PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32863934-6 2020 The results also revealed that EVO exposure induced the activation of caspase-3, caspase-9 and poly (ADP-ribose) polymerase 1, as well as mitochondrial membrane potential dissipation in a time-dependent manner, indicating that EVO induced intrinsic apoptosis in A-375 cells. evodiamine 31-34 caspase 3 Homo sapiens 70-79 34916690-11 2021 Molecular docking results showed that EVO interacted with apoptosis-associated proteins (caspase-9 and caspase-3) better. evodiamine 38-41 caspase 3 Homo sapiens 103-112 34916690-13 2021 Western blot results indicated that the protein expressions of cleaved caspase-9 and cleaved caspase-3 were upregulated in the HepG2 cell treated with EVO for 48 h. In contrast, the protein expressions of pro-caspase-3, BSEP and MRP2 were downregulated. evodiamine 151-154 caspase 3 Homo sapiens 93-102 34916690-13 2021 Western blot results indicated that the protein expressions of cleaved caspase-9 and cleaved caspase-3 were upregulated in the HepG2 cell treated with EVO for 48 h. In contrast, the protein expressions of pro-caspase-3, BSEP and MRP2 were downregulated. evodiamine 151-154 caspase 3 Homo sapiens 205-218 31920329-7 2019 Evo treatment significantly activated caspase-3 and -9 in MM cells. evodiamine 0-3 caspase 3 Homo sapiens 38-54 31786843-12 2019 Evodiamine-induced apoptosis was also accompanied by upregulation of caspase-3 and Bax and suppression of Bcl-2. evodiamine 0-10 caspase 3 Homo sapiens 69-78 27483435-3 2016 Pharmacological studies using chemical inhibitors of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) indicated that phosphorylation of the c-Jun N-terminal kinase (JNK) protein participated in EVO-induced cell death of A498 cells, and application of the JNK inhibitor, SP600125 (SP), inhibited EVO-induced cleavage of the Casp-3/PARP proteins and chromatin condensation according to Giemsa staining. evodiamine 222-225 caspase 3 Homo sapiens 351-357 29535541-8 2018 Finally, Evo induced apoptosis in cancer cells by suppressing PI3K/AKT signaling and inducing MAPK phosphorylation (p38 and JNK, but not ERK) to regulate apoptotic proteins (Bax, Bcl-2, Cytochrome c, Caspase-3, and PARP). evodiamine 9-12 caspase 3 Homo sapiens 200-209 27485202-4 2016 The results indicated that evodiamine significantly inhibited proliferation, induced apoptosis and the expression of reactive oxygen species, arrested the cell cycle, regulated the expression of Survivin, Bcl-2 and Cyclin B1, regulated the activity of caspase-3/8 and glutathione in tumor cells, and decreased the activity of AKT/nuclear factor-kappaB (NF-kappaB) and Sonic hedgehog/GLI family zinc finger 1 (SHH/GLI1) signaling pathways in A549 cells. evodiamine 27-37 caspase 3 Homo sapiens 252-263 25337567-9 2014 Evodiamine also significantly increased the ratio of Bax/Bcl-2 and decreased procaspase-3, suggesting evodiamine-induced apoptosis via the intrinsic apoptotic pathway. evodiamine 0-10 caspase 3 Homo sapiens 77-89 27468551-10 2016 In addition, evodiamine treatment led to the activation of caspase-8, caspase-9, and caspase-3 and the cleavage of poly (ADP-ribose)-polymerase (PARP). evodiamine 13-23 caspase 3 Homo sapiens 85-94 25903972-3 2015 Our data revealed that evodiamine significantly inhibited the proliferation of human oral cancer cells and resulted in the cleavages of PARP (poly (ADP-ribose) polymerase) and caspase-3, in addition to causing the typical characteristics of apoptosis. evodiamine 23-33 caspase 3 Homo sapiens 176-185 26171032-9 2015 Messenger (m)RNA levels of survivin decreased and those of caspase-3 increase in a dose-dependent manner in SGC7901 cells treated with various concentrations of evodiamine for 24 h. In conclusion, the results of the present study demonstrated that evodiamine inhibited proliferation and induced apoptosis in gastric cancer cells via the downregulation of survivin and upregulation of caspase-3 mRNA. evodiamine 161-171 caspase 3 Homo sapiens 59-68 26171032-9 2015 Messenger (m)RNA levels of survivin decreased and those of caspase-3 increase in a dose-dependent manner in SGC7901 cells treated with various concentrations of evodiamine for 24 h. In conclusion, the results of the present study demonstrated that evodiamine inhibited proliferation and induced apoptosis in gastric cancer cells via the downregulation of survivin and upregulation of caspase-3 mRNA. evodiamine 161-171 caspase 3 Homo sapiens 384-393 26171032-9 2015 Messenger (m)RNA levels of survivin decreased and those of caspase-3 increase in a dose-dependent manner in SGC7901 cells treated with various concentrations of evodiamine for 24 h. In conclusion, the results of the present study demonstrated that evodiamine inhibited proliferation and induced apoptosis in gastric cancer cells via the downregulation of survivin and upregulation of caspase-3 mRNA. evodiamine 248-258 caspase 3 Homo sapiens 59-68 26171032-9 2015 Messenger (m)RNA levels of survivin decreased and those of caspase-3 increase in a dose-dependent manner in SGC7901 cells treated with various concentrations of evodiamine for 24 h. In conclusion, the results of the present study demonstrated that evodiamine inhibited proliferation and induced apoptosis in gastric cancer cells via the downregulation of survivin and upregulation of caspase-3 mRNA. evodiamine 248-258 caspase 3 Homo sapiens 384-393 25652471-6 2015 Besides, evodiamine or MTDH shRNA-induced activation of the caspase-3 in A549 cells under same conditions. evodiamine 9-19 caspase 3 Homo sapiens 60-69 25621054-6 2015 The effect of evodiamine on the protein expression levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3 and survivin were detected by performing western blot analysis. evodiamine 14-24 caspase 3 Homo sapiens 122-131 25621054-8 2015 Western blotting demonstrated that evodiamine downregulated the expression of Bcl-2, caspase-3 and survivin, and upregulated the expression of Bax in human osteosarcoma cells. evodiamine 35-45 caspase 3 Homo sapiens 85-94 25621054-9 2015 Evodiamine effectively inhibited proliferation and induced apoptosis of osteosarcoma cells in a dose-dependent manner via downregulation of Bcl-2, caspase-3 and survivin protein expression levels and upregulation of Bax protein expression levels. evodiamine 0-10 caspase 3 Homo sapiens 147-156 24481835-7 2014 Analysis of the enzymatic activity demonstrated that evodiamine increased the activity of caspase-3, -8 and -9 in SGC-7901 cells. evodiamine 53-63 caspase 3 Homo sapiens 90-110 24481835-8 2014 The protein expression of caspase-3, -8 and -9 and Bax increased, and the expression of Bcl-2 decreased following treatment with evodiamine. evodiamine 129-139 caspase 3 Homo sapiens 26-46 24481835-9 2014 These results suggest that evodiamine is able to inhibit the proliferation of SGC-7901 cells by inhibiting the cell cycle at G2/M phase and inducing apoptosis in SGC-7901 cells by activating caspase-3, -8 and -9, and altering the expression of caspase-3, Bax and Bcl-2. evodiamine 27-37 caspase 3 Homo sapiens 191-211 24481835-9 2014 These results suggest that evodiamine is able to inhibit the proliferation of SGC-7901 cells by inhibiting the cell cycle at G2/M phase and inducing apoptosis in SGC-7901 cells by activating caspase-3, -8 and -9, and altering the expression of caspase-3, Bax and Bcl-2. evodiamine 27-37 caspase 3 Homo sapiens 191-200 25337567-9 2014 Evodiamine also significantly increased the ratio of Bax/Bcl-2 and decreased procaspase-3, suggesting evodiamine-induced apoptosis via the intrinsic apoptotic pathway. evodiamine 102-112 caspase 3 Homo sapiens 77-89 20503248-10 2010 Furthermore, by using the TUNEL assay, evodiamine-induced apoptosis was observed at 48 h and extended to 72 h. Western blotting demonstrated that evodiamine treatment induced the activation of caspase-8, caspase-9, caspase-3, and the cleavage of poly ADP-ribose polymerase (PARP). evodiamine 39-49 caspase 3 Homo sapiens 215-224 20647931-5 2010 Western blot indicated that evodiamine treatment decreased the expression of procaspase-8, procaspase-9, and procaspase-3 in lovo cells, accompanied by the activation of caspase-8, caspase-9, and caspase-3. evodiamine 28-38 caspase 3 Homo sapiens 109-121 20647931-5 2010 Western blot indicated that evodiamine treatment decreased the expression of procaspase-8, procaspase-9, and procaspase-3 in lovo cells, accompanied by the activation of caspase-8, caspase-9, and caspase-3. evodiamine 28-38 caspase 3 Homo sapiens 112-121 20647931-8 2010 In-vivo antineoplastic characteristics of evodiamine were examined in a human colon carcinoma lovo xenograft model and results showed that evodiamine increased the number of TUNEL-positive cells accompanied by the downregulated expression of procaspase-8, procaspase-9, and procaspase-3. evodiamine 139-149 caspase 3 Homo sapiens 274-286 20503248-10 2010 Furthermore, by using the TUNEL assay, evodiamine-induced apoptosis was observed at 48 h and extended to 72 h. Western blotting demonstrated that evodiamine treatment induced the activation of caspase-8, caspase-9, caspase-3, and the cleavage of poly ADP-ribose polymerase (PARP). evodiamine 146-156 caspase 3 Homo sapiens 215-224 15102520-10 2004 Moreover, treatment of CCRF-CEM cells with evodiamine was associated with increased levels of pro-apoptotic protein Bax, activation of caspase-3, and proteolytic cleavage of poly (ADP-ribose) polymerase, an endogenous caspase-3 substrate. evodiamine 43-53 caspase 3 Homo sapiens 135-144 17340628-7 2007 TUNEL examination showed that EVO-induced apoptosis was observed at 72 h. EVO elevated the activities of caspase 3, 8, and 9 in DU145 cells, while in PC3 cells only the activities of caspase 3 and 9 were elevated. evodiamine 30-33 caspase 3 Homo sapiens 105-114 17340628-7 2007 TUNEL examination showed that EVO-induced apoptosis was observed at 72 h. EVO elevated the activities of caspase 3, 8, and 9 in DU145 cells, while in PC3 cells only the activities of caspase 3 and 9 were elevated. evodiamine 30-33 caspase 3 Homo sapiens 183-192 17340628-7 2007 TUNEL examination showed that EVO-induced apoptosis was observed at 72 h. EVO elevated the activities of caspase 3, 8, and 9 in DU145 cells, while in PC3 cells only the activities of caspase 3 and 9 were elevated. evodiamine 74-77 caspase 3 Homo sapiens 105-114 17340628-8 2007 EVO also triggered the processing of caspase 3 and 9 in both DU145 and PC3 cells. evodiamine 0-3 caspase 3 Homo sapiens 37-46 15146552-13 2004 Evodiamine elevated caspase-3, and caspase-9 activities and the processing of caspase-3 and caspase-9. evodiamine 0-10 caspase 3 Homo sapiens 20-29 15146552-13 2004 Evodiamine elevated caspase-3, and caspase-9 activities and the processing of caspase-3 and caspase-9. evodiamine 0-10 caspase 3 Homo sapiens 78-87 15102520-10 2004 Moreover, treatment of CCRF-CEM cells with evodiamine was associated with increased levels of pro-apoptotic protein Bax, activation of caspase-3, and proteolytic cleavage of poly (ADP-ribose) polymerase, an endogenous caspase-3 substrate. evodiamine 43-53 caspase 3 Homo sapiens 218-227 15102520-12 2004 Furthermore, several biological events including the Bcl-2 phosphorylation, Bax up-regulation and increase of caspase-3 activity could explain evodiamine-induced cell apoptosis. evodiamine 143-153 caspase 3 Homo sapiens 110-119 14600398-3 2003 Although caspase-1 and -10 inhibitors failed to block cell death, pan-caspase inhibitor and caspase-3, -8, and -9 inhibitors had marked inhibitory effects on apoptosis induced by 15 microM evodiamine. evodiamine 189-199 caspase 3 Homo sapiens 92-113 14704127-8 2004 Caspase-3 and -8 were activated in apoptosis induced by evodiamine 15 micromol/L. evodiamine 56-66 caspase 3 Homo sapiens 0-16 14704127-11 2004 CONCLUSION: Evodiamine induces caspase-3,8-dependent apoptosis in HeLa cells which is related to G2/M arrest of the cell cycle. evodiamine 12-22 caspase 3 Homo sapiens 31-40 14704127-12 2004 On the other hand, in A375-S2 cells, evodiamine initiates caspase-3,8-mediated apoptosis at early stages and the induction of MAPK-mediated necrosis at later stages of cell culture. evodiamine 37-47 caspase 3 Homo sapiens 58-67 14600398-4 2003 Furthermore, evodiamine-induced activation of caspase-3 resulted in the down-regulation of anti-apoptotic Bcl-2 expression and up-regulation of proapoptotic Bax expression. evodiamine 13-23 caspase 3 Homo sapiens 46-55 12708481-4 2003 Both evodiamine-induced DNA fragmentation and caspase-3 activity were effectively inhibited by a caspase-3 inhibitor, z-DEVD-fmk (z-Asp-Glu-Val-Asp-fmk). evodiamine 5-15 caspase 3 Homo sapiens 46-55 12708481-3 2003 The results showed that evodiamine induced oligonucleosomal fragmentation of DNA in HeLa cells and increased the activity of caspase-3, but not that of caspase-1, in vitro. evodiamine 24-34 caspase 3 Homo sapiens 125-134 12708481-4 2003 Both evodiamine-induced DNA fragmentation and caspase-3 activity were effectively inhibited by a caspase-3 inhibitor, z-DEVD-fmk (z-Asp-Glu-Val-Asp-fmk). evodiamine 5-15 caspase 3 Homo sapiens 97-106 12567888-9 2002 Evodiamine-induced apoptosis is partially dependent on caspase-3 pathway in HeLa cells. evodiamine 0-10 caspase 3 Homo sapiens 55-64 12567888-6 2002 Caspase-3 inhibitor, z-Asp-Glu-Val-Asp-fmk (z-DEVD-fmk) was shown to partially inhibit evodiamine-induced apoptosis. evodiamine 87-97 caspase 3 Homo sapiens 0-9