PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11022035-1 2001 Cellular retinol-binding protein, type I (CRBP-I) and type II (CRBP-II) are the only members of the fatty acid-binding protein (FABP) family that process intracellular retinol. Vitamin A 9-16 retinol binding protein 1, cellular Mus musculus 42-48 11874492-4 2002 CRBP-I expression was increased 2-fold 8 h following UVA exposure (10 J per cm2), and this increase persisted for at least 16 h. A single UVA exposure induced a concentration-dependent epidermal lipid peroxidation (EC50 = 3.5 J per cm2) giving rise to 55.4 +/- 4.2 nmol lipid peroxides per g at 20 J per cm2, whereas UVB, up to 1 J per cm2, did not increase the basal concentration of 6.7 +/- 0.9 nmol lipid peroxides per g. On the other hand, topical menadione induced a concentration-dependent lipid peroxidation, but did not affect vitamin A content. Vitamin A 535-544 retinol binding protein 1, cellular Mus musculus 0-6 11874492-7 2002 These observations indicate (i) that CRBP-I neither provides protection to UVB- and UVA-induced epidermal vitamin A depletion, nor interferes significantly with reconstitution, and (ii) that the UV-induced vitamin A depletion and lipid peroxidation in mouse epidermis are unrelated processes. Vitamin A 206-215 retinol binding protein 1, cellular Mus musculus 37-43 12590612-5 2003 Inhibition of lecithin retinol acyltransferase (LRAT) with 10-N-acetamidodecyl chloromethyl ketone (AcDCMK) or cellular retinol-binding protein I (CRBP) diminished the generation of both retinyl esters and 11-cis retinol from all-trans retinol. Vitamin A 206-220 retinol binding protein 1, cellular Mus musculus 111-145 12031254-5 2001 In order to distinguish the intrinsic enzyme activity from modulation of retinol uptake and CRBP-retinol content of the cytosol in the studied cells, we monitored enzyme kinetics in the purified microsomal fraction. Vitamin A 97-104 retinol binding protein 1, cellular Mus musculus 92-96 10946560-2 2000 These experimental data integrate into a model of CRBP as a chaperone that protects retinol from the cellular milieu and interacts with certain retinoid-metabolizing enzymes. Vitamin A 84-91 retinol binding protein 1, cellular Mus musculus 50-54 9328436-7 1997 First, high Ca2+ induces the synthesis of mCRBPI, which binds ROL released from retinyl ester stores and makes it accessible to the ROL-RA converting enzyme system. Vitamin A 62-65 retinol binding protein 1, cellular Mus musculus 42-48 10460195-1 1999 The suggested function of cellular retinol-binding protein type I [CRBP(I)] is to carry retinol to esterifying or oxidizing enzymes. Vitamin A 35-42 retinol binding protein 1, cellular Mus musculus 67-74 10487743-0 1999 Cellular retinol-binding protein I is essential for vitamin A homeostasis. Vitamin A 52-61 retinol binding protein 1, cellular Mus musculus 0-34 10487743-1 1999 The gene encoding cellular retinol (ROL, vitA)-binding protein type I (CRBPI) has been inactivated. Vitamin A 27-34 retinol binding protein 1, cellular Mus musculus 71-76 9193722-1 1997 In the adult, as well as in the embryo, a number of specific extra- and intracellular binding proteins such as the plasma retinol binding protein (RBP), the cellular retinol binding protein type I (CRBP I), and also the cellular receptors for RBP are thought to regulate transport and metabolism of retinol (vitamin A). Vitamin A 308-317 retinol binding protein 1, cellular Mus musculus 157-189 9193722-1 1997 In the adult, as well as in the embryo, a number of specific extra- and intracellular binding proteins such as the plasma retinol binding protein (RBP), the cellular retinol binding protein type I (CRBP I), and also the cellular receptors for RBP are thought to regulate transport and metabolism of retinol (vitamin A). Vitamin A 308-317 retinol binding protein 1, cellular Mus musculus 198-204 9193722-7 1997 The chorio-allantoic placenta, on the other hand, does not appear to have this capacity, while the presence of CRBP I does suggest a retinol-metabolizing capability. Vitamin A 133-140 retinol binding protein 1, cellular Mus musculus 111-117 8392461-4 1993 As revealed by immunohistochemistry using antibodies to cellular retinol-binding protein I (CRBP I), retinol accumulates in regions of the embryo expressing CRBP I. Vitamin A 65-72 retinol binding protein 1, cellular Mus musculus 92-98 8392461-8 1993 Thus, the spatially closely related but non-overlapping domains of expression of CRBP I and CRABP I suggests a role of a retinol/RA pathway in epithelial-mesenchymal interactions during pattern formation of limbs and of craniofacial structures. Vitamin A 121-128 retinol binding protein 1, cellular Mus musculus 81-87 1966045-3 1990 We report here the gene expression patterns, as revealed by in situ hybridisation, of the retinoic acid receptors alpha, beta and gamma (RAR-alpha, -beta and -gamma), and the cellular binding proteins for retinol and retinoic acid (CRBP, CRABP) in non-neural tissues of mouse embryos during the period of organogenesis. Vitamin A 205-212 retinol binding protein 1, cellular Mus musculus 232-236 1333403-6 1992 Interestingly, the expression of the three genes, RAR-beta, CRABP II and CRBP I, is induced by retinoic acid, which suggests a link between the synthesis of RA from retinol and the control of expression of subsets of RA-responsive genes. Vitamin A 165-172 retinol binding protein 1, cellular Mus musculus 73-79 1966045-10 1990 Correlation of these expression patterns with the morphogenetic effects of vitamin A deficiency and retinoid excess lead us to propose that the function of CRBP is to store and release retinol where high levels of RA are required for specific morphogenetic processes, while CRABP serves to sequester RA in regions where normal developmental functions require RA levels to be low. Vitamin A 185-192 retinol binding protein 1, cellular Mus musculus 156-160 1966045-11 1990 Where both binding protein genes are expressed in a non-overlapping pattern within a large area of mesenchyme, a gradient of free RA may be created between them by release of retinol-derived RA from CRBP-expressing cells, with binding to CRABP enhancing the steepness of the decline in concentration distant to the source. Vitamin A 175-182 retinol binding protein 1, cellular Mus musculus 199-203 33570783-2 2021 In mice, Rbp1 deficiency decreases the capacity of hepatic stellate cells to take up all-trans retinol and sustain retinyl ester stores. Vitamin A 95-102 retinol binding protein 1, cellular Mus musculus 9-13 35253263-4 2022 Cellular retinol-binding protein, type 1 (CRBP1), encoded by retinol-binding protein, type 1 (Rbp1), regulates RA homeostasis by delivering vitamin A to enzymes for RA synthesis and protecting it from non-specific oxidation. Vitamin A 140-149 retinol binding protein 1, cellular Mus musculus 61-92 35253263-4 2022 Cellular retinol-binding protein, type 1 (CRBP1), encoded by retinol-binding protein, type 1 (Rbp1), regulates RA homeostasis by delivering vitamin A to enzymes for RA synthesis and protecting it from non-specific oxidation. Vitamin A 140-149 retinol binding protein 1, cellular Mus musculus 94-98 2554331-9 1989 First, all of the tissues that are known to be teratogenic targets of retinoic acid and retinol also express CRABP and CRBP transcripts. Vitamin A 88-95 retinol binding protein 1, cellular Mus musculus 119-123 3029143-5 1987 However, treatment with the detergent after the binding reaction is complete removes about half of the bound [3H]RA-CRABP and almost all of the bound [3H]retinol-CRBP. Vitamin A 154-161 retinol binding protein 1, cellular Mus musculus 162-166 32587255-1 2020 Retinol-binding protein 1 (RBP1) is involved in several physiological functions, including the regulation of the metabolism and retinol transport. Vitamin A 128-135 retinol binding protein 1, cellular Mus musculus 0-25 32587255-1 2020 Retinol-binding protein 1 (RBP1) is involved in several physiological functions, including the regulation of the metabolism and retinol transport. Vitamin A 128-135 retinol binding protein 1, cellular Mus musculus 27-31 26151058-8 2015 These differences are associated with significantly increased expression, by 2.8-fold, of cellular retinol-binding protein, type I (RBP1) in freshly isolated HSCs from Dgat1-deficient mice, raising the possibility that RBP1, which contributes to retinol uptake into cells and retinyl ester synthesis, accounts for the differences. Vitamin A 99-106 retinol binding protein 1, cellular Mus musculus 132-136 26151058-8 2015 These differences are associated with significantly increased expression, by 2.8-fold, of cellular retinol-binding protein, type I (RBP1) in freshly isolated HSCs from Dgat1-deficient mice, raising the possibility that RBP1, which contributes to retinol uptake into cells and retinyl ester synthesis, accounts for the differences. Vitamin A 99-106 retinol binding protein 1, cellular Mus musculus 219-223 26151058-8 2015 These differences are associated with significantly increased expression, by 2.8-fold, of cellular retinol-binding protein, type I (RBP1) in freshly isolated HSCs from Dgat1-deficient mice, raising the possibility that RBP1, which contributes to retinol uptake into cells and retinyl ester synthesis, accounts for the differences. Vitamin A 246-253 retinol binding protein 1, cellular Mus musculus 132-136 26151058-8 2015 These differences are associated with significantly increased expression, by 2.8-fold, of cellular retinol-binding protein, type I (RBP1) in freshly isolated HSCs from Dgat1-deficient mice, raising the possibility that RBP1, which contributes to retinol uptake into cells and retinyl ester synthesis, accounts for the differences. Vitamin A 246-253 retinol binding protein 1, cellular Mus musculus 219-223 23362116-2 2013 CrbpI delivers vitamin A to enzymes for metabolism into an active metabolite, all-trans retinoic acid (atRA), where atRA is essential to cell proliferation, apoptosis, differentiation, and migration. Vitamin A 15-24 retinol binding protein 1, cellular Mus musculus 0-5 26030625-3 2015 We show here that mice lacking cellular retinol binding protein (Rbp1-/-) display memory deficits reflecting compromised RXR signaling. Vitamin A 40-47 retinol binding protein 1, cellular Mus musculus 65-69 18295589-4 2008 Our studies suggest that cellular retinol-binding protein, type I (RBP1) acts as an intracellular sensor of retinoid status that, when present as apo-RBP1, stimulates BCMO1 activity and the conversion of carotenoids to retinoids. Vitamin A 34-41 retinol binding protein 1, cellular Mus musculus 67-71 21670153-1 2011 Cellular retinol-binding protein type I (CrbpI), encoded by Rpb1, serves as a chaperone of retinol homeostasis, but its physiological effects remain incompletely understood. Vitamin A 9-16 retinol binding protein 1, cellular Mus musculus 41-46 21670153-3 2011 The Rbp1(-/-) pancreas has increased retinol and intense ectopic expression of Rpb2 mRNA, which encodes CrbpII: both would contribute to increased beta-cell 9cRA biosynthesis. Vitamin A 37-44 retinol binding protein 1, cellular Mus musculus 4-8 21670153-9 2011 Thus, glucose homeostasis and energy metabolism rely on Rbp1 expression and its moderation of pancreas retinol and of the autacoid 9cRA. Vitamin A 103-110 retinol binding protein 1, cellular Mus musculus 56-60 20498279-3 2010 Here we show that cellular retinol-binding protein type I (CRBP-I), a small cytosolic binding protein for retinol and retinaldehyde, is specifically restricted to preadipocytes in white adipose tissue. Vitamin A 27-34 retinol binding protein 1, cellular Mus musculus 59-65 20498279-3 2010 Here we show that cellular retinol-binding protein type I (CRBP-I), a small cytosolic binding protein for retinol and retinaldehyde, is specifically restricted to preadipocytes in white adipose tissue. Vitamin A 106-113 retinol binding protein 1, cellular Mus musculus 59-65 18295589-4 2008 Our studies suggest that cellular retinol-binding protein, type I (RBP1) acts as an intracellular sensor of retinoid status that, when present as apo-RBP1, stimulates BCMO1 activity and the conversion of carotenoids to retinoids. Vitamin A 34-41 retinol binding protein 1, cellular Mus musculus 150-154 16109390-5 2005 Mice absent in the three proteins CRBP I, CRABP I, and CRABP II (CI/CAI/CAII-/-) displayed significantly lower hepatic retinyl ester, retinol, and all-trans-retinoic acid levels compared to wildtype mice, whereas the liver concentrations of 9-cis-4-oxo-13,14-dihydro-retinoic acid was considerably higher. Vitamin A 134-141 retinol binding protein 1, cellular Mus musculus 34-40 15632377-3 2005 We hypothesized that retinol storage might be linked to RAR activation and thus that lowered CRBP-I function might impair RAR activity and cell differentiation. Vitamin A 21-28 retinol binding protein 1, cellular Mus musculus 93-99 15632377-8 2005 RESULTS: In cells expressing wild-type CRBP-I but not the CRBP-I mutants, CRBP-I was found mainly in lipid droplets, the retinol storage organelle, and this localization was associated with promotion of retinol storage by wild-type CRBP-I only. Vitamin A 121-128 retinol binding protein 1, cellular Mus musculus 39-45 15632377-8 2005 RESULTS: In cells expressing wild-type CRBP-I but not the CRBP-I mutants, CRBP-I was found mainly in lipid droplets, the retinol storage organelle, and this localization was associated with promotion of retinol storage by wild-type CRBP-I only. Vitamin A 203-210 retinol binding protein 1, cellular Mus musculus 39-45 15632377-12 2005 CONCLUSIONS: Physiologic RAR activation is dependent on CRBP-I-mediated retinol storage, and CRBP-I downregulation chronically compromises RAR activity, leading to loss of cell differentiation and tumor progression. Vitamin A 72-79 retinol binding protein 1, cellular Mus musculus 56-62