PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17516864-1 2007 Retinol inhibits the growth of all-trans-retinoic acid (ATRA)-resistant human colon cancer cell lines through a retinoic acid receptor (RAR)-independent mechanism. Vitamin A 0-7 retinoic acid receptor alpha Homo sapiens 112-134 18689151-4 2008 Their effects are mediated through nuclear receptors called Retinoic Acid Receptor (RAR) and regulated by molecules such as Cellular Retinol-Binding Protein 1 (CRBP1) that function in retinol storage. Vitamin A 184-191 retinoic acid receptor alpha Homo sapiens 60-82 18689151-4 2008 Their effects are mediated through nuclear receptors called Retinoic Acid Receptor (RAR) and regulated by molecules such as Cellular Retinol-Binding Protein 1 (CRBP1) that function in retinol storage. Vitamin A 184-191 retinoic acid receptor alpha Homo sapiens 84-87 17512397-1 2007 Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). Vitamin A 39-48 retinoic acid receptor alpha Homo sapiens 99-121 17512397-1 2007 Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). Vitamin A 39-48 retinoic acid receptor alpha Homo sapiens 123-126 17516864-1 2007 Retinol inhibits the growth of all-trans-retinoic acid (ATRA)-resistant human colon cancer cell lines through a retinoic acid receptor (RAR)-independent mechanism. Vitamin A 0-7 retinoic acid receptor alpha Homo sapiens 136-139 17516864-8 2007 In conclusion, retinol reduces the metastatic potential of ATRA-resistant colon cancer cells via a novel RAR-independent mechanism that may involve decreased MMP mRNA levels and activity. Vitamin A 15-22 retinoic acid receptor alpha Homo sapiens 105-108 16267017-1 2005 Retinol (vitamin A) is thought to exert its effects through the actions of its metabolite, all-trans-retinoic acid (ATRA), on gene transcription mediated by retinoic acid receptors (RAR) and retinoic acid response elements (RARE). Vitamin A 0-7 retinoic acid receptor alpha Homo sapiens 157-180 16339527-2 2005 The vitamin A metabolites all-trans- and 9-cis-retinoic acid regulate gene expression by binding to the retinoic acid receptor (RAR), while 9-cis-retinoic acid also binds to the retinoid X receptor (RXR). Vitamin A 4-13 retinoic acid receptor alpha Homo sapiens 128-131 16267017-1 2005 Retinol (vitamin A) is thought to exert its effects through the actions of its metabolite, all-trans-retinoic acid (ATRA), on gene transcription mediated by retinoic acid receptors (RAR) and retinoic acid response elements (RARE). Vitamin A 0-7 retinoic acid receptor alpha Homo sapiens 182-185 16267017-1 2005 Retinol (vitamin A) is thought to exert its effects through the actions of its metabolite, all-trans-retinoic acid (ATRA), on gene transcription mediated by retinoic acid receptors (RAR) and retinoic acid response elements (RARE). Vitamin A 9-18 retinoic acid receptor alpha Homo sapiens 157-180 16267017-1 2005 Retinol (vitamin A) is thought to exert its effects through the actions of its metabolite, all-trans-retinoic acid (ATRA), on gene transcription mediated by retinoic acid receptors (RAR) and retinoic acid response elements (RARE). Vitamin A 9-18 retinoic acid receptor alpha Homo sapiens 182-185 16267017-9 2005 To show that growth inhibition due to retinol was ATRA, RAR, and RARE independent, a pan-RAR antagonist was used to block RAR signaling. Vitamin A 38-45 retinoic acid receptor alpha Homo sapiens 56-59 16267017-9 2005 To show that growth inhibition due to retinol was ATRA, RAR, and RARE independent, a pan-RAR antagonist was used to block RAR signaling. Vitamin A 38-45 retinoic acid receptor alpha Homo sapiens 65-68 16267017-9 2005 To show that growth inhibition due to retinol was ATRA, RAR, and RARE independent, a pan-RAR antagonist was used to block RAR signaling. Vitamin A 38-45 retinoic acid receptor alpha Homo sapiens 65-68 16267017-12 2005 Our data show that retinol acts through a novel, RAR-independent mechanism to inhibit colon cancer cell growth. Vitamin A 19-26 retinoic acid receptor alpha Homo sapiens 49-52 15041701-7 2004 These karyometric changes correlated with increases in retinoic acid receptor alpha, retinoic acid receptor beta, and retinoid X receptor alpha at the 50000 IU/day vitamin A dose. Vitamin A 164-173 retinoic acid receptor alpha Homo sapiens 55-83 15180561-4 2004 Receptor interacting protein 140 (RIP140) represents a novel RAR/RXR coregulator that suppresses vitamin A-regulated gene expression in a retinoid- dependent manner. Vitamin A 97-106 retinoic acid receptor alpha Homo sapiens 61-64 12606456-3 2003 It is known that retinoic acid receptor alpha (RARalpha) and its retinoic acid ligand, the acid form of vitamin A, are required for spermatogenesis. Vitamin A 104-113 retinoic acid receptor alpha Homo sapiens 17-45 14710892-11 2003 In addition, new agonists of RAR and RXR, either selective or pan agonists, will become available and will enlarge the spectrum of vitamin A analogs that have antitumoral properties. Vitamin A 131-140 retinoic acid receptor alpha Homo sapiens 29-32 12901928-7 2003 At 1 microM treatment, like retinol, derivatives 3 and 4 were specifically active for RARalpha out of six retinoid receptors (RAR/RXRalpha, beta, gamma). Vitamin A 28-35 retinoic acid receptor alpha Homo sapiens 86-94 12901928-7 2003 At 1 microM treatment, like retinol, derivatives 3 and 4 were specifically active for RARalpha out of six retinoid receptors (RAR/RXRalpha, beta, gamma). Vitamin A 28-35 retinoic acid receptor alpha Homo sapiens 86-89 12901928-13 2003 Taken together, our results suggest that retinol derivative 3 is a promising antiwrinkle agent based on its higher photo-stability, lower RARalpha activity (possibly indicating reduced side effects), and similar effect on collagenase expression. Vitamin A 41-48 retinoic acid receptor alpha Homo sapiens 138-146 12835288-3 2003 Hence, RARA may influence disease risk via an interaction with vitamin A and related compounds. Vitamin A 63-72 retinoic acid receptor alpha Homo sapiens 7-11 12606456-3 2003 It is known that retinoic acid receptor alpha (RARalpha) and its retinoic acid ligand, the acid form of vitamin A, are required for spermatogenesis. Vitamin A 104-113 retinoic acid receptor alpha Homo sapiens 47-55 12392597-1 2002 BACKGROUND: The effects of the vitamin A metabolite retinoic acid (RA) are mediated at the transcriptional level by retinoic acid receptors (RAR). Vitamin A 31-40 retinoic acid receptor alpha Homo sapiens 141-144 12479981-1 2003 In vertebrates, both nuclear all-trans and 9-cis retinoic acid receptors (RAR and RXR) belonging to the steroid/thyroid/retinoid nuclear receptor superfamily play a crucial role in the vitamin A action. Vitamin A 185-194 retinoic acid receptor alpha Homo sapiens 74-77 10609868-1 1999 Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR). Vitamin A 11-18 retinoic acid receptor alpha Homo sapiens 253-275 11742801-6 2002 Depletion of vitamin A abrogated phase II response, and the effect could be partially reversed only with retinoic acid receptor (RAR)-selective retinoids but not retinoid X receptor (RXR) agonists. Vitamin A 13-22 retinoic acid receptor alpha Homo sapiens 129-132 10609868-1 1999 Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR). Vitamin A 0-9 retinoic acid receptor alpha Homo sapiens 253-275 10609868-1 1999 Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR). Vitamin A 0-9 retinoic acid receptor alpha Homo sapiens 277-280 10609868-1 1999 Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR). Vitamin A 11-18 retinoic acid receptor alpha Homo sapiens 277-280 9607169-1 1997 The discovery and development of information surrounding the retinoic acid receptors (RAR and RXR) has ushered in a new era in understanding the molecular mechanism of action of vitamin A in embryonic development and cellular differentiation. Vitamin A 178-187 retinoic acid receptor alpha Homo sapiens 86-89 9609098-1 1998 Mutations in receptors for the vitamin A metabolite retinoic acid (RAR) that repress retinoic acid (RA)-responsive gene expression have been identified and characterized. Vitamin A 31-40 retinoic acid receptor alpha Homo sapiens 67-70 9506453-6 1998 [3H]All-trans retinol (t-ROL) added to suspensions of intact epidermal cells was metabolically converted to [3H]t-RA, which bound to RAR. Vitamin A 14-21 retinoic acid receptor alpha Homo sapiens 133-136 35406069-2 2022 Acting through the retinoic acid receptors RARalpha, RARbeta, and RARgamma, all-trans-retinoic acid, an active metabolite of VA, is a potent regulator of numerous biological pathways, including embryonic and somatic cellular differentiation, immune functions, and energy metabolism. Vitamin A 125-127 retinoic acid receptor alpha Homo sapiens 43-51 33801011-6 2021 Mechanistically, vitamin A differentially influenced the stages of osteogenesis by enhancing early osteoblastic differentiation and inhibiting bone mineralisation via retinoic acid receptor (RAR) signalling and modulation of osteocyte/osteoblast-related bone peptides. Vitamin A 17-26 retinoic acid receptor alpha Homo sapiens 167-189 33801011-6 2021 Mechanistically, vitamin A differentially influenced the stages of osteogenesis by enhancing early osteoblastic differentiation and inhibiting bone mineralisation via retinoic acid receptor (RAR) signalling and modulation of osteocyte/osteoblast-related bone peptides. Vitamin A 17-26 retinoic acid receptor alpha Homo sapiens 191-194 35406069-2 2022 Acting through the retinoic acid receptors RARalpha, RARbeta, and RARgamma, all-trans-retinoic acid, an active metabolite of VA, is a potent regulator of numerous biological pathways, including embryonic and somatic cellular differentiation, immune functions, and energy metabolism. Vitamin A 125-127 retinoic acid receptor alpha Homo sapiens 53-60 31343737-1 2019 Retinoid acid receptors (RAR) are transcription factors that bind retinoic acid (RA), a metabolite of vitamin A. Vitamin A 102-111 retinoic acid receptor alpha Homo sapiens 25-28 33472949-7 2021 Moreover, activation of the YAP/RAR-RXR crosstalk in CRC cells promoted RAR self-activation loops via vitamin A metabolism, RA and active RAR ligands generated by ALDH1A3. Vitamin A 102-111 retinoic acid receptor alpha Homo sapiens 32-35 33472949-7 2021 Moreover, activation of the YAP/RAR-RXR crosstalk in CRC cells promoted RAR self-activation loops via vitamin A metabolism, RA and active RAR ligands generated by ALDH1A3. Vitamin A 102-111 retinoic acid receptor alpha Homo sapiens 72-75 33472949-7 2021 Moreover, activation of the YAP/RAR-RXR crosstalk in CRC cells promoted RAR self-activation loops via vitamin A metabolism, RA and active RAR ligands generated by ALDH1A3. Vitamin A 102-111 retinoic acid receptor alpha Homo sapiens 72-75 24992177-2 2015 It is now becoming apparent that signaling through vitamin A metabolites, such as all-trans retinoic acid (ATRA), is indispensable for spermatogenesis and disruption of retinoic acid receptor-alpha (RARalpha) function may result in male sterility and aberrant spermatogenesis. Vitamin A 51-60 retinoic acid receptor alpha Homo sapiens 199-207 28370539-1 2017 Retinoids, natural and synthetic derivatives of vitamin A, induce cellular changes by activating nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR). Vitamin A 48-57 retinoic acid receptor alpha Homo sapiens 130-133 28111285-7 2017 Recent data reveal an intricate crosstalk between vitamin A metabolites and bile acids, in part via the Retinoic Acid Receptor (RAR), Retinoid X Receptor (RXR) and the Farnesoid X Receptor (FXR), in maintaining vitamin A and bile acid homeostasis. Vitamin A 50-59 retinoic acid receptor alpha Homo sapiens 104-126 28111285-7 2017 Recent data reveal an intricate crosstalk between vitamin A metabolites and bile acids, in part via the Retinoic Acid Receptor (RAR), Retinoid X Receptor (RXR) and the Farnesoid X Receptor (FXR), in maintaining vitamin A and bile acid homeostasis. Vitamin A 50-59 retinoic acid receptor alpha Homo sapiens 128-131 28111285-7 2017 Recent data reveal an intricate crosstalk between vitamin A metabolites and bile acids, in part via the Retinoic Acid Receptor (RAR), Retinoid X Receptor (RXR) and the Farnesoid X Receptor (FXR), in maintaining vitamin A and bile acid homeostasis. Vitamin A 211-220 retinoic acid receptor alpha Homo sapiens 128-131 26483874-7 2015 Our laboratory focuses on the ability of dietary vitamin A to decrease CRC cell proliferation and invasion via RAR-independent pathways. Vitamin A 49-58 retinoic acid receptor alpha Homo sapiens 111-114 29748133-1 2018 Retinoic acid is the active metabolite of vitamin A and regulates several important cellular processes by activating retinoic acid receptors (RAR) and retinoid X receptors (RXR). Vitamin A 42-51 retinoic acid receptor alpha Homo sapiens 117-140 29748133-1 2018 Retinoic acid is the active metabolite of vitamin A and regulates several important cellular processes by activating retinoic acid receptors (RAR) and retinoid X receptors (RXR). Vitamin A 42-51 retinoic acid receptor alpha Homo sapiens 142-145 28981191-15 2017 They also reveal an additional non-genomic role for RARalpha in platelets that may have implications for the vitamin A-dependent signaling in humans. Vitamin A 109-118 retinoic acid receptor alpha Homo sapiens 52-60 24939557-1 2015 Retinoid, a derivative of vitamin A, is a general term used to describe compounds that bind to and activate retinoic acid receptors [RARs (RARalpha, RARbeta, and RARgamma)] and/or retinoid X receptors [RXRs (RXRalpha, RXRbeta, and RXRgamma)]. Vitamin A 26-35 retinoic acid receptor alpha Homo sapiens 139-147 25134739-1 2015 Retinoic acid (RA) is a terpenoid that is synthesized from vitamin A/retinol (ROL) and binds to the nuclear receptors retinoic acid receptor (RAR)/retinoid X receptor (RXR) to control multiple developmental processes in vertebrates. Vitamin A 59-68 retinoic acid receptor alpha Homo sapiens 142-145 25134739-1 2015 Retinoic acid (RA) is a terpenoid that is synthesized from vitamin A/retinol (ROL) and binds to the nuclear receptors retinoic acid receptor (RAR)/retinoid X receptor (RXR) to control multiple developmental processes in vertebrates. Vitamin A 69-76 retinoic acid receptor alpha Homo sapiens 142-145 26237391-3 2014 Retinoic acid, the active metabolite of vitamin A, is involved in a wide range of biological processes, through binding and activation of nuclear receptors: retinoic acid receptors (RAR) and retinoid X receptors (RXR). Vitamin A 40-49 retinoic acid receptor alpha Homo sapiens 157-180 26237391-3 2014 Retinoic acid, the active metabolite of vitamin A, is involved in a wide range of biological processes, through binding and activation of nuclear receptors: retinoic acid receptors (RAR) and retinoid X receptors (RXR). Vitamin A 40-49 retinoic acid receptor alpha Homo sapiens 182-185 24962883-1 2014 The nuclear retinoic acid receptors (RAR alpha, beta and gamma) and their isoforms are ligand-dependent regulators of transcription Transcription , which mediate the effects of all-trans retinoic acid (RA), the active endogenous metabolite of Vitamin A. Vitamin A 243-252 retinoic acid receptor alpha Homo sapiens 37-62 23814022-6 2013 Moreover, transgenic donor T cells expressing a retinoic acid receptor (RAR) response element luciferase reporter responded to increased vitamin A metabolites in GVHD-affected organs. Vitamin A 137-146 retinoic acid receptor alpha Homo sapiens 48-70 23955709-0 2013 Impact of vitamin A supplementation on RAR gene expression in multiple sclerosis patients. Vitamin A 10-19 retinoic acid receptor alpha Homo sapiens 39-42 23955709-1 2013 Vitamin A and its derivatives have been shown to modulate the immune system via retinoic acid receptor (RAR). Vitamin A 0-9 retinoic acid receptor alpha Homo sapiens 80-102 23955709-1 2013 Vitamin A and its derivatives have been shown to modulate the immune system via retinoic acid receptor (RAR). Vitamin A 0-9 retinoic acid receptor alpha Homo sapiens 104-107 23955709-8 2013 These results show that vitamin A supplementation can significantly downregulate the expression of RAR-alpha gene in PBMCs of MS patients that suggest the presence of in vivo regulatory mechanisms for the action of vitamin A on the immune system. Vitamin A 24-33 retinoic acid receptor alpha Homo sapiens 99-108 23955709-8 2013 These results show that vitamin A supplementation can significantly downregulate the expression of RAR-alpha gene in PBMCs of MS patients that suggest the presence of in vivo regulatory mechanisms for the action of vitamin A on the immune system. Vitamin A 215-224 retinoic acid receptor alpha Homo sapiens 99-108 23814022-6 2013 Moreover, transgenic donor T cells expressing a retinoic acid receptor (RAR) response element luciferase reporter responded to increased vitamin A metabolites in GVHD-affected organs. Vitamin A 137-146 retinoic acid receptor alpha Homo sapiens 72-75 22871568-1 2012 The vitamin A derivative retinoic acid (RA) is an important regulator of mammalian adiposity and lipid metabolism, primarily acting at the gene expression level through nuclear receptors of the RA receptor (RAR) and retinoid X receptor (RXR) subfamilies. Vitamin A 4-13 retinoic acid receptor alpha Homo sapiens 194-205 23352986-1 2013 All-trans retinoic acid (atRA) is the active form of vitamin A, known to activate retinoid receptors, especially the heterodimer retinoid X receptor (RXR):retinoic acid receptor (RAR) that otherwise may play a role in regulation of some drug transporters. Vitamin A 53-62 retinoic acid receptor alpha Homo sapiens 179-182 24564241-8 2013 It was found that Vitamin A, retinoid acid and a few other immune response agents modulated by RARA and LCK genes may be potential treatments for both schizophrenia and hepatocellular carcinoma. Vitamin A 18-27 retinoic acid receptor alpha Homo sapiens 95-99 22871568-1 2012 The vitamin A derivative retinoic acid (RA) is an important regulator of mammalian adiposity and lipid metabolism, primarily acting at the gene expression level through nuclear receptors of the RA receptor (RAR) and retinoid X receptor (RXR) subfamilies. Vitamin A 4-13 retinoic acid receptor alpha Homo sapiens 207-210 20664956-1 2010 Retinoids including natural vitamin A, its derivatives and synthetic compounds work as transcription factors through the retinoic acid receptors (RAR, RXR). Vitamin A 28-37 retinoic acid receptor alpha Homo sapiens 146-149