PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31786843-12 2019 Evodiamine-induced apoptosis was also accompanied by upregulation of caspase-3 and Bax and suppression of Bcl-2. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 83-86 32425601-14 2020 Subsequently, EVO induced cell cycle arrest at the G2/M phase that correlated with reduced levels of cyclin D1 protein, while the apoptotic effects of EVO were associated with the upregulation of Bax and Bad and a decrease in Bcl-2 protein levels. evodiamine 151-154 BCL2 associated X, apoptosis regulator Homo sapiens 196-199 28189683-12 2017 Evodiamine decreased p-Akt levels activated by SC79, which led to the increase of bax/bcl-2 and cleaved-caspase3. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 82-85 31102069-5 2019 In cells treated with both evodiamine and PXD101, compared with PXD101 alone, decrement of cell viability, the percentage of viable cells, and Bcl2 protein levels as well as increment of cytotoxic activity, the percentage of apoptotic cells, the protein levels of gammaH2AX and cleaved PARP, and ROS production were significant, causing decrement of Bcl2/Bax ratio. evodiamine 27-37 BCL2 associated X, apoptosis regulator Homo sapiens 355-358 29535541-8 2018 Finally, Evo induced apoptosis in cancer cells by suppressing PI3K/AKT signaling and inducing MAPK phosphorylation (p38 and JNK, but not ERK) to regulate apoptotic proteins (Bax, Bcl-2, Cytochrome c, Caspase-3, and PARP). evodiamine 9-12 BCL2 associated X, apoptosis regulator Homo sapiens 174-177 25652471-7 2015 In addition, Western blotting analysis showed that treatment of A549 cells with evodiamine or MTDH shRNA resulted in an increase of proapoptotic protein Bax expression but decreased the expression levels of antiapoptotic protein Bcl-2 and MTDH, which altogether account for apoptotic cell death. evodiamine 80-90 BCL2 associated X, apoptosis regulator Homo sapiens 153-156 27468551-9 2016 Evodiamine induced G2/M arrest with an increase of cyclin B1 level, and promoted cell apoptosis with a decrease of B cell lymphoma/lewkmia-2 (Bcl-2) and an increase of Bcl-2-associated X protein (Bax) level. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 196-199 27402273-7 2016 Further, evodiamine increased (4-fold) mitochondrial membrane depolarization with 6-fold increase in apoptosis and a slight increase in Bax/Bcl-2 ratio. evodiamine 9-19 BCL2 associated X, apoptosis regulator Homo sapiens 136-139 27468551-9 2016 Evodiamine induced G2/M arrest with an increase of cyclin B1 level, and promoted cell apoptosis with a decrease of B cell lymphoma/lewkmia-2 (Bcl-2) and an increase of Bcl-2-associated X protein (Bax) level. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 168-194 25903972-4 2015 Evodiamine also increased Bax protein levels and caused translocation of Bax into mitochondria and Bax oligomerization. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 26-29 25903972-4 2015 Evodiamine also increased Bax protein levels and caused translocation of Bax into mitochondria and Bax oligomerization. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 73-76 25903972-4 2015 Evodiamine also increased Bax protein levels and caused translocation of Bax into mitochondria and Bax oligomerization. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 73-76 25337567-9 2014 Evodiamine also significantly increased the ratio of Bax/Bcl-2 and decreased procaspase-3, suggesting evodiamine-induced apoptosis via the intrinsic apoptotic pathway. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 53-56 25621054-6 2015 The effect of evodiamine on the protein expression levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3 and survivin were detected by performing western blot analysis. evodiamine 14-24 BCL2 associated X, apoptosis regulator Homo sapiens 88-114 25621054-6 2015 The effect of evodiamine on the protein expression levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3 and survivin were detected by performing western blot analysis. evodiamine 14-24 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 25621054-8 2015 Western blotting demonstrated that evodiamine downregulated the expression of Bcl-2, caspase-3 and survivin, and upregulated the expression of Bax in human osteosarcoma cells. evodiamine 35-45 BCL2 associated X, apoptosis regulator Homo sapiens 143-146 25621054-9 2015 Evodiamine effectively inhibited proliferation and induced apoptosis of osteosarcoma cells in a dose-dependent manner via downregulation of Bcl-2, caspase-3 and survivin protein expression levels and upregulation of Bax protein expression levels. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 216-219 25506932-7 2014 EVO induced cell cycle arrest at G2/M phase, induced apoptosis by up-regulating the expression of caspase-12 and cytochrome C protein, and induced the expression of Bax mRNA and by down-regulating of the expression of Bcl-2 mRNA in both H446 and H1688 cells. evodiamine 0-3 BCL2 associated X, apoptosis regulator Homo sapiens 165-168 24481835-8 2014 The protein expression of caspase-3, -8 and -9 and Bax increased, and the expression of Bcl-2 decreased following treatment with evodiamine. evodiamine 129-139 BCL2 associated X, apoptosis regulator Homo sapiens 51-54 24481835-9 2014 These results suggest that evodiamine is able to inhibit the proliferation of SGC-7901 cells by inhibiting the cell cycle at G2/M phase and inducing apoptosis in SGC-7901 cells by activating caspase-3, -8 and -9, and altering the expression of caspase-3, Bax and Bcl-2. evodiamine 27-37 BCL2 associated X, apoptosis regulator Homo sapiens 255-258 23840656-6 2013 Evodiamine inhibited the proliferation of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner with concentration of 1x10(-6) and 1x10(-5) M. Evodiamine also induced apoptosis via up-regulation of caspase 7 activation, PARP cleavage (Bik and Bax expression). evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 252-255 23708383-5 2013 Evodiamine-induced G0/G1 arrest and apoptosis were associated with a decrease in Bcl-2, cyclin D1 and cyclin-dependent kinase 6 (CDK6) expression and an increase in Bax and p27Kip1 expression. evodiamine 0-10 BCL2 associated X, apoptosis regulator Homo sapiens 165-168 23840656-6 2013 Evodiamine inhibited the proliferation of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner with concentration of 1x10(-6) and 1x10(-5) M. Evodiamine also induced apoptosis via up-regulation of caspase 7 activation, PARP cleavage (Bik and Bax expression). evodiamine 152-162 BCL2 associated X, apoptosis regulator Homo sapiens 252-255 15821341-5 2005 The inhibition of the PI3-K/PKC survival pathway might be responsible for SIRT1 inactivation and increased Bax/Bcl-2 expression ratio in evodiamine-induced cell death. evodiamine 137-147 BCL2 associated X, apoptosis regulator Homo sapiens 107-110 18484413-2 2008 This study reported that reactive oxygen species (ROS) and nitric oxide (NO) generations were induced by evodiamine time-dependently; while they acted in synergy to trigger mitochondria-dependent apoptosis by induction of mitochondrial membrane permeabilization (MMP) through increasing the Bax/Bcl-2 or Bcl-x(L) ratio. evodiamine 105-115 BCL2 associated X, apoptosis regulator Homo sapiens 291-294 22367117-13 2012 Additionally, Beclin-1 is involved in evodiamine-induced autophagy and the pro-apoptotic mechanisms of evodiamine may be associated with down-regulation of Bcl-2 and up-regulation of Bax expression. evodiamine 115-125 BCL2 associated X, apoptosis regulator Homo sapiens 207-210 15930731-1 2005 We have reported that caspase cascade accompanied by the regulation of Bax/Bcl-2 and MAPK signaling were involved in evodiamine-induced A375-S2 cell death. evodiamine 117-127 BCL2 associated X, apoptosis regulator Homo sapiens 71-74 15930731-4 2005 Subsequently, IL-1Ra reduced evodiamine-induced DNA degradation, p53 activation and up-regulation of Bax/Bcl-2 ratio. evodiamine 29-39 BCL2 associated X, apoptosis regulator Homo sapiens 101-104 14600398-4 2003 Furthermore, evodiamine-induced activation of caspase-3 resulted in the down-regulation of anti-apoptotic Bcl-2 expression and up-regulation of proapoptotic Bax expression. evodiamine 13-23 BCL2 associated X, apoptosis regulator Homo sapiens 157-160 15102520-10 2004 Moreover, treatment of CCRF-CEM cells with evodiamine was associated with increased levels of pro-apoptotic protein Bax, activation of caspase-3, and proteolytic cleavage of poly (ADP-ribose) polymerase, an endogenous caspase-3 substrate. evodiamine 43-53 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 15102520-12 2004 Furthermore, several biological events including the Bcl-2 phosphorylation, Bax up-regulation and increase of caspase-3 activity could explain evodiamine-induced cell apoptosis. evodiamine 143-153 BCL2 associated X, apoptosis regulator Homo sapiens 76-79 14600398-7 2003 Consequently, evodiamine induced the caspase- and Bax-mediated apoptosis at an early stage, but, initiated MAPKs-dependent necrosis at a later stage. evodiamine 14-24 BCL2 associated X, apoptosis regulator Homo sapiens 50-53 12708481-5 2003 In addition, evodiamine increased the expression of the apoptosis inducer Bax, but decreased the expression of the apoptosis suppressor Bcl-2 in mitochondria. evodiamine 13-23 BCL2 associated X, apoptosis regulator Homo sapiens 74-77 12708481-6 2003 Taken together, our data indicated that evodiamine alters the balance of Bcl-2 and Bax gene expression and induces apoptosis through the caspase pathway in HeLa cells. evodiamine 40-50 BCL2 associated X, apoptosis regulator Homo sapiens 83-86