PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24655440-0 2014 Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo. garcinol 52-60 signal transducer and activator of transcription 3 Homo sapiens 14-19 33019761-2 2020 Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. garcinol 96-104 signal transducer and activator of transcription 3 Homo sapiens 108-116 30001777-7 2018 Treatment with garcinol also decreased Stat3 and Akt activation in GBC-SD cells. garcinol 15-23 signal transducer and activator of transcription 3 Homo sapiens 39-44 30001777-8 2018 Taken together, the effects of garcinol on GBC-SD cells may be associated with the suppression of Stat3 and Akt signaling pathways, which may contribute to inhibiting their downstream targets such as mRNA levels of MMP2 and MMP9. garcinol 31-39 signal transducer and activator of transcription 3 Homo sapiens 98-103 31783691-0 2019 Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. garcinol 96-104 signal transducer and activator of transcription 3 Homo sapiens 108-113 31783691-10 2019 Garcinol-mediated anti-GBM effects were associated with an increased hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratio. garcinol 0-8 signal transducer and activator of transcription 3 Homo sapiens 82-87 31783691-12 2019 CONCLUSIONS: We present evidence of anti-GBM efficacy of garcinol mediated by enhancing the hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratios in GBM cells. garcinol 57-65 signal transducer and activator of transcription 3 Homo sapiens 105-110 29414668-0 2018 Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/beta-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas. garcinol 0-8 signal transducer and activator of transcription 3 Homo sapiens 90-95 29414668-9 2018 Mechanistically, garcinol impaired phosphorylation of LRP6, a co-receptor of Wnt and STAT3. garcinol 17-25 signal transducer and activator of transcription 3 Homo sapiens 85-90 29414668-12 2018 Taken together, we demonstrated herein that garcinol modulates the LCSC phenotype via regulation of Wnt/beta-catenin signaling and inactivation of STAT3, thus showing that garcinol may be a putative novel anti-LCSC therapeutic agent. garcinol 44-52 signal transducer and activator of transcription 3 Homo sapiens 147-152 29414668-12 2018 Taken together, we demonstrated herein that garcinol modulates the LCSC phenotype via regulation of Wnt/beta-catenin signaling and inactivation of STAT3, thus showing that garcinol may be a putative novel anti-LCSC therapeutic agent. garcinol 172-180 signal transducer and activator of transcription 3 Homo sapiens 147-152 24655440-6 2014 RESULTS: Garcinol could inhibit both constitutive and interleukin (IL-6) inducible STAT3 activation in HCC cells. garcinol 9-17 signal transducer and activator of transcription 3 Homo sapiens 83-88 24655440-7 2014 Computational modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppress its dimerization in vitro. garcinol 35-43 signal transducer and activator of transcription 3 Homo sapiens 76-81 24655440-8 2014 Being an acetyltransferase inhibitor, garcinol also inhibits STAT3 acetylation and thus impairs its DNA binding ability. garcinol 38-46 signal transducer and activator of transcription 3 Homo sapiens 61-66 24655440-9 2014 The inhibition of STAT3 activation by garcinol led to the suppression of expression of various genes involved in proliferation, survival, and angiogenesis. garcinol 38-46 signal transducer and activator of transcription 3 Homo sapiens 18-23 24655440-12 2014 CONCLUSION: Overall, our results suggest that garcinol exerts its anti-proliferative and pro-apoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo. garcinol 46-54 signal transducer and activator of transcription 3 Homo sapiens 134-139