PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27468551-10	2016	In addition, evodiamine treatment led to the activation of caspase-8, caspase-9, and caspase-3 and the cleavage of poly (ADP-ribose)-polymerase (PARP).	evodiamine	13-23	caspase 8	Homo sapiens	59-68	
25333675-9	2015	Further investigation of the mechanism underlying these effects revealed that the evodiamine + TRAIL effect is associated with the increased expression of death receptor (DR)4, DR5, caspase-8 and cleaved caspase-3.	evodiamine	82-92	caspase 8	Homo sapiens	182-191	
20647931-5	2010	Western blot indicated that evodiamine treatment decreased the expression of procaspase-8, procaspase-9, and procaspase-3 in lovo cells, accompanied by the activation of caspase-8, caspase-9, and caspase-3.	evodiamine	28-38	caspase 8	Homo sapiens	80-89	
20503248-10	2010	Furthermore, by using the TUNEL assay, evodiamine-induced apoptosis was observed at 48 h and extended to 72 h. Western blotting demonstrated that evodiamine treatment induced the activation of caspase-8, caspase-9, caspase-3, and the cleavage of poly ADP-ribose polymerase (PARP).	evodiamine	39-49	caspase 8	Homo sapiens	193-202	
20503248-10	2010	Furthermore, by using the TUNEL assay, evodiamine-induced apoptosis was observed at 48 h and extended to 72 h. Western blotting demonstrated that evodiamine treatment induced the activation of caspase-8, caspase-9, caspase-3, and the cleavage of poly ADP-ribose polymerase (PARP).	evodiamine	146-156	caspase 8	Homo sapiens	193-202	
20503248-11	2010	These results suggested that evodiamine inhibited the growth of the ARO cells, arrested them at M phase, and induced apoptosis through caspases signaling.	evodiamine	29-39	caspase 8	Homo sapiens	135-143