PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33945347-7	2021	Our results revealed that Evodiamine significantly decreased TNF-alpha, IL-6, and IL-1beta in BEAS-2B cells.	evodiamine	26-36	interleukin 1 alpha	Homo sapiens	82-90	
20005289-2	2010	We have previously reported that evodiamine has a marked inhibitory effect on IL-1 sensitive human melanoma A375-S2 cells proliferation, and this action might be through inactivation of PI3K signaling.	evodiamine	33-43	interleukin 1 alpha	Homo sapiens	78-82	
15930731-0	2005	Evodiamine induced human melanoma A375-S2 cell death partially through interleukin 1 mediated pathway.	evodiamine	0-10	interleukin 1 alpha	Homo sapiens	71-84	
22087636-4	2012	The results revealed that Sinomenine, Oxymartrine and Evodiamine inhibited the production of IL-1alpha; Stachydrine, Chuanxionggzine and Evodiamine inhibited the secretion of TXB(2); Sinomenine and Oxymartrine down-regulated ET-1 expression; Fangchinoline and Evodiamine decreased the level of E-selectin.	evodiamine	54-64	interleukin 1 alpha	Homo sapiens	93-102	
15930731-6	2005	In conclusion, IL-1-induced death cascade in melanoma A375-S2 cell might be one of the targets for natural product evodiamine, and increased Fas-L expression via IL-1 mediated pathway stands at the initiation phase, leading to consequent events that culminate in the death of the cells.	evodiamine	115-125	interleukin 1 alpha	Homo sapiens	15-19