2017 Transthyretin (TTR) is a 56-kDa homotetrameric protein that binds thyroid hormone and retinol binding protein. Vitamin A 86-93 transthyretin Homo sapiens 15-18 26235916-1 2016 Transthyretin (TTR) is a 54 kDa homotetrameric protein that transports thyroxine (T4) and retinol (vitamin A), through its association with retinol binding protein (RBP). Vitamin A 90-97 transthyretin Homo sapiens 0-13 26235916-1 2016 Transthyretin (TTR) is a 54 kDa homotetrameric protein that transports thyroxine (T4) and retinol (vitamin A), through its association with retinol binding protein (RBP). Vitamin A 90-97 transthyretin Homo sapiens 15-18 26235916-1 2016 Transthyretin (TTR) is a 54 kDa homotetrameric protein that transports thyroxine (T4) and retinol (vitamin A), through its association with retinol binding protein (RBP). Vitamin A 99-108 transthyretin Homo sapiens 0-13 26235916-1 2016 Transthyretin (TTR) is a 54 kDa homotetrameric protein that transports thyroxine (T4) and retinol (vitamin A), through its association with retinol binding protein (RBP). Vitamin A 99-108 transthyretin Homo sapiens 15-18 27402536-1 2016 Transthyretin (TTR) is a 54 kDa homotetrameric serum protein that transports thyroxine (T4) and retinol. Vitamin A 96-103 transthyretin Homo sapiens 15-18 27501389-1 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Vitamin A 70-77 transthyretin Homo sapiens 24-37 27501389-1 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Vitamin A 70-77 transthyretin Homo sapiens 153-156 26729422-1 2016 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP4) which, in turn, associates with another serum protein, transthyretin (TTR), to form a ternary retinol-RBP4-TTR complex. Vitamin A 0-9 transthyretin Homo sapiens 135-148 26894299-1 2016 Transthyretin (TTR) transports the retinol-binding protein-vitamin A complex and is a minor transporter of thyroxine in blood. Vitamin A 59-68 transthyretin Homo sapiens 0-13 26894299-1 2016 Transthyretin (TTR) transports the retinol-binding protein-vitamin A complex and is a minor transporter of thyroxine in blood. Vitamin A 59-68 transthyretin Homo sapiens 15-18 26729422-1 2016 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP4) which, in turn, associates with another serum protein, transthyretin (TTR), to form a ternary retinol-RBP4-TTR complex. Vitamin A 0-9 transthyretin Homo sapiens 150-153 26729422-1 2016 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP4) which, in turn, associates with another serum protein, transthyretin (TTR), to form a ternary retinol-RBP4-TTR complex. Vitamin A 0-9 transthyretin Homo sapiens 187-190 26729422-1 2016 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP4) which, in turn, associates with another serum protein, transthyretin (TTR), to form a ternary retinol-RBP4-TTR complex. Vitamin A 11-18 transthyretin Homo sapiens 135-148 26729422-1 2016 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP4) which, in turn, associates with another serum protein, transthyretin (TTR), to form a ternary retinol-RBP4-TTR complex. Vitamin A 11-18 transthyretin Homo sapiens 150-153 26729422-1 2016 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP4) which, in turn, associates with another serum protein, transthyretin (TTR), to form a ternary retinol-RBP4-TTR complex. Vitamin A 11-18 transthyretin Homo sapiens 187-190 25781688-0 2015 First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus. Vitamin A 47-54 transthyretin Homo sapiens 38-41 27650990-1 2016 Since transthyretin (TTR) was discovered, it has been regarded as a serum protein carrier of thyroid hormones and retinol. Vitamin A 114-121 transthyretin Homo sapiens 6-19 27650990-1 2016 Since transthyretin (TTR) was discovered, it has been regarded as a serum protein carrier of thyroid hormones and retinol. Vitamin A 114-121 transthyretin Homo sapiens 21-24 26131827-2 2015 In addition, we also examined the association between HNC risk and 2 single nucleotide polymorphisms, TTR rs1667255 and RBP4 rs10882272, that have been associated with serum retinol levels. Vitamin A 174-181 transthyretin Homo sapiens 102-105 26131827-7 2015 TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. Vitamin A 40-47 transthyretin Homo sapiens 0-3 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 0-9 transthyretin Homo sapiens 111-124 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 0-9 transthyretin Homo sapiens 126-129 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 0-9 transthyretin Homo sapiens 153-156 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 11-18 transthyretin Homo sapiens 111-124 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 11-18 transthyretin Homo sapiens 126-129 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 11-18 transthyretin Homo sapiens 153-156 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 49-56 transthyretin Homo sapiens 111-124 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 49-56 transthyretin Homo sapiens 126-129 25481334-1 2015 Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. Vitamin A 49-56 transthyretin Homo sapiens 153-156 23664144-1 2013 Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. Vitamin A 135-142 transthyretin Homo sapiens 21-34 25380591-2 2015 Transthyretin (TTR) is a plasma protein mainly secreted by the liver within a trimolecular TTR-RBP-retinol complex revealing from birth to old age strikingly similar evolutionary patterns with LBM in health and disease. Vitamin A 99-106 transthyretin Homo sapiens 0-13 25380591-2 2015 Transthyretin (TTR) is a plasma protein mainly secreted by the liver within a trimolecular TTR-RBP-retinol complex revealing from birth to old age strikingly similar evolutionary patterns with LBM in health and disease. Vitamin A 99-106 transthyretin Homo sapiens 15-18 25380591-2 2015 Transthyretin (TTR) is a plasma protein mainly secreted by the liver within a trimolecular TTR-RBP-retinol complex revealing from birth to old age strikingly similar evolutionary patterns with LBM in health and disease. Vitamin A 99-106 transthyretin Homo sapiens 91-94 24035612-3 2013 Herein, we provide evidence that transthyretin, a transporter of thyroxine and retinol, is aggregated in preeclampsia and is present at reduced levels in sera of preeclamptic women, as detected by proteomic screen. Vitamin A 79-86 transthyretin Homo sapiens 33-46 23664144-1 2013 Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. Vitamin A 135-142 transthyretin Homo sapiens 36-39 23350588-1 2013 BACKGROUND: Serum retinol binding protein (RBP4) is the binding protein for retinol, being delivered into the circulation through the carrier protein transthyretin (TTR) together with thyroxin (T4). Vitamin A 18-25 transthyretin Homo sapiens 150-163 23350588-1 2013 BACKGROUND: Serum retinol binding protein (RBP4) is the binding protein for retinol, being delivered into the circulation through the carrier protein transthyretin (TTR) together with thyroxin (T4). Vitamin A 18-25 transthyretin Homo sapiens 165-168 23129325-1 2012 Retinol-binding protein 4 (RBP4) is the principle carrier of retinol in the human plasma, which circulates as a complex with transthyretin (TTR), a homotetrameric thyroxine transport protein. Vitamin A 61-68 transthyretin Homo sapiens 125-138 23000319-1 2013 Transthyretin (TTR) is a plasma protein transporter of thyroxine (T(4)) and retinol and also has peptidase activity. Vitamin A 76-83 transthyretin Homo sapiens 0-13 23000319-1 2013 Transthyretin (TTR) is a plasma protein transporter of thyroxine (T(4)) and retinol and also has peptidase activity. Vitamin A 76-83 transthyretin Homo sapiens 15-18 23270597-4 2012 Transthyretin (TTR) is a plasma transport protein for thyroid hormone and forms a complex with retinol-binding protein. Vitamin A 95-102 transthyretin Homo sapiens 0-13 23270597-4 2012 Transthyretin (TTR) is a plasma transport protein for thyroid hormone and forms a complex with retinol-binding protein. Vitamin A 95-102 transthyretin Homo sapiens 15-18 23129325-1 2012 Retinol-binding protein 4 (RBP4) is the principle carrier of retinol in the human plasma, which circulates as a complex with transthyretin (TTR), a homotetrameric thyroxine transport protein. Vitamin A 61-68 transthyretin Homo sapiens 140-143 22329529-3 2012 Abnormalities in the protein transthyretin (TTR), a serum transporter of thyroxine and retinol, is the most common cause of cardiac amyloidoses in elderly adults. Vitamin A 87-94 transthyretin Homo sapiens 29-42 22645360-2 2012 ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Vitamin A 132-141 transthyretin Homo sapiens 0-4 22645360-2 2012 ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Vitamin A 132-141 transthyretin Homo sapiens 34-47 22645360-2 2012 ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Vitamin A 132-141 transthyretin Homo sapiens 1-4 22264585-10 2012 This may have important implications for materno-fetal transfer of thyroid hormones, retinol/retinol binding protein and xenobiotics (such as polychlorinated biphenyls) all of which bind to TTR. Vitamin A 85-92 transthyretin Homo sapiens 190-193 22264585-10 2012 This may have important implications for materno-fetal transfer of thyroid hormones, retinol/retinol binding protein and xenobiotics (such as polychlorinated biphenyls) all of which bind to TTR. Vitamin A 93-100 transthyretin Homo sapiens 190-193 30764010-0 2012 Transthyretin: roles in the nervous system beyond thyroxine and retinol transport. Vitamin A 64-71 transthyretin Homo sapiens 0-13 30764010-2 2012 Besides the primordially attributed systemic role as a transporter molecule of thyroxine (T4) and retinol (through the binding to retinol-binding protein [RBP]), TTR has been recognized as a protein with important functions in several aspects of the nervous system physiology. Vitamin A 98-105 transthyretin Homo sapiens 162-165 30764010-6 2012 The purpose of this review is to highlight the roles of TTR in the nervous system, beyond its systemic role as a transporter molecule of T4 and RBP-retinol. Vitamin A 148-155 transthyretin Homo sapiens 56-59 22329529-3 2012 Abnormalities in the protein transthyretin (TTR), a serum transporter of thyroxine and retinol, is the most common cause of cardiac amyloidoses in elderly adults. Vitamin A 87-94 transthyretin Homo sapiens 44-47 22286025-3 2012 Human transthyretin (TTR) is a transporter of thyroxine and retinol in blood and cerebrospinal fluid (CSF). Vitamin A 60-67 transthyretin Homo sapiens 6-19 22286025-3 2012 Human transthyretin (TTR) is a transporter of thyroxine and retinol in blood and cerebrospinal fluid (CSF). Vitamin A 60-67 transthyretin Homo sapiens 21-24 21422279-1 2011 Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Vitamin A 78-85 transthyretin Homo sapiens 15-18 22973437-1 2012 BACKGROUND: Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that transports thyroxine (T4) and retinol by binding to retinol binding protein. Vitamin A 125-132 transthyretin Homo sapiens 12-25 22973437-1 2012 BACKGROUND: Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that transports thyroxine (T4) and retinol by binding to retinol binding protein. Vitamin A 125-132 transthyretin Homo sapiens 27-30 21591606-1 2011 Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Vitamin A 6-13 transthyretin Homo sapiens 82-95 21591606-1 2011 Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Vitamin A 6-13 transthyretin Homo sapiens 97-100 22015466-3 2012 Retinol-binding protein (RBP) and transthyretin (TTR) are transport proteins for delivery of retinol to the tissues via circulation. Vitamin A 93-100 transthyretin Homo sapiens 34-47 22015466-3 2012 Retinol-binding protein (RBP) and transthyretin (TTR) are transport proteins for delivery of retinol to the tissues via circulation. Vitamin A 93-100 transthyretin Homo sapiens 49-52 22015466-7 2012 RBP and TTR synthesized in the fetus are essential for retinol transport to the developing organs including lung morphogenesis. Vitamin A 55-62 transthyretin Homo sapiens 8-11 22471981-1 2012 Transthyretin (TTR), a beta-strand rich tetrameric protein present in human serum and cerebrospinal fluid is involved in the transport of thyroxine and retinol binding protein:retinol complex (holo-RBP). Vitamin A 152-159 transthyretin Homo sapiens 0-13 22471981-1 2012 Transthyretin (TTR), a beta-strand rich tetrameric protein present in human serum and cerebrospinal fluid is involved in the transport of thyroxine and retinol binding protein:retinol complex (holo-RBP). Vitamin A 152-159 transthyretin Homo sapiens 15-18 22471981-1 2012 Transthyretin (TTR), a beta-strand rich tetrameric protein present in human serum and cerebrospinal fluid is involved in the transport of thyroxine and retinol binding protein:retinol complex (holo-RBP). Vitamin A 176-183 transthyretin Homo sapiens 0-13 22471981-1 2012 Transthyretin (TTR), a beta-strand rich tetrameric protein present in human serum and cerebrospinal fluid is involved in the transport of thyroxine and retinol binding protein:retinol complex (holo-RBP). Vitamin A 176-183 transthyretin Homo sapiens 15-18 22471982-2 2012 TTR is a transport protein for thyroid hormones and vitamin A and is predominantly synthesised in the liver. Vitamin A 52-61 transthyretin Homo sapiens 0-3 22002789-3 2012 Among these, one of the most interesting candidates is transthyretin (TTR), the carrier of thyroxine and retinol, which also binds with amyloid-beta (Abeta), and it has been suggested that it protects against Abeta deposition. Vitamin A 105-112 transthyretin Homo sapiens 55-68 22002789-3 2012 Among these, one of the most interesting candidates is transthyretin (TTR), the carrier of thyroxine and retinol, which also binds with amyloid-beta (Abeta), and it has been suggested that it protects against Abeta deposition. Vitamin A 105-112 transthyretin Homo sapiens 70-73 21878437-3 2011 We identified two independent single-nucleotide polymorphisms associated with circulating retinol levels, which are located near the transthyretin (TTR) and retinol binding protein 4 (RBP4) genes which encode major carrier proteins of retinol: rs1667255 (P =2.30x 10(-17)) and rs10882272 (P =6.04x 10(-12)). Vitamin A 90-97 transthyretin Homo sapiens 148-151 22098747-1 2011 Transthyretin (TTR) is a largely beta-sheet serum protein responsible for transporting thyroxine and vitamin A. Vitamin A 101-110 transthyretin Homo sapiens 0-13 22098747-1 2011 Transthyretin (TTR) is a largely beta-sheet serum protein responsible for transporting thyroxine and vitamin A. Vitamin A 101-110 transthyretin Homo sapiens 15-18 22299423-2 2011 Retinol is carried and transported to the tissues bound to retinol binding protein 4 (RBP4) and transthyretin (TTR). Vitamin A 0-7 transthyretin Homo sapiens 96-109 22299423-2 2011 Retinol is carried and transported to the tissues bound to retinol binding protein 4 (RBP4) and transthyretin (TTR). Vitamin A 0-7 transthyretin Homo sapiens 111-114 21777382-8 2011 These results suggest an influence of the N-terminal primary structure of TTR on its function as a co-carrier for retinol with RBP. Vitamin A 114-121 transthyretin Homo sapiens 74-77 20845945-0 2010 Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex. Vitamin A 0-7 transthyretin Homo sapiens 46-59 20845945-0 2010 Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex. Vitamin A 12-19 transthyretin Homo sapiens 46-59 20845945-2 2010 Plasma transport of retinol is carried out exclusively by the retinol-binding protein (RBP), through complexation with transthyretin. Vitamin A 20-27 transthyretin Homo sapiens 119-132 20845945-3 2010 Using mass spectrometry to examine the subunit exchange dynamics, we find that retinol stabilizes the quaternary structure of transthyretin, through its interactions with RBP, reducing the rate of transthyretin disassembly ~17-fold compared to apoTTR. Vitamin A 79-86 transthyretin Homo sapiens 126-139 20845945-3 2010 Using mass spectrometry to examine the subunit exchange dynamics, we find that retinol stabilizes the quaternary structure of transthyretin, through its interactions with RBP, reducing the rate of transthyretin disassembly ~17-fold compared to apoTTR. Vitamin A 79-86 transthyretin Homo sapiens 197-210 20845945-5 2010 Surprisingly, we found two retinoids that stabilize transthyretin directly, in the absence of RBP, whereas retinol itself requires RBP in order to stabilize transthyretin. Vitamin A 107-114 transthyretin Homo sapiens 157-170 20832065-1 2010 OBJECTIVE: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. Vitamin A 11-18 transthyretin Homo sapiens 89-102 20832065-1 2010 OBJECTIVE: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. Vitamin A 11-18 transthyretin Homo sapiens 104-107 20503435-1 2010 Transthyretin (TTR) is a plasma and cerebrospinal fluid protein mainly recognized as the transporter of thyroxine (T(4)) and retinol. Vitamin A 125-132 transthyretin Homo sapiens 0-13 20503435-1 2010 Transthyretin (TTR) is a plasma and cerebrospinal fluid protein mainly recognized as the transporter of thyroxine (T(4)) and retinol. Vitamin A 125-132 transthyretin Homo sapiens 15-18