PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11312881-5	2001	Treatment with garcinol caused induction of caspase-3/CPP32 activity in a dose- and time-dependent manner, but not caspase-1 activity, and induced the degradation of poly(ADP-ribose) polymerase (PARP).	garcinol	15-23	caspase 3	Homo sapiens	44-53	
11312881-5	2001	Treatment with garcinol caused induction of caspase-3/CPP32 activity in a dose- and time-dependent manner, but not caspase-1 activity, and induced the degradation of poly(ADP-ribose) polymerase (PARP).	garcinol	15-23	caspase 3	Homo sapiens	54-59	
11312881-6	2001	Pretreatment with caspase-3 inhibitor inhibited garcinol-induced DNA fragmentation.	garcinol	48-56	caspase 3	Homo sapiens	18-27	
11312881-12	2001	It is suggested that garcinol-induced apoptosis is triggered by the release of cytochrome c into the cytosol, procaspase-9 processing, activation of caspase-3 and caspase-2, degradation of PARP, and DNA fragmentation caused by the caspase-activated deoxyribonuclease through the digestion of DFF-45.	garcinol	21-29	caspase 3	Homo sapiens	149-158	
21462088-6	2011	The molecular mechanism of garcinol"s action on PaCa cells was investigated by targeting signaling moieties involved in apoptosis (X-IAP, cIAP, caspase-3, 9, and PARP cleavage), transcription factor NF-kappaB, believed to contribute toward a chemoresistance phenotype in pancreatic tumors, and molecules associated with neovascularization and metastasis (MMP-9, VEGF, IL-8, and PGE(2)).	garcinol	27-35	caspase 3	Homo sapiens	144-153	
32489337-8	2020	The garcinol-induced apoptosis was further confirmed by the detection of cleavage forms of PARP and caspase 3.	garcinol	4-12	caspase 3	Homo sapiens	100-109	
27481098-7	2017	The proportion of cells in sub-G1 phase and caspase 3 activity were increased by garcinol treatment whereas the cell proliferation, PGE2 level, and cell migration were decreased in these cells, compared to the control group.	garcinol	81-89	caspase 3	Homo sapiens	44-53	
17382202-7	2007	Induction of apoptosis by garcinol and cambogin (2-10 microM) was also observed based on caspase-3 activation and enhanced annexin V staining.	garcinol	26-34	caspase 3	Homo sapiens	89-98	
17382202-7	2007	Induction of apoptosis by garcinol and cambogin (2-10 microM) was also observed based on caspase-3 activation and enhanced annexin V staining.	garcinol	39-47	caspase 3	Homo sapiens	89-98