PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30682488-8	2019	Mechanistically, our studies demonstrated that evodiamine inhibited the activation of IL-6 -induced STAT3 signaling activation, and the inhibitory effect was likely due to the upregulation of phosphatase shatterproof 2 (SHP-2), a negative feedback regulator of IL-6/STAT3.	evodiamine	47-57	signal transducer and activator of transcription 3	Homo sapiens	100-105	
32183146-2	2020	We investigated the ability of EVO to affect hepatocyte growth factor (HGF)-induced c-Met/Src/STAT3 activation cascades in castration-resistant prostate cancer (CRPC).	evodiamine	31-34	signal transducer and activator of transcription 3	Homo sapiens	94-99	
32183146-4	2020	Next, we found that EVO markedly inhibited HGF-induced c-Met/Src/STAT3 phosphorylation and impaired the nuclear translocation of STAT3 protein.	evodiamine	20-23	signal transducer and activator of transcription 3	Homo sapiens	65-70	
32183146-4	2020	Next, we found that EVO markedly inhibited HGF-induced c-Met/Src/STAT3 phosphorylation and impaired the nuclear translocation of STAT3 protein.	evodiamine	20-23	signal transducer and activator of transcription 3	Homo sapiens	129-134	
32183146-6	2020	Moreover, it was observed that in cPC-3 and DU145 cells transfected with c-Met small interfering RNA (siRNA), Src/STAT3 activation was also mitigated and led to a decrease in EVO-induced apoptotic cell death.	evodiamine	175-178	signal transducer and activator of transcription 3	Homo sapiens	114-119	
32183146-7	2020	According to our results, EVO can abrogate the activation of the c-Met/Src/STAT3 signaling axis and thus plays a role as a robust suppressor of tumor cell survival, proliferation, and angiogenesis.	evodiamine	26-29	signal transducer and activator of transcription 3	Homo sapiens	75-80	
30682488-8	2019	Mechanistically, our studies demonstrated that evodiamine inhibited the activation of IL-6 -induced STAT3 signaling activation, and the inhibitory effect was likely due to the upregulation of phosphatase shatterproof 2 (SHP-2), a negative feedback regulator of IL-6/STAT3.	evodiamine	47-57	signal transducer and activator of transcription 3	Homo sapiens	266-271	
30682488-9	2019	Blockage of SHP-2 through small interference RNA (siRNA) abolished the evodiamine -induced IL-6/STAT3 signaling inhibition.	evodiamine	71-81	signal transducer and activator of transcription 3	Homo sapiens	96-101	
30682488-11	2019	In summary, our results implied evodiamine as a promising anti-cancer agent in the treatment of CCA, and the mechanism is likely due to the inhibition of IL-6/STAT3 signaling with upregulating the expression levels of SHP-2.	evodiamine	32-42	signal transducer and activator of transcription 3	Homo sapiens	159-164	
26580615-9	2015	Taken together, our results suggest that EVO modulates the activity of the p53 signaling pathway to induce apoptosis and downregulate MMP3 expression by inactivating the JAK2/STAT3 pathway through the downregulation of PGI to inhibit migration of HCT-116 human colorectal cancer cells.	evodiamine	41-44	signal transducer and activator of transcription 3	Homo sapiens	175-180	
23032719-0	2013	Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.	evodiamine	0-10	signal transducer and activator of transcription 3	Homo sapiens	20-25	
23032719-4	2013	We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively.	evodiamine	14-24	signal transducer and activator of transcription 3	Homo sapiens	101-106	
23032719-6	2013	Interestingly, treatment of cells with sodium pervanadate abrogated the inhibition of evodiamine on IL-6-induced STAT3 (Tyr(705)) activation indicating the involvement of protein tyrosine phosphatases.	evodiamine	86-96	signal transducer and activator of transcription 3	Homo sapiens	113-118	
23032719-8	2013	Moreover, inhibition of SHP-1 gene by small interference RNA abolished the ability of evodiamine to inhibit IL-6-induced STAT3 (Tyr(705)) activation.	evodiamine	86-96	signal transducer and activator of transcription 3	Homo sapiens	121-126	
23032719-9	2013	Evodiamine also suppressed STAT3 DNA binding activity and down-regulated the expression of STAT3-mediated genes leading to the suppression of proliferation, induction of cell apoptosis and cell cycle arrest.	evodiamine	0-10	signal transducer and activator of transcription 3	Homo sapiens	27-32	
23032719-9	2013	Evodiamine also suppressed STAT3 DNA binding activity and down-regulated the expression of STAT3-mediated genes leading to the suppression of proliferation, induction of cell apoptosis and cell cycle arrest.	evodiamine	0-10	signal transducer and activator of transcription 3	Homo sapiens	91-96	
23032719-11	2013	In summary, evodiamine blocked STAT3 signaling pathway by inducing SHP-1 and exhibited anticancer effect in vitro and in vivo.	evodiamine	12-22	signal transducer and activator of transcription 3	Homo sapiens	31-36