PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11027136-1 2000 Cellular retinoic acid-binding proteins I and II (CRABP-I and -II, respectively) are transport proteins for all-trans-retinoic acid (RA), an active metabolite of vitamin A (retinol), and have been reported to be directly involved in the metabolism of RA. Vitamin A 173-180 cellular retinoic acid binding protein 1 Homo sapiens 50-65 11027136-1 2000 Cellular retinoic acid-binding proteins I and II (CRABP-I and -II, respectively) are transport proteins for all-trans-retinoic acid (RA), an active metabolite of vitamin A (retinol), and have been reported to be directly involved in the metabolism of RA. Vitamin A 162-171 cellular retinoic acid binding protein 1 Homo sapiens 50-65 1768424-2 1991 Tritiated analogues of retinol (ROL) and retinoic acid corresponding to substituted benzo[b]thiophene (CD-270) alcohol and carboxylic acid, respectively, were used for the binding studies of the cellular retinoic acid-(CRABP-) and retinol-(CRBP-) binding proteins in human epidermal cells and serum retinol-binding protein (RBP). Vitamin A 23-30 cellular retinoic acid binding protein 1 Homo sapiens 219-224 2833143-2 1987 Studies on CRBP and CRABP suggest that both retinol and retinoic acid are involved in maintaining testicular function. Vitamin A 44-51 cellular retinoic acid binding protein 1 Homo sapiens 20-25 2163611-8 1990 Using PAGE/radiobinding assay, we demonstrated that retinoic acid formed from retinol was bound in differentiating keratinocytes to endogenous cellular retinoic acid-binding protein (CRABP). Vitamin A 78-85 cellular retinoic acid binding protein 1 Homo sapiens 143-181 2163611-8 1990 Using PAGE/radiobinding assay, we demonstrated that retinoic acid formed from retinol was bound in differentiating keratinocytes to endogenous cellular retinoic acid-binding protein (CRABP). Vitamin A 78-85 cellular retinoic acid binding protein 1 Homo sapiens 183-188 2645590-4 1989 Human skin extracts incubated with either [3H]retinol or [3H]retinoic acid and analyzed by PAGE is a novel technique for the study of cellular retinol-(CRBP) and retinoic acid-(CRABP) binding proteins; it allows one to more specifically analyse these binding proteins and differentiate them from RBP. Vitamin A 46-53 cellular retinoic acid binding protein 1 Homo sapiens 177-182 35565751-1 2022 Cellular retinoic acid binding proteins (CRABP1 and CRABP2) bind all-trans-retinoic acid (atRA), the active metabolite of vitamin A, with high affinity. Vitamin A 122-131 cellular retinoic acid binding protein 1 Homo sapiens 41-47 2543582-3 1989 We found increased CRABP after daily application during 4 days of natural or synthetic retinoids (RA, acitretin, isotretinoin, Ro137410, retinol), that have either a high affinity to CRABP or can be transformed into RA. Vitamin A 137-144 cellular retinoic acid binding protein 1 Homo sapiens 19-24 2543582-3 1989 We found increased CRABP after daily application during 4 days of natural or synthetic retinoids (RA, acitretin, isotretinoin, Ro137410, retinol), that have either a high affinity to CRABP or can be transformed into RA. Vitamin A 137-144 cellular retinoic acid binding protein 1 Homo sapiens 183-188 2826263-6 1987 A polyacrylamide gel electrophoresis binding assay was developed for studying cellular retinol-(CRABP) and retinoic acid-(CRABP) binding protein in human skin cytosolic extracts. Vitamin A 87-94 cellular retinoic acid binding protein 1 Homo sapiens 96-101 3025302-1 1987 Since cellular retinol- and retinoic acid-binding proteins (CRBP and CRABP) mediate the effects of vitamin A on epidermal differentiation, the levels of these binding proteins were measured in the epidermal and dermal layers of newborn, human foreskin as well as in primary cultures of keratinocytes and fibroblasts from these layers. Vitamin A 99-108 cellular retinoic acid binding protein 1 Homo sapiens 69-74 2992894-6 1985 Retinol and RA might be translocated to nuclei by their respective binding proteins [cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP)]: isolated EC nuclei have specific, independent binding sites for both holoproteins but not their ligands. Vitamin A 0-7 cellular retinoic acid binding protein 1 Homo sapiens 129-167 2992894-6 1985 Retinol and RA might be translocated to nuclei by their respective binding proteins [cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP)]: isolated EC nuclei have specific, independent binding sites for both holoproteins but not their ligands. Vitamin A 0-7 cellular retinoic acid binding protein 1 Homo sapiens 169-174 2992894-8 1985 Interestingly, incubation with retinol promotes movement of both CRBP and CRABP into the nucleoplasmic fraction. Vitamin A 31-38 cellular retinoic acid binding protein 1 Homo sapiens 74-79 25262571-3 2015 Vitamin A and its derivatives, collectively called retinoids, are solubilized by intracellular retinoid-binding proteins such as cellular retinol-binding protein (CRBP), cellular retinoic acid-binding protein (CRABP) and cellular retinal-binding protein (CRALBP). Vitamin A 0-9 cellular retinoic acid binding protein 1 Homo sapiens 170-208 30728260-8 2019 In summary, our study demonstrates that CRABPs serve as an on-off switch that modulates the efficiency of the HCV life cycle and elucidates how HCV evades the antiviral properties of ATRA via the exploitation of CRABP1 functionality.IMPORTANCE ATRA, a biologically active metabolite of vitamin A, exerts pleiotropic biological effects, including the activation of both innate and adaptive immunity, thereby serving as a potent antimicrobial compound against numerous viral pathogens. Vitamin A 286-295 cellular retinoic acid binding protein 1 Homo sapiens 212-218 6685481-5 1983 Thus, this method, which resolves CRABP and CRBP in crude mixtures from the majority of cytosolic proteins, should be a valuable tool in the evaluation of vitamin A-binding protein interactions and their biological significance. Vitamin A 155-164 cellular retinoic acid binding protein 1 Homo sapiens 34-39 6684744-6 1983 CRBP and CRABP are assumed to be mediating factors for the retinol and retinoic acid action. Vitamin A 59-66 cellular retinoic acid binding protein 1 Homo sapiens 9-14 25262571-3 2015 Vitamin A and its derivatives, collectively called retinoids, are solubilized by intracellular retinoid-binding proteins such as cellular retinol-binding protein (CRBP), cellular retinoic acid-binding protein (CRABP) and cellular retinal-binding protein (CRALBP). Vitamin A 0-9 cellular retinoic acid binding protein 1 Homo sapiens 210-215 14585314-10 2003 Recent studies proved that the control occurs by different expressions of retinoid receptors as well as by time-dependent changes of the vitamin-A-metabolism respectively via cellular vitamin-A-binding proteins (CRBP: cytoplasmatic retinol binding protein; CRABP: cytoplasmatic retinoic acid binding protein). Vitamin A 137-146 cellular retinoic acid binding protein 1 Homo sapiens 257-262 14585314-10 2003 Recent studies proved that the control occurs by different expressions of retinoid receptors as well as by time-dependent changes of the vitamin-A-metabolism respectively via cellular vitamin-A-binding proteins (CRBP: cytoplasmatic retinol binding protein; CRABP: cytoplasmatic retinoic acid binding protein). Vitamin A 184-193 cellular retinoic acid binding protein 1 Homo sapiens 257-262 12034496-1 2002 Members of the cellular retinoic acid (CRABP) and retinol binding (CRBP) proteins family are involved in the metabolic pathways of retinoic acid (RA) and retinal respectively. Vitamin A 50-57 cellular retinoic acid binding protein 1 Homo sapiens 39-44