PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21247881-2 2011 Huntington"s disease and spinobulbar muscular atrophy (SBMA) are examples of these diseases in which underlying mutations are localized near other trinucleotide repeats in the huntingtin (HTT) and androgen receptor (AR) genes, respectively. trinucleotide 147-160 huntingtin Homo sapiens 176-186 21247881-2 2011 Huntington"s disease and spinobulbar muscular atrophy (SBMA) are examples of these diseases in which underlying mutations are localized near other trinucleotide repeats in the huntingtin (HTT) and androgen receptor (AR) genes, respectively. trinucleotide 147-160 huntingtin Homo sapiens 188-191 21503105-2 2011 METHODS: The clinical data of HD cases from 2 Chinese families were analyzed and trinucleotide repeat in the IT15 gene were investigated in 9 of the two families by polymerase chain reaction and GeneScan. trinucleotide 81-94 huntingtin Homo sapiens 109-113 21539755-2 2011 The underlying molecular genetic defect is an expanded trinucleotide (CAG)n repeat encoding a polyglutamine stretch in the N-terminus of the huntingtin protein. trinucleotide 55-68 huntingtin Homo sapiens 141-151 21882412-7 2011 This feature was an important clue for discovery of the causal mutation, as a trinucleotide repeat expansion encoding an elongated glutamine tract in the htt protein was determined to be responsible for HD in 1993, and a relationship between the length of the expanded glutamine tract and the severity of the HD phenotype was uncovered at that time [1]. trinucleotide 78-91 huntingtin Homo sapiens 154-157 21028906-1 2010 Huntington"s disease (HD) is a currently incurable neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat within the huntingtin (HTT) gene. trinucleotide 110-123 huntingtin Homo sapiens 142-152 21028906-1 2010 Huntington"s disease (HD) is a currently incurable neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat within the huntingtin (HTT) gene. trinucleotide 110-123 huntingtin Homo sapiens 154-157 20154343-1 2010 Huntington"s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by an expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene [Huntington"s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington"s disease chromosomes. trinucleotide 120-133 huntingtin Homo sapiens 148-158 19530012-3 2010 Genetic testing confirmed the presence of expanded trinucleotide repeats in huntingtin, consistent with a diagnosis of Huntington"s disease. trinucleotide 51-64 huntingtin Homo sapiens 76-86 20154343-1 2010 Huntington"s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by an expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene [Huntington"s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington"s disease chromosomes. trinucleotide 120-133 huntingtin Homo sapiens 160-163 20154343-1 2010 Huntington"s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by an expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene [Huntington"s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington"s disease chromosomes. trinucleotide 254-267 huntingtin Homo sapiens 148-158 20154343-1 2010 Huntington"s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by an expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene [Huntington"s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington"s disease chromosomes. trinucleotide 254-267 huntingtin Homo sapiens 160-163 20145031-1 2010 Huntington disease (HD) is a neurodegenerative disorder associated with an expanded CAG trinucleotide repeat length in the huntingtin gene. trinucleotide 88-101 huntingtin Homo sapiens 123-133 19039036-1 2009 Huntington"s disease (HD) is caused by an expansion of a CAG trinucleotide sequence that encodes a polyglutamine tract in the huntingtin (Htt) protein. trinucleotide 61-74 huntingtin Homo sapiens 126-136 20802793-2 2010 The pathophysiology of Huntington disease is linked to an expanded trinucleotide repeat of cytosine-adenine-guanine (CAG) in the IT-15 gene on chromosome 4. trinucleotide 67-80 huntingtin Homo sapiens 129-134 21048629-1 2009 Huntington"s disease is caused by a trinucleotide repeat expansion (CAG)n in the gene coding for Huntingtin (Htt) and is one of the several polyglutamine diseases. trinucleotide 36-49 huntingtin Homo sapiens 97-107 21048629-1 2009 Huntington"s disease is caused by a trinucleotide repeat expansion (CAG)n in the gene coding for Huntingtin (Htt) and is one of the several polyglutamine diseases. trinucleotide 36-49 huntingtin Homo sapiens 109-112 20056037-1 2010 Expansion of an unstable trinucleotide (CAG)(n) repeat region within exon 1 of the gene IT15 causes autosomal, dominantly inherited Huntington"s disease (HD). trinucleotide 25-38 huntingtin Homo sapiens 88-92 19039036-1 2009 Huntington"s disease (HD) is caused by an expansion of a CAG trinucleotide sequence that encodes a polyglutamine tract in the huntingtin (Htt) protein. trinucleotide 61-74 huntingtin Homo sapiens 138-141 19076433-2 2008 It is caused by an expanded trinucleotide CAG repeat in the gene coding for the protein, huntingtin. trinucleotide 28-41 huntingtin Homo sapiens 89-99 18466116-1 2008 Huntington"s disease (HD) is a devastating autosomal dominant neurodegenerative disease caused by a CAG trinucleotide repeat expansion encoding an abnormally long polyglutamine tract in the huntingtin protein. trinucleotide 104-117 huntingtin Homo sapiens 190-200 18488016-3 2008 HD is caused by the expansion of cytosine-adenine-guanine (CAG, translated into glutamine) trinucleotide repeats in the first exon of the human huntingtin (HTT) gene. trinucleotide 91-104 huntingtin Homo sapiens 144-154 18488016-3 2008 HD is caused by the expansion of cytosine-adenine-guanine (CAG, translated into glutamine) trinucleotide repeats in the first exon of the human huntingtin (HTT) gene. trinucleotide 91-104 huntingtin Homo sapiens 156-159 18403567-1 2008 BACKGROUND: Huntington disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by an unstable expansion of the CAG trinucleotide repeat in exon 1 of the HTT (huntingtin) gene and typically has an adult onset. trinucleotide 136-149 huntingtin Homo sapiens 174-177 18403567-1 2008 BACKGROUND: Huntington disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by an unstable expansion of the CAG trinucleotide repeat in exon 1 of the HTT (huntingtin) gene and typically has an adult onset. trinucleotide 136-149 huntingtin Homo sapiens 179-189 17184144-4 2007 Neurochemical changes are specifically oriented to deplete GABAergic and cholinergic systems, while molecular alterations include an increased expression of CAG trinucleotide at exon 1 from the huntingtin (htt) gene, as well as aggregation of mutant htt. trinucleotide 161-174 huntingtin Homo sapiens 194-204 17687393-5 2007 CONCLUSION: The results definitely confirm the diagnosis of HD and indicate the CAG trinucleotide repeat expansion of IT15 gene in this HD family. trinucleotide 84-97 huntingtin Homo sapiens 118-122 17189290-1 2007 Huntington disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded CAG trinucleotide repeat in the first exon of the HD gene, which results in a toxic polyglutamine stretch within huntingtin, the protein it encodes. trinucleotide 101-114 huntingtin Homo sapiens 210-220 17115386-1 2007 Huntington"s disease (HD) is a neurodegenerative disorder associated with expansion of CAG trinucleotide repeats in the huntingtin gene. trinucleotide 91-104 huntingtin Homo sapiens 120-130 17184144-4 2007 Neurochemical changes are specifically oriented to deplete GABAergic and cholinergic systems, while molecular alterations include an increased expression of CAG trinucleotide at exon 1 from the huntingtin (htt) gene, as well as aggregation of mutant htt. trinucleotide 161-174 huntingtin Homo sapiens 206-209 16570300-1 2006 Huntington"s disease (HD) is an autosomal dominant progressive neurodegenerative disorder that results from an expanded trinucleotide (CAG) repeat on the huntingtin gene. trinucleotide 120-133 huntingtin Homo sapiens 154-164 17041811-2 2006 The defective gene in HD contains a trinucleotide CAG repeat expansion within its coding region that expresses a polyglutamine repeat in the protein huntingtin. trinucleotide 36-49 huntingtin Homo sapiens 149-159 17007735-1 2006 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat in the gene making huntingtin (Htt). trinucleotide 154-167 huntingtin Homo sapiens 194-204 17007735-1 2006 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat in the gene making huntingtin (Htt). trinucleotide 154-167 huntingtin Homo sapiens 206-209 16829072-1 2006 Thirteen years ago, the culmination of genetic rather than biochemical strategies resulted in the identification of the root cause of Huntington"s disease: an expanded CAG trinucleotide repeat that leads to an elongated polyglutamine tract in the huntingtin protein. trinucleotide 172-185 huntingtin Homo sapiens 247-257 15720212-5 2005 Certainly htt is required for cell survival and impairment of wild-type htt function can be involved in neurodegeneration, but considerable evidence also shows that trinucleotide repeat expansion into glutamine (polyQ domain) endows the protein with a newly acquired toxic activity. trinucleotide 165-178 huntingtin Homo sapiens 10-13 16055197-2 2005 HD is caused by an expanded trinucleotide CAG repeat in the gene coding for the protein huntingtin. trinucleotide 28-41 huntingtin Homo sapiens 88-98 15832309-2 2005 The disease is caused by the abnormal expansion of a CAG trinucleotide repeat in the first exon of the huntingtin gene in chromosome 4p16.3. trinucleotide 57-70 huntingtin Homo sapiens 103-113 15916486-1 2005 Huntington"s disease (HD) is an inherited autosomal dominant, neurodegenerative disease that is caused by a gain of function mutation characterized by the expansion of a CAG trinucleotide repeat in exon 1 of the huntingtin (htt) gene. trinucleotide 174-187 huntingtin Homo sapiens 212-222 15916486-1 2005 Huntington"s disease (HD) is an inherited autosomal dominant, neurodegenerative disease that is caused by a gain of function mutation characterized by the expansion of a CAG trinucleotide repeat in exon 1 of the huntingtin (htt) gene. trinucleotide 174-187 huntingtin Homo sapiens 224-227 16595690-1 2006 Huntington disease is an inherited neurodegenerative disorder that is caused by expanded CAG trinucleotide repeats, resulting in a polyglutamine stretch of >37 on the N terminus of the protein huntingtin (htt). trinucleotide 93-106 huntingtin Homo sapiens 196-206 16595690-1 2006 Huntington disease is an inherited neurodegenerative disorder that is caused by expanded CAG trinucleotide repeats, resulting in a polyglutamine stretch of >37 on the N terminus of the protein huntingtin (htt). trinucleotide 93-106 huntingtin Homo sapiens 208-211 11035034-1 2001 Huntington"s disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the huntingtin protein. trinucleotide 50-63 huntingtin Homo sapiens 117-127 15218539-2 2004 HD is caused by a trinucleotide (CAG) repeat mutation, encoding an expanded polyglutamine tract in the huntingtin protein. trinucleotide 18-31 huntingtin Homo sapiens 103-113 13679594-2 2003 HD is caused by the expansion of a CAG trinucleotide repeat stretch in the coding sequence of the HD gene that gives rise to a long polyglutamine tract in the huntingtin protein. trinucleotide 39-52 huntingtin Homo sapiens 159-169 16471265-3 2005 The defective gene in HD contains a trinucleotide CAG repeat expansion within its coding region that is expressed as a polyglutamine (polyQ) repeat in the protein huntingtin. trinucleotide 36-49 huntingtin Homo sapiens 163-173 12824708-4 2003 The genetic defect is a CAG trinucleotide repeat expansion at the 5" end of the IT-15 gene on chromosome 4. trinucleotide 28-41 huntingtin Homo sapiens 80-85 12523115-0 2002 [Clinical picture of patients with Huntington"s disease in relation to the number of trinucleotide CAG repeats in IT-15 gene]. trinucleotide 85-98 huntingtin Homo sapiens 114-119 10410676-1 1998 Huntington"s disease (HD) is caused by an expanded CAG trinucleotide repeat encoding a tract of consecutive glutamines near the amino terminus of huntingtin, a large protein of unknown function. trinucleotide 55-68 huntingtin Homo sapiens 146-156 10502848-6 1999 We evaluated a polymerase chain reaction (PCR) technique for the detection of CAG trinucleotide repeats in the Huntington IT15 gene on chromosome 4 for the diagnosis of HD. trinucleotide 82-95 huntingtin Homo sapiens 122-126 10502848-11 1999 RESULTS: We successfully identified four subjects with expansion of CAG trinucleotide repeats in Huntington gene IT15 on chromosome 4. trinucleotide 72-85 huntingtin Homo sapiens 113-117 10222786-2 1999 An unstable CAG trinucleotide repeat expansion within the first exon of the responsible gene "IT15", encoding huntingtin, was identified. trinucleotide 16-29 huntingtin Homo sapiens 110-120 9932964-2 1999 The expanded IT-15 allele was only detected with the use of modified PCR and Southern transfer techniques, which showed a CAG trinucleotide repeat expansion of approximately 250 repeats-the largest CAG expansion reported within the huntingtin gene. trinucleotide 126-139 huntingtin Homo sapiens 232-242 10090478-1 1999 Huntington disease (HD) is an autosomal dominant neurodegenerative disorder associated with expansions of an unstable CAG trinucleotide repeat in exon 1 of the IT15 gene. trinucleotide 122-135 huntingtin Homo sapiens 160-164 11013077-1 2000 Huntington"s disease (HD) is associated with a significant expansion of a CAG trinucleotide repeat, which results in a lengthened polyglutamine tract in the single gene product, huntingtin, on human 4p16.3. trinucleotide 78-91 huntingtin Homo sapiens 178-188 10970063-1 2000 Huntington"s disease is a progressive and fatal neurological disorder caused by the expansion of a CAG trinucleotide repeat in exon 1 of the gene coding for a protein of unknown function that has been named huntingtin. trinucleotide 103-116 huntingtin Homo sapiens 207-217 10023115-2 1999 The genetic defect is a CAG trinucleotide repeat expansion at the 5" end of the IT 15 gene on chromosome 4. trinucleotide 28-41 huntingtin Homo sapiens 80-85 9792871-2 1998 The disease is associated with a CAG trinucleotide-repeat expansion in the Huntington gene (IT15) on chromosome 4p16.3. trinucleotide 37-50 huntingtin Homo sapiens 92-96 9768849-2 1998 Disease alleles contain a trinucleotide repeat expansion of variable length, which encodes polyglutamine tracts near the amino terminus of the HD protein, huntingtin. trinucleotide 26-39 huntingtin Homo sapiens 155-165 9392570-1 1997 Huntington"s disease is an inherited disorder caused by expansion of a CAG trinucleotide repeat in the IT15 gene, which leads to expansion of a polyglutamine tract within the protein called huntingtin. trinucleotide 75-88 huntingtin Homo sapiens 103-107 9392570-1 1997 Huntington"s disease is an inherited disorder caused by expansion of a CAG trinucleotide repeat in the IT15 gene, which leads to expansion of a polyglutamine tract within the protein called huntingtin. trinucleotide 75-88 huntingtin Homo sapiens 190-200 8755937-0 1996 Errors in Huntington disease diagnostic test caused by trinucleotide deletion in the IT15 gene. trinucleotide 55-68 huntingtin Homo sapiens 85-89 9211185-2 1997 The mutation is an expansion of a CAG trinucleotide repeat, which translates to give a polyglutamine tract at the N-terminus of a large protein, huntingtin. trinucleotide 38-51 huntingtin Homo sapiens 145-155 8855141-1 1996 Huntington disease (HD) is a neurodegenerative disorder caused by an expanded trinucleotide repeat (CAG)n located at the 5" end of the novel IT15 gene. trinucleotide 78-91 huntingtin Homo sapiens 141-145 9299885-1 1997 The defect causing Huntington"s disease (HD) has recently been discovered as an expanded CAG trinucleotide repeat located at the 5" end of the IT15 gene. trinucleotide 93-106 huntingtin Homo sapiens 143-147 9303588-4 1997 Gene IT15 analysis revealed an abnormal expansion of (CAG) trinucleotide repeats in 18 subjects, being normal in the remaining 18. trinucleotide 59-72 huntingtin Homo sapiens 5-9 9143014-1 1997 We correlated trinucleotide CAG repeat numbers in the huntingtin gene with the regional brain atrophy and clinical phenotype in 23 adult autopsy cases of Huntington"s disease (HD). trinucleotide 14-27 huntingtin Homo sapiens 54-64 8614526-1 1996 We examined the relationship between length of the trinucleotide (CAG) repeat at IT-15 and clinical progression of Huntington"s disease in 46 mildly to moderately affected patients over a 2-year interval. trinucleotide 51-64 huntingtin Homo sapiens 81-86 8774958-1 1995 Positional cloning has shown that the Huntington disease (HD) mutation is an expanded trinucleotide repeat in the IT15 gene. trinucleotide 86-99 huntingtin Homo sapiens 114-118 8954302-2 1996 We examined the expanded trinucleotide (CAG) repeat sequence in the IT15 gene of 27 "sporadic" cases, classified as having clinically probable or clinically doubtful HD. trinucleotide 25-38 huntingtin Homo sapiens 68-72 7576661-1 1995 A trinucleotide repeat (CAG) expansion in the huntingtin gene causes Huntington"s disease (HD). trinucleotide 2-15 huntingtin Homo sapiens 46-56 8720339-0 1995 [Chorea with prominent spasticity associated with an expansion of the CAG trinucleotide repeat in the IT15 gene: a case report]. trinucleotide 74-87 huntingtin Homo sapiens 102-106 7668287-1 1995 Huntington disease (HD) is an autosomal dominant degenerative disorder caused by an expanded and unstable trinucleotide repeat (CAG)n in a gene (IT-15) on chromosome 4. trinucleotide 106-119 huntingtin Homo sapiens 145-150 7568002-1 1995 The Huntington disease (HD) phenotype is associated with expansion of a trinucleotide repeat in the IT15 gene, which is predicted to encode a 348-kDa protein named huntington. trinucleotide 72-85 huntingtin Homo sapiens 100-104 7847863-3 1995 An expansion of a trinucleotide repeat on chromosome 4p16.3 within the coding region of a gene termed IT15 has been identified as the mutation causing HD. trinucleotide 18-31 huntingtin Homo sapiens 102-106 7484060-6 1995 INTRODUCTION--The discovery of an expansion of a trinucleotide (CAG) repeat region in the IT15 gene on the short arm of chromosome 4 has identified the mutational mechanism causing Huntington"s disease (HD) and enables the direct diagnosis of affected subjects based on DNA analysis alone. trinucleotide 49-62 huntingtin Homo sapiens 90-94 7711729-1 1995 Huntington"s disease (HD) is an inherited neurodegenerative disorder expressed when a trinucleotide repeat in the gene IT-15 is expanded. trinucleotide 86-99 huntingtin Homo sapiens 119-124 7750074-6 1995 The gene for HD has recently been discovered and characterized as an unstable CAG trinucleotide repeat sequence on the short arm of chromosome 4 (now known as IT15). trinucleotide 82-95 huntingtin Homo sapiens 159-163 7888133-0 1994 Trinucleotide repeat elongation in the huntingtin gene in Huntington"s disease patients from 85 French families. trinucleotide 0-13 huntingtin Homo sapiens 39-49 7853373-1 1994 The genetic defect causing Huntington"s disease (HD) has been identified as an unstable expansion of a trinucleotide (CAG) repeat sequence within the coding region of the IT15 gene on chromosome 4. trinucleotide 103-116 huntingtin Homo sapiens 171-175 8208412-1 1994 The specific mutation in Huntington"s disease (HD) is an expansion of the unstable CAG trinucleotide repeat in the IT15 gene in chromosome 4p. trinucleotide 87-100 huntingtin Homo sapiens 115-119 8162020-0 1994 A single allele from the polymorphic CCG rich sequence immediately 3" to the unstable CAG trinucleotide in the IT15 cDNA shows almost complete disequilibrium with Huntington"s disease chromosomes in the Scottish population. trinucleotide 90-103 huntingtin Homo sapiens 111-115 7909529-0 1994 A Sau3A polymorphism in the 5" end of the IT15 gene that nonrandomly segregates with the Huntington disease trinucleotide expansion. trinucleotide 108-121 huntingtin Homo sapiens 42-46 8044653-2 1994 Recently the IT15 gene on chromosome 4p has been identified containing an unstable and expanded trinucleotide repeat in patients with HD. trinucleotide 96-109 huntingtin Homo sapiens 13-17 8242074-0 1993 Trinucleotide repeat elongation in the Huntingtin gene in Huntington disease patients from 71 Danish families. trinucleotide 0-13 huntingtin Homo sapiens 39-49 8268907-0 1993 Correlation between the onset age of Huntington"s disease and length of the trinucleotide repeat in IT-15. trinucleotide 76-89 huntingtin Homo sapiens 100-105 8268927-0 1993 Analysis of the huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington"s disease and CAG repeat number. trinucleotide 42-55 huntingtin Homo sapiens 16-26 28094373-1 2017 Huntington"s disease is caused by a CAG trinucleotide expansion mutation in the Huntingtin gene that leads to an artificially long polyglutamine sequence in the Huntingtin protein. trinucleotide 40-53 huntingtin Homo sapiens 80-90 8366869-1 1993 The Huntington"s Disease (HD) Collaborative Research Group has recently published the sequence of a new cDNA, IT15, containing a polymorphic trinucleotide (CAG)n repeat that is expanded and unstable on HD chromosomes. trinucleotide 141-154 huntingtin Homo sapiens 110-114 8458085-4 1993 A new gene, IT15, isolated using cloned trapped exons from the target area contains a polymorphic trinucleotide repeat that is expanded and unstable on HD chromosomes. trinucleotide 98-111 huntingtin Homo sapiens 12-16 8411732-6 1993 IT 15 contains a polymorphic trinucleotide repeat that is expanded and unstable on HD chromosomes. trinucleotide 29-42 huntingtin Homo sapiens 0-5 28094373-1 2017 Huntington"s disease is caused by a CAG trinucleotide expansion mutation in the Huntingtin gene that leads to an artificially long polyglutamine sequence in the Huntingtin protein. trinucleotide 40-53 huntingtin Homo sapiens 161-171 34520257-3 2021 HD is caused by a CAG CTG trinucleotide-repeat expansion in exon 1 of the huntingtin (HTT) gene leading to the formation of mutant HTT (mtHTT) protein aggregates. trinucleotide 26-39 huntingtin Homo sapiens 74-84 19515365-10 2009 Three pairs of primers were used for the amplification of the IT15 gene at the: 1) trinucleotide expansion site; 2) trinucleotide expansion site plus the polymorphic site situated on its 3"-end; and 3) polymorphic marker located downstream of the trinucleotide repeats. trinucleotide 83-96 huntingtin Homo sapiens 62-66 19515365-10 2009 Three pairs of primers were used for the amplification of the IT15 gene at the: 1) trinucleotide expansion site; 2) trinucleotide expansion site plus the polymorphic site situated on its 3"-end; and 3) polymorphic marker located downstream of the trinucleotide repeats. trinucleotide 116-129 huntingtin Homo sapiens 62-66 19515365-10 2009 Three pairs of primers were used for the amplification of the IT15 gene at the: 1) trinucleotide expansion site; 2) trinucleotide expansion site plus the polymorphic site situated on its 3"-end; and 3) polymorphic marker located downstream of the trinucleotide repeats. trinucleotide 116-129 huntingtin Homo sapiens 62-66 34942093-1 2022 It is well known that the length of the CAG trinucleotide expansion of the huntingtin gene is associated with many aspects of Huntington disease progression. trinucleotide 44-57 huntingtin Homo sapiens 75-85 34911927-1 2021 Huntington"s disease (HD) is a hereditary neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. trinucleotide 123-136 huntingtin Homo sapiens 152-162 34911927-1 2021 Huntington"s disease (HD) is a hereditary neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. trinucleotide 123-136 huntingtin Homo sapiens 164-167 34786953-6 2021 Genetic testing revealed a 47 CAG trinucleotide repeats in the Huntingtin gene; family history is negative. trinucleotide 34-47 huntingtin Homo sapiens 63-73 34520257-3 2021 HD is caused by a CAG CTG trinucleotide-repeat expansion in exon 1 of the huntingtin (HTT) gene leading to the formation of mutant HTT (mtHTT) protein aggregates. trinucleotide 26-39 huntingtin Homo sapiens 86-89 34520257-3 2021 HD is caused by a CAG CTG trinucleotide-repeat expansion in exon 1 of the huntingtin (HTT) gene leading to the formation of mutant HTT (mtHTT) protein aggregates. trinucleotide 26-39 huntingtin Homo sapiens 131-134 34520257-6 2021 Previously, we designed a novel anti-gene oligonucleotide (AGO)-based strategy directly targeting the HTT trinucleotide-repeats in DNA and reported downregulation of mRNA and protein in HD patient fibroblasts. trinucleotide 106-119 huntingtin Homo sapiens 102-105 34831058-2 2021 One of these diseases is Huntington"s, which is caused by increased glutamine-encoding trinucleotide repeats within the Huntingtin gene. trinucleotide 87-100 huntingtin Homo sapiens 120-130 34884576-1 2021 Visual deficit is one of the complications of Huntington disease (HD), a fatal neurological disorder caused by CAG trinucleotide expansions in the Huntingtin gene, leading to the production of mutant Huntingtin (mHTT) protein. trinucleotide 115-128 huntingtin Homo sapiens 147-157 34884576-1 2021 Visual deficit is one of the complications of Huntington disease (HD), a fatal neurological disorder caused by CAG trinucleotide expansions in the Huntingtin gene, leading to the production of mutant Huntingtin (mHTT) protein. trinucleotide 115-128 huntingtin Homo sapiens 200-210 34830381-1 2021 Huntington"s disease (HD) is a rare neurodegenerative disorder caused by an expansion of CAG trinucleotide repeat located in the exon 1 of Huntingtin (HTT) gene in human chromosome 4. trinucleotide 93-106 huntingtin Homo sapiens 139-149 34830381-1 2021 Huntington"s disease (HD) is a rare neurodegenerative disorder caused by an expansion of CAG trinucleotide repeat located in the exon 1 of Huntingtin (HTT) gene in human chromosome 4. trinucleotide 93-106 huntingtin Homo sapiens 151-154 34098113-1 2021 Huntington"s disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. trinucleotide 88-101 huntingtin Homo sapiens 124-127 34504195-1 2021 Huntington"s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. trinucleotide 45-58 huntingtin Homo sapiens 101-111 34504195-1 2021 Huntington"s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. trinucleotide 45-58 huntingtin Homo sapiens 113-116 34504195-1 2021 Huntington"s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. trinucleotide 45-58 huntingtin Homo sapiens 138-148 34504195-1 2021 Huntington"s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. trinucleotide 45-58 huntingtin Homo sapiens 150-153 34206228-2 2021 HD results from an autosomal dominant mutation that causes a trinucleotide CAG repeat expansion and the production of mutant Huntingtin protein (mHTT). trinucleotide 61-74 huntingtin Homo sapiens 125-135 34423068-1 2021 Huntington disease (HD) is caused by a pathologic cytosine-adenine-guanine (CAG) trinucleotide repeat expansion in the HTT gene. trinucleotide 81-94 huntingtin Homo sapiens 119-122 34211373-2 2021 HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT). trinucleotide 22-35 huntingtin Homo sapiens 60-70 34211373-2 2021 HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT). trinucleotide 22-35 huntingtin Homo sapiens 72-75 34211373-2 2021 HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT). trinucleotide 22-35 huntingtin Homo sapiens 138-141 34180418-1 2021 BACKGROUND: Huntington"s disease (HD) is caused by an expanded (>35) CAG trinucleotide repeat in huntingtin (HTT). trinucleotide 73-86 huntingtin Homo sapiens 97-107 34266596-6 2021 However, translation of these findings from bench-to-bedside is hampered by differences in murine HD models and HD patients, including mutant huntingtin trinucleotide repeat length, which is highly heterogeneous across the various models. trinucleotide 153-166 huntingtin Homo sapiens 142-152 34180418-1 2021 BACKGROUND: Huntington"s disease (HD) is caused by an expanded (>35) CAG trinucleotide repeat in huntingtin (HTT). trinucleotide 73-86 huntingtin Homo sapiens 109-112 35608753-1 2022 Huntington"s disease (HD) is an autosomal dominantly-inherited neurodegenerative disease, which is caused by CAG trinucleotide expansion in exon 1 of the Huntingtin (HTT) gene. trinucleotide 113-126 huntingtin Homo sapiens 154-164 35608753-1 2022 Huntington"s disease (HD) is an autosomal dominantly-inherited neurodegenerative disease, which is caused by CAG trinucleotide expansion in exon 1 of the Huntingtin (HTT) gene. trinucleotide 113-126 huntingtin Homo sapiens 166-169 35108063-1 2022 Huntington"s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. trinucleotide 95-108 huntingtin Homo sapiens 126-136 35241644-1 2022 Huntington"s Disease (HD) is a progressive neurodegenerative disorder caused by CAG trinucleotide repeat expansions in exon 1 of the huntingtin (HTT) gene. trinucleotide 84-97 huntingtin Homo sapiens 133-143 35241644-1 2022 Huntington"s Disease (HD) is a progressive neurodegenerative disorder caused by CAG trinucleotide repeat expansions in exon 1 of the huntingtin (HTT) gene. trinucleotide 84-97 huntingtin Homo sapiens 145-148 35615642-1 2022 Huntington"s disease (HD) is an autosomal neurodegenerative disease that is characterized by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). trinucleotide 120-133 huntingtin Homo sapiens 153-163 35615642-1 2022 Huntington"s disease (HD) is an autosomal neurodegenerative disease that is characterized by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). trinucleotide 120-133 huntingtin Homo sapiens 170-173 35395060-1 2022 Huntington"s disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant huntingtin protein (mHTT) containing an expanded polyglutamine tract in the amino terminus. trinucleotide 63-76 huntingtin Homo sapiens 98-108 35395060-1 2022 Huntington"s disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant huntingtin protein (mHTT) containing an expanded polyglutamine tract in the amino terminus. trinucleotide 63-76 huntingtin Homo sapiens 153-163 35108063-1 2022 Huntington"s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. trinucleotide 95-108 huntingtin Homo sapiens 138-141 35108063-1 2022 Huntington"s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. trinucleotide 95-108 huntingtin Homo sapiens 183-186 33576024-2 2021 It is caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin (HTT) gene located on chromosome 4 1 . trinucleotide 22-35 huntingtin Homo sapiens 70-80 33576024-2 2021 It is caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin (HTT) gene located on chromosome 4 1 . trinucleotide 22-35 huntingtin Homo sapiens 82-85 33517535-10 2021 Our findings further support emerging evidence that pathogenic trinucleotide repeat expansions of the HTT gene may impact neurodevelopment. trinucleotide 63-76 huntingtin Homo sapiens 102-105 34038804-1 2021 Huntington"s disease (HD) is a devastating and fatal monogenic neurodegenerative disorder characterized by progressive loss of selective neurons in the brain and is caused by an abnormal expansion of CAG trinucleotide repeats in a coding exon of the huntingtin (HTT) gene. trinucleotide 204-217 huntingtin Homo sapiens 250-260 34038804-1 2021 Huntington"s disease (HD) is a devastating and fatal monogenic neurodegenerative disorder characterized by progressive loss of selective neurons in the brain and is caused by an abnormal expansion of CAG trinucleotide repeats in a coding exon of the huntingtin (HTT) gene. trinucleotide 204-217 huntingtin Homo sapiens 262-265 33567536-0 2021 A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT). trinucleotide 61-74 huntingtin Homo sapiens 94-104 33606279-1 2021 Huntington"s disease (HD) is a fatal disorder associated with germline trinucleotide repeat expansions in the HTT gene and characterised by striatal neurodegeneration. trinucleotide 71-84 huntingtin Homo sapiens 110-113 33586075-3 2021 The etiology of Huntington"s disease (HD) is well-known as an abnormally expanded trinucleotide repeat within the huntingtin gene. trinucleotide 82-95 huntingtin Homo sapiens 114-124 33567536-0 2021 A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT). trinucleotide 61-74 huntingtin Homo sapiens 111-114 32979507-1 2020 Huntington"s disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. trinucleotide 74-87 huntingtin Homo sapiens 122-132 33049985-1 2020 Huntington"s disease is a rare neurodegenerative disease caused by a cytosine-adenine-guanine (CAG) trinucleotide expansion in the Huntingtin (HTT) gene. trinucleotide 100-113 huntingtin Homo sapiens 131-141 33329316-1 2020 Huntington"s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the Huntingtin gene. trinucleotide 102-115 huntingtin Homo sapiens 140-150 33049985-1 2020 Huntington"s disease is a rare neurodegenerative disease caused by a cytosine-adenine-guanine (CAG) trinucleotide expansion in the Huntingtin (HTT) gene. trinucleotide 100-113 huntingtin Homo sapiens 143-146 32235053-2 2021 A glutamine stretch (PolyQ) at the N-terminal of the Huntingtin protein is generated by the abnormal expansion of CAG trinucleotide repeats in exon 1 of the HTT gene. trinucleotide 118-131 huntingtin Homo sapiens 53-63 32657893-1 2020 PURPOSE OF REVIEW: Huntington"s disease is a fatal autosomal dominant neurodegenerative disorder caused by a trinucleotide expansion in the HTT gene, and current therapies focus on symptomatic treatment. trinucleotide 109-122 huntingtin Homo sapiens 140-143 32279715-1 2020 Huntington disease, a neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, is caused by a CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4. trinucleotide 138-151 huntingtin Homo sapiens 176-186 32407769-1 2020 Huntington"s disease (HD) is caused by a highly polymorphic CAG trinucleotide expansion in the gene encoding for the huntingtin protein (HTT). trinucleotide 64-77 huntingtin Homo sapiens 117-127 32407769-1 2020 Huntington"s disease (HD) is caused by a highly polymorphic CAG trinucleotide expansion in the gene encoding for the huntingtin protein (HTT). trinucleotide 64-77 huntingtin Homo sapiens 137-140 32555394-1 2020 Trinucleotide (CAG) repeat expansions longer than 39 in the huntingtin (HTT) gene cause Huntington"s disease (HD). trinucleotide 0-13 huntingtin Homo sapiens 60-70 32555394-1 2020 Trinucleotide (CAG) repeat expansions longer than 39 in the huntingtin (HTT) gene cause Huntington"s disease (HD). trinucleotide 0-13 huntingtin Homo sapiens 72-75 32555394-3 2020 The Swedish Huntingtin Alleles and Phenotype (SHAPE) study aims to assess the frequency of trinucleotide repeat expansions in the HTT gene in north Sweden. trinucleotide 91-104 huntingtin Homo sapiens 12-22 32555394-3 2020 The Swedish Huntingtin Alleles and Phenotype (SHAPE) study aims to assess the frequency of trinucleotide repeat expansions in the HTT gene in north Sweden. trinucleotide 91-104 huntingtin Homo sapiens 130-133 20301482-2 1993 DIAGNOSIS/TESTING: The diagnosis of HD rests on positive family history, characteristic clinical findings, and the detection of an expansion of 36 or more CAG trinucleotide repeats in HTT. trinucleotide 159-172 huntingtin Homo sapiens 184-187 32235053-2 2021 A glutamine stretch (PolyQ) at the N-terminal of the Huntingtin protein is generated by the abnormal expansion of CAG trinucleotide repeats in exon 1 of the HTT gene. trinucleotide 118-131 huntingtin Homo sapiens 157-160 31899071-1 2020 Despite being an autosomal dominant disorder caused by a known coding mutation in the gene HTT, Huntington"s disease (HD) patients with similar trinucleotide repeat mutations can have an age of onset that varies by decades. trinucleotide 144-157 huntingtin Homo sapiens 91-94 32566927-5 2020 The length of the disease-causing trinucleotide repeat expansion in the huntingtin gene predicted the change in the precentral gyrus (P = 0.03) and the intensity of the exercise intervention predicted hippocampal perfusion change in Huntington"s disease participants (P < 0.001). trinucleotide 34-47 huntingtin Homo sapiens 72-82 31223078-3 2020 Huntington"s disease is a genetic neurological disorder caused by a repeated expansion of the CAG trinucleotide, causing instability in the N-terminal of the gene coding for the Huntingtin protein. trinucleotide 98-111 huntingtin Homo sapiens 178-188 31103960-2 2019 BACKGROUND: Huntington disease (HD) is caused by a mutation in the HTT gene of 36 or more CAG trinucleotide repeats. trinucleotide 94-107 huntingtin Homo sapiens 67-70 31358058-3 2019 HD is caused by expanded CAG trinucleotide repeats at the N-terminus of IT15 that encodes the huntingtin (HTT) protein, though the molecular mechanisms through which the mutant HTT (mHTT) exerts toxic effects remain obscure. trinucleotide 29-42 huntingtin Homo sapiens 72-76 31358058-3 2019 HD is caused by expanded CAG trinucleotide repeats at the N-terminus of IT15 that encodes the huntingtin (HTT) protein, though the molecular mechanisms through which the mutant HTT (mHTT) exerts toxic effects remain obscure. trinucleotide 29-42 huntingtin Homo sapiens 94-104 31358058-3 2019 HD is caused by expanded CAG trinucleotide repeats at the N-terminus of IT15 that encodes the huntingtin (HTT) protein, though the molecular mechanisms through which the mutant HTT (mHTT) exerts toxic effects remain obscure. trinucleotide 29-42 huntingtin Homo sapiens 106-109 31296921-1 2019 Huntington"s disease (HD) is caused by an expanded CAG trinucleotide repeat in the first exon of the huntingtin gene (HTT). trinucleotide 55-68 huntingtin Homo sapiens 101-111 31296921-1 2019 Huntington"s disease (HD) is caused by an expanded CAG trinucleotide repeat in the first exon of the huntingtin gene (HTT). trinucleotide 55-68 huntingtin Homo sapiens 118-121 30007561-1 2018 Huntington"s disease (HD) is a fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. trinucleotide 80-93 huntingtin Homo sapiens 118-128 30573872-1 2019 Huntington"s disease (HD) is an autosomal dominant disorder caused by a trinucleotide expansion in the huntingtin gene. trinucleotide 72-85 huntingtin Homo sapiens 103-113 30419368-2 2019 It is caused by an expansion of a trinucleotide repeat in the huntingtin gene (HTT) on chromosome 4. trinucleotide 34-47 huntingtin Homo sapiens 62-72 30419368-2 2019 It is caused by an expansion of a trinucleotide repeat in the huntingtin gene (HTT) on chromosome 4. trinucleotide 34-47 huntingtin Homo sapiens 79-82 29440125-0 2018 Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells. trinucleotide 43-56 huntingtin Homo sapiens 32-42 29898922-1 2018 Huntington"s disease (HD) is a rare autosomal dominant neurodegenerative disorder caused by a cytosine-adenine-guanine (CAG) trinucleotide repeat (TNR) expansion within the HTT gene. trinucleotide 125-138 huntingtin Homo sapiens 173-176 29218782-2 2018 In 1993, a CAG trinucleotide repeat expansion in the coding region of the huntingtin (HTT) gene was identified as the cause of this disorder. trinucleotide 15-28 huntingtin Homo sapiens 74-84 29218782-2 2018 In 1993, a CAG trinucleotide repeat expansion in the coding region of the huntingtin (HTT) gene was identified as the cause of this disorder. trinucleotide 15-28 huntingtin Homo sapiens 86-89 29802276-2 2018 Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the huntingtin (HTT) gene. trinucleotide 103-116 huntingtin Homo sapiens 131-141 29802276-2 2018 Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the huntingtin (HTT) gene. trinucleotide 103-116 huntingtin Homo sapiens 143-146 29427096-3 2018 The causative genetic mutation is an expanded CAG trinucleotide repeat in the gene encoding the Huntingtin protein, which leads to a prolonged polyglutamine stretch at the N-terminus of the protein. trinucleotide 50-63 huntingtin Homo sapiens 96-106 29134321-2 2018 Huntington"s disease (HD) is an inherited NDD caused by autosomal-dominant expanded CAG trinucleotide repeat mutation in the gene coding for Huntingtin (Htt). trinucleotide 88-101 huntingtin Homo sapiens 141-151 29134321-2 2018 Huntington"s disease (HD) is an inherited NDD caused by autosomal-dominant expanded CAG trinucleotide repeat mutation in the gene coding for Huntingtin (Htt). trinucleotide 88-101 huntingtin Homo sapiens 153-156 29212816-1 2018 Huntington"s disease (HD) is a neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the huntingtin gene (HTT). trinucleotide 84-97 huntingtin Homo sapiens 112-122 29212816-1 2018 Huntington"s disease (HD) is a neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the huntingtin gene (HTT). trinucleotide 84-97 huntingtin Homo sapiens 129-132 28817209-1 2018 Huntington"s disease (HD) is a fully penetrant neurodegenerative disease caused by a dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4. trinucleotide 110-123 huntingtin Homo sapiens 148-158 29889077-2 2018 The Huntingtin gene (HTT) carries a polymorphic trinucleotide expansion of CAGs in exon 1 that ranges from 9 to 35 in the non-HD affected population. trinucleotide 48-61 huntingtin Homo sapiens 4-14 30459039-2 2018 Since the identification of an abnormal expansion of a trinucleotide repeat tract in the huntingtin gene as the underlying genetic defect, a broad range of transgenic animal models of the disease has become available and these have helped to unravel the relevant molecular pathways in unprecedented detail. trinucleotide 55-68 huntingtin Homo sapiens 89-99 30409256-1 2018 Huntington"s disease (HD) is a rare monogenic neurodegenerative disorder caused by a trinucleotide CAG repeat expansion in the huntingtin gene resulting in the formation of intranuclear inclusions of mutated huntingtin. trinucleotide 85-98 huntingtin Homo sapiens 127-137 30409256-1 2018 Huntington"s disease (HD) is a rare monogenic neurodegenerative disorder caused by a trinucleotide CAG repeat expansion in the huntingtin gene resulting in the formation of intranuclear inclusions of mutated huntingtin. trinucleotide 85-98 huntingtin Homo sapiens 208-218 29889077-2 2018 The Huntingtin gene (HTT) carries a polymorphic trinucleotide expansion of CAGs in exon 1 that ranges from 9 to 35 in the non-HD affected population. trinucleotide 48-61 huntingtin Homo sapiens 21-24 30103339-1 2018 BACKGROUND: Huntington"s disease is a late onset neurological disorder caused by a trinucleotide CAG repeat expansion mutation in the HTT gene encoding for the protein huntingtin. trinucleotide 83-96 huntingtin Homo sapiens 134-137 30103339-1 2018 BACKGROUND: Huntington"s disease is a late onset neurological disorder caused by a trinucleotide CAG repeat expansion mutation in the HTT gene encoding for the protein huntingtin. trinucleotide 83-96 huntingtin Homo sapiens 168-178 30452421-1 2018 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the HTT gene, which encodes for an abnormal polyglutamine tract in the huntingtin protein (HTT). trinucleotide 94-107 huntingtin Homo sapiens 125-128 30452421-1 2018 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the HTT gene, which encodes for an abnormal polyglutamine tract in the huntingtin protein (HTT). trinucleotide 94-107 huntingtin Homo sapiens 192-202 30452421-1 2018 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the HTT gene, which encodes for an abnormal polyglutamine tract in the huntingtin protein (HTT). trinucleotide 94-107 huntingtin Homo sapiens 212-215 29089980-2 2017 HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. trinucleotide 18-31 huntingtin Homo sapiens 80-90 28832564-1 2017 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by expansion of a CAG trinucleotide repeat in HTT, resulting in an extended polyglutamine tract in huntingtin. trinucleotide 106-119 huntingtin Homo sapiens 130-133 28832564-1 2017 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by expansion of a CAG trinucleotide repeat in HTT, resulting in an extended polyglutamine tract in huntingtin. trinucleotide 106-119 huntingtin Homo sapiens 183-193 28265888-1 2017 Huntington disease (HD) is an autosomal dominant neurodegenerative condition caused by a CAG trinucleotide expansion in the huntingtin gene. trinucleotide 93-106 huntingtin Homo sapiens 124-134 28789621-1 2017 BACKGROUND: Huntington"s disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juvenile HD (JHD) are atypical. trinucleotide 116-129 huntingtin Homo sapiens 154-157 28590448-1 2017 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. trinucleotide 110-123 huntingtin Homo sapiens 194-204 28590448-1 2017 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. trinucleotide 110-123 huntingtin Homo sapiens 206-209 28377290-6 2017 HD is one of the most common tandem repeat disorders and is caused by a trinucleotide (CAG) repeat expansion, encoding an extended polyglutamine tract in the huntingtin protein. trinucleotide 72-85 huntingtin Homo sapiens 158-168 27940602-1 2017 Huntington"s disease is a late-onset neurodegenerative disease caused by a CAG trinucleotide repeat in the gene encoding the huntingtin protein. trinucleotide 79-92 huntingtin Homo sapiens 125-135 28027448-1 2017 Huntington"s disease (HD) is a neurodegenerative disease caused by an expansion of CAG trinucleotide repeat (polyglutamine [polyQ]) in the huntingtin ( HTT) gene, which leads to the formation of mutant HTT (mHTT) protein aggregates. trinucleotide 87-100 huntingtin Homo sapiens 139-149 28027448-1 2017 Huntington"s disease (HD) is a neurodegenerative disease caused by an expansion of CAG trinucleotide repeat (polyglutamine [polyQ]) in the huntingtin ( HTT) gene, which leads to the formation of mutant HTT (mHTT) protein aggregates. trinucleotide 87-100 huntingtin Homo sapiens 152-155 28027448-1 2017 Huntington"s disease (HD) is a neurodegenerative disease caused by an expansion of CAG trinucleotide repeat (polyglutamine [polyQ]) in the huntingtin ( HTT) gene, which leads to the formation of mutant HTT (mHTT) protein aggregates. trinucleotide 87-100 huntingtin Homo sapiens 202-205 28674491-1 2017 Huntington"s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by expanded CAG trinucleotide repeats (>36) in exon 1 of HTT gene that encodes huntingtin protein. trinucleotide 113-126 huntingtin Homo sapiens 157-160 28674491-1 2017 Huntington"s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by expanded CAG trinucleotide repeats (>36) in exon 1 of HTT gene that encodes huntingtin protein. trinucleotide 113-126 huntingtin Homo sapiens 179-189 28334749-3 2017 HD is caused by expansion of the CAG trinucleotide repeat region in exon 1 of the Huntingtin gene (HTT), leading to the formation of mutant HTT transcripts (muHTT). trinucleotide 37-50 huntingtin Homo sapiens 82-92 28334749-3 2017 HD is caused by expansion of the CAG trinucleotide repeat region in exon 1 of the Huntingtin gene (HTT), leading to the formation of mutant HTT transcripts (muHTT). trinucleotide 37-50 huntingtin Homo sapiens 99-102 28334749-3 2017 HD is caused by expansion of the CAG trinucleotide repeat region in exon 1 of the Huntingtin gene (HTT), leading to the formation of mutant HTT transcripts (muHTT). trinucleotide 37-50 huntingtin Homo sapiens 140-143 28334749-7 2017 We herein present a novel strategy for HD treatment using oligonucleotides (ONs) directly targeting the HTT trinucleotide repeat DNA. trinucleotide 108-121 huntingtin Homo sapiens 104-107 27870408-1 2017 Huntington disease is a neurodegenerative disorder caused by a gene (HTT) with a unique feature of trinucleotide repeats ranging from 10 to 35 in healthy people; when expanded beyond 39 repeats, Huntington disease develops. trinucleotide 99-112 huntingtin Homo sapiens 69-72 27479945-1 2016 Age of Huntington"s disease (HD) motoric onset is strongly related to the number of CAG trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an important role in disease etiology. trinucleotide 88-101 huntingtin Homo sapiens 117-127 28606048-2 2017 HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding the protein huntingtin. trinucleotide 18-31 huntingtin Homo sapiens 88-98 28947125-1 2017 Huntington disease (HD) is caused by a CAG trinucleotide expansion in the huntingtin gene. trinucleotide 43-56 huntingtin Homo sapiens 74-84 29036832-1 2017 BACKGROUND: Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in huntingtin (HTT) on chromosome 4. trinucleotide 101-114 huntingtin Homo sapiens 141-151 29036832-1 2017 BACKGROUND: Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in huntingtin (HTT) on chromosome 4. trinucleotide 101-114 huntingtin Homo sapiens 153-156 27257945-3 2016 RECENT FINDINGS: A genome-wide association study in Huntington"s disease identified genetic disease modifiers involved in controlling DNA repair mechanisms and stability of the HTT trinucleotide repeat expansion. trinucleotide 181-194 huntingtin Homo sapiens 177-180 27578922-2 2016 Although the cause of HD is well described-HD is a genetic disorder caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin (HTT) on chromosome 4p16.3-the ultimate cause of neuronal death is still uncertain. trinucleotide 80-93 huntingtin Homo sapiens 142-152 26846325-1 2016 Huntington"s Disease (HD) is an autosomal dominant disease that occurs as a result of expansion of the trinucleotide repeat CAG (glutamine) on the HTT gene. trinucleotide 103-116 huntingtin Homo sapiens 147-150 27069383-2 2016 The Huntingtin gene (HTT) has a unique feature of a DNA trinucleotide (triplet) repeat, with repeat length ranging from 10 to 35 in the normal population. trinucleotide 56-69 huntingtin Homo sapiens 4-14 27069383-2 2016 The Huntingtin gene (HTT) has a unique feature of a DNA trinucleotide (triplet) repeat, with repeat length ranging from 10 to 35 in the normal population. trinucleotide 56-69 huntingtin Homo sapiens 21-24 27014581-5 2016 Moreover, a 38 CAG trinucleotide repeat expansion was found on the huntingtin gene, thus configuring a singular CPEO/"reduced penetrance" Huntington disease "double trouble". trinucleotide 19-32 huntingtin Homo sapiens 67-77 26428929-1 2016 UNLABELLED: Huntington"s disease (HD) is a genetic disease caused by a CAG trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin (HTT) protein, ultimately leading to neuronal loss and consequent cognitive decline and death. trinucleotide 75-88 huntingtin Homo sapiens 144-154 26428929-1 2016 UNLABELLED: Huntington"s disease (HD) is a genetic disease caused by a CAG trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin (HTT) protein, ultimately leading to neuronal loss and consequent cognitive decline and death. trinucleotide 75-88 huntingtin Homo sapiens 156-159 26881734-2 2016 It results from an expanded unstable trinucleotide repeat in the coding region of the huntingtin gene. trinucleotide 37-50 huntingtin Homo sapiens 86-96 27578922-2 2016 Although the cause of HD is well described-HD is a genetic disorder caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin (HTT) on chromosome 4p16.3-the ultimate cause of neuronal death is still uncertain. trinucleotide 80-93 huntingtin Homo sapiens 154-157 25726852-1 2015 OBJECTIVES: Huntington"s disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. trinucleotide 170-183 huntingtin Homo sapiens 144-154 26439718-1 2015 Huntington disease (HD) is caused by expansion of a CAG trinucleotide repeat in the first exon of the Huntingtin (HTT) gene. trinucleotide 56-69 huntingtin Homo sapiens 102-112 26439718-1 2015 Huntington disease (HD) is caused by expansion of a CAG trinucleotide repeat in the first exon of the Huntingtin (HTT) gene. trinucleotide 56-69 huntingtin Homo sapiens 114-117 26300964-5 2015 This stretch is encoded by a trinucleotide CAG repetition in exon 1 of HTT. trinucleotide 29-42 huntingtin Homo sapiens 71-74 25596342-1 2015 Huntington disease (HD), an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG trinucleotide repeat in the Huntingtin (HTT) gene, is characterized by extensive neurodegeneration of striatum and cortex and severe diffuse atrophy at MRI. trinucleotide 113-126 huntingtin Homo sapiens 141-151 25596342-1 2015 Huntington disease (HD), an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG trinucleotide repeat in the Huntingtin (HTT) gene, is characterized by extensive neurodegeneration of striatum and cortex and severe diffuse atrophy at MRI. trinucleotide 113-126 huntingtin Homo sapiens 153-156 25995452-1 2015 Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). trinucleotide 158-171 huntingtin Homo sapiens 186-196 25995452-1 2015 Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). trinucleotide 158-171 huntingtin Homo sapiens 203-206 26636579-1 2015 Huntington"s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. trinucleotide 104-117 huntingtin Homo sapiens 132-142 26636579-1 2015 Huntington"s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. trinucleotide 104-117 huntingtin Homo sapiens 144-147 26210848-1 2015 UNLABELLED: Huntington"s disease (HD) is an autosomal dominant, progressive neurodegenerative disorder, caused by an expanded trinucleotide CAG sequence of the huntingtin (Htt) gene, which encodes a stretch of glutamines in the Htt protein. trinucleotide 126-139 huntingtin Homo sapiens 160-170 26210848-1 2015 UNLABELLED: Huntington"s disease (HD) is an autosomal dominant, progressive neurodegenerative disorder, caused by an expanded trinucleotide CAG sequence of the huntingtin (Htt) gene, which encodes a stretch of glutamines in the Htt protein. trinucleotide 126-139 huntingtin Homo sapiens 172-175 25726852-1 2015 OBJECTIVES: Huntington"s disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. trinucleotide 170-183 huntingtin Homo sapiens 161-164 25149514-1 2014 Huntington s disease is a neurodegenerative disorder, attributable to an expanded trinucleotide repeat in the coding region of the human HTT gene, which encodes the protein huntingtin. trinucleotide 82-95 huntingtin Homo sapiens 137-140 25687118-1 2015 Huntington"s disease (HD) is a neurological genetic disorder caused by the expansion of the CAG trinucleotide repeats (TNR) in the N-terminal region of coding sequence of the Huntingtin"s (HTT) gene. trinucleotide 96-109 huntingtin Homo sapiens 175-187 25687118-1 2015 Huntington"s disease (HD) is a neurological genetic disorder caused by the expansion of the CAG trinucleotide repeats (TNR) in the N-terminal region of coding sequence of the Huntingtin"s (HTT) gene. trinucleotide 96-109 huntingtin Homo sapiens 189-192 27188817-2 2015 The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene that encodes the protein huntingtin. trinucleotide 41-54 huntingtin Homo sapiens 86-89 27188817-2 2015 The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene that encodes the protein huntingtin. trinucleotide 41-54 huntingtin Homo sapiens 125-135 25673747-1 2015 The Q175 knockin mouse model of Huntington"s disease (HD) carries a CAG trinucleotide expansion of the human mutant huntingtin allele in its native mouse genomic context and recapitulates the genotype more closely than transgenic models. trinucleotide 72-85 huntingtin Homo sapiens 116-126 25205327-4 2015 Following its clinical and pathologic characterization, the causative genetic mutation in HD was subsequently identified as a trinucleotide (CAG) repeat expansion in the huntingtin (HTT) gene, and consequently, the HTT gene and huntingtin protein have been studied in great detail. trinucleotide 126-139 huntingtin Homo sapiens 170-180 25205327-4 2015 Following its clinical and pathologic characterization, the causative genetic mutation in HD was subsequently identified as a trinucleotide (CAG) repeat expansion in the huntingtin (HTT) gene, and consequently, the HTT gene and huntingtin protein have been studied in great detail. trinucleotide 126-139 huntingtin Homo sapiens 182-185 25205327-4 2015 Following its clinical and pathologic characterization, the causative genetic mutation in HD was subsequently identified as a trinucleotide (CAG) repeat expansion in the huntingtin (HTT) gene, and consequently, the HTT gene and huntingtin protein have been studied in great detail. trinucleotide 126-139 huntingtin Homo sapiens 215-218 25205327-4 2015 Following its clinical and pathologic characterization, the causative genetic mutation in HD was subsequently identified as a trinucleotide (CAG) repeat expansion in the huntingtin (HTT) gene, and consequently, the HTT gene and huntingtin protein have been studied in great detail. trinucleotide 126-139 huntingtin Homo sapiens 228-238 25149514-1 2014 Huntington s disease is a neurodegenerative disorder, attributable to an expanded trinucleotide repeat in the coding region of the human HTT gene, which encodes the protein huntingtin. trinucleotide 82-95 huntingtin Homo sapiens 173-183 25034271-1 2014 Huntington disease (HD), the most common inherited cause of chorea, is an autosomal dominant disorder, caused by an expanded trinucleotide CAG repeat (>39) in the HTT gene on chromosome 4p16.3. trinucleotide 125-138 huntingtin Homo sapiens 163-166 24646433-3 2014 Huntington disease (HD) is an autosomal dominant disorder caused by an expanded CAG trinucleotide repeat in the Huntingtin gene (HTT). trinucleotide 84-97 huntingtin Homo sapiens 112-122 25154728-5 2014 In past decades, genetics, the study of DNA sequence variation and its consequences, provided the tools to map the HD gene to chromosome 4 and ultimately to identify its mutation as an expanded CAG trinucleotide repeat in the coding sequence of a large protein, dubbed huntingtin. trinucleotide 198-211 huntingtin Homo sapiens 269-279 25642374-0 2014 Trinucleotide repeats and haplotypes at the huntingtin locus in an Indian sample overlaps with European haplogroup a. Huntington"s disease (HD), an autosomal dominant neurodegenerative syndrome, has a world-wide distribution. trinucleotide 0-13 huntingtin Homo sapiens 44-54 24646433-3 2014 Huntington disease (HD) is an autosomal dominant disorder caused by an expanded CAG trinucleotide repeat in the Huntingtin gene (HTT). trinucleotide 84-97 huntingtin Homo sapiens 129-132 23463025-1 2013 Huntington disease (HD) is a neurodegenerative disorder resulting from the expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene. trinucleotide 94-107 huntingtin Homo sapiens 122-132 24976932-1 2014 Huntington"s disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded trinucleotide CAG sequence in huntingtin gene (HTT) on chromosome 4. trinucleotide 102-115 huntingtin Homo sapiens 132-142 24976932-1 2014 Huntington"s disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded trinucleotide CAG sequence in huntingtin gene (HTT) on chromosome 4. trinucleotide 102-115 huntingtin Homo sapiens 149-152 24816435-1 2014 The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington"s disease (HD). trinucleotide 23-36 huntingtin Homo sapiens 51-61 24816435-1 2014 The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington"s disease (HD). trinucleotide 23-36 huntingtin Homo sapiens 83-93 24196395-1 2014 Huntington disease is a monogenic, autosomal dominant, progressive neurodegenerative disorder caused by a trinucleotide CAG repeat expansion in exon 1 of the huntingtin (HTT) gene; age of onset of clinical symptoms inversely correlates with expanded CAG repeat length. trinucleotide 106-119 huntingtin Homo sapiens 158-168 24196395-1 2014 Huntington disease is a monogenic, autosomal dominant, progressive neurodegenerative disorder caused by a trinucleotide CAG repeat expansion in exon 1 of the huntingtin (HTT) gene; age of onset of clinical symptoms inversely correlates with expanded CAG repeat length. trinucleotide 106-119 huntingtin Homo sapiens 170-173 24452335-2 2014 HD is caused by a trinucleotide CAG repeat expansion that encodes a polyglutamine stretch in the huntingtin (HTT) protein. trinucleotide 18-31 huntingtin Homo sapiens 97-107 24452335-2 2014 HD is caused by a trinucleotide CAG repeat expansion that encodes a polyglutamine stretch in the huntingtin (HTT) protein. trinucleotide 18-31 huntingtin Homo sapiens 109-112 24266403-3 2013 Here we test how UNA substitutions affect allele-selective inhibition of expression of trinucleotide repeat genes Huntingtin (HTT) and Ataxin-3 (ATX-3). trinucleotide 87-100 huntingtin Homo sapiens 114-124 24266403-3 2013 Here we test how UNA substitutions affect allele-selective inhibition of expression of trinucleotide repeat genes Huntingtin (HTT) and Ataxin-3 (ATX-3). trinucleotide 87-100 huntingtin Homo sapiens 126-129 24555239-1 2013 BACKGROUND: Huntington"s disease is a progressive neurodegenerative disease, genetically determined by CAG trinucleotide expansions in the IT15 gene. trinucleotide 107-120 huntingtin Homo sapiens 139-143 24278347-1 2013 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. trinucleotide 111-124 huntingtin Homo sapiens 139-142 24278347-1 2013 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. trinucleotide 111-124 huntingtin Homo sapiens 157-167 23463025-1 2013 Huntington disease (HD) is a neurodegenerative disorder resulting from the expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene. trinucleotide 94-107 huntingtin Homo sapiens 134-137 23953200-1 2013 Huntington"s disease (HD) is a neurodegenerative disorder caused by trinucleotide CAG (Cytosine-Adenine-Guanine) expansion on the Huntingtin gene (HTT) encoding for the Huntingtin protein (Htt). trinucleotide 68-81 huntingtin Homo sapiens 130-140 23953200-1 2013 Huntington"s disease (HD) is a neurodegenerative disorder caused by trinucleotide CAG (Cytosine-Adenine-Guanine) expansion on the Huntingtin gene (HTT) encoding for the Huntingtin protein (Htt). trinucleotide 68-81 huntingtin Homo sapiens 147-150 23953200-1 2013 Huntington"s disease (HD) is a neurodegenerative disorder caused by trinucleotide CAG (Cytosine-Adenine-Guanine) expansion on the Huntingtin gene (HTT) encoding for the Huntingtin protein (Htt). trinucleotide 68-81 huntingtin Homo sapiens 169-179 23953200-1 2013 Huntington"s disease (HD) is a neurodegenerative disorder caused by trinucleotide CAG (Cytosine-Adenine-Guanine) expansion on the Huntingtin gene (HTT) encoding for the Huntingtin protein (Htt). trinucleotide 68-81 huntingtin Homo sapiens 189-192 22422149-3 2013 According to previous studies, the exon 1 region of the huntingtin (HTT) gene with expanded CAG trinucleotide repeats plays a critical role in causing HD. trinucleotide 96-109 huntingtin Homo sapiens 68-71 22990145-1 2013 Huntington disease (HD) is caused by the expansion of an unstable polymorphic trinucleotide (CAG)n repeat in exon 1 of the HTT gene, which translates into an extended polyglutamine tract in the protein. trinucleotide 78-91 huntingtin Homo sapiens 123-126 22993450-2 2013 Differentiating among these HD-like syndromes is necessary when a patient with a combination of movement disorders, cognitive decline, behavioural abnormalities and progressive disease course proves negative to the genetic testing for HD causative mutations, that is, IT15 gene trinucleotide-repeat expansion. trinucleotide 278-291 huntingtin Homo sapiens 268-272 23394029-3 2012 IT-15 mutation includes multiple (36-250) repetitions of trinucleotide sequence (CAG) encoding a glutamine at the amino end of Huntington (mHtt). trinucleotide 57-70 huntingtin Homo sapiens 0-5 22627493-1 2012 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. trinucleotide 93-106 huntingtin Homo sapiens 124-134 22627493-1 2012 Huntington"s disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. trinucleotide 93-106 huntingtin Homo sapiens 136-139 23042244-1 2012 Huntington"s disease is an incurable neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat within one allele of the huntingtin (HTT) gene. trinucleotide 93-106 huntingtin Homo sapiens 139-149 23042244-1 2012 Huntington"s disease is an incurable neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat within one allele of the huntingtin (HTT) gene. trinucleotide 93-106 huntingtin Homo sapiens 151-154 23042244-3 2012 We have previously demonstrated that mismatch-containing duplex RNAs complementary to the expanded trinucleotide repeat are potent and allele-selective inhibitors of mutant HTT expression, but the mechanism of allele selectivity was not explored. trinucleotide 99-112 huntingtin Homo sapiens 173-176 24209441-2 2013 The cause of HD is an expanded CAG trinucleotide repeat in the Htt gene. trinucleotide 35-48 huntingtin Homo sapiens 63-66 25062733-1 2013 BACKGROUND: Huntington"s disease is caused by expansion of CAG trinucleotide repeats in the first exon of the huntingtin gene, which is essential for both development and neurogenesis. trinucleotide 63-76 huntingtin Homo sapiens 110-120 22891683-1 2012 Huntington"s disease (HD) is a devastating neurodegenerative disorder caused by an expansion of CAG trinucleotide repeats encoding for polyglutamine (polyQ) in the huntingtin (Htt) gene. trinucleotide 100-113 huntingtin Homo sapiens 164-174 22891683-1 2012 Huntington"s disease (HD) is a devastating neurodegenerative disorder caused by an expansion of CAG trinucleotide repeats encoding for polyglutamine (polyQ) in the huntingtin (Htt) gene. trinucleotide 100-113 huntingtin Homo sapiens 176-179 22071633-2 2011 HD is caused by a highly polymorphic CAG trinucleotide repeat expansion in the exon-1 of the gene encoding for huntingtin protein. trinucleotide 41-54 huntingtin Homo sapiens 111-121 22198539-1 2012 Huntington"s disease (HD) is a fatal, autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide (CAG) repeat in exon 1 of the huntingtin gene (Htt). trinucleotide 106-119 huntingtin Homo sapiens 150-160 22198539-1 2012 Huntington"s disease (HD) is a fatal, autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide (CAG) repeat in exon 1 of the huntingtin gene (Htt). trinucleotide 106-119 huntingtin Homo sapiens 167-170 22970194-1 2012 The CAG trinucleotide repeat mutation in the Huntington"s disease gene (HTT) exhibits age-dependent tissue-specific expansion that correlates with disease onset in patients, implicating somatic expansion as a disease modifier and potential therapeutic target. trinucleotide 8-21 huntingtin Homo sapiens 72-75 22359536-3 2012 We collected demographic and clinical data, conducted the Unified Huntington"s Disease Rating Scale and Mini-Mental State Examination, and determined Huntingtin trinucleotide CAG repeat length. trinucleotide 161-174 huntingtin Homo sapiens 150-160 22170268-2 2011 An age of onset in the late sixties and a negative family history suggest a relatively small expanded trinucleotide repeat in the HTT gene in the patient and reduced penetrance of an even shorter repeat allele in one of his parents. trinucleotide 102-115 huntingtin Homo sapiens 130-133 22613578-3 2012 The causative mutation of this hereditary disease is a trinucleotide repeat expansion (CAG) in the Huntingtin gene that results in an expanded polyglutamine tract. trinucleotide 55-68 huntingtin Homo sapiens 99-109 21199443-2 2011 HD is caused by a trinucleotide repeat expansion in the HTT gene and a corresponding neurotoxic polyglutamine expansion in the huntingtin protein. trinucleotide 18-31 huntingtin Homo sapiens 56-59 21519949-1 2011 Huntington"s Disease (HD) is caused by trinucleotide CAG repeat expansion >36 in huntingtin (htt), a protein with several documented functions. trinucleotide 39-52 huntingtin Homo sapiens 81-91 21519949-1 2011 Huntington"s Disease (HD) is caused by trinucleotide CAG repeat expansion >36 in huntingtin (htt), a protein with several documented functions. trinucleotide 39-52 huntingtin Homo sapiens 93-96 21465263-1 2011 Huntington"s disease (HD) occurs through an expansion of the trinucleotide repeat in the HD gene resulting in the lengthening of the polyglutamine stretch within the N terminus of the protein, huntingtin (Htt). trinucleotide 61-74 huntingtin Homo sapiens 205-208 21854390-1 2011 Huntington"s disease is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. trinucleotide 81-94 huntingtin Homo sapiens 119-129 21278081-2 2011 HD is caused by the extension of trinucleotide repeats encoding a stretch of glutamine residues at the amino-terminal end of the large huntingtin (HTT) protein. trinucleotide 33-46 huntingtin Homo sapiens 135-145 21278081-2 2011 HD is caused by the extension of trinucleotide repeats encoding a stretch of glutamine residues at the amino-terminal end of the large huntingtin (HTT) protein. trinucleotide 33-46 huntingtin Homo sapiens 147-150 21465263-1 2011 Huntington"s disease (HD) occurs through an expansion of the trinucleotide repeat in the HD gene resulting in the lengthening of the polyglutamine stretch within the N terminus of the protein, huntingtin (Htt). trinucleotide 61-74 huntingtin Homo sapiens 193-203 21983719-6 2011 CONCLUSION: This family showed reduced CAG trinucleotide repeats of IT15 gene during maternal transmission. trinucleotide 43-56 huntingtin Homo sapiens 68-72