PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24655440-0	2014	Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.	garcinol	52-60	signal transducer and activator of transcription 3	Homo sapiens	14-19	
33019761-2	2020	Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma.	garcinol	96-104	signal transducer and activator of transcription 3	Homo sapiens	108-116	
30001777-7	2018	Treatment with garcinol also decreased Stat3 and Akt activation in GBC-SD cells.	garcinol	15-23	signal transducer and activator of transcription 3	Homo sapiens	39-44	
30001777-8	2018	Taken together, the effects of garcinol on GBC-SD cells may be associated with the suppression of Stat3 and Akt signaling pathways, which may contribute to inhibiting their downstream targets such as mRNA levels of MMP2 and MMP9.	garcinol	31-39	signal transducer and activator of transcription 3	Homo sapiens	98-103	
31783691-0	2019	Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma.	garcinol	96-104	signal transducer and activator of transcription 3	Homo sapiens	108-113	
31783691-10	2019	Garcinol-mediated anti-GBM effects were associated with an increased hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratio.	garcinol	0-8	signal transducer and activator of transcription 3	Homo sapiens	82-87	
31783691-12	2019	CONCLUSIONS: We present evidence of anti-GBM efficacy of garcinol mediated by enhancing the hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratios in GBM cells.	garcinol	57-65	signal transducer and activator of transcription 3	Homo sapiens	105-110	
29414668-0	2018	Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/beta-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas.	garcinol	0-8	signal transducer and activator of transcription 3	Homo sapiens	90-95	
29414668-9	2018	Mechanistically, garcinol impaired phosphorylation of LRP6, a co-receptor of Wnt and STAT3.	garcinol	17-25	signal transducer and activator of transcription 3	Homo sapiens	85-90	
29414668-12	2018	Taken together, we demonstrated herein that garcinol modulates the LCSC phenotype via regulation of Wnt/beta-catenin signaling and inactivation of STAT3, thus showing that garcinol may be a putative novel anti-LCSC therapeutic agent.	garcinol	44-52	signal transducer and activator of transcription 3	Homo sapiens	147-152	
29414668-12	2018	Taken together, we demonstrated herein that garcinol modulates the LCSC phenotype via regulation of Wnt/beta-catenin signaling and inactivation of STAT3, thus showing that garcinol may be a putative novel anti-LCSC therapeutic agent.	garcinol	172-180	signal transducer and activator of transcription 3	Homo sapiens	147-152	
24655440-6	2014	RESULTS: Garcinol could inhibit both constitutive and interleukin (IL-6) inducible STAT3 activation in HCC cells.	garcinol	9-17	signal transducer and activator of transcription 3	Homo sapiens	83-88	
24655440-7	2014	Computational modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppress its dimerization in vitro.	garcinol	35-43	signal transducer and activator of transcription 3	Homo sapiens	76-81	
24655440-8	2014	Being an acetyltransferase inhibitor, garcinol also inhibits STAT3 acetylation and thus impairs its DNA binding ability.	garcinol	38-46	signal transducer and activator of transcription 3	Homo sapiens	61-66	
24655440-9	2014	The inhibition of STAT3 activation by garcinol led to the suppression of expression of various genes involved in proliferation, survival, and angiogenesis.	garcinol	38-46	signal transducer and activator of transcription 3	Homo sapiens	18-23	
24655440-12	2014	CONCLUSION: Overall, our results suggest that garcinol exerts its anti-proliferative and pro-apoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo.	garcinol	46-54	signal transducer and activator of transcription 3	Homo sapiens	134-139