PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17019373-16 2006 The level of CD4 cell count influenced the association of retinol with log VL in men, however. Vitamin A 58-65 CD4 molecule Homo sapiens 13-16 17785809-1 2007 In this study, we report a novel biological function of vitamin A metabolites in conversion of naive FoxP3- CD4+ T cells into a unique FoxP3+ regulatory T cell subset (termed "retinoid-induced FoxP3+ T cells") in both human and mouse T cells. Vitamin A 56-65 CD4 molecule Homo sapiens 108-111 17019373-17 2006 In men with CD4 counts >350 cells/mm, those with higher retinol had higher log VLs compared with the lowest quartile, whereas in men with CD4 counts <350, those with higher retinol levels had lower log VLs compared with the lowest quartile. Vitamin A 59-66 CD4 molecule Homo sapiens 12-15 17019373-20 2006 Decreased retinol levels in women and in men with CD4 counts >350 cells/mm and increased zinc and selenium levels in both genders may be associated with improved virologic control. Vitamin A 10-17 CD4 molecule Homo sapiens 50-53 15215767-10 2004 Among those youths with CD4(+) T cells between 200 and 499 cells/microL, a high anxiety score was associated with a sixfold increase in vitamin A intake as compared with those with a low score.Applications/conclusions Given the increased micronutrient requirements, nutrition counseling with HIV-infected youths should focus on early increase of intake of foods rich in micronutrients to improve growth, slow disease progression, and increase survival. Vitamin A 136-145 CD4 molecule Homo sapiens 24-27 8093291-8 1993 5 weeks later the vitamin A group had higher CD4/CD8 ratios (p < 0.001), higher proportions of CD4 naive T cells (p < 0.01), and lower proportions of CD8, CD45RO T cells (p < 0.05) than the placebo group. Vitamin A 18-27 CD4 molecule Homo sapiens 45-48 9434661-9 1998 Subjects treated with vitamin A experienced a reduction in the number of CD3 + T-cells (P = .012) and CD4 + T-cells (P = .012). Vitamin A 22-31 CD4 molecule Homo sapiens 102-105 8602309-4 1996 RESULTS: Compared with controls, women with HIV-1 infection and CD4 count below 200 cells/microliter exhibited 37% lower mean serum vitamin A levels (0.820 versus 1.308 micromol/L, P < .001) and 37% lower mean serum beta-carotene levels (1.486 versus 2.362 micromol/L, P < .001). Vitamin A 132-141 CD4 molecule Homo sapiens 64-67 8602309-6 1996 In addition, serum vitamin A levels correlated significantly with the percentage of CD4 lymphocytes (r = 0.589, P < .001), CD4 count (r = 0.772, P < .001), and CD4 to CD8 ratio (r = 0.593, P < .001). Vitamin A 19-28 CD4 molecule Homo sapiens 84-87 8602309-6 1996 In addition, serum vitamin A levels correlated significantly with the percentage of CD4 lymphocytes (r = 0.589, P < .001), CD4 count (r = 0.772, P < .001), and CD4 to CD8 ratio (r = 0.593, P < .001). Vitamin A 19-28 CD4 molecule Homo sapiens 126-129 8602309-6 1996 In addition, serum vitamin A levels correlated significantly with the percentage of CD4 lymphocytes (r = 0.589, P < .001), CD4 count (r = 0.772, P < .001), and CD4 to CD8 ratio (r = 0.593, P < .001). Vitamin A 19-28 CD4 molecule Homo sapiens 126-129 8602309-8 1996 CONCLUSION: Compared with levels in uninfected women, serum vitamin A and beta-carotene are decreased in HIV-1-infected pregnant women in the first trimester with CD4 counts lower than 200 cells/microliter. Vitamin A 60-69 CD4 molecule Homo sapiens 163-166 15490719-10 2004 RESULTS: Predictors of CD4 counts were gestational age, serum retinol and season. Vitamin A 62-69 CD4 molecule Homo sapiens 23-26 15490719-11 2004 CD4 counts declined by 25 (95% confidence interval [CI]; 11 to 40; p = 0.001) cells/L for each week"s increase in gestation among women with low serum retinol, while low serum retinol was independently associated with lower CD4 counts (-127; 95% CI, -233 to 20 cells/L; p = 0.02) at 35 weeks gestation. Vitamin A 151-158 CD4 molecule Homo sapiens 0-3 15490719-11 2004 CD4 counts declined by 25 (95% confidence interval [CI]; 11 to 40; p = 0.001) cells/L for each week"s increase in gestation among women with low serum retinol, while low serum retinol was independently associated with lower CD4 counts (-127; 95% CI, -233 to 20 cells/L; p = 0.02) at 35 weeks gestation. Vitamin A 176-183 CD4 molecule Homo sapiens 224-227 12654165-7 2003 Weak, positive associations were found between CD4+ lymphocyte count and plasma levels of retinol (r 0.27; 95 % CI 0.1, 0.43) and Zn (r 0.31; 95 % CI 0.25, 0.46). Vitamin A 90-97 CD4 molecule Homo sapiens 47-50 12514921-11 2002 The correlation analysis among dietary intake and immune status, showed a positive association among vitamin A intake and vitamin D with CD4+ (r = 0.35; p < 0.01) and (r = 0.51; p < 0.001), respectively. Vitamin A 101-110 CD4 molecule Homo sapiens 137-140 12514921-13 2002 CONCLUSION: Vitamin A, and D intakes were correlated with CD4 count, only vitamin D remained as a independent predictor parameter in a in multivariant model. Vitamin A 12-21 CD4 molecule Homo sapiens 58-61 8527077-5 1995 RESULTS: Development of deficiency of vitamin A or vitamin B12 was associated with a decline in CD4 cell count (P = 0.0255 and 0.0377, respectively), while normalization of vitamin A, vitamin B12 and zinc was associated with higher CD4 cell counts (P = 0.0492, 0.0061 and 0.0112, respectively). Vitamin A 38-47 CD4 molecule Homo sapiens 96-99 8527077-5 1995 RESULTS: Development of deficiency of vitamin A or vitamin B12 was associated with a decline in CD4 cell count (P = 0.0255 and 0.0377, respectively), while normalization of vitamin A, vitamin B12 and zinc was associated with higher CD4 cell counts (P = 0.0492, 0.0061 and 0.0112, respectively). Vitamin A 38-47 CD4 molecule Homo sapiens 232-235 8093291-8 1993 5 weeks later the vitamin A group had higher CD4/CD8 ratios (p < 0.001), higher proportions of CD4 naive T cells (p < 0.01), and lower proportions of CD8, CD45RO T cells (p < 0.05) than the placebo group. Vitamin A 18-27 CD4 molecule Homo sapiens 98-101 21179414-5 2010 METHODOLOGY/PRINCIPAL FINDINGS: The addition of the vitamin A metabolite, all-trans retinoic acid (atRA) to human naive CD4+ cells suboptimally activated with IL-2 and TGF-beta enhanced and stabilized FOXP3 expression, and accelerated their maturation to protective regulatory T cells. Vitamin A 52-61 CD4 molecule Homo sapiens 120-123 25256923-6 2014 Patients who were deficient in retinol had a significantly lower median CD4(+) T cell counts (P = 0.002) compared to non-deficient subjects. Vitamin A 31-38 CD4 molecule Homo sapiens 72-75 25256923-8 2014 Accordingly, patients who had retinol levels in quartile 4 had a significantly lower mean CD4(+) T cell count compared to quartile 3 (P = 0.02). Vitamin A 30-37 CD4 molecule Homo sapiens 90-93 25256923-9 2014 The significantly higher CD4(+) T cell counts in patients who were non-deficient in retinol imply the role of retinol in improving the production of CD4(+) T cells. Vitamin A 84-91 CD4 molecule Homo sapiens 25-28 25256923-9 2014 The significantly higher CD4(+) T cell counts in patients who were non-deficient in retinol imply the role of retinol in improving the production of CD4(+) T cells. Vitamin A 110-117 CD4 molecule Homo sapiens 25-28 25256923-9 2014 The significantly higher CD4(+) T cell counts in patients who were non-deficient in retinol imply the role of retinol in improving the production of CD4(+) T cells. Vitamin A 110-117 CD4 molecule Homo sapiens 149-152 25256923-10 2014 However, both lower and higher retinol levels were associated with suppressed immunity (CD4 < 200 cells/mm(3)), suggesting an adverse effect of higher retinol levels. Vitamin A 31-38 CD4 molecule Homo sapiens 88-91 29885777-10 2019 Vitamin A, selenium and sCD14 were associated with CD4 recovery but future studies are needed to further explore these relationships. Vitamin A 0-9 CD4 molecule Homo sapiens 51-54 30647705-10 2018 Both of Tbeta4 and CD4 had positive correlation with vitamin A level at P < .000 and P < .003 respectively as well as with each other at p < .000. Vitamin A 53-62 CD4 molecule Homo sapiens 19-22 28169875-8 2017 In multivariable models after adjusting for age, sex, country, treatment arm, previous TB, baseline CD4 count, HIV viral load, body mass index, and C-reactive protein, pretreatment deficiency in vitamin A (adjusted hazard ratio, aHR 5.33, 95% confidence interval, CI: 1.54 to 18.43) and vitamin D (aHR 3.66, 95% CI: 1.16 to 11.51) were associated with TB post-ART. Vitamin A 195-204 CD4 molecule Homo sapiens 100-103 23675205-7 2010 Similarly there was a positive correlation between CD4 count and serum vitamin A concentration (Pearson r=0.89 p<0.01). Vitamin A 71-80 CD4 molecule Homo sapiens 51-54